// Created by libAntimony v2.8.0 model *MODEL1406130001() // Compartments and Species: compartment default; species s11 in default, s14 in default, s15 in default, s16 in default; species s17 in default, s18 in default, s21 in default, s19 in default; species s36 in default, s37 in default, s38 in default; substanceOnly species $s1 in default, s2 in default, s3 in default, s4 in default; substanceOnly species s5 in default, s6 in default, s7 in default, s8 in default; substanceOnly species s9 in default, s10 in default, s12 in default, s13 in default; substanceOnly species s23 in default, $s24 in default, s25 in default, s26 in default; substanceOnly species s27 in default, $s28 in default, s29 in default, $s30 in default; substanceOnly species s31 in default, $s32 in default, s33 in default, $s34 in default; substanceOnly species s35 in default, $s22 in default; // Assignment Rules: s22 := s3; // Reactions: re30: $s22 => s4; s9/(K_PFKL_f26bp + s9)*(K_PFKL_akg/(K_PFKL_akg + s7))*(K_PFKL_pep/(K_PFKL_pep + s5))*(K_PFKL_cit/(K_PFKL_cit + s10))*(K_PFKL_icit/(K_PFKL_icit + s6))*(K_PFKL_mal/(K_PFKL_mal + s8))*(s13/(K_PFKL_PHOS_S775 + s13))*((Vf_PFKL*s22)/(K_PFKL_f6p + s22)); re31: s4 => $s22; K_FBPase_f26bp/(K_FBPase_f26bp + s9)*(s10/(K_FBPase_cit + s10))*((Vf_FBPase*s4)/(K_FBPase_f16bp + s4)); re32: s4 => s11; k_ALDO*s4; re33: s8 => s14; -k_mal; re34: s7 => s15; -k_akg; re35: s5 => s16; -k_pep; re36: s6 => s17; -k_icit; re37: s9 => s18; -k_f26bp; re38: s10 => s19; -k_cit; re39: s3 => s21; -k_f6p; re40: $s24 => s23; re40_k1*(s24 - s23); re41: s23 -> s25; re41_k1*insulin*s23 - re41_k2*s25; re42: s23 => s26; re42_k1*s23*s31; re43: s26 -> s27; re43_k1*insulin*s26 - re43_k2*s27; re44: s25 => s27; re44_k1*s25*s31; re45: s27 => s25; re45_k1*s27; re46: s26 => s23; re46_k1*s26; re47: s27 => s36; re47_k1*s27; re48: $s28 => s29; re48_k1*(s28 - s29)*s25; re49: s29 => $s28; re49_k1*s29; re50: s26 => s37; re50_k1*s26; re51: s25 => s38; re51_k1*s25; re52: $s30 => s31; re52_k1*(s30 - s31)*s29; re53: s31 => $s30; re53_k1*s31; re54: $s32 => s33; re54_k1*(s32 - s33)*s31; re55: s33 => $s32; re55_k1*s33*s35; re56: $s34 => s35; re56_k1*(s34 - s35)*s31; re57: s35 => $s34; re57_k1*s35; re58: $s1 => s13; re58_k1*(s1 - s13)*s33; re59: s13 => $s1; re59_k1*s13; // Events: ev2min: at time > 2: k_pep = 7.54147813, k_mal = -1.508295626, k_f26bp = 0.028924455, k_icit = -0.038210156, k_f6p = 1.357466063, k_cit = 0.351935646, k_akg = -1.357466063; ev5min: at time > 5: k_pep = -6.334841629, k_mal = -0.904977376, k_f26bp = 0.119075279, k_icit = -0.038210156, k_f6p = 0.271493213, k_cit = -0.211161388, k_akg = 0; ev10min: at time > 10: k_pep = 9.049773756, k_mal = 3.921568627, k_f26bp = -0.050207413, k_icit = -0.038210156, k_f6p = -1.055806938, k_cit = 1.085972851, k_akg = 0.36199095; ev15min: at time > 15: k_pep = -4.826546003, k_mal = 1.809954751, k_f26bp = 0.100115778, k_icit = -0.018099548, k_f6p = -0.12066365, k_cit = 0.452488688, k_akg = 1.085972851; ev20min: at time > 20: k_pep = -3.619909502, k_mal = 1.206636501, k_f26bp = -0.032601514, k_icit = 0.031674208, k_f6p = -0.165912519, k_cit = 0.377073906, k_akg = 0.226244344; ev30min: at time > 30: k_pep = -0.301659125, k_mal = 0.502765209, k_f26bp = -0.003055632, k_icit = 0.031674208, k_f6p = 0.070387129, k_cit = 0.306686777, k_akg = 0.369532428; ev45min: at time > 45: k_pep = -0.301659125, k_mal = 0.502765209, k_f26bp = -0.003055632, k_icit = 0.031674208, k_f6p = 0.070387129, k_cit = 0.306686777, k_akg = 0.369532428; // Species initializations: s1 = 1.235570941/default; s1 has substance_per_volume; s2 = 1/default; s3 = 14.0774258421/default; s4 = 104.07239819/default; s5 = 108.094519859/default; s6 = 1.79487179487/default; s7 = 25.1885369533/default; s8 = 68.8788335846/default; s9 = 1/default; s10 = 17.7476118652/default; s11 = 0; s12 = 1/default; s13 = 0.759332005/default; s13 has substance_per_volume; s14 = 0; s15 = 0; s16 = 0; s17 = 0; s18 = 0; s21 = 0; s19 = 0; s23 = 37.81914621/default; s24 = 46.2222520609226/default; s25 = 2.507671281/default; s26 = 852.608418/default; s27 = 3.930695895/default; s28 = 4.33812187331668/default; s29 = 0.012942682/default; s30 = 0.0959163701057347/default; s31 = 0.004015031/default; s32 = 2.7769943784158/default; s33 = 0.000988831/default; s34 = 14.9913345914433/default; s35 = 0.043352951/default; s36 = 0; s37 = 0; s38 = 0; s22 has substance_per_volume; // Compartment initializations: default = 1; default has volume; // Variable initializations: k_akg = -3.544494721; k_akg has substance; k_cit = -0.351935646; k_cit has substance; k_f6p = -0.930115636; k_f6p has dimensionless; k_icit = -0.038210156; k_icit has substance; k_f26bp = -0.083430336; k_f26bp has substance; k_mal = 1.005530417; k_mal has substance; k_pep = 43.99195576; k_pep has substance; K_FBPase_cit = 0.0211646; K_FBPase_cit has dimensionless; K_FBPase_f16bp = 0.104089638; K_FBPase_f16bp has dimensionless; K_FBPase_f26bp = 17.51744342; K_FBPase_f26bp has dimensionless; K_PFKL_PHOS_S775 = 6.283705757; K_PFKL_PHOS_S775 has dimensionless; K_PFKL_akg = 24661.01154; K_PFKL_akg has dimensionless; K_PFKL_cit = 41.30426029; K_PFKL_cit has dimensionless; K_PFKL_f26bp = 1.282443082; K_PFKL_f26bp has dimensionless; K_PFKL_f6p = 0.014114844; K_PFKL_f6p has dimensionless; K_PFKL_icit = 1784.508205; K_PFKL_icit has dimensionless; K_PFKL_mal = 9.544729149; K_PFKL_mal has dimensionless; K_PFKL_pep = 0.633518366; K_PFKL_pep has dimensionless; Vf_FBPase = 9.932861302; Vf_FBPase has dimensionless; Vf_PFKL = 695063.7194; Vf_PFKL has dimensionless; k_ALDO = 0.008187906; k_ALDO has dimensionless; insulin = 1; insulin has dimensionless; re40_k1 = 0.0477985900779305; re40_k1 has dimensionless; re41_k1 = 7.78160761103111; re41_k1 has dimensionless; re41_k2 = 1.61147523779118; re41_k2 has dimensionless; re42_k1 = 9.93311225447353; re42_k1 has dimensionless; re43_k1 = 0.363030286526969; re43_k1 has dimensionless; re43_k2 = 0.408127912886804; re43_k2 has dimensionless; re44_k1 = 3.88248960751442e-005; re44_k1 has dimensionless; re45_k1 = 0.28442597446931; re45_k1 has dimensionless; re46_k1 = 1.00000000282413e-005; re46_k1 has dimensionless; re47_k1 = 0.0948960328385619; re47_k1 has dimensionless; re48_k1 = 0.00919578911309774; re48_k1 has dimensionless; re49_k1 = 7.70618517548016; re49_k1 has dimensionless; re50_k1 = 1.00277786609339e-005; re50_k1 has dimensionless; re51_k1 = 0.00792717614041237; re51_k1 has substance; re52_k1 = 0.419682384304397; re52_k1 has dimensionless; re53_k1 = 0.124330492920416; re53_k1 has dimensionless; re54_k1 = 0.00752464611370891; re54_k1 has dimensionless; re55_k1 = 1.95497593092361; re55_k1 has dimensionless; re56_k1 = 0.00105342379833469; re56_k1 has dimensionless; re57_k1 = 0.00145811601430322; re57_k1 has substance; re58_k1 = 26.8316707654711; re58_k1 has dimensionless; re59_k1 = 0.0166525139097609; re59_k1 has dimensionless; // Other declarations: var k_akg, k_cit, k_f6p, k_icit, k_f26bp, k_mal, k_pep; const default, K_FBPase_cit, K_FBPase_f16bp, K_FBPase_f26bp, K_PFKL_PHOS_S775; const K_PFKL_akg, K_PFKL_cit, K_PFKL_f26bp, K_PFKL_f6p, K_PFKL_icit, K_PFKL_mal; const K_PFKL_pep, Vf_FBPase, Vf_PFKL, k_ALDO, insulin; // Unit definitions: unit substance = mole; unit volume = litre; unit area = metre^2; unit length = metre; unit time_unit = second; unit substance_per_volume = mole / litre; // Display Names: time_unit is "time"; s1 is "PFKL"; s2 is "FBPase"; s3 is "F6P"; s4 is "F1,6BP"; s5 is "PEP"; s6 is "Isocitrate"; s7 is "2-oxoglutarate"; s8 is "Malate"; s9 is "F2,6BP"; s10 is "Citrate"; s11 is "sa4_degraded"; s12 is "ALDO"; s13 is "pPFKL"; s14 is "sa8_degraded"; s15 is "sa7_degraded"; s16 is "sa5_degraded"; s17 is "sa6_degraded"; s18 is "sa9_degraded"; s21 is "sa3_degraded"; s19 is "sa10_degraded"; s23 is "IR_complex"; s24 is "pro_IR_complex"; s25 is "p1IR_complex"; s26 is "p2IR_complex"; s27 is "p1p2IRcomplex"; s28 is "AKT"; s29 is "pAKT"; s30 is "mTOR"; s31 is "pmTOR"; s32 is "S6K"; s33 is "pS6K"; s34 is "X"; s35 is "pX"; s36 is "sa28_degraded"; s37 is "sa27_degraded"; s38 is "sa26_degraded"; s22 is "F6P_proxy"; end