// Created by libAntimony v2.8.0
model *MODEL1305280001()

  // Compartments and Species:
  compartment cytoplasm, nucleus, membrane, ecm;
  substanceOnly species ADAMTS4_mRNA in cytoplasm, cFos in cytoplasm, cFos_mRNA in cytoplasm;
  substanceOnly species cJun in cytoplasm, cJun_mRNA in cytoplasm, DUSP16 in cytoplasm;
  substanceOnly species IRAK2 in cytoplasm, IRAK2_TRAF6 in cytoplasm, IRAK2_TRAF6_PP4 in cytoplasm;
  substanceOnly species JAK1 in cytoplasm, JAK1_P in cytoplasm, JNK in cytoplasm;
  substanceOnly species JNK_P in cytoplasm, Matriptase in cytoplasm, MKP1 in cytoplasm;
  substanceOnly species MMP1_mRNA in cytoplasm, MMP3_mRNA in cytoplasm, MMP13_mRNA in cytoplasm;
  substanceOnly species p38 in cytoplasm, p38_P in cytoplasm, PP4 in cytoplasm;
  substanceOnly species proMMP1 in cytoplasm, proMMP3 in cytoplasm, proMMP13 in cytoplasm;
  substanceOnly species PTPRT in cytoplasm, SOCS3 in cytoplasm, SOCS3_mRNA in cytoplasm;
  substanceOnly species STAT3_cyt in cytoplasm, STAT3_P_cyt in cytoplasm;
  substanceOnly species TIMP1_mRNA in cytoplasm, TIMP3_mRNA in cytoplasm;
  substanceOnly species TRAF6 in cytoplasm, TRAF6_PP4 in cytoplasm, ADAMTS4 in ecm;
  substanceOnly species ADAMTS4_TIMP1 in ecm, ADAMTS4_TIMP3 in ecm, Aggrecan in ecm;
  substanceOnly species Aggrecan_Collagen2 in ecm, AggFrag in ecm, ColFrag in ecm;
  substanceOnly species Collagen2 in ecm, IL1 in ecm, MMP1 in ecm, MMP1_TIMP1 in ecm;
  substanceOnly species MMP1_TIMP3 in ecm, MMP3 in ecm, MMP3_TIMP1 in ecm;
  substanceOnly species MMP3_TIMP3 in ecm, MMP13 in ecm, MMP13_TIMP1 in ecm;
  substanceOnly species MMP13_TIMP3 in ecm, OSM in ecm, TIMP1 in ecm, TIMP3 in ecm;
  substanceOnly species IL1_IL1R in membrane, IL1_IL1Ra in membrane, IL1_IL1R_IRAK2 in membrane;
  substanceOnly species IL1R in membrane, IL1Ra in membrane, OSM_OSMR in membrane;
  substanceOnly species OSM_OSMRa in membrane, OSMR_SOCS3 in membrane, OSMR in membrane;
  substanceOnly species OSMRa in membrane, cFos_cJun in nucleus, cFos_P in nucleus;
  substanceOnly species cJun_P in nucleus, cJun_dimer in nucleus, SP1 in nucleus;
  substanceOnly species SP1_TIMP1_DNA in nucleus, STAT3_nuc in nucleus, STAT3_P_nuc in nucleus;
  substanceOnly species TIMP1_DNA in nucleus, $Source in cytoplasm, $Sink in cytoplasm;

  // Reactions:
  IL1binding: IL1 + IL1R => IL1_IL1R; kbinIL1IL1R*IL1*IL1R;
  IL1release: IL1_IL1R => IL1 + IL1R; krelIL1IL1R*IL1_IL1R;
  IL1antagonistbinding: IL1 + IL1Ra => IL1_IL1Ra; kbinIL1IL1Ra*IL1*IL1Ra;
  IL1antagonistrelease: IL1_IL1Ra => IL1 + IL1Ra; krelIL1IL1Ra*IL1_IL1Ra;
  IL1degradation: IL1 => $Sink; kdegIL1*IL1;
  IRAK2binding: IL1_IL1R + IRAK2 => IL1_IL1R_IRAK2; kbinIRAK2*IL1_IL1R*IRAK2;
  IRAK2release: IL1_IL1R_IRAK2 => IL1_IL1R + IRAK2; krelIRAK2*IL1_IL1R_IRAK2;
  TRAF6binding: IL1_IL1R_IRAK2 + TRAF6 => IL1_IL1R + IRAK2_TRAF6; kbinTRAF6*IL1_IL1R_IRAK2*TRAF6;
  TRAF6release: IRAK2_TRAF6 => IRAK2 + TRAF6; krelTRAF6*IRAK2_TRAF6;
  JNKphosphorylation: JNK + IRAK2_TRAF6 => JNK_P + IRAK2_TRAF6; kphosJNK*JNK*IRAK2_TRAF6;
  JNKdephosphorylation: JNK_P => JNK; kdephosJNK*JNK_P;
  JNKdephosphorylationByDUSP16: JNK_P + DUSP16 => JNK + DUSP16; kdephosJNKDUSP16*JNK_P*DUSP16;
  cJunPhosphorylation: cJun + JNK_P => cJun_P + JNK_P; kphoscJun*cJun*JNK_P;
  cJunDephosphorylation: cJun_P => cJun; kdephoscJun*cJun_P;
  cJunDimerisation: 2cJun_P => cJun_dimer; kdimercJun*cJun_P*(cJun_P - 1)*0.5;
  cJunDedimerisation: cJun_dimer => 2cJun_P; kdedimercJun*cJun_dimer;
  cJunTranscriptionAP1: cFos_cJun => cJun_mRNA + cFos_cJun; ksyncJunmRNA*cFos_cJun*kAP1activity;
  cJunTranscriptioncJun: cJun_dimer => cJun_mRNA + cJun_dimer; ksyncJunmRNAcJun*cJun_dimer;
  cJunBasalTranscription: $Source => cJun_mRNA; ksynbasalcJunmRNA*Source;
  cJunmRNADegradation: cJun_mRNA => $Sink; kdegcJunmRNA*cJun_mRNA;
  cJunTranslation: cJun_mRNA => cJun_mRNA + cJun; ksyncJun*cJun_mRNA;
  cJunDegradation: cJun => $Sink; kdegcJun*cJun;
  p38phosphorylation: p38 + IRAK2_TRAF6 => p38_P + IRAK2_TRAF6; kphosp38*p38*IRAK2_TRAF6;
  p38dephosphorylation: p38_P => p38; kdephosp38*p38_P;
  p38dephosphorylationMKP1: p38_P + MKP1 => p38 + MKP1; kdephosp38MKP1*p38_P*MKP1;
  MMP1Transcription_AP1: cFos_cJun => cFos_cJun + MMP1_mRNA; ksynMMP1mRNA*cFos_cJun*kAP1activity;
  MMP1Transcription_cJun_dimer: cJun_dimer => cJun_dimer + MMP1_mRNA; ksynMMP1mRNAcJun*cJun_dimer;
  MMP1Translation: MMP1_mRNA => MMP1_mRNA + proMMP1; ksynMMP1*MMP1_mRNA;
  MMP1mRNADegradation: MMP1_mRNA => $Sink; kdegMMP1mRNA*MMP1_mRNA;
  proMMP1cleavageByMatriptase: proMMP1 + Matriptase => MMP1 + Matriptase; kactMMP1mat*proMMP1*Matriptase;
  proMMP1cleavageByMMP3: proMMP1 + MMP3 => MMP1 + MMP3; kactMMP1mmp3*proMMP1*MMP3;
  MMP1Degradation: MMP1 => $Sink; kdegMMP1*MMP1;
  MMP3Transcription_AP1: cFos_cJun => cFos_cJun + MMP3_mRNA; ksynMMP3mRNA*cFos_cJun*kAP1activity;
  MMP3Transcription_cJun_dimer: cJun_dimer => cJun_dimer + MMP3_mRNA; ksynMMP3mRNAcJun*cJun_dimer;
  MMP3Translation: MMP3_mRNA => MMP3_mRNA + proMMP3; ksynMMP3*MMP3_mRNA;
  MMP3mRNADegradation: MMP3_mRNA => $Sink; kdegMMP3mRNA*MMP3_mRNA;
  proMMP3cleavageByMatriptase: proMMP3 + Matriptase => MMP3 + Matriptase; kactMMP3mat*proMMP3*Matriptase;
  MMP3Degradation: MMP3 => $Sink; kdegMMP3*MMP3;
  MMP13Transcription_AP1: cFos_cJun => cFos_cJun + MMP13_mRNA; ksynMMP13mRNA*cFos_cJun*kAP1activity;
  MMP13Transcription_cJun_dimer: cJun_dimer => cJun_dimer + MMP13_mRNA; ksynMMP13mRNAcJun*cJun_dimer;
  MMP13Translation: MMP13_mRNA => MMP13_mRNA + proMMP13; ksynMMP13*MMP13_mRNA;
  MMP13mRNADegradation: MMP13_mRNA => $Sink; kdegMMP13mRNA*MMP13_mRNA;
  proMMP13cleavageByMMP3: proMMP13 + MMP3 => MMP13 + MMP3; kactMMP13mmp3*proMMP13*MMP3;
  MMP13Degradation: MMP13 => $Sink; kdegMMP13*MMP13;
  TIMP1Translation: TIMP1_mRNA => TIMP1_mRNA + TIMP1; ksynTIMP1*TIMP1_mRNA;
  TIMP1mRNADegradation: TIMP1_mRNA => $Sink; kdegTIMP1mRNA*TIMP1_mRNA;
  TIMP1Degradation: TIMP1 => $Sink; kdegTIMP1*TIMP1;
  ADAMTS4Transcription_AP1: cFos_cJun => cFos_cJun + ADAMTS4_mRNA; ksynADAMTS4mRNA*cFos_cJun*kAP1activity;
  ADAMTS4Transcription_cJun_dimer: cJun_dimer => cJun_dimer + ADAMTS4_mRNA; ksynADAMTS4mRNAcJun*cJun_dimer;
  ADAMTS4Translation: ADAMTS4_mRNA => ADAMTS4_mRNA + ADAMTS4; ksynADAMTS4*ADAMTS4_mRNA;
  ADAMTS4mRNADegradation: ADAMTS4_mRNA => $Sink; kdegADAMTS4mRNA*ADAMTS4_mRNA;
  ADAMTS4Degradation: ADAMTS4 => $Sink; kdegADAMTS4*ADAMTS4;
  PP4Synthesis: cFos_cJun => cFos_cJun + PP4; ksynPP4*cFos_cJun*kAP1activity;
  PP4Synthesis_cJun_dimer: cJun_dimer => cJun_dimer + PP4; ksynPP4cJun*cJun_dimer;
  DUSP16Synthesis: cFos_cJun => cFos_cJun + DUSP16; ksynDUSP16*cFos_cJun*kAP1activity;
  DUSP16Synthesis_cJun_dimer: cJun_dimer => cJun_dimer + DUSP16; ksynDUSP16cJun*cJun_dimer;
  PP4Degradation: PP4 => $Sink; kdegPP4*PP4;
  DUSP16Degradation: DUSP16 => $Sink; kdegDUSP16*DUSP16;
  TRAF6Inhibition: TRAF6 + PP4 => TRAF6_PP4; kinhibTRAF6*TRAF6*PP4;
  BoundTRAF6Inhibition: IRAK2_TRAF6 + PP4 => IRAK2_TRAF6_PP4; kinhibTRAF6*IRAK2_TRAF6*PP4;
  TRAF6PP4Disassociation: TRAF6_PP4 => TRAF6 + PP4; krelTRAF6PP4*TRAF6_PP4;
  IRAK2_TRAF6PP4Disassociation: IRAK2_TRAF6_PP4 => IRAK2_TRAF6 + PP4; krelTRAF6PP4*IRAK2_TRAF6_PP4;
  Transcription_cFos_byAP1: cFos_cJun => cFos_cJun + cFos_mRNA; ksyncFosmRNA*cFos_cJun*kAP1activity;
  cFosmRNA_Degradation: cFos_mRNA => $Sink; kdegcFosmRNA*cFos_mRNA;
  cFosSynthesis: cFos_mRNA => cFos_mRNA + cFos; ksyncFos*cFos_mRNA;
  cFosDegradation: cFos => $Sink; kdegcFos*cFos;
  cFosPhosphorylation_p38: p38_P + cFos => p38_P + cFos_P; kphoscFos*p38_P*cFos;
  cFosDephosphorylation: cFos_P => cFos; kdephoscFos*cFos_P;
  MKP1Synthesis: cFos_cJun => MKP1 + cFos_cJun; ksynMKP1*cFos_cJun*kAP1activity;
  MKP1Synthesis_cJun_dimer: cJun_dimer => MKP1 + cJun_dimer; ksynMKP1cJun*cJun_dimer;
  MKP1Degradation: MKP1 => $Sink; kdegMKP1*MKP1;
  cFosDephosphorylationByDusp16: cFos_P + DUSP16 => cFos + DUSP16; kdephoscFosDUSP16*cFos_P*DUSP16;
  cFoscJunBinding: cFos_P + cJun_P => cFos_cJun; kbincFoscJun*cFos_P*cJun_P;
  cFoscJunRelease: cFos_cJun => cFos_P + cJun_P; krelcFoscJun*cFos_cJun;
  OSM_OSMR_binding: OSM + OSMR => OSM_OSMR; kbinOSMOSMR*OSM*OSMR;
  OSM_OSMR_release: OSM_OSMR => OSM + OSMR; krelOSMOSMR*OSM_OSMR;
  OSM_OSMRa_binding: OSM + OSMRa => OSM_OSMRa; kbinOSMOSMRa*OSM*OSMRa;
  OSM_OSMRa_release: OSM_OSMRa => OSM + OSMRa; krelOSMOSMRa*OSM_OSMRa;
  JAK1_Phosphorylation: JAK1 + OSM_OSMR => JAK1_P + OSM_OSMR; kphosJAK1*JAK1*OSM_OSMR;
  JAK1_Dephosphorylation: JAK1_P => JAK1; kdephosJAK1*JAK1_P;
  JAK1_DephosphorylationByPTPRT: JAK1_P + PTPRT => JAK1 + PTPRT; kdephosJAK1PTPRT*JAK1_P*PTPRT;
  STAT3_Phosphorylation: STAT3_cyt + JAK1_P => STAT3_P_cyt + JAK1_P; kphosSTAT3*STAT3_cyt*JAK1_P;
  STAT3_cyt_Dephosphorylation: STAT3_P_cyt => STAT3_cyt; kdephosSTAT3*STAT3_P_cyt;
  STAT3_cyt_DephosphorylationByPTPRT: STAT3_P_cyt + PTPRT => STAT3_cyt + PTPRT; kdephosSTAT3PTPRT*STAT3_P_cyt*PTPRT;
  STAT3_nuc_Dephosphorylation: STAT3_P_nuc => STAT3_nuc; kdephosSTAT3nuc*STAT3_P_nuc;
  STAT3_nuc_DephosphorylationByPTPRT: STAT3_P_nuc + PTPRT => STAT3_nuc + PTPRT; kdephosSTAT3nucPTPRT*STAT3_P_nuc*PTPRT;
  STAT3_transport_to_nucleus: STAT3_P_cyt => STAT3_P_nuc; kcyt2nucSTAT3*STAT3_P_cyt;
  STAT3_transport_from_nucleus: STAT3_nuc => STAT3_cyt; knuc2cytSTAT3*STAT3_nuc;
  cFos_induction_by_STAT3: STAT3_P_nuc => STAT3_P_nuc + cFos_mRNA; ksyncFosmRNAStat3*STAT3_P_nuc;
  PTPRT_induction_by_STAT3: STAT3_P_nuc => STAT3_P_nuc + PTPRT; ksynPTPRT*STAT3_P_nuc;
  PTPRT_degradation: PTPRT => $Sink; kdegPTPRT*PTPRT;
  STAT3_induction_of_SOCS3: STAT3_P_nuc => STAT3_P_nuc + SOCS3_mRNA; ksynSOCS3mRNA*STAT3_P_nuc;
  SOCS3mRNAdegradation: SOCS3_mRNA => $Sink; kdegSOCS3mRNA*SOCS3_mRNA;
  SOCS3_translation: SOCS3_mRNA => SOCS3_mRNA + SOCS3; ksynSOCS3*SOCS3_mRNA;
  SOCS3_degradation: SOCS3 => $Sink; kdegSOCS3*SOCS3;
  SOCS3_OSMR_binding: SOCS3 + OSMR => OSMR_SOCS3; kbinSOCS3OSMR*SOCS3*OSMR;
  SOCS3_OSMR_release: OSMR_SOCS3 => SOCS3 + OSMR; krelSOCS3OSMR*OSMR_SOCS3;
  OSM_degradation: OSM => $Sink; kdegOSM*OSM;
  MMP1InhibtionByTIMP1: MMP1 + TIMP1 => MMP1_TIMP1; kinhibMMP1TIMP1*MMP1*TIMP1;
  MMP1_TIMP1release: MMP1_TIMP1 => MMP1 + TIMP1; krelMMP1*MMP1_TIMP1;
  MMP3InhibtionByTIMP1: MMP3 + TIMP1 => MMP3_TIMP1; kinhibMMP3TIMP1*MMP3*TIMP1;
  MMP3_TIMP1release: MMP3_TIMP1 => MMP3 + TIMP1; krelMMP3*MMP3_TIMP1;
  MMP13InhibtionByTIMP1: MMP13 + TIMP1 => MMP13_TIMP1; kinhibMMP13TIMP1*MMP13*TIMP1;
  MMP13_TIMP1release: MMP13_TIMP1 => MMP13 + TIMP1; krelMMP13*MMP13_TIMP1;
  ADAMTS4InhibtionByTIMP1: ADAMTS4 + TIMP1 => ADAMTS4_TIMP1; kinhibADAMTS4TIMP1*ADAMTS4*TIMP1;
  ADAMTS4_TIMP1release: ADAMTS4_TIMP1 => ADAMTS4 + TIMP1; krelADAMTS4TIMP1*ADAMTS4_TIMP1;
  Collagen2DegradationByMMP1: Collagen2 + MMP1 => MMP1 + ColFrag; kdegCollagen2mmp1*Collagen2*MMP1;
  Collagen2DegradationByMMP13: Collagen2 + MMP13 => MMP13 + ColFrag; kdegCollagen2mmp13*Collagen2*MMP13;
  AggrecanDegradationByADAMTS4: Aggrecan_Collagen2 + ADAMTS4 => ADAMTS4 + Collagen2 + AggFrag; kdegAggrecan*Aggrecan_Collagen2*ADAMTS4;
  MatriptaseSynthesis: cFos_cJun => Matriptase + cFos_cJun; ksynMatriptase*cFos_cJun*kAP1activity;
  MatriptaseDegradation: Matriptase => $Sink; kdegMatriptase*Matriptase;
  SP1Synthesis: cFos_cJun => SP1 + cFos_cJun; ksynSP1*cFos_cJun*kAP1activity;
  SP1Degradation: SP1 => $Sink; kdegSP1*SP1;
  SP1_TIMP1_DNAbinding: SP1 + TIMP1_DNA => SP1_TIMP1_DNA; kbinSP1TIMP1DNA*SP1*TIMP1_DNA;
  SP1_TIMP1_DNArelease: SP1_TIMP1_DNA => SP1 + TIMP1_DNA; krelSP1TIMP1DNA*SP1_TIMP1_DNA;
  TIMP1_transcription_STAT3: STAT3_P_nuc + TIMP1_DNA => STAT3_P_nuc + TIMP1_DNA + TIMP1_mRNA; ksynTIMP1mRNAStat3*STAT3_P_nuc*TIMP1_DNA;
  TIMP1BasalTranscription: TIMP1_DNA => TIMP1_mRNA + TIMP1_DNA; ksynbasalTIMP1mRNA*TIMP1_DNA;
  TIMP1Transcription_AP1: cFos_cJun + TIMP1_DNA => cFos_cJun + TIMP1_mRNA + TIMP1_DNA; ksynTIMP1mRNA*cFos_cJun*TIMP1_DNA*kAP1activity;
  TIMP3BasalTranscriptionn: $Source => TIMP3_mRNA; ksynbasalTIMP3mRNA*Source;
  TIMP3Transcription_AP1: cFos_cJun => cFos_cJun + TIMP3_mRNA; ksynTIMP3mRNA*cFos_cJun*kAP1activity;
  TIMP3Transcription_STAT3: STAT3_P_nuc => STAT3_P_nuc + TIMP3_mRNA; ksynTIMP3mRNAStat3*STAT3_P_nuc*kAP1activity;
  TIMP3Translation: TIMP3_mRNA => TIMP3_mRNA + TIMP3; ksynTIMP3*TIMP3_mRNA;
  TIMP3mRNADegradation: TIMP3_mRNA => $Sink; kdegTIMP3mRNA*TIMP3_mRNA;
  TIMP3Degradation: TIMP3 => $Sink; kdegTIMP3*TIMP3;
  ADAMTS4InhibitionByTimp3: TIMP3 + ADAMTS4 => ADAMTS4_TIMP3; kinhibADAMTS4TIMP3*TIMP3*ADAMTS4;
  ADAMTS4_TIMP3release: ADAMTS4_TIMP3 => ADAMTS4 + TIMP3; krelADAMTS4TIMP3*ADAMTS4_TIMP3;
  MMP1InhibtionByTIMP3: MMP1 + TIMP3 => MMP1_TIMP3; kinhibMMP1TIMP3*MMP1*TIMP3;
  MMP1_TIMP3release: MMP1_TIMP3 => MMP1 + TIMP3; krelMMP1TIMP3*MMP1_TIMP3;
  MMP3InhibtionByTIMP3: MMP3 + TIMP3 => MMP3_TIMP3; kinhibMMP3TIMP3*MMP3*TIMP3;
  MMP3_TIMP3release: MMP3_TIMP3 => MMP3 + TIMP3; krelMMP3TIMP3*MMP3_TIMP3;
  MMP13InhibtionByTIMP3: MMP13 + TIMP3 => MMP13_TIMP3; kinhibMMP13TIMP3*MMP13*TIMP3;
  MMP13_TIMP3release: MMP13_TIMP3 => MMP13 + TIMP3; krelMMP13TIMP3*MMP13_TIMP3;

  // Species initializations:
  ADAMTS4_mRNA = 0;
  cFos = 0;
  cFos_mRNA = 0;
  cJun = 100/cytoplasm;
  cJun_mRNA = 5/cytoplasm;
  DUSP16 = 0;
  IRAK2 = 100/cytoplasm;
  IRAK2_TRAF6 = 0;
  IRAK2_TRAF6_PP4 = 0;
  JAK1 = 100/cytoplasm;
  JAK1_P = 0;
  JNK = 100/cytoplasm;
  JNK_P = 0;
  Matriptase = 100/cytoplasm;
  MKP1 = 0;
  MMP1_mRNA = 0;
  MMP3_mRNA = 0;
  MMP13_mRNA = 0;
  p38 = 100/cytoplasm;
  p38_P = 0;
  PP4 = 0;
  proMMP1 = 0;
  proMMP3 = 0;
  proMMP13 = 0;
  PTPRT = 0;
  SOCS3 = 0;
  SOCS3_mRNA = 0;
  STAT3_cyt = 100/cytoplasm;
  STAT3_P_cyt = 0;
  TIMP1_mRNA = 20/cytoplasm;
  TIMP3_mRNA = 20/cytoplasm;
  TRAF6 = 100/cytoplasm;
  TRAF6_PP4 = 0;
  ADAMTS4 = 0;
  ADAMTS4_TIMP1 = 0;
  ADAMTS4_TIMP3 = 0;
  Aggrecan = 0;
  Aggrecan_Collagen2 = 100000/ecm;
  AggFrag = 0;
  ColFrag = 0;
  Collagen2 = 0;
  IL1 = 100/ecm;
  MMP1 = 0;
  MMP1_TIMP1 = 0;
  MMP1_TIMP3 = 0;
  MMP3 = 0;
  MMP3_TIMP1 = 0;
  MMP3_TIMP3 = 0;
  MMP13 = 0;
  MMP13_TIMP1 = 0;
  MMP13_TIMP3 = 0;
  OSM = 1000/ecm;
  TIMP1 = 200/ecm;
  TIMP3 = 200/ecm;
  IL1_IL1R = 0;
  IL1_IL1Ra = 0;
  IL1_IL1R_IRAK2 = 0;
  IL1R = 100/membrane;
  IL1Ra = 0;
  OSM_OSMR = 0;
  OSM_OSMRa = 0;
  OSMR_SOCS3 = 0;
  OSMR = 100/membrane;
  OSMRa = 0;
  cFos_cJun = 0;
  cFos_P = 0;
  cJun_P = 0;
  cJun_dimer = 0;
  SP1 = 0;
  SP1_TIMP1_DNA = 0;
  STAT3_nuc = 0;
  STAT3_P_nuc = 0;
  TIMP1_DNA = 2/nucleus;
  Source = 1/cytoplasm;
  Sink = 1/cytoplasm;

  // Compartment initializations:
  cytoplasm = 1;
  nucleus = 1;
  membrane = 1;
  ecm = 1;

  // Variable initializations:
  kactMMP13mmp3 = 5e-008;
  kactMMP1mat = 1e-009;
  kactMMP1mmp3 = 1e-008;
  kactMMP3mat = 4e-006;
  kAP1activity = 1;
  kbincFoscJun = 5e-005;
  kbinIL1IL1R = 0.0001;
  kbinIL1IL1Ra = 0.0001;
  kbinIRAK2 = 5e-005;
  kbinOSMOSMR = 1e-005;
  kbinOSMOSMRa = 0.0001;
  kbinSOCS3OSMR = 0.005;
  kbinSP1TIMP1DNA = 1e-005;
  kbinTRAF6 = 1e-005;
  kcyt2nucSTAT3 = 0.001;
  kdedimercJun = 0.01;
  kdegADAMTS4 = 5e-005;
  kdegADAMTS4mRNA = 1.4e-005;
  kdegAggrecan = 3e-008;
  kdegcFos = 0.0002;
  kdegcFosmRNA = 0.003;
  kdegcJun = 0.00013;
  kdegcJunmRNA = 0.003;
  kdegCollagen2mmp1 = 5e-012;
  kdegCollagen2mmp13 = 5e-011;
  kdegDUSP16 = 0.00013;
  kdegIL1 = 0.0002;
  kdegMatriptase = 8e-006;
  kdegMKP1 = 0.0001;
  kdegMMP1 = 1e-006;
  kdegMMP13 = 1e-006;
  kdegMMP13mRNA = 6.4e-006;
  kdegMMP1mRNA = 6.4e-006;
  kdegMMP3 = 1e-006;
  kdegMMP3mRNA = 6.4e-006;
  kdegOSM = 4.8e-005;
  kdegPP4 = 0.0001;
  kdegPTPRT = 5e-005;
  kdegSOCS3 = 0.0008;
  kdegSOCS3mRNA = 0.0004;
  kdegSP1 = 2e-005;
  kdegTIMP1 = 2e-005;
  kdegTIMP1mRNA = 1.4e-005;
  kdegTIMP3 = 2e-005;
  kdegTIMP3mRNA = 1.4e-005;
  kdephoscFos = 0.0001;
  kdephoscFosDUSP16 = 0.0001;
  kdephoscJun = 0.01;
  kdephosJAK1 = 0.0004;
  kdephosJAK1PTPRT = 0.004;
  kdephosJNK = 0.001;
  kdephosJNKDUSP16 = 0.001;
  kdephosp38 = 0.001;
  kdephosp38MKP1 = 1e-005;
  kdephosSTAT3 = 1e-005;
  kdephosSTAT3nuc = 1e-007;
  kdephosSTAT3nucPTPRT = 0.0005;
  kdephosSTAT3PTPRT = 0.0008;
  kdimercJun = 5e-005;
  kinhibADAMTS4TIMP1 = 3e-006;
  kinhibADAMTS4TIMP3 = 0.0005;
  kinhibMMP13TIMP1 = 3e-007;
  kinhibMMP13TIMP3 = 1e-008;
  kinhibMMP1TIMP1 = 3e-007;
  kinhibMMP1TIMP3 = 1e-008;
  kinhibMMP3TIMP1 = 3e-007;
  kinhibMMP3TIMP3 = 1e-008;
  kinhibTRAF6 = 0.5;
  knuc2cytSTAT3 = 0.001;
  kphoscFos = 5e-007;
  kphoscJun = 0.0001;
  kphosJAK1 = 1e-005;
  kphosJNK = 0.0001;
  kphosp38 = 0.0001;
  kphosSTAT3 = 0.005;
  krelADAMTS4TIMP1 = 0.001;
  krelADAMTS4TIMP3 = 0.001;
  krelcFoscJun = 4e-005;
  krelIL1IL1R = 0.001;
  krelIL1IL1Ra = 0.0001;
  krelIRAK2 = 0.001;
  krelMMP1 = 0.001;
  krelMMP13 = 0.001;
  krelMMP13TIMP3 = 0.001;
  krelMMP1TIMP3 = 0.001;
  krelMMP3 = 0.001;
  krelMMP3TIMP3 = 0.001;
  krelOSMOSMR = 1e-005;
  krelOSMOSMRa = 1e-005;
  krelSOCS3OSMR = 1e-005;
  krelSP1TIMP1DNA = 5e-006;
  krelTRAF6 = 0.0001;
  krelTRAF6PP4 = 1e-006;
  ksynADAMTS4 = 0.0005;
  ksynADAMTS4mRNA = 0.0005;
  ksynADAMTS4mRNAcJun = 4e-006;
  ksynbasalcJunmRNA = 0.015;
  ksynbasalTIMP1mRNA = 0.00014;
  ksynbasalTIMP3mRNA = 0.00028;
  ksyncFos = 0.001;
  ksyncFosmRNA = 5e-006;
  ksyncFosmRNAStat3 = 0.05;
  ksyncJun = 0.0026;
  ksyncJunmRNA = 0.0125;
  ksyncJunmRNAcJun = 0.005;
  ksynDUSP16 = 0.005;
  ksynDUSP16cJun = 0.0002;
  ksynMatriptase = 9e-010;
  ksynMKP1 = 2.5e-005;
  ksynMKP1cJun = 1e-006;
  ksynMMP1 = 0.00015;
  ksynMMP13 = 1.5e-005;
  ksynMMP13mRNA = 0.0005;
  ksynMMP13mRNAcJun = 2e-005;
  ksynMMP1mRNA = 0.005;
  ksynMMP1mRNAcJun = 0.0002;
  ksynMMP3 = 3e-005;
  ksynMMP3mRNA = 0.005;
  ksynMMP3mRNAcJun = 0.0002;
  ksynPP4 = 0.005;
  ksynPP4cJun = 0.0002;
  ksynPTPRT = 0.0001;
  ksynSOCS3 = 0.001;
  ksynSOCS3mRNA = 0.006;
  ksynSP1 = 2e-005;
  ksynTIMP1 = 0.0002;
  ksynTIMP1mRNA = 5e-007;
  ksynTIMP1mRNAStat3 = 4e-005;
  ksynTIMP3 = 0.0004;
  ksynTIMP3mRNA = 5e-007;
  ksynTIMP3mRNAStat3 = 4e-005;

  // Other declarations:
  const cytoplasm, nucleus, membrane, ecm, kactMMP13mmp3, kactMMP1mat, kactMMP1mmp3;
  const kactMMP3mat, kAP1activity, kbincFoscJun, kbinIL1IL1R, kbinIL1IL1Ra;
  const kbinIRAK2, kbinOSMOSMR, kbinOSMOSMRa, kbinSOCS3OSMR, kbinSP1TIMP1DNA;
  const kbinTRAF6, kcyt2nucSTAT3, kdedimercJun, kdegADAMTS4, kdegADAMTS4mRNA;
  const kdegAggrecan, kdegcFos, kdegcFosmRNA, kdegcJun, kdegcJunmRNA, kdegCollagen2mmp1;
  const kdegCollagen2mmp13, kdegDUSP16, kdegIL1, kdegMatriptase, kdegMKP1;
  const kdegMMP1, kdegMMP13, kdegMMP13mRNA, kdegMMP1mRNA, kdegMMP3, kdegMMP3mRNA;
  const kdegOSM, kdegPP4, kdegPTPRT, kdegSOCS3, kdegSOCS3mRNA, kdegSP1, kdegTIMP1;
  const kdegTIMP1mRNA, kdegTIMP3, kdegTIMP3mRNA, kdephoscFos, kdephoscFosDUSP16;
  const kdephoscJun, kdephosJAK1, kdephosJAK1PTPRT, kdephosJNK, kdephosJNKDUSP16;
  const kdephosp38, kdephosp38MKP1, kdephosSTAT3, kdephosSTAT3nuc, kdephosSTAT3nucPTPRT;
  const kdephosSTAT3PTPRT, kdimercJun, kinhibADAMTS4TIMP1, kinhibADAMTS4TIMP3;
  const kinhibMMP13TIMP1, kinhibMMP13TIMP3, kinhibMMP1TIMP1, kinhibMMP1TIMP3;
  const kinhibMMP3TIMP1, kinhibMMP3TIMP3, kinhibTRAF6, knuc2cytSTAT3, kphoscFos;
  const kphoscJun, kphosJAK1, kphosJNK, kphosp38, kphosSTAT3, krelADAMTS4TIMP1;
  const krelADAMTS4TIMP3, krelcFoscJun, krelIL1IL1R, krelIL1IL1Ra, krelIRAK2;
  const krelMMP1, krelMMP13, krelMMP13TIMP3, krelMMP1TIMP3, krelMMP3, krelMMP3TIMP3;
  const krelOSMOSMR, krelOSMOSMRa, krelSOCS3OSMR, krelSP1TIMP1DNA, krelTRAF6;
  const krelTRAF6PP4, ksynADAMTS4, ksynADAMTS4mRNA, ksynADAMTS4mRNAcJun, ksynbasalcJunmRNA;
  const ksynbasalTIMP1mRNA, ksynbasalTIMP3mRNA, ksyncFos, ksyncFosmRNA, ksyncFosmRNAStat3;
  const ksyncJun, ksyncJunmRNA, ksyncJunmRNAcJun, ksynDUSP16, ksynDUSP16cJun;
  const ksynMatriptase, ksynMKP1, ksynMKP1cJun, ksynMMP1, ksynMMP13, ksynMMP13mRNA;
  const ksynMMP13mRNAcJun, ksynMMP1mRNA, ksynMMP1mRNAcJun, ksynMMP3, ksynMMP3mRNA;
  const ksynMMP3mRNAcJun, ksynPP4, ksynPP4cJun, ksynPTPRT, ksynSOCS3, ksynSOCS3mRNA;
  const ksynSP1, ksynTIMP1, ksynTIMP1mRNA, ksynTIMP1mRNAStat3, ksynTIMP3;
  const ksynTIMP3mRNA, ksynTIMP3mRNAStat3;

  // Unit definitions:
  unit substance = item;
end