// Created by libAntimony v2.8.0 model *MODEL1501300000() // Compartments and Species: compartment cyt; species CRP in cyt, CRPsiteI_crp in cyt, CRPsiteII_crp in cyt, CRPsite_cyaA in cyt; species CRPsite_genome in cyt, CRPsite_ptsGp1 in cyt, CRPsite_ptsGp2 in cyt; species CRPsite_ptsHp0 in cyt, CRPsite_ptsHp1 in cyt, CRPsite_ptsIp0 in cyt; species CRPsite_ptsIp1 in cyt, CRPsite_mlcp1 in cyt, CRPsite_mlcp2 in cyt; species Mlc in cyt, Mlcsite_mlcp1 in cyt, Mlcsite_mlcp2 in cyt, Mlcsite_ptsGp1 in cyt; species Mlcsite_ptsGp2 in cyt, Mlcsite_ptsHp0 in cyt, Mlcsite_ptsIp0 in cyt; species CRP_cAMP in cyt, CRP_cAMP_CRPsiteI_crp in cyt, CRP_cAMP_CRPsiteII_crp in cyt; species CRP_cAMP_CRPsite_cyaA in cyt, CRP_cAMP_CRPsite_genome in cyt, CRP_cAMP_CRPsite_ptsGp1 in cyt; species CRP_cAMP_CRPsite_ptsGp2 in cyt, CRP_cAMP_CRPsite_ptsHp0 in cyt; species CRP_cAMP_CRPsite_ptsHp1 in cyt, CRP_cAMP_CRPsite_ptsIp0 in cyt; species CRP_cAMP_CRPsite_ptsIp1 in cyt, CRP_cAMP_CRPsite_mlcp1 in cyt, CRP_cAMP_CRPsite_mlcp2 in cyt; species Mlc_Mlcsite_ptsGp1 in cyt, Mlc_Mlcsite_ptsGp2 in cyt, Mlc_Mlcsite_ptsIp0 in cyt; species Mlc_Mlcsite_ptsHp0 in cyt, Mlc_Mlcsite_mlcp1 in cyt, Mlc_Mlcsite_mlcp2 in cyt; species IICB in cyt, IICB_Mlc in cyt, CYA in cyt, IIA_P in cyt, IIA_P_CYA in cyt; species mRNA_cyaA in cyt, mRNA_crp in cyt, mRNA_ptsG in cyt, mRNA_ptsH in cyt; species mRNA_ptsI in cyt, mRNA_crr in cyt, mRNA_mlc in cyt, IICB_P in cyt; species IIA in cyt, HPr_P in cyt, HPr in cyt, EI_P in cyt, EI in cyt, cAMP in cyt; species $cyaA in cyt, $cyaA_basal in cyt, $crp in cyt, $crp_basal in cyt; species $ptsGp1 in cyt, $ptsGp2 in cyt, $ptsHp0 in cyt, $ptsHp1 in cyt; species $ptsIp0 in cyt, $ptsIp1 in cyt, $crr in cyt, $mlcp1 in cyt, $mlcp2 in cyt; species $Pyr in cyt, $PEP in cyt, $Glc6P in cyt, $Glucose in cyt, $ATP in cyt; // Assignment Rules: TCRPsite_cyaA := CRPsite_cyaA + CRP_cAMP_CRPsite_cyaA; TCRPsiteI_crp := CRPsiteI_crp + CRP_cAMP_CRPsiteI_crp; TCRPsiteII_crp := CRPsiteII_crp + CRP_cAMP_CRPsiteII_crp; TCRPsite_ptsGp1 := CRPsite_ptsGp1 + CRP_cAMP_CRPsite_ptsGp1; TMlcsite_ptsGp1 := Mlcsite_ptsGp1 + Mlc_Mlcsite_ptsGp1; TCRPsite_ptsGp2 := CRPsite_ptsGp2 + CRP_cAMP_CRPsite_ptsGp2; TMlcsite_ptsGp2 := Mlcsite_ptsGp2 + Mlc_Mlcsite_ptsGp2; TCRPsite_ptsHp0 := CRPsite_ptsHp0 + CRP_cAMP_CRPsite_ptsHp0; TMlcsite_ptsHp0 := Mlcsite_ptsHp0 + Mlc_Mlcsite_ptsHp0; TCRPsite_ptsHp1 := CRPsite_ptsHp1 + CRP_cAMP_CRPsite_ptsHp1; TCRPsite_ptsIp0 := CRPsite_ptsIp0 + CRP_cAMP_CRPsite_ptsIp0; TMlcsite_ptsIp0 := Mlcsite_ptsIp0 + Mlc_Mlcsite_ptsIp0; TCRPsite_ptsIp1 := CRPsite_ptsIp1 + CRP_cAMP_CRPsite_ptsIp1; TCRPsite_mlcp1 := CRPsite_mlcp1 + CRP_cAMP_CRPsite_mlcp1; TMlcsite_mlcp1 := Mlcsite_mlcp1 + Mlc_Mlcsite_mlcp1; TCRPsite_mlcp2 := CRPsite_mlcp2 + CRP_cAMP_CRPsite_mlcp2; TMlcsite_mlcp2 := Mlcsite_mlcp2 + Mlc_Mlcsite_mlcp2; // Reactions: binding_CRP_cAMP: CRP + cAMP -> CRP_cAMP; cyt*fast*binding_CRP_cAMP_one_per_M*(binding_CRP_cAMP_Kb^2*(CRP*cAMP)^2 - CRP_cAMP^2); binding_CRP_cAMP_CRPsite_cyaA: CRP_cAMP + CRPsite_cyaA -> CRP_cAMP_CRPsite_cyaA; cyt*fast*(binding_CRP_cAMP_CRPsite_cyaA_Kb*CRP_cAMP*CRPsite_cyaA - CRP_cAMP_CRPsite_cyaA); binding_CRP_cAMP_CRPsiteI_crp: CRP_cAMP + CRPsiteI_crp -> CRP_cAMP_CRPsiteI_crp; cyt*fast*(binding_CRP_cAMP_CRPsiteI_crp_Kb*CRP_cAMP*CRPsiteI_crp - CRP_cAMP_CRPsiteI_crp); binding_CRP_cAMP_CRPsiteII_crp: CRP_cAMP + CRPsiteII_crp -> CRP_cAMP_CRPsiteII_crp; cyt*fast*(binding_CRP_cAMP_CRPsiteII_crp_Kb*CRP_cAMP*CRPsiteII_crp - CRP_cAMP_CRPsiteII_crp); binding_CRP_cAMP_CRPsite_ptsGp1: CRP_cAMP + CRPsite_ptsGp1 -> CRP_cAMP_CRPsite_ptsGp1; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsGp1_Kb*CRP_cAMP*CRPsite_ptsGp1 - CRP_cAMP_CRPsite_ptsGp1); binding_CRP_cAMP_CRPsite_ptsGp2: CRP_cAMP + CRPsite_ptsGp2 -> CRP_cAMP_CRPsite_ptsGp2; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsGp2_Kb*CRP_cAMP*CRPsite_ptsGp2 - CRP_cAMP_CRPsite_ptsGp2); binding_CRP_cAMP_CRPsite_ptsHp0: CRP_cAMP + CRPsite_ptsHp0 -> CRP_cAMP_CRPsite_ptsHp0; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsHp0_Kb*CRP_cAMP*CRPsite_ptsHp0 - CRP_cAMP_CRPsite_ptsHp0); binding_CRP_cAMP_CRPsite_ptsHp1: CRP_cAMP + CRPsite_ptsHp1 -> CRP_cAMP_CRPsite_ptsHp1; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsHp1_Kb*CRP_cAMP*CRPsite_ptsHp1 - CRP_cAMP_CRPsite_ptsHp1); binding_CRP_cAMP_CRPsite_ptsIp0: CRP_cAMP + CRPsite_ptsIp0 -> CRP_cAMP_CRPsite_ptsIp0; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsIp0_Kb*CRP_cAMP*CRPsite_ptsIp0 - CRP_cAMP_CRPsite_ptsIp0); binding_CRP_cAMP_CRPsite_ptsIp1: CRP_cAMP + CRPsite_ptsIp1 -> CRP_cAMP_CRPsite_ptsIp1; cyt*fast*(binding_CRP_cAMP_CRPsite_ptsIp1_Kb*CRP_cAMP*CRPsite_ptsIp1 - CRP_cAMP_CRPsite_ptsIp1); binding_CRP_cAMP_CRPsite_mlcp1: CRP_cAMP + CRPsite_mlcp1 -> CRP_cAMP_CRPsite_mlcp1; cyt*fast*(binding_CRP_cAMP_CRPsite_mlcp1_Kb*CRP_cAMP*CRPsite_mlcp1 - CRP_cAMP_CRPsite_mlcp1); binding_CRP_cAMP_CRPsite_mlcp2: CRP_cAMP + CRPsite_mlcp2 -> CRP_cAMP_CRPsite_mlcp2; cyt*fast*(binding_CRP_cAMP_CRPsite_mlcp2_Kb*CRP_cAMP*CRPsite_mlcp2 - CRP_cAMP_CRPsite_mlcp2); binding_CRP_cAMP_CRPsite_genome: CRP_cAMP + CRPsite_genome -> CRP_cAMP_CRPsite_genome; cyt*fast*(binding_CRP_cAMP_CRPsite_genome_Kb*CRP_cAMP*CRPsite_genome - CRP_cAMP_CRPsite_genome); binding_Mlc_Mlcsite_ptsGp1: Mlc + Mlcsite_ptsGp1 -> Mlc_Mlcsite_ptsGp1; cyt*fast*(binding_Mlc_Mlcsite_ptsGp1_Kb*Mlc*Mlcsite_ptsGp1 - Mlc_Mlcsite_ptsGp1); binding_Mlc_Mlcsite_ptsGp2: Mlc + Mlcsite_ptsGp2 -> Mlc_Mlcsite_ptsGp2; cyt*fast*(binding_Mlc_Mlcsite_ptsGp2_Kb*Mlc*Mlcsite_ptsGp2 - Mlc_Mlcsite_ptsGp2); binding_Mlc_Mlcsite_ptsHp0: Mlc + Mlcsite_ptsHp0 -> Mlc_Mlcsite_ptsHp0; cyt*fast*(binding_Mlc_Mlcsite_ptsHp0_Kb*Mlc*Mlcsite_ptsHp0 - Mlc_Mlcsite_ptsHp0); binding_Mlc_Mlcsite_ptsIp0: Mlc + Mlcsite_ptsIp0 -> Mlc_Mlcsite_ptsIp0; cyt*fast*(binding_Mlc_Mlcsite_ptsIp0_Kb*Mlc*Mlcsite_ptsIp0 - Mlc_Mlcsite_ptsIp0); binding_Mlc_Mlcsite_mlcp1: Mlc + Mlcsite_mlcp1 -> Mlc_Mlcsite_mlcp1; cyt*fast*(binding_Mlc_Mlcsite_mlcp1_Kb*Mlc*Mlcsite_mlcp1 - Mlc_Mlcsite_mlcp1); binding_Mlc_Mlcsite_mlcp2: Mlc + Mlcsite_mlcp2 -> Mlc_Mlcsite_mlcp2; cyt*fast*(binding_Mlc_Mlcsite_mlcp2_Kb*Mlc*Mlcsite_mlcp2 - Mlc_Mlcsite_mlcp2); binding_IICB_Mlc: IICB + Mlc -> IICB_Mlc; cyt*fast*(binding_IICB_Mlc_Kb*IICB*Mlc - IICB_Mlc); binding_IIA_P_CYA: CYA + IIA_P -> IIA_P_CYA; cyt*fast*(binding_IIA_P_CYA_Kb*CYA*IIA_P^2 - IIA_P_CYA); transcription_CRP_cAMP_CRPsite_cyaA_cyaA: -> mRNA_cyaA; cyt*transcription_CRP_cAMP_CRPsite_cyaA_cyaA_km*(1 - CRP_cAMP_CRPsite_cyaA/TCRPsite_cyaA)*cyaA; transcription_cyaA_basal: -> mRNA_cyaA; cyt*transcription_cyaA_basal_km*cyaA_basal; transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp: -> mRNA_crp; cyt*transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_km*((1 + (transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_RelativeactivityatTCRPsiteII_crp*CRP_cAMP_CRPsiteII_crp)/TCRPsiteII_crp) - CRP_cAMP_CRPsiteI_crp/TCRPsiteI_crp)*crp; transcription_crp_basal: -> mRNA_crp; cyt*transcription_crp_basal_km*crp_basal; transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1: -> mRNA_ptsG; cyt*transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1_km*(CRP_cAMP_CRPsite_ptsGp1/TCRPsite_ptsGp1)*(1 - Mlc_Mlcsite_ptsGp1/TMlcsite_ptsGp1)*ptsGp1; transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2: -> mRNA_ptsG; cyt*transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2_km*(CRP_cAMP_CRPsite_ptsGp2/TCRPsite_ptsGp2)*(1 - Mlc_Mlcsite_ptsGp2/TMlcsite_ptsGp2)*ptsGp2; transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0: -> mRNA_ptsH; cyt*transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0_km*(CRP_cAMP_CRPsite_ptsHp0/TCRPsite_ptsHp0)*(1 - Mlc_Mlcsite_ptsHp0/TMlcsite_ptsHp0)*ptsHp0; transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1: -> mRNA_ptsH; cyt*transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1_km*(CRP_cAMP_CRPsite_ptsHp1/TCRPsite_ptsHp1)*ptsHp1; transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0: -> mRNA_ptsI; cyt*transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0_km*(CRP_cAMP_CRPsite_ptsIp0/TCRPsite_ptsIp0)*(1 - Mlc_Mlcsite_ptsIp0/TMlcsite_ptsIp0)*ptsIp0; transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1: -> mRNA_ptsI; cyt*transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1_km*(CRP_cAMP_CRPsite_ptsIp1/TCRPsite_ptsIp1)*ptsIp1; transcription_crr: -> mRNA_crr; cyt*transcription_crr_km*crr; transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1: -> mRNA_mlc; cyt*transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1_km*(1 - CRP_cAMP_CRPsite_mlcp1/TCRPsite_mlcp1)*(1 - Mlc_Mlcsite_mlcp1/TMlcsite_mlcp1)*mlcp1; transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2: -> mRNA_mlc; cyt*transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2_km*(CRP_cAMP_CRPsite_mlcp2/TCRPsite_mlcp2)*(1 - Mlc_Mlcsite_mlcp2/TMlcsite_mlcp2)*mlcp2; decomposition_mRNA_cyaA: mRNA_cyaA -> ; cyt*decomposition_mRNA_cyaA_kmd*mRNA_cyaA; decomposition_mRNA_crp: mRNA_crp -> ; cyt*decomposition_mRNA_crp_kmd*mRNA_crp; decomposition_mRNA_ptsG: mRNA_ptsG -> ; cyt*decomposition_mRNA_ptsG_kmd*mRNA_ptsG; decomposition_mRNA_ptsH: mRNA_ptsH -> ; cyt*decomposition_mRNA_ptsH_kmd*mRNA_ptsH; decomposition_mRNA_ptsI: mRNA_ptsI -> ; cyt*decomposition_mRNA_ptsI_kmd*mRNA_ptsI; decomposition_mRNA_crr: mRNA_crr -> ; cyt*decomposition_mRNA_crr_kmd*mRNA_crr; decomposition_mRNA_mlc: mRNA_mlc -> ; cyt*decomposition_mRNA_mlc_kmd*mRNA_mlc; translation_mRNA_cyaA: -> CYA; cyt*translation_mRNA_cyaA_kp*mRNA_cyaA; translation_mRNA_crp: -> CRP; cyt*translation_mRNA_crp_kp*mRNA_crp; translation_mRNA_ptsG: -> IICB; cyt*translation_mRNA_ptsG_kp*mRNA_ptsG; translation_mRNA_ptsH: -> HPr; cyt*translation_mRNA_ptsH_kp*mRNA_ptsH; translation_mRNA_ptsI: -> EI; cyt*translation_mRNA_ptsI_kp*mRNA_ptsI; translation_mRNA_crr: -> IIA; cyt*translation_mRNA_crr_kp*mRNA_crr; translation_mlc: -> Mlc; cyt*translation_mlc_kp*mRNA_mlc; decomposition_CYA: CYA -> ; cyt*decomposition_CYA_kpd*CYA; decomposition_CRP: CRP -> ; cyt*decomposition_CRP_kpd*CRP; decomposition_Mlc: Mlc -> ; cyt*decomposition_Mlc_kpd*Mlc; decomposition_cAMP: cAMP -> ; cyt*decomposition_cAMP_kpd*cAMP; decomposition_CRP_cAMP: CRP_cAMP -> ; cyt*decomposition_CRP_cAMP_kpd*CRP_cAMP; decomposition_CRP_cAMP_CRPsite_cyaA: CRP_cAMP_CRPsite_cyaA -> CRPsite_cyaA; cyt*decomposition_CRP_cAMP_CRPsite_cyaA_kpd*CRP_cAMP_CRPsite_cyaA; decomposition_CRP_cAMP_CRPsiteI_crp: CRP_cAMP_CRPsiteI_crp -> CRPsiteI_crp; cyt*decomposition_CRP_cAMP_CRPsiteI_crp_kpd*CRP_cAMP_CRPsiteI_crp; decomposition_CRP_cAMP_CRPsiteII_crp: CRP_cAMP_CRPsiteII_crp -> CRPsiteII_crp; cyt*decomposition_CRP_cAMP_CRPsiteII_crp_kpd*CRP_cAMP_CRPsiteII_crp; decomposition_CRP_cAMP_CRPsite_ptsGp1: CRP_cAMP_CRPsite_ptsGp1 -> CRPsite_ptsGp1; cyt*decomposition_CRP_cAMP_CRPsite_ptsGp1_kpd*CRP_cAMP_CRPsite_ptsGp1; decomposition_CRP_cAMP_CRPsite_ptsGp2: CRP_cAMP_CRPsite_ptsGp2 -> CRPsite_ptsGp2; cyt*decomposition_CRP_cAMP_CRPsite_ptsGp2_kpd*CRP_cAMP_CRPsite_ptsGp2; decomposition_CRP_cAMP_CRPsite_ptsHp0: CRP_cAMP_CRPsite_ptsHp0 -> CRPsite_ptsHp0; cyt*decomposition_CRP_cAMP_CRPsite_ptsHp0_kpd*CRP_cAMP_CRPsite_ptsHp0; decomposition_CRP_cAMP_CRPsite_ptsHp1: CRP_cAMP_CRPsite_ptsHp1 -> CRPsite_ptsHp1; cyt*decomposition_CRP_cAMP_CRPsite_ptsHp1_kpd*CRP_cAMP_CRPsite_ptsHp1; decomposition_CRP_cAMP_CRPsite_ptsIp0: CRP_cAMP_CRPsite_ptsIp0 -> CRPsite_ptsIp0; cyt*decomposition_CRP_cAMP_CRPsite_ptsIp0_kpd*CRP_cAMP_CRPsite_ptsIp0; decomposition_CRP_cAMP_CRPsite_ptsIp1: CRP_cAMP_CRPsite_ptsIp1 -> CRPsite_ptsIp1; cyt*decomposition_CRP_cAMP_CRPsite_ptsIp1_kpd*CRP_cAMP_CRPsite_ptsIp1; decomposition_CRP_cAMP_CRPsite_mlcp1: CRP_cAMP_CRPsite_mlcp1 -> CRPsite_mlcp1; cyt*decomposition_CRP_cAMP_CRPsite_mlcp1_kpd*CRP_cAMP_CRPsite_mlcp1; decomposition_CRP_cAMP_CRPsite_mlcp2: CRP_cAMP_CRPsite_mlcp2 -> CRPsite_mlcp2; cyt*decomposition_CRP_cAMP_CRPsite_mlcp2_kpd*CRP_cAMP_CRPsite_mlcp2; decomposition_CRP_cAMP_CRPsite_genome: CRP_cAMP_CRPsite_genome -> CRPsite_genome; cyt*decomposition_CRP_cAMP_CRPsite_genome_kpd*CRP_cAMP_CRPsite_genome; decomposition_Mlc_Mlcsite_ptsGp1: Mlc_Mlcsite_ptsGp1 -> Mlcsite_ptsGp1; cyt*decomposition_Mlc_Mlcsite_ptsGp1_kpd*Mlc_Mlcsite_ptsGp1; decomposition_Mlc_Mlcsite_ptsGp2: Mlc_Mlcsite_ptsGp2 -> Mlcsite_ptsGp2; cyt*decomposition_Mlc_Mlcsite_ptsGp2_kpd*Mlc_Mlcsite_ptsGp2; decomposition_Mlc_Mlcsite_ptsHp0: Mlc_Mlcsite_ptsHp0 -> Mlcsite_ptsHp0; cyt*decomposition_Mlc_Mlcsite_ptsHp0_kpd*Mlc_Mlcsite_ptsHp0; decomposition_Mlc_Mlcsite_ptsIp0: Mlc_Mlcsite_ptsIp0 -> Mlcsite_ptsIp0; cyt*decomposition_Mlc_Mlcsite_ptsIp0_kpd*Mlc_Mlcsite_ptsIp0; decomposition_Mlc_Mlcsite_mlcp1: Mlc_Mlcsite_mlcp1 -> Mlcsite_mlcp1; cyt*decomposition_Mlc_Mlcsite_mlcp1_kpd*Mlc_Mlcsite_mlcp1; decomposition_Mlc_Mlcsite_mlcp2: Mlc_Mlcsite_mlcp2 -> Mlcsite_mlcp2; cyt*decomposition_Mlc_Mlcsite_mlcp2_kpd*Mlc_Mlcsite_mlcp2; decomposition_IICB_Mlc: IICB_Mlc -> ; cyt*decomposition_IICB_Mlc_kpd*IICB_Mlc; decomposition_EI_P: EI_P -> ; cyt*decomposition_EI_P_kpd*EI_P; decomposition_EI: EI -> ; cyt*decomposition_EI_kpd*EI; decomposition_HPr_P: HPr_P -> ; cyt*decomposition_HPr_P_kpd*HPr_P; decomposition_HPr: HPr -> ; cyt*decomposition_HPr_kpd*HPr; decomposition_IIA_P: IIA_P -> ; cyt*decomposition_IIA_P_kpd*IIA_P; decomposition_IIA: IIA -> ; cyt*decomposition_IIA_kpd*IIA; decomposition_IICB_P: IICB_P -> ; cyt*decomposition_IICB_P_kpd*IICB_P; decomposition_IICB: IICB -> ; cyt*decomposition_IICB_kpd*IICB; PTS2for: HPr + EI_P -> HPr_P + EI; cyt*PTS2for_kx*HPr*EI_P; PTS2rev: HPr_P + EI -> HPr + EI_P; cyt*PTS2rev_kx*EI*HPr_P; PTS3for: IIA + HPr_P -> IIA_P + HPr; cyt*PTS3for_kx*IIA*HPr_P; PTS3rev: IIA_P + HPr -> IIA + HPr_P; cyt*PTS3rev_kx*HPr*IIA_P; PTS4for: IICB + IIA_P -> IICB_P + IIA; cyt*PTS4for_kx*IICB*IIA_P; PTS4rev: IICB_P + IIA -> IICB + IIA_P; cyt*PTS4rev_kx*IIA*IICB_P; reaction_CYA_ATP: $ATP -> cAMP; cyt*((reaction_CYA_ATP_Q*CYA*ATP)/(reaction_CYA_ATP_Kmich + ATP)); reaction_IIA_P_CYA_ATP: $ATP -> cAMP; cyt*((reaction_IIA_P_CYA_ATP_Q*IIA_P_CYA*ATP)/(reaction_IIA_P_CYA_ATP_Kmich + ATP)); reaction_EI_PEP: EI + $PEP -> EI_P + $Pyr; cyt*((2*reaction_EI_PEP_Q*EI*PEP^2)/(reaction_EI_PEP_Kmich^2 + PEP^2)); reaction_EIP_Pyr: EI_P + $Pyr -> EI + $PEP; cyt*((2*reaction_EIP_Pyr_Q*EI_P*Pyr^2)/(reaction_EIP_Pyr_Kmich^2 + Pyr^2)); reaction_IICB_P_Glucose: IICB_P + $Glucose -> IICB + $Glc6P; cyt*((reaction_IICB_P_Glucose_Q*IICB_P*Glucose)/(reaction_IICB_P_Glucose_Kmich + Glucose)); reaction_IICB_Glc6P: IICB + $Glc6P -> IICB_P + $Glucose; cyt*((reaction_IICB_Glc6P_Q*IICB*Glc6P)/(reaction_IICB_Glc6P_Kmich + Glc6P)); // Events: _E0: at time >= 500: Glucose = 2.000000e-009; // Species initializations: CRP = 5.4207e-006; CRPsiteI_crp = 7.4368e-011; CRPsiteII_crp = 1.9047e-010; CRPsite_cyaA = 3.1103e-011; CRPsite_genome = 3.6756e-009; CRPsite_ptsGp1 = 1.2021e-010; CRPsite_ptsGp2 = 1.2021e-010; CRPsite_ptsHp0 = 1.2021e-010; CRPsite_ptsHp1 = 1.2021e-010; CRPsite_ptsIp0 = 1.2021e-010; CRPsite_ptsIp1 = 1.2021e-010; CRPsite_mlcp1 = 1.2021e-010; CRPsite_mlcp2 = 1.2021e-010; Mlc = 5.5172e-010; Mlcsite_mlcp1 = 2.4267e-010; Mlcsite_mlcp2 = 2.4282e-010; Mlcsite_ptsGp1 = 2.1885e-010; Mlcsite_ptsGp2 = 2.1885e-010; Mlcsite_ptsHp0 = 2.1885e-010; Mlcsite_ptsIp0 = 2.1885e-010; CRP_cAMP = 1.0214e-007; CRP_cAMP_CRPsiteI_crp = 1.6863e-010; CRP_cAMP_CRPsiteII_crp = 5.2529e-011; CRP_cAMP_CRPsite_cyaA = 2.119e-010; CRP_cAMP_CRPsite_genome = 3.7544e-009; CRP_cAMP_CRPsite_ptsGp1 = 1.2279e-010; CRP_cAMP_CRPsite_ptsGp2 = 1.2279e-010; CRP_cAMP_CRPsite_ptsHp0 = 1.2279e-010; CRP_cAMP_CRPsite_ptsHp1 = 1.2279e-010; CRP_cAMP_CRPsite_ptsIp0 = 1.2279e-010; CRP_cAMP_CRPsite_ptsIp1 = 1.2279e-010; CRP_cAMP_CRPsite_mlcp1 = 1.2279e-010; CRP_cAMP_CRPsite_mlcp2 = 1.2279e-010; Mlc_Mlcsite_ptsGp1 = 2.4149e-011; Mlc_Mlcsite_ptsGp2 = 2.4149e-011; Mlc_Mlcsite_ptsIp0 = 2.4149e-011; Mlc_Mlcsite_ptsHp0 = 2.4149e-011; Mlc_Mlcsite_mlcp1 = 3.2535e-013; Mlc_Mlcsite_mlcp2 = 1.8086e-013; IICB = 4.2844e-005; IICB_Mlc = 1.6546e-007; CYA = 1.4934e-006; IIA_P = 7.0094e-006; IIA_P_CYA = 7.3371e-009; mRNA_cyaA = 1.3643e-008; mRNA_crp = 5.0254e-008; mRNA_ptsG = 4.5559e-007; mRNA_ptsH = 1.1411e-007; mRNA_ptsI = 1.0038e-008; mRNA_crr = 9.3861e-007; mRNA_mlc = 1.5101e-009; IICB_P = 7.1055e-006; IIA = 9.623e-005; HPr_P = 7.5867e-007; HPr = 1.1793e-005; EI_P = 2.4319e-007; EI = 8.6098e-007; cAMP = 4.7107e-007; cyaA = 2.43e-010; cyaA_basal = 2.43e-010; crp = 2.43e-010; crp_basal = 2.43e-010; ptsGp1 = 2.43e-010; ptsGp2 = 2.43e-010; ptsHp0 = 2.43e-010; ptsHp1 = 2.43e-010; ptsIp0 = 2.43e-010; ptsIp1 = 2.43e-010; crr = 2.43e-010; mlcp1 = 2.43e-010; mlcp2 = 2.43e-010; Pyr = 0.00267; PEP = 0.00267; Glc6P = 0.00148; Glucose = 0.2; ATP = 0.0069942; // Compartment initializations: cyt = 1; // Variable initializations: fast = 1000000000; fast has per_min; TCRPsite_cyaA has M; TCRPsiteI_crp has M; TCRPsiteII_crp has M; TCRPsite_ptsGp1 has M; TMlcsite_ptsGp1 has M; TCRPsite_ptsGp2 has M; TMlcsite_ptsGp2 has M; TCRPsite_ptsHp0 has M; TMlcsite_ptsHp0 has M; TCRPsite_ptsHp1 has M; TCRPsite_ptsIp0 has M; TMlcsite_ptsIp0 has M; TCRPsite_ptsIp1 has M; TCRPsite_mlcp1 has M; TMlcsite_mlcp1 has M; TCRPsite_mlcp2 has M; TMlcsite_mlcp2 has M; binding_CRP_cAMP_Kb = 40000; binding_CRP_cAMP_Kb has per_M; binding_CRP_cAMP_one_per_M = 1; binding_CRP_cAMP_one_per_M has per_M; binding_CRP_cAMP_CRPsite_cyaA_Kb = 66700000; binding_CRP_cAMP_CRPsite_cyaA_Kb has per_M; binding_CRP_cAMP_CRPsiteI_crp_Kb = 22200000; binding_CRP_cAMP_CRPsiteI_crp_Kb has per_M; binding_CRP_cAMP_CRPsiteII_crp_Kb = 2700000; binding_CRP_cAMP_CRPsiteII_crp_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsGp1_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsGp1_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsGp2_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsGp2_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsHp0_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsHp0_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsHp1_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsHp1_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsIp0_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsIp0_Kb has per_M; binding_CRP_cAMP_CRPsite_ptsIp1_Kb = 10000000; binding_CRP_cAMP_CRPsite_ptsIp1_Kb has per_M; binding_CRP_cAMP_CRPsite_mlcp1_Kb = 10000000; binding_CRP_cAMP_CRPsite_mlcp1_Kb has per_M; binding_CRP_cAMP_CRPsite_mlcp2_Kb = 10000000; binding_CRP_cAMP_CRPsite_mlcp2_Kb has per_M; binding_CRP_cAMP_CRPsite_genome_Kb = 10000000; binding_CRP_cAMP_CRPsite_genome_Kb has per_M; binding_Mlc_Mlcsite_ptsGp1_Kb = 200000000; binding_Mlc_Mlcsite_ptsGp1_Kb has per_M; binding_Mlc_Mlcsite_ptsGp2_Kb = 200000000; binding_Mlc_Mlcsite_ptsGp2_Kb has per_M; binding_Mlc_Mlcsite_ptsHp0_Kb = 200000000; binding_Mlc_Mlcsite_ptsHp0_Kb has per_M; binding_Mlc_Mlcsite_ptsIp0_Kb = 200000000; binding_Mlc_Mlcsite_ptsIp0_Kb has per_M; binding_Mlc_Mlcsite_mlcp1_Kb = 2430000; binding_Mlc_Mlcsite_mlcp1_Kb has per_M; binding_Mlc_Mlcsite_mlcp2_Kb = 1350000; binding_Mlc_Mlcsite_mlcp2_Kb has per_M; binding_IICB_Mlc_Kb = 7000000; binding_IICB_Mlc_Kb has per_M; binding_IIA_P_CYA_Kb = 100000000; binding_IIA_P_CYA_Kb has per_M_squared; transcription_CRP_cAMP_CRPsite_cyaA_cyaA_km = 45.26; transcription_CRP_cAMP_CRPsite_cyaA_cyaA_km has per_min; transcription_cyaA_basal_km = 1.281; transcription_cyaA_basal_km has per_min; transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_km = 20; transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_km has per_min; transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_RelativeactivityatTCRPsiteII_crp = 5; transcription_CRP_cAMP_CRPsiteI_crp_CRP_cAMP_CRPsiteII_crp_crp_RelativeactivityatTCRPsiteII_crp has dimensionless; transcription_crp_basal_km = 1.00886; transcription_crp_basal_km has per_min; transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1_km = 892; transcription_CRP_cAMP_CRPsite_ptsGp1_Mlc_Mlcsite_ptsGp1_ptsGp1_km has per_min; transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2_km = 2; transcription_CRP_cAMP_CRPsite_ptsGp2_Mlc_Mlcsite_ptsGp2_ptsGp2_km has per_min; transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0_km = 71.8; transcription_CRP_cAMP_CRPsite_ptsHp0_Mlc_Mlcsite_ptsHp0_ptsHp0_km has per_min; transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1_km = 17.95; transcription_CRP_cAMP_CRPsite_ptsHp1_ptsHp1_km has per_min; transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0_km = 6.244; transcription_CRP_cAMP_CRPsite_ptsIp0_Mlc_Mlcsite_ptsIp0_ptsIp0_km has per_min; transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1_km = 0.892; transcription_CRP_cAMP_CRPsite_ptsIp1_ptsIp1_km has per_min; transcription_crr_km = 334.5; transcription_crr_km has per_min; transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1_km = 1.875; transcription_CRP_cAMP_CRPsite_mlcp1_Mlc_Mlcsite_mlcp1_mlcp1_km has per_min; transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2_km = 1.875; transcription_CRP_cAMP_CRPsite_mlcp2_Mlc_Mlcsite_mlcp2_mlcp2_km has per_min; decomposition_mRNA_cyaA_kmd = 0.126; decomposition_mRNA_cyaA_kmd has per_min; decomposition_mRNA_crp_kmd = 0.139; decomposition_mRNA_crp_kmd has per_min; decomposition_mRNA_ptsG_kmd = 0.217; decomposition_mRNA_ptsG_kmd has per_min; decomposition_mRNA_ptsH_kmd = 0.0889; decomposition_mRNA_ptsH_kmd has per_min; decomposition_mRNA_ptsI_kmd = 0.0797; decomposition_mRNA_ptsI_kmd has per_min; decomposition_mRNA_crr_kmd = 0.0866; decomposition_mRNA_crr_kmd has per_min; decomposition_mRNA_mlc_kmd = 0.3014; decomposition_mRNA_mlc_kmd has per_min; translation_mRNA_cyaA_kp = 11; translation_mRNA_cyaA_kp has per_min; translation_mRNA_crp_kp = 11; translation_mRNA_crp_kp has per_min; translation_mRNA_ptsG_kp = 11; translation_mRNA_ptsG_kp has per_min; translation_mRNA_ptsH_kp = 11; translation_mRNA_ptsH_kp has per_min; translation_mRNA_ptsI_kp = 11; translation_mRNA_ptsI_kp has per_min; translation_mRNA_crr_kp = 11; translation_mRNA_crr_kp has per_min; translation_mlc_kp = 11; translation_mlc_kp has per_min; decomposition_CYA_kpd = 0.1; decomposition_CYA_kpd has per_min; decomposition_CRP_kpd = 0.1; decomposition_CRP_kpd has per_min; decomposition_Mlc_kpd = 0.1; decomposition_Mlc_kpd has per_min; decomposition_cAMP_kpd = 400; decomposition_cAMP_kpd has per_min; decomposition_CRP_cAMP_kpd = 0.1; decomposition_CRP_cAMP_kpd has per_min; decomposition_CRP_cAMP_CRPsite_cyaA_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_cyaA_kpd has per_min; decomposition_CRP_cAMP_CRPsiteI_crp_kpd = 0.1; decomposition_CRP_cAMP_CRPsiteI_crp_kpd has per_min; decomposition_CRP_cAMP_CRPsiteII_crp_kpd = 0.1; decomposition_CRP_cAMP_CRPsiteII_crp_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsGp1_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsGp1_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsGp2_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsGp2_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsHp0_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsHp0_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsHp1_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsHp1_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsIp0_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsIp0_kpd has per_min; decomposition_CRP_cAMP_CRPsite_ptsIp1_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_ptsIp1_kpd has per_min; decomposition_CRP_cAMP_CRPsite_mlcp1_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_mlcp1_kpd has per_min; decomposition_CRP_cAMP_CRPsite_mlcp2_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_mlcp2_kpd has per_min; decomposition_CRP_cAMP_CRPsite_genome_kpd = 0.1; decomposition_CRP_cAMP_CRPsite_genome_kpd has per_min; decomposition_Mlc_Mlcsite_ptsGp1_kpd = 0.1; decomposition_Mlc_Mlcsite_ptsGp1_kpd has per_min; decomposition_Mlc_Mlcsite_ptsGp2_kpd = 0.1; decomposition_Mlc_Mlcsite_ptsGp2_kpd has per_min; decomposition_Mlc_Mlcsite_ptsHp0_kpd = 0.1; decomposition_Mlc_Mlcsite_ptsHp0_kpd has per_min; decomposition_Mlc_Mlcsite_ptsIp0_kpd = 0.1; decomposition_Mlc_Mlcsite_ptsIp0_kpd has per_min; decomposition_Mlc_Mlcsite_mlcp1_kpd = 0.1; decomposition_Mlc_Mlcsite_mlcp1_kpd has per_min; decomposition_Mlc_Mlcsite_mlcp2_kpd = 0.1; decomposition_Mlc_Mlcsite_mlcp2_kpd has per_min; decomposition_IICB_Mlc_kpd = 0.1; decomposition_IICB_Mlc_kpd has per_min; decomposition_EI_P_kpd = 0.1; decomposition_EI_P_kpd has per_min; decomposition_EI_kpd = 0.1; decomposition_EI_kpd has per_min; decomposition_HPr_P_kpd = 0.1; decomposition_HPr_P_kpd has per_min; decomposition_HPr_kpd = 0.1; decomposition_HPr_kpd has per_min; decomposition_IIA_P_kpd = 0.1; decomposition_IIA_P_kpd has per_min; decomposition_IIA_kpd = 0.1; decomposition_IIA_kpd has per_min; decomposition_IICB_P_kpd = 0.1; decomposition_IICB_P_kpd has per_min; decomposition_IICB_kpd = 0.1; decomposition_IICB_kpd has per_min; PTS2for_kx = 12000000000; PTS2for_kx has per_M_per_min; PTS2rev_kx = 480000000; PTS2rev_kx has per_M_per_min; PTS3for_kx = 3660000000; PTS3for_kx has per_M_per_min; PTS3rev_kx = 2820000000; PTS3rev_kx has per_M_per_min; PTS4for_kx = 660000000; PTS4for_kx has per_M_per_min; PTS4rev_kx = 240000000; PTS4rev_kx has per_M_per_min; reaction_CYA_ATP_Kmich = 0.001; reaction_CYA_ATP_Kmich has M; reaction_CYA_ATP_Q = 100; reaction_CYA_ATP_Q has per_min; reaction_IIA_P_CYA_ATP_Kmich = 0.001; reaction_IIA_P_CYA_ATP_Kmich has M; reaction_IIA_P_CYA_ATP_Q = 9000; reaction_IIA_P_CYA_ATP_Q has per_min; reaction_EI_PEP_Kmich = 0.0003; reaction_EI_PEP_Kmich has M; reaction_EI_PEP_Q = 108000; reaction_EI_PEP_Q has per_min; reaction_EIP_Pyr_Kmich = 0.002; reaction_EIP_Pyr_Kmich has M; reaction_EIP_Pyr_Q = 480000; reaction_EIP_Pyr_Q has per_min; reaction_IICB_P_Glucose_Kmich = 2e-005; reaction_IICB_P_Glucose_Kmich has M; reaction_IICB_P_Glucose_Q = 4800; reaction_IICB_P_Glucose_Q has per_min; reaction_IICB_Glc6P_Kmich = 9.61; reaction_IICB_Glc6P_Kmich has M; reaction_IICB_Glc6P_Q = 389; reaction_IICB_Glc6P_Q has per_min; // Other declarations: var TCRPsite_cyaA, TCRPsiteI_crp, TCRPsiteII_crp, TCRPsite_ptsGp1, TMlcsite_ptsGp1; var TCRPsite_ptsGp2, TMlcsite_ptsGp2, TCRPsite_ptsHp0, TMlcsite_ptsHp0; var TCRPsite_ptsHp1, TCRPsite_ptsIp0, TMlcsite_ptsIp0, TCRPsite_ptsIp1; var TCRPsite_mlcp1, TMlcsite_mlcp1, TCRPsite_mlcp2, TMlcsite_mlcp2; const cyt, fast; // Unit definitions: unit substance = mole; unit time_unit = 60 second; unit volume = litre; unit M = mole / litre; unit per_min = 1 / 60 second; unit per_M = litre / mole; unit per_M_per_min = litre / (mole * 60 second); unit per_M_squared = litre^2 / mole^2; end