//Created by libAntimony v2.4 model aguda_tang_1999__environment(time_) // Variable initializations: time_ = ; end model aguda_tang_1999__rate_constants(k1, k1_, k1__, kn1, k2, kn2, k3, k3_, kn4, k5, kn6, k8, k9, k10, k17, k18, k19, k20, k21, k22, k24, k25, k25_, k26, k26_, k28, k29) // Variable initializations: k1 = 0.1; k1_ = 0.5; k1__ = 0.5; kn1 = 0.001; k2 = 0.1; kn2 = 1; k3 = 1.42; k3_ = 0; kn4 = 0.016; k5 = 0.02; kn6 = 5; k8 = 2; k9 = 2; k10 = 0.035; k17 = 3.5; k18 = 0.0001; k19 = 0.05; k20 = 0.01; k21 = 0.1; k22 = 0.001; k24 = 0.1; k25 = 0.01; k25_ = 0.02; k26 = 0.01; k26_ = 0.1; k28 = 0.01; k29 = 0.001; end model aguda_tang_1999__a_CyclinE_Cdk2(a_CyclinE_Cdk2, V_2, V_10, V_n2, V_9, V_21, time_) // Rate Rules: a_CyclinE_Cdk2' = (V_2 + V_10) - (V_n2 + V_9 + V_21); // Variable initializations: a_CyclinE_Cdk2 = 0; V_2 = ; V_10 = ; V_n2 = ; V_9 = ; V_21 = ; time_ = ; end model aguda_tang_1999__i_CyclinE_Cdk2(i_CyclinE_Cdk2, V_3, V_2, V_n2, V_5, time_) // Rate Rules: i_CyclinE_Cdk2' = (V_3 + V_n2) - (V_2 + V_5); // Variable initializations: i_CyclinE_Cdk2 = 0.01; V_3 = ; V_2 = ; V_n2 = ; V_5 = ; time_ = ; end model aguda_tang_1999__pRB_E2F(pRB_E2F, V_n1, V_1, time_) // Rate Rules: pRB_E2F' = V_n1 - V_1; // Variable initializations: pRB_E2F = 1.95; V_n1 = ; V_1 = ; time_ = ; end model aguda_tang_1999__E2F(E2F, V_1, V_18, V_n1, V_n4, time_) // Rate Rules: E2F' = (V_1 + V_4 + V_18) - (V_n1 + V_n4); // Variable initializations: E2F = 0; V_1 = ; V_4 = 0.000001; V_18 = ; V_n1 = ; V_n4 = ; time_ = ; end model aguda_tang_1999__pRB(pRB, V_26, V_29, V_n1, V_28, time_) // Rate Rules: pRB' = (V_27 + V_26 + V_29) - (V_n1 + V_28); // Variable initializations: pRB = 0.05; V_27 = 0.01; V_26 = ; V_29 = ; V_n1 = ; V_28 = ; time_ = ; end model aguda_tang_1999__CycD_Cdk4(CycD_Cdk4, V_20, V_n6, V_19, V_17, time_) // Rate Rules: CycD_Cdk4' = (V_6 + V_20) - (V_n6 + V_19 + V_17); // Variable initializations: CycD_Cdk4 = 0; V_6 = 0.018; V_20 = ; V_n6 = ; V_19 = ; V_17 = ; time_ = ; end model aguda_tang_1999__p27(p27, V_10, V_20, V_8, V_9, V_19, V_22, time_) // Rate Rules: p27' = (V_7 + V_10 + V_20) - (V_8 + V_9 + V_19 + V_22); // Variable initializations: p27 = 5; V_7 = 0.0001; V_10 = ; V_20 = ; V_8 = ; V_9 = ; V_19 = ; V_22 = ; time_ = ; end model aguda_tang_1999__CycE_Cdk2_p27(CycE_Cdk2_p27, V_9, V_10, time_) // Rate Rules: CycE_Cdk2_p27' = V_9 - V_10; // Variable initializations: CycE_Cdk2_p27 = 1; V_9 = ; V_10 = ; time_ = ; end model aguda_tang_1999__CycD_Cdk4_p27(CycD_Cdk4_p27, V_19, V_20, time_) // Rate Rules: CycD_Cdk4_p27' = V_19 - V_20; // Variable initializations: CycD_Cdk4_p27 = 0; V_19 = ; V_20 = ; time_ = ; end model aguda_tang_1999__p16(p16, V_25, V_17, V_24, time_) // Rate Rules: p16' = (V_23 + V_25) - (V_17 + V_24); // Variable initializations: p16 = 5; V_23 = 0.2; V_25 = ; V_17 = ; V_24 = ; time_ = ; end model aguda_tang_1999__pRB_P(pRB_P, V_1, V_29, time_) // Rate Rules: pRB_P' = V_1 - V_29; // Variable initializations: pRB_P = 0.01; V_1 = ; V_29 = ; time_ = ; end model aguda_tang_1999__V_1(V_1, k1, k1_, k1__, CycD_Cdk4, CycD_Cdk4_p27, a_CyclinE_Cdk2, pRB_E2F) // Assignment Rules: V_1 := k1_ * CycD_Cdk4 * pRB_E2F + k1__ * CycD_Cdk4_p27 * pRB_E2F + k1 * a_CyclinE_Cdk2 * pRB_E2F; // Variable initializations: k1 = ; k1_ = ; k1__ = ; CycD_Cdk4 = ; CycD_Cdk4_p27 = ; a_CyclinE_Cdk2 = ; pRB_E2F = ; end model aguda_tang_1999__V_n1(V_n1, kn1) // Assignment Rules: V_n1 := kn1; // Variable initializations: kn1 = ; end model aguda_tang_1999__V_2(V_2, k2, a_CyclinE_Cdk2, i_CyclinE_Cdk2) // Assignment Rules: V_2 := k2 * a_CyclinE_Cdk2 * i_CyclinE_Cdk2; // Variable initializations: k2 = ; a_CyclinE_Cdk2 = ; i_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_n2(V_n2, kn2, a_CyclinE_Cdk2) // Assignment Rules: V_n2 := kn2 * a_CyclinE_Cdk2; // Variable initializations: kn2 = ; a_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_3(V_3, k3, k3_, E2F) // Assignment Rules: V_3 := k3 * E2F + k3_; // Variable initializations: k3 = ; k3_ = ; E2F = ; end model aguda_tang_1999__V_n4(V_n4, kn4, E2F) // Assignment Rules: V_n4 := kn4 * E2F; // Variable initializations: kn4 = ; E2F = ; end model aguda_tang_1999__V_5(V_5, k5, i_CyclinE_Cdk2) // Assignment Rules: V_5 := k5 * i_CyclinE_Cdk2; // Variable initializations: k5 = ; i_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_n6(V_n6, kn6, CycD_Cdk4) // Assignment Rules: V_n6 := kn6 * CycD_Cdk4; // Variable initializations: kn6 = ; CycD_Cdk4 = ; end model aguda_tang_1999__V_8(V_8, k8, p27, a_CyclinE_Cdk2) // Assignment Rules: V_8 := k8 * p27 * a_CyclinE_Cdk2; // Variable initializations: k8 = ; p27 = ; a_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_9(V_9, k9, p27, a_CyclinE_Cdk2) // Assignment Rules: V_9 := k9 * p27 * a_CyclinE_Cdk2; // Variable initializations: k9 = ; p27 = ; a_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_10(V_10, k10, CycE_Cdk2_p27) // Assignment Rules: V_10 := k10 * CycE_Cdk2_p27; // Variable initializations: k10 = ; CycE_Cdk2_p27 = ; end model aguda_tang_1999__V_17(V_17, k17, p16, CycD_Cdk4) // Assignment Rules: V_17 := k17 * p16 * CycD_Cdk4; // Variable initializations: k17 = ; p16 = ; CycD_Cdk4 = ; end model aguda_tang_1999__V_18(V_18, k18, E2F) // Assignment Rules: V_18 := k18 * E2F; // Variable initializations: k18 = ; E2F = ; end model aguda_tang_1999__V_19(V_19, k19, CycD_Cdk4, p27) // Assignment Rules: V_19 := k19 * p27 * CycD_Cdk4; // Variable initializations: k19 = ; CycD_Cdk4 = ; p27 = ; end model aguda_tang_1999__V_20(V_20, k20, CycD_Cdk4_p27) // Assignment Rules: V_20 := k20 * CycD_Cdk4_p27; // Variable initializations: k20 = ; CycD_Cdk4_p27 = ; end model aguda_tang_1999__V_21(V_21, k21, a_CyclinE_Cdk2) // Assignment Rules: V_21 := k21 * power(a_CyclinE_Cdk2, 2); // Variable initializations: k21 = ; a_CyclinE_Cdk2 = ; end model aguda_tang_1999__V_22(V_22, k22, p27) // Assignment Rules: V_22 := k22 * p27; // Variable initializations: k22 = ; p27 = ; end model aguda_tang_1999__V_24(V_24, k24, p16) // Assignment Rules: V_24 := k24 * p16; // Variable initializations: k24 = ; p16 = ; end model aguda_tang_1999__V_25(V_25, k25, k25_, pRB) // Assignment Rules: V_25 := k25 / ((1 + k25_ * pRB) * 1); // Variable initializations: k25 = ; k25_ = ; pRB = ; end model aguda_tang_1999__V_26(V_26, k26, k26_, p16) // Assignment Rules: V_26 := k26 / ((1 + k26_ * p16) * 1); // Variable initializations: k26 = ; k26_ = ; p16 = ; end model aguda_tang_1999__V_28(V_28, k28, pRB) // Assignment Rules: V_28 := k28 * pRB; // Variable initializations: k28 = ; pRB = ; end model aguda_tang_1999__V_29(V_29, k29, pRB_P) // Assignment Rules: V_29 := k29 * pRB_P; // Variable initializations: k29 = ; pRB_P = ; end model *aguda_tang_1999____main() // Sub-modules, and any changes to those submodules: environment: aguda_tang_1999__environment(time_); rate_constants: aguda_tang_1999__rate_constants(k1, k1_, k1__, kn1, k2, kn2, k3, k3_, kn4, k5, kn6, k8, k9, k10, k17, k18, k19, k20, k21, k22, k24, k25, k25_, k26, k26_, k28, k29); a_CyclinE_Cdk2: aguda_tang_1999__a_CyclinE_Cdk2(a_CyclinE_Cdk20, V_23, V_100, V_n20, V_90, V_210, time_); i_CyclinE_Cdk2: aguda_tang_1999__i_CyclinE_Cdk2(i_CyclinE_Cdk20, V_30, V_23, V_n20, V_50, time_); pRB_E2F: aguda_tang_1999__pRB_E2F(pRB_E2F0, V_n10, V_11, time_); E2F: aguda_tang_1999__E2F(E2F0, V_11, V_180, V_n10, V_n40, time_); pRB: aguda_tang_1999__pRB(pRB0, V_260, V_290, V_n10, V_280, time_); CycD_Cdk4: aguda_tang_1999__CycD_Cdk4(CycD_Cdk40, V_200, V_n60, V_190, V_170, time_); p27: aguda_tang_1999__p27(p270, V_100, V_200, V_80, V_90, V_190, V_220, time_); CycE_Cdk2_p27: aguda_tang_1999__CycE_Cdk2_p27(CycE_Cdk2_p270, V_90, V_100, time_); CycD_Cdk4_p27: aguda_tang_1999__CycD_Cdk4_p27(CycD_Cdk4_p270, V_190, V_200, time_); p16: aguda_tang_1999__p16(p160, V_250, V_170, V_240, time_); pRB_P: aguda_tang_1999__pRB_P(pRB_P0, V_11, V_290, time_); V_1: aguda_tang_1999__V_1(V_11, k1, k1_, k1__, CycD_Cdk40, CycD_Cdk4_p270, a_CyclinE_Cdk20, pRB_E2F0); V_n1: aguda_tang_1999__V_n1(V_n10, kn1); V_2: aguda_tang_1999__V_2(V_23, k2, a_CyclinE_Cdk20, i_CyclinE_Cdk20); V_n2: aguda_tang_1999__V_n2(V_n20, kn2, a_CyclinE_Cdk20); V_3: aguda_tang_1999__V_3(V_30, k3, k3_, E2F0); V_n4: aguda_tang_1999__V_n4(V_n40, kn4, E2F0); V_5: aguda_tang_1999__V_5(V_50, k5, i_CyclinE_Cdk20); V_n6: aguda_tang_1999__V_n6(V_n60, kn6, CycD_Cdk40); V_8: aguda_tang_1999__V_8(V_80, k8, p270, a_CyclinE_Cdk20); V_9: aguda_tang_1999__V_9(V_90, k9, p270, a_CyclinE_Cdk20); V_10: aguda_tang_1999__V_10(V_100, k10, CycE_Cdk2_p270); V_17: aguda_tang_1999__V_17(V_170, k17, p160, CycD_Cdk40); V_18: aguda_tang_1999__V_18(V_180, k18, E2F0); V_19: aguda_tang_1999__V_19(V_190, k19, CycD_Cdk40, p270); V_20: aguda_tang_1999__V_20(V_200, k20, CycD_Cdk4_p270); V_21: aguda_tang_1999__V_21(V_210, k21, a_CyclinE_Cdk20); V_22: aguda_tang_1999__V_22(V_220, k22, p270); V_24: aguda_tang_1999__V_24(V_240, k24, p160); V_25: aguda_tang_1999__V_25(V_250, k25, k25_, pRB0); V_26: aguda_tang_1999__V_26(V_260, k26, k26_, p160); V_28: aguda_tang_1999__V_28(V_280, k28, pRB0); V_29: aguda_tang_1999__V_29(V_290, k29, pRB_P0); end