// Created by libAntimony v2.8.0 function J3Sub(K, X1, G1, X2, G2, X3, G3) K*X1^G1*X2^G2*X3^G3; end function J1Sub(K, X, G) K*X^G; end function J2Sub(K, X1, G1, X2, G2) K*X1^G1*X2^G2; end function J1Sub3Mod(K, X1, G1, X2, G2, X3, G3, X4, G4) K*X1^G1*X2^G2*X3^G3*X4^G4; end function J2Sub1Mod(K, X1, G1, X2, G2, X3, G3) K*X1^G1*X2^G2*X3^G3; end function J1Sub1Mod(K, X1, G1, X2, G2) K*X1^G1*X2^G2; end function J3Sub1Mod(K, X1, G1, X2, G2, X3, G3, X4, G4) K*X1^G1*X2^G2*X3^G3*X4^G4; end model *MODEL1504130001() // Compartments and Species: compartment Neuronal_cytosol, Vesicle, Autophagosome, Proteasome, Lysosome; species Protofibril in Neuronal_cytosol, Fibril in Neuronal_cytosol, Lewy_body in Neuronal_cytosol; species Dopamine in Neuronal_cytosol, OH in Neuronal_cytosol, OH_radical in Neuronal_cytosol; species H2O2 in Neuronal_cytosol, DA_quinone in Neuronal_cytosol, Ubiquitin in Neuronal_cytosol; species E1 in Neuronal_cytosol, Ub_E1 in Neuronal_cytosol, UbcH8 in Neuronal_cytosol; species UbcH8_Ub in Neuronal_cytosol, Parkin in Neuronal_cytosol, Parkin_sub in Neuronal_cytosol; species Parkin_synphilin_1 in Neuronal_cytosol, Parkin_synphilin_1_ub in Neuronal_cytosol; species Parkin_sub_ub4 in Neuronal_cytosol, Fragments in Neuronal_cytosol; species UCH_L1 in Neuronal_cytosol, L_Dopa in Neuronal_cytosol, DOPAL in Neuronal_cytosol; species DOPAC in Neuronal_cytosol, GSH in Neuronal_cytosol, GSSG in Neuronal_cytosol; species $Fe2 in Neuronal_cytosol, Fe3 in Neuronal_cytosol, UbcH8ub2 in Neuronal_cytosol; species UbcH8ub3 in Neuronal_cytosol, UbcH8ub4 in Neuronal_cytosol, UbcH13_Uev1a in Neuronal_cytosol; species UbcH13_Uev1a_ub in Neuronal_cytosol, asyn_UCH_L1 in Neuronal_cytosol; species asyn_ub in Neuronal_cytosol, Protofibril_UCH_L1 in Neuronal_cytosol; species Protofibril_Ub in Neuronal_cytosol, UCH_L1_asyn_ub4 in Neuronal_cytosol; species Hsc70_asyn in Neuronal_cytosol, Hsc70_Protofibril in Neuronal_cytosol; species Hsc70_fibril in Neuronal_cytosol, Hsc70 in Neuronal_cytosol, DA_S_parkin in Neuronal_cytosol; species O2 in Neuronal_cytosol, DA_GSH in Neuronal_cytosol, Neuromelanin in Neuronal_cytosol; species Neuromelanin_ntox_Fe3 in Neuronal_cytosol, $Alpha_synuclein in Neuronal_cytosol; species $ATP in Neuronal_cytosol, $Synphilin_1 in Neuronal_cytosol, $Substrate in Neuronal_cytosol; species $TH in Neuronal_cytosol, $L_Tyr in Neuronal_cytosol, $CO2 in Neuronal_cytosol; species $Neurotoxins in Neuronal_cytosol, $Bioamines in Neuronal_cytosol; species $VMAT2 in Neuronal_cytosol, $O2_0 in Neuronal_cytosol, $MAO in Neuronal_cytosol; species $NH3 in Neuronal_cytosol, $ALDH in Neuronal_cytosol, $NAD in Neuronal_cytosol; species $NADH in Neuronal_cytosol, $Catalase in Neuronal_cytosol, $H2O in Neuronal_cytosol; species $Gluta_per in Neuronal_cytosol, $Gluta_red in Neuronal_cytosol; species $DDC in Neuronal_cytosol, $Preautophagosome_membrane in Neuronal_cytosol; species $SOD in Neuronal_cytosol, $Cysteine in Neuronal_cytosol, V_DA in Vesicle; species V_ntox_ba in Vesicle, $Vesicle_0 in Vesicle, Autophagosome_0 in Autophagosome; species $Proteasome_0 in Proteasome, $Lysosome_0 in Lysosome; // Assignment Rules: k1_0 := 0.0003*(p18*OH_radical + p19*H2O2 + p110*DA_quinone + p186*O2); k2_0 := 0.0001*(i26*Dopamine + p28*OH_radical + p29*H2O2 + p210*DA_quinone + p286*O2); k4_0 := 0.009*(i41*Alpha_synuclein + i42*Protofibril + i43*Fibril); k13_0 := 0.001*(i131*Alpha_synuclein + i1310*DA_quinone); k15_0 := 0.002*i152*Protofibril; k32_0 := 1.000000e-005*(p328*OH_radical + p329*H2O2 + p3210*DA_quinone + p3286*O2); k35_0 := 1.000000e-005*(p358*OH_radical + p359*H2O2 + p3510*DA_quinone + p3586*O2); k36_0 := 0.0005*(i368*OH_radical + i369*H2O2 + i3610*DA_quinone + i3686*O2); k38_0 := 0.007*(i381*Alpha_synuclein + i382*Protofibril + i383*Fibril); k46_0 := 0.0003*(i468*OH_radical + i469*H2O2 + i4610*DA_quinone + i4686*O2); k47_0 := 0.0003*(i478*OH_radical + i479*H2O2 + i4710*DA_quinone + i4786*O2); k48_0 := 0.0003*(i488*OH_radical + i489*H2O2 + i4810*DA_quinone + i4886*O2); // Rate Rules: Fe2' = J21 - J20 + 0.01; // Reactions: J21: Fe3 => $Fe2; Neuronal_cytosol*J1Sub(k21, Fe3, g2166); J20: H2O2 + $Fe2 => Fe3 + OH_radical + OH; Neuronal_cytosol*J2Sub(k20, H2O2, g209, Fe2, g2065); J1: $Alpha_synuclein => Protofibril; Neuronal_cytosol*J1Sub(k1, Alpha_synuclein, g11); J2: Protofibril => Fibril; Neuronal_cytosol*J1Sub(k2, Protofibril, g22); J3: Fibril + Parkin_synphilin_1_ub => Lewy_body; Neuronal_cytosol*J2Sub(k3, Fibril, g23, Parkin_synphilin_1_ub, g326); J4: Parkin_sub_ub4 => Parkin + Fragments + 4Ubiquitin; Neuronal_cytosol*J1Sub3Mod(k4, Parkin_sub_ub4, g427, Proteasome_0, g412, ATP, g415, UCH_L1, g430); J6: Ubiquitin + E1 => Ub_E1; Neuronal_cytosol*J2Sub1Mod(k6, Ubiquitin, g613, E1, g614, ATP, g615); J7: Ub_E1 + UbcH8 => E1 + UbcH8_Ub; Neuronal_cytosol*J2Sub1Mod(k7, Ub_E1, g716, UbcH8, g717, ATP, g715); J8: Parkin + $Substrate => Parkin_sub; Neuronal_cytosol*J2Sub(k8, Parkin, g819, Substrate, g821); J9: Parkin + $Synphilin_1 => Parkin_synphilin_1; Neuronal_cytosol*J2Sub(k9, Parkin, g919, Synphilin_1, g920); J10: Parkin_synphilin_1 + UbcH13_Uev1a_ub => Parkin_synphilin_1_ub + UbcH13_Uev1a; Neuronal_cytosol*J2Sub(k10, Parkin_synphilin_1, g1025, UbcH13_Uev1a_ub, g1072); J11: Parkin_sub + UbcH8ub4 => Parkin_sub_ub4 + UbcH8; Neuronal_cytosol*J2Sub(k11, Parkin_sub, g1124, UbcH8ub4, g1170); J13: $L_Tyr + $O2_0 => L_Dopa; Neuronal_cytosol*J2Sub1Mod(k13, L_Tyr, g1336, O2_0, g1351, TH, g1335); J14: L_Dopa => Dopamine + $CO2; Neuronal_cytosol*J1Sub1Mod(k14, L_Dopa, g1437, DDC, g1467); J15: Dopamine + $Vesicle_0 => V_DA; J2Sub1Mod(k15, Dopamine, g156, Vesicle_0, g1544, VMAT2, g1545); J16: $Bioamines + $Vesicle_0 => V_ntox_ba; J2Sub(k16, Bioamines, g1643, Vesicle_0, g1644); J17: $Neurotoxins + $Vesicle_0 => V_ntox_ba; J2Sub(k17, Neurotoxins, g1742, Vesicle_0, g1744); J18: Dopamine + $O2_0 => DA_quinone + O2; Neuronal_cytosol*J2Sub(k18, Dopamine, g186, O2_0, g1851); J19: Dopamine + $O2_0 + $H2O => $NH3 + DOPAL + H2O2; Neuronal_cytosol*J3Sub1Mod(k19, Dopamine, g196, O2_0, g1951, H2O, g1960, MAO, g1953); J22: H2O2 => $H2O + $O2_0; Neuronal_cytosol*J1Sub1Mod(k22, H2O2, g229, Catalase, g2259); J23: H2O2 + GSH => $H2O + GSSG; Neuronal_cytosol*J2Sub1Mod(k23, H2O2, g239, GSH, g2362, Gluta_per, g2361); J24: GSSG => GSH; Neuronal_cytosol*J1Sub1Mod(k24, GSSG, g2463, Gluta_red, g2464); J25: DOPAL + $NAD => DOPAC + $NADH; Neuronal_cytosol*J2Sub1Mod(k25, DOPAL, g2552, NAD, g2556, ALDH, g2555); J26f: Ub_E1 + UbcH8_Ub => E1 + UbcH8ub2; Neuronal_cytosol*J2Sub1Mod(k26f, Ub_E1, g26f16, UbcH8_Ub, g26f18, ATP, g26f15); J26r: UbcH8ub2 => UbcH8 + 2Ubiquitin; Neuronal_cytosol*J1Sub1Mod(k26r, UbcH8ub2, g26r68, UCH_L1, g26r30); J27f: Ub_E1 + UbcH8ub2 => E1 + UbcH8ub3; Neuronal_cytosol*J2Sub1Mod(k27f, Ub_E1, g27f16, UbcH8ub2, g27f68, ATP, g27f15); J27r: UbcH8ub3 => UbcH8 + 3Ubiquitin; Neuronal_cytosol*J1Sub1Mod(k27r, UbcH8ub3, g27r69, UCH_L1, g27r30); J28f: Ub_E1 + UbcH8ub3 => E1 + UbcH8ub4; Neuronal_cytosol*J2Sub1Mod(k28f, Ub_E1, g28f16, UbcH8ub3, g28f69, ATP, g28f15); J28r: UbcH8ub4 => UbcH8 + 4Ubiquitin; Neuronal_cytosol*J1Sub1Mod(k28r, UbcH8ub4, g28r70, UCH_L1, g28r30); J29: Ub_E1 + UbcH13_Uev1a => E1 + UbcH13_Uev1a_ub; Neuronal_cytosol*J2Sub1Mod(k29, Ub_E1, g2916, UbcH13_Uev1a, g2971, ATP, g2915); J30: $Alpha_synuclein + UCH_L1 => asyn_UCH_L1; Neuronal_cytosol*J2Sub(k30, Alpha_synuclein, g301, UCH_L1, g3030); J31: UbcH13_Uev1a_ub + asyn_UCH_L1 => UbcH13_Uev1a + UCH_L1 + asyn_ub; Neuronal_cytosol*J2Sub(k31, UbcH13_Uev1a_ub, g3172, asyn_UCH_L1, g3173); J32: $Alpha_synuclein + asyn_ub => Protofibril; Neuronal_cytosol*J2Sub(k32, Alpha_synuclein, g321, asyn_ub, g3274); J33: Protofibril + UCH_L1 => Protofibril_UCH_L1; Neuronal_cytosol*J2Sub(k33, Protofibril, g332, UCH_L1, g3330); J34: UbcH13_Uev1a_ub + Protofibril_UCH_L1 => UbcH13_Uev1a + UCH_L1 + Protofibril_Ub; Neuronal_cytosol*J2Sub(k34, UbcH13_Uev1a_ub, g3472, Protofibril_UCH_L1, g3475); J35: Protofibril + Protofibril_Ub => Fibril; Neuronal_cytosol*J2Sub(k35, Protofibril, g352, Protofibril_Ub, g3576); J36: Autophagosome_0 => Fragments; J1Sub1Mod(k36, Autophagosome_0, g3679, Lysosome_0, g3677); J37: UbcH8ub4 + asyn_UCH_L1 => UCH_L1_asyn_ub4 + UbcH8; Neuronal_cytosol*J2Sub(k37, UbcH8ub4, g3770, asyn_UCH_L1, g3773); J38: UCH_L1_asyn_ub4 => Fragments + UCH_L1 + 4Ubiquitin; Neuronal_cytosol*J1Sub3Mod(k38, UCH_L1_asyn_ub4, g3878, Proteasome_0, g3812, ATP, g3815, UCH_L1, g3830); J43: $Alpha_synuclein + Hsc70 => Hsc70_asyn; Neuronal_cytosol*J2Sub(k43, Alpha_synuclein, g431, Hsc70, g4384); J44: Protofibril + Hsc70 => Hsc70_Protofibril; Neuronal_cytosol*J2Sub(k44, Protofibril, g442, Hsc70, g4484); J45: Fibril + Hsc70 => Hsc70_fibril; Neuronal_cytosol*J2Sub(k45, Fibril, g453, Hsc70, g4584); J46: Hsc70_asyn => Hsc70 + Fragments; Neuronal_cytosol*J1Sub1Mod(k46, Hsc70_asyn, g4681, Lysosome_0, g4677); J47: Hsc70_Protofibril => Hsc70 + Fragments; Neuronal_cytosol*J1Sub1Mod(k47, Hsc70_Protofibril, g4782, Lysosome_0, g4777); J48: Hsc70_fibril => Hsc70 + Fragments; Neuronal_cytosol*J1Sub1Mod(k48, Hsc70_fibril, g4883, Lysosome_0, g4877); J50: $Alpha_synuclein + $Preautophagosome_membrane => Autophagosome_0; J2Sub(k50, Alpha_synuclein, g501, Preautophagosome_membrane, g5080); J51: Protofibril + $Preautophagosome_membrane => Autophagosome_0; J2Sub(k51, Protofibril, g512, Preautophagosome_membrane, g5180); J52: Fibril + $Preautophagosome_membrane => Autophagosome_0; J2Sub(k52, Fibril, g523, Preautophagosome_membrane, g5280); J53: Lewy_body + $Preautophagosome_membrane => Autophagosome_0; J2Sub(k53, Lewy_body, g534, Preautophagosome_membrane, g5380); J54: DA_quinone + Parkin => DA_S_parkin; Neuronal_cytosol*J2Sub(k54, DA_quinone, g5410, Parkin, g5419); J55: Dopamine + O2 => H2O2 + DA_quinone; Neuronal_cytosol*J2Sub(k55, Dopamine, g556, O2, g5586); J56: O2 => H2O2 + $O2_0; Neuronal_cytosol*J1Sub1Mod(k56, O2, g5686, SOD, g5687); J57: DA_quinone + GSH => DA_GSH; Neuronal_cytosol*J2Sub(k57, DA_quinone, g5710, GSH, g5762); J100: L_Dopa + $O2_0 + $Cysteine => Neuromelanin + H2O2 + $CO2; Neuronal_cytosol*J3Sub(k100, L_Dopa, g10037, O2_0, g10051, Cysteine, g100115); J101: $L_Tyr + $O2_0 + $Cysteine => Neuromelanin + H2O2 + $CO2; Neuronal_cytosol*J3Sub(k101, L_Tyr, g10136, O2_0, g10151, Cysteine, g101115); J102: DA_quinone + $O2_0 + $Cysteine => Neuromelanin + $CO2; Neuronal_cytosol*J3Sub(k102, DA_quinone, g10210, O2_0, g10251, Cysteine, g102115); J115: Fe3 + Neuromelanin => Neuromelanin_ntox_Fe3; Neuronal_cytosol*J2Sub(k115, Fe3, g11565, Neuromelanin, g115118); J116: Neuromelanin + $Neurotoxins => Neuromelanin_ntox_Fe3; Neuronal_cytosol*J2Sub(k116, Neuromelanin, g116118, Neurotoxins, g11642); // Species initializations: Protofibril = 0.05; Fibril = 0.025; Lewy_body = 0.01; Dopamine = 2; OH = 0.5; OH_radical = 0.02; H2O2 = 0.1; DA_quinone = 0.05; Ubiquitin = 1; E1 = 0.2; Ub_E1 = 0.35; UbcH8 = 0.2; UbcH8_Ub = 0.35; Parkin = 0.2; Parkin_sub = 0.1; Parkin_synphilin_1 = 1.3; Parkin_synphilin_1_ub = 2.5; Parkin_sub_ub4 = 0.2; Fragments = 0.1; UCH_L1 = 0.5; L_Dopa = 1; DOPAL = 0.05; DOPAC = 0.3; GSH = 1.5; GSSG = 1.5; Fe2 = 0.5; Fe3 = 0.5; UbcH8ub2 = 0.35; UbcH8ub3 = 0.35; UbcH8ub4 = 0.35; UbcH13_Uev1a = 0.2; UbcH13_Uev1a_ub = 0.35; asyn_UCH_L1 = 0.1; asyn_ub = 0.05; Protofibril_UCH_L1 = 0.025; Protofibril_Ub = 0.013; UCH_L1_asyn_ub4 = 0.1; Hsc70_asyn = 0.1; Hsc70_Protofibril = 0.025; Hsc70_fibril = 0.013; Hsc70 = 0.5; DA_S_parkin = 0.2; O2 = 0.02; DA_GSH = 0.2; Neuromelanin = 1; Neuromelanin_ntox_Fe3 = 0.5; Alpha_synuclein = 0.2; ATP = 2; Synphilin_1 = 0.05; Substrate = 0.4; TH = 0.6; L_Tyr = 5; CO2 = 0.5; Neurotoxins = 0.01; Bioamines = 0.1; VMAT2 = 2; O2_0 = 2; MAO = 1.5; NH3 = 0.5; ALDH = 1.5; NAD = 1.5; NADH = 1.5; Catalase = 1; H2O = 3; Gluta_per = 0.8; Gluta_red = 0.8; DDC = 1.5; Preautophagosome_membrane = 1; SOD = 0.6; Cysteine = 0.5; V_DA = 10; V_ntox_ba = 0.3; Vesicle_0 = 1; Autophagosome_0 = 0.5; Proteasome_0 = 1.5; Lysosome_0 = 2.5; // Compartment initializations: Neuronal_cytosol = 1; Vesicle = 1; Autophagosome = 1; Proteasome = 1; Lysosome = 1; // Variable initializations: g11 = 1; p186 = 0.5; p110 = 1; p19 = 1; p18 = 1; k1 = 0.03; g22 = 1; p286 = 0.25; p210 = 0.5; p29 = 0.5; p28 = 0.5; i26 = -1; k2 = 0.01; g326 = 1; g23 = 1; k3 = 0.007; k4 = 0.9; i41 = -0.01; i42 = -0.01; i43 = -0.01; g412 = 1; g415 = 1; g427 = 1; g430 = 1; k6 = 0.5; g613 = 1; g614 = 1; g615 = 1; k7 = 0.03; g715 = 1; g716 = 1; g717 = 1; k8 = 0.001; g819 = 1; g821 = 1; k9 = 0.001; g919 = 1; g920 = 1; k10 = 0.05; g1025 = 1; g1072 = 1; k11 = 0.05; g1124 = 1; g1170 = 1; k13 = 0.1; i131 = -0.01; i1310 = -0.01; g1335 = 1; g1336 = 1; g1351 = 1; k14 = 3; g1437 = 1; g1467 = 1; k15 = 0.2; i152 = -0.1; g156 = 1; g1544 = 1; g1545 = 1; k16 = 0.0001; g1643 = 1; g1644 = 1; k17 = 0.0001; g1742 = 1; g1744 = 1; k18 = 0.02; g186 = 1; g1851 = 1; k19 = 0.01; g196 = 1; g1951 = 1; g1953 = 1; g1960 = 1; k20 = 0.1; g209 = 1; g2065 = 1; k21 = 0.1; g2166 = 1; k22 = 0.5; g229 = 1; g2259 = 1; k23 = 0.5; g239 = 1; g2361 = 1; g2362 = 1; k24 = 1; g2463 = 1; g2464 = 1; k25 = 0.05; g2552 = 1; g2555 = 0.3; g2556 = 0.25; k26f = 0.05; g26f15 = 1; g26f16 = 1; g26f18 = 1; k26r = 0.005; g26r30 = 1; g26r68 = 1; k27f = 0.05; g27f15 = 1; g27f16 = 1; g27f68 = 1; k27r = 0.005; g27r30 = 1; g27r69 = 1; k28f = 0.05; g28f15 = 1; g28f16 = 1; g28f69 = 1; k28r = 0.005; g28r30 = 1; g28r70 = 1; k29 = 0.05; g2915 = 1; g2916 = 1; g2971 = 1; k30 = 0.001; g301 = 1; g3030 = 1; k31 = 0.05; g3172 = 1; g3173 = 1; k32 = 0.001; g321 = 1; p328 = 0.1; p329 = 0.1; p3210 = 0.1; p3286 = 0.05; g3274 = 1; k33 = 0.001; g332 = 1; g3330 = 1; k34 = 0.05; g3472 = 1; g3475 = 1; k35 = 0.001; g352 = 1; p358 = 0.1; p359 = 0.1; p3510 = 0.1; p3586 = 0.05; g3576 = 1; k36 = 0.05; i368 = -0.1; i369 = -0.1; i3610 = -0.1; i3686 = -0.05; g3677 = 1; g3679 = 1; k37 = 0.05; g3770 = 1; g3773 = 1; k38 = 0.7; i381 = -0.01; i382 = -0.01; i383 = -0.01; g3812 = 1; g3815 = 1; g3830 = 1; g3878 = 1; k43 = 0.05; g431 = 1; g4384 = 1; k44 = 0.045; g442 = 1; g4484 = 1; k45 = 0.04; g453 = 1; g4584 = 1; k46 = 0.03; i468 = -0.1; i469 = -0.1; i4610 = -0.1; i4686 = -0.05; g4677 = 1; g4681 = 1; k47 = 0.03; i478 = -0.1; i479 = -0.1; i4710 = -0.1; i4786 = -0.05; g4777 = 1; g4782 = 1; k48 = 0.03; i488 = -0.1; i489 = -0.1; i4810 = -0.1; i4886 = -0.05; g4877 = 1; g4883 = 1; k50 = 0.05; g501 = 1; g5080 = 1; k51 = 0.05; g512 = 1; g5180 = 1; k52 = 0.05; g523 = 1; g5280 = 1; k53 = 0.05; g534 = 1; g5380 = 1; k54 = 0.005; g5410 = 1; g5419 = 1; k55 = 0.05; g556 = 1; g5586 = 1; k56 = 0.05; g5686 = 1; g5687 = 1; k57 = 0.005; g5710 = 1; g5762 = 1; k100 = 0.005; g10037 = 1; g10051 = 1; g100115 = 1; k101 = 0.005; g10136 = 1; g10151 = 1; g101115 = 1; k102 = 0.005; g10210 = 1; g10251 = 1; g102115 = 1; k115 = 0.5; g11565 = 1; g11566 = 1; g115118 = 1; k116 = 0.5; g11642 = 1; g116118 = 1; // Other declarations: var k1_0, k2_0, k4_0, k13_0, k15_0, k32_0, k35_0, k36_0, k38_0, k46_0, k47_0; var k48_0; const Neuronal_cytosol, Vesicle, Autophagosome, Proteasome, Lysosome, g11; const p186, p110, p19, p18, k1, g22, p286, p210, p29, p28, i26, k2, g326; const g23, k3, k4, i41, i42, i43, g412, g415, g427, g430, k6, g613, g614; const g615, k7, g715, g716, g717, k8, g819, g821, k9, g919, g920, k10, g1025; const g1072, k11, g1124, g1170, k13, i131, i1310, g1335, g1336, g1351, k14; const g1437, g1467, k15, i152, g156, g1544, g1545, k16, g1643, g1644, k17; const g1742, g1744, k18, g186, g1851, k19, g196, g1951, g1953, g1960, k20; const g209, g2065, k21, g2166, k22, g229, g2259, k23, g239, g2361, g2362; const k24, g2463, g2464, k25, g2552, g2555, g2556, k26f, g26f15, g26f16; const g26f18, k26r, g26r30, g26r68, k27f, g27f15, g27f16, g27f68, k27r; const g27r30, g27r69, k28f, g28f15, g28f16, g28f69, k28r, g28r30, g28r70; const k29, g2915, g2916, g2971, k30, g301, g3030, k31, g3172, g3173, k32; const g321, p328, p329, p3210, p3286, g3274, k33, g332, g3330, k34, g3472; const g3475, k35, g352, p358, p359, p3510, p3586, g3576, k36, i368, i369; const i3610, i3686, g3677, g3679, k37, g3770, g3773, k38, i381, i382, i383; const g3812, g3815, g3830, g3878, k43, g431, g4384, k44, g442, g4484, k45; const g453, g4584, k46, i468, i469, i4610, i4686, g4677, g4681, k47, i478; const i479, i4710, i4786, g4777, g4782, k48, i488, i489, i4810, i4886, g4877; const g4883, k50, g501, g5080, k51, g512, g5180, k52, g523, g5280, k53; const g534, g5380, k54, g5410, g5419, k55, g556, g5586, k56, g5686, g5687; const k57, g5710, g5762, k100, g10037, g10051, g100115, k101, g10136, g10151; const g101115, k102, g10210, g10251, g102115, k115, g11565, g11566, g115118; const k116, g11642, g116118; // Unit definitions: unit volume = dimensionless; unit time_unit = dimensionless; unit substance = dimensionless; // Display Names: time_unit is "time"; Neuronal_cytosol is "Neuronal cytosol"; OH is "OH-"; Ub_E1 is "Ub-E1"; UbcH8_Ub is "UbcH8-Ub"; Parkin_sub is "Parkin-sub"; Parkin_synphilin_1 is "Parkin-synphilin-1"; Parkin_synphilin_1_ub is "Parkin-synphilin-1-ub"; Parkin_sub_ub4 is "Parkin-sub-ub4"; UCH_L1 is "UCH-L1"; L_Dopa is "L-Dopa"; Fe2 is "Fe2+"; Fe3 is "Fe3+"; UbcH13_Uev1a is "UbcH13/Uev1a"; UbcH13_Uev1a_ub is "UbcH13/Uev1a-ub"; asyn_UCH_L1 is "asyn-UCH-L1"; asyn_ub is "asyn-ub"; Protofibril_UCH_L1 is "Protofibril-UCH-L1"; Protofibril_Ub is "Protofibril-Ub"; UCH_L1_asyn_ub4 is "UCH-L1-asyn-ub4"; Hsc70_asyn is "Hsc70-asyn"; Hsc70_Protofibril is "Hsc70-Protofibril"; Hsc70_fibril is "Hsc70-fibril"; DA_S_parkin is "DA-S-parkin"; O2 is "O2-"; DA_GSH is "DA-GSH"; Neuromelanin_ntox_Fe3 is "Neuromelanin-ntox-Fe3+"; Synphilin_1 is "Synphilin-1"; L_Tyr is "L-Tyr"; O2_0 is "O2"; NAD is "NAD+"; V_DA is "V-DA"; V_ntox_ba is "V-ntox-ba"; Vesicle_0 is "Vesicle"; Autophagosome_0 is "Autophagosome"; Proteasome_0 is "Proteasome"; Lysosome_0 is "Lysosome"; k1_0 is "k1'"; k2_0 is "k2'"; k4_0 is "k4'"; k13_0 is "k13'"; k15_0 is "k15'"; k32_0 is "k32'"; k35_0 is "k35'"; k36_0 is "k36'"; k38_0 is "k38'"; k46_0 is "k46'"; k47_0 is "k47'"; k48_0 is "k48'"; end