// Created by libAntimony v2.8.0
model *MODEL1406130000()
// Compartments and Species:
compartment default;
species s11 in default, s14 in default, s15 in default, s16 in default;
species s17 in default, s18 in default, s20 in default, s21 in default;
species s19 in default;
substanceOnly species s1 in default, s2 in default, s3 in default, s4 in default;
substanceOnly species s5 in default, s6 in default, s7 in default, s8 in default;
substanceOnly species s9 in default, s10 in default, s12 in default, s13 in default;
substanceOnly species $s22 in default;
// Assignment Rules:
s22 := s3;
// Reactions:
re1: $s22 => s4; s9/(K_PFKL_f26bp + s9)*(K_PFKL_akg/(K_PFKL_akg + s7))*(K_PFKL_pep/(K_PFKL_pep + s5))*(K_PFKL_cit/(K_PFKL_cit + s10))*(K_PFKL_icit/(K_PFKL_icit + s6))*(K_PFKL_mal/(K_PFKL_mal + s8))*(s13/(K_PFKL_PHOS_S775 + s13))*((Vf_PFKL*s22)/(K_PFKL_f6p + s22));
re2: s4 => $s22; K_FBPase_f26bp/(K_FBPase_f26bp + s9)*(s10/(K_FBPase_cit + s10))*((Vf_FBPase*s4)/(K_FBPase_f16bp + s4));
re3: s4 => s11; k_ALDO*s4;
re4: s8 => s14; -k_mal;
re5: s7 => s15; -k_akg;
re6: s5 => s16; -k_pep;
re7: s6 => s17; -k_icit;
re8: s9 => s18; -k_f26bp;
re9: s10 => s19; -k_cit;
re10: s13 => s20; -k_pfkl_s775;
re11: s3 => s21; -k_f6p;
// Events:
ev2min: at time > 2: k_pfkl_s775 = -0.011384308, k_pep = 7.54147813, k_mal = -1.508295626, k_f26bp = 0.028924455, k_icit = -0.038210156, k_f6p = 1.357466063, k_cit = 0.351935646, k_akg = -1.357466063;
ev5min: at time > 5: k_pfkl_s775 = 0.057596439, k_pep = -6.334841629, k_mal = -0.904977376, k_f26bp = 0.119075279, k_icit = -0.038210156, k_f6p = 0.271493213, k_cit = -0.211161388, k_akg = 0;
ev10min: at time > 10: k_pfkl_s775 = 0.006730598, k_pep = 9.049773756, k_mal = 3.921568627, k_f26bp = -0.050207413, k_icit = -0.038210156, k_f6p = -1.055806938, k_cit = 1.085972851, k_akg = 0.36199095;
ev15min: at time > 15: k_pfkl_s775 = 0.006730598, k_pep = -4.826546003, k_mal = 1.809954751, k_f26bp = 0.100115778, k_icit = -0.018099548, k_f6p = -0.12066365, k_cit = 0.452488688, k_akg = 1.085972851;
ev20min: at time > 20: k_pfkl_s775 = 0.006730598, k_pep = -3.619909502, k_mal = 1.206636501, k_f26bp = -0.032601514, k_icit = 0.031674208, k_f6p = -0.165912519, k_cit = 0.377073906, k_akg = 0.226244344;
ev30min: at time > 30: k_pfkl_s775 = 0.006730598, k_pep = -0.301659125, k_mal = 0.502765209, k_f26bp = -0.003055632, k_icit = 0.031674208, k_f6p = 0.070387129, k_cit = 0.306686777, k_akg = 0.369532428;
ev45min: at time > 45: k_pfkl_s775 = 0.00673059831429, k_pep = -0.301659125, k_mal = 0.502765209, k_f26bp = -0.003055632, k_icit = 0.031674208, k_f6p = 0.070387129, k_cit = 0.306686777, k_akg = 0.369532428;
// Species initializations:
s1 = 1/default;
s2 = 1/default;
s3 = 14.0774258421/default;
s4 = 104.07239819/default;
s5 = 108.094519859/default;
s6 = 1.79487179487/default;
s7 = 25.1885369533/default;
s8 = 68.8788335846/default;
s9 = 1/default;
s10 = 17.7476118652/default;
s11 = 0;
s12 = 1/default;
s13 = 0.768939345/default;
s14 = 0;
s15 = 0;
s16 = 0;
s17 = 0;
s18 = 0;
s20 = 0;
s21 = 0;
s19 = 0;
s22 has substance_per_volume;
// Compartment initializations:
default = 1;
default has volume;
// Variable initializations:
k_akg = -3.544494721;
k_akg has substance;
k_cit = -0.351935646;
k_cit has substance;
k_f6p = -0.930115636;
k_f6p has dimensionless;
k_icit = -0.038210156;
k_icit has substance;
k_f26bp = -0.083430336;
k_f26bp has substance;
k_mal = 1.005530417;
k_mal has substance;
k_pep = 43.99195576;
k_pep has substance;
k_pfkl_s775 = -0.011384308;
k_pfkl_s775 has substance;
K_FBPase_cit = 0.0211646;
K_FBPase_cit has dimensionless;
K_FBPase_f16bp = 0.104089638;
K_FBPase_f16bp has dimensionless;
K_FBPase_f26bp = 17.51744342;
K_FBPase_f26bp has dimensionless;
K_PFKL_PHOS_S775 = 6.283705757;
K_PFKL_PHOS_S775 has dimensionless;
K_PFKL_akg = 24661.01154;
K_PFKL_akg has dimensionless;
K_PFKL_cit = 41.30426029;
K_PFKL_cit has dimensionless;
K_PFKL_f26bp = 1.282443082;
K_PFKL_f26bp has dimensionless;
K_PFKL_f6p = 0.014114844;
K_PFKL_f6p has dimensionless;
K_PFKL_icit = 1784.508205;
K_PFKL_icit has dimensionless;
K_PFKL_mal = 9.544729149;
K_PFKL_mal has dimensionless;
K_PFKL_pep = 0.633518366;
K_PFKL_pep has dimensionless;
Vf_FBPase = 9.932861302;
Vf_FBPase has dimensionless;
Vf_PFKL = 695063.7194;
Vf_PFKL has dimensionless;
k_ALDO = 0.008187906;
k_ALDO has dimensionless;
// Other declarations:
var k_akg, k_cit, k_f6p, k_icit, k_f26bp, k_mal, k_pep, k_pfkl_s775;
const default, K_FBPase_cit, K_FBPase_f16bp, K_FBPase_f26bp, K_PFKL_PHOS_S775;
const K_PFKL_akg, K_PFKL_cit, K_PFKL_f26bp, K_PFKL_f6p, K_PFKL_icit, K_PFKL_mal;
const K_PFKL_pep, Vf_FBPase, Vf_PFKL, k_ALDO;
// Unit definitions:
unit substance = mole;
unit volume = litre;
unit area = metre^2;
unit length = metre;
unit time_unit = second;
unit substance_per_volume = mole / litre;
// Display Names:
time_unit is "time";
s1 is "PFKL";
s2 is "FBPase";
s3 is "F6P";
s4 is "F1,6BP";
s5 is "PEP";
s6 is "Isocitrate";
s7 is "2-oxoglutarate";
s8 is "Malate";
s9 is "F2,6BP";
s10 is "Citrate";
s11 is "sa4_degraded";
s12 is "ALDO";
s13 is "pPFKL";
s14 is "sa8_degraded";
s15 is "sa7_degraded";
s16 is "sa5_degraded";
s17 is "sa6_degraded";
s18 is "sa9_degraded";
s20 is "sa13_degraded";
s21 is "sa3_degraded";
s19 is "sa10_degraded";
s22 is "F6P_proxy";
end