// Created by libAntimony v2.8.0 model *MODEL1401200001() // Compartments and Species: compartment cell; species $d in cell, $ad in cell, $e in cell, $ca in cell, $rs in cell, $x in cell; species $r in cell, $ip3 in cell, $gstar in cell, $kg in cell, $ro in cell; species $delta in cell, $atp in cell, $ip3con in cell, $rscon in cell, $y in cell; // Assignment Rules: ad := addash + gamma*(ca - p1); ca := p1 + (p2*ip3^m)/(p3^m + ip3^m) + (p4*ip3^n)/(p5^n + ip3^n); gstar := (ro + delta)/(kg + delta + ro); kg := kd/ka; ro := atp/(kr + atp); delta := (kg*kdeg*ip30)/(rhstar - kdeg*ip30); ip3con := (tanh((ip3 - ip3min)/0.01) + 1)/2; rscon := (tanh((rscrit - rs)/0.01) + 1)/2; // Rate Rules: d' = ad*((k*gf)/(1 + k*gf)) - ddd*e*d; e' = ae*(1 + af*(yo - rs)) - dee*x*e; rs' = ps*(yo - rs)*r - (pd*rs*d)/(qd + rs + d) - (pe*rs*e)/(qe + rs + e); x' = (ax*e + f*(yo - rs) + g*x^2*e) - dxx*x; r' = (px*(rt - rs - r)*x)/(qx + (rt - rs - r) + x) - ps*(yo - rs)*r; ip3' = scale*(rhstar*gstar - kdeg*ip3); atp' = scale*(vatp_s*(y - atp)*rscon*ip3con*((ip3 - ip3min)/(krel + ip3)) - (vdeg*atp)/(kkdeg + atp)); y' = scale*(alpha*(ymax - y) - rscon*ip3con*vatp_s*(y - atp)*((ip3 - ip3min)/(krel + ip3))); // Species initializations: d = 0; e = 1; rs = 1.1; x = 0; r = 0; ip3 = 0; atp = 0; y = 0; // Compartment initializations: cell = 1; // Variable initializations: k = 0.05; gf = 6.3; ddd = 0.4; addash = 0.41; p1 = 0.0159835; ae = 0.16; af = 0.9; yo = 1.5; dee = 0.2; px = 0.48; rt = 2.5; qx = 0.8; ps = 0.6; pd = 0.48; qd = 0.6; pe = 0.096; qe = 0.6; ax = 0.08; f = 0.2; g = 0.528; dxx = 1.04; scale = 3600; rhstar = 0.6; kdeg = 0.0625; kd = 0.15; ka = 0.017; kr = 25; ip3min = 0.012; rscrit = 1; vatp_s = 50; krel = 10; vdeg = 2; kkdeg = 50; alpha = 0.083; ymax = 500; ip30 = 0.013; p2 = 0.514987; m = 24.1946; p3 = 1.31319; p4 = 0.332195; n = 9.79183; p5 = 0.787902; smoothness = 0.01; gamma = 1; dip = 280; datpp = 300; cabasil = 0.02055236; dist = 50; // Other declarations: const cell, k, gf, ddd, addash, p1, ae, af, yo, dee, px, rt, qx, ps, pd; const qd, pe, qe, ax, f, g, dxx, scale, rhstar, kdeg, kd, ka, kr, ip3min; const rscrit, vatp_s, krel, vdeg, kkdeg, alpha, ymax, ip30, p2, m, p3, p4; const n, p5, smoothness, gamma, dip, datpp, cabasil, dist; end