// Created by libAntimony v2.8.0 model *Model_1() // Compartments and Species: compartment compartment_1; species $species_1 in compartment_1, $species_20 in compartment_1, $species_15 in compartment_1; species $species_13 in compartment_1, $species_11 in compartment_1, $species_2 in compartment_1; species $species_18 in compartment_1, $species_21 in compartment_1, $species_17 in compartment_1; species $species_16 in compartment_1, $species_3 in compartment_1, $species_26 in compartment_1; species species_22 in compartment_1, $species_6 in compartment_1, $species_4 in compartment_1; species $species_9 in compartment_1, $species_5 in compartment_1, $species_10 in compartment_1; species $species_7 in compartment_1, $species_25 in compartment_1, $species_8 in compartment_1; species $species_12 in compartment_1, $species_19 in compartment_1, $species_14 in compartment_1; species $species_23 in compartment_1, $species_24 in compartment_1; // Assignment Rules: parameter_9 := parameter_8/parameter_10; species_20 := species_8 - 2*species_13 - species_17; species_15 := species_14 - 2*species_11 - species_16; species_11 := (parameter_13 + 1)*species_1 - parameter_13*species_13; species_18 := species_19 - species_17; species_21 := species_12 - species_16; species_16 := (parameter_13 + 1)*species_2 - parameter_13*species_17; species_9 := species_7*(parameter_21/(1 + parameter_21)); species_10 := (parameter_13 + 1)*(parameter_14 - species_3) - parameter_13*species_6; species_25 := species_7*(1/(1 + parameter_21)); parameter_21 := parameter_16/(1 - parameter_16)*((parameter_4 + 1)/parameter_4); species_12 := (parameter_13 + 1)*parameter_15 - parameter_13*species_19; species_14 := (parameter_13 + 1)*species_3 - parameter_13*species_8; parameter_19 := parameter_3; species_23 := species_5 + species_7 + species_24 + species_26; parameter_10 := 0.171; parameter_20 := (species_10 + species_14)/Metabolite_9; // Rate Rules: species_1' = 1/(1 + parameter_13)*(parameter_9*(parameter_13*species_20^2 + species_15^2) - parameter_8*(parameter_13*species_13 + species_11)); species_13' = parameter_9*species_20^2 - (parameter_8 + parameter_3*parameter_11)*species_13; species_2' = 1/(parameter_13 + 1)*(parameter_9*(parameter_13*species_18*species_20 + species_15*species_21) - parameter_8*(parameter_13*species_17 + species_16)); species_17' = parameter_9*species_18*species_20 - (parameter_8 + parameter_3*parameter_11)*species_17; species_3' = 1/(1 + parameter_13)*(parameter_13*parameter_6*species_26*(parameter_17/(parameter_17 + species_22))*species_6 - parameter_7*species_15); species_26' = parameter_1*(parameter_22*species_24 - parameter_12*(1 - parameter_28)*species_26); species_6' = parameter_2*species_10 - (parameter_3 + parameter_6*species_26*(parameter_17/(parameter_17 + species_22)))*species_6; species_4' = parameter_1*((parameter_27 + parameter_26*species_16) - (parameter_18*species_9 + parameter_25)*species_4); species_5' = parameter_1*((1 - parameter_5)*(1 - parameter_16) - (parameter_4 + (1 - parameter_28))*species_5); species_7' = parameter_1*(parameter_4*species_5 - (1 - parameter_28)*species_25 - parameter_18*species_4*species_9); species_8' = (parameter_6*species_26*(parameter_17/(parameter_17 + species_22))*species_6 + parameter_2*species_15) - parameter_3*(species_20 + parameter_11*(species_17 + 2*species_13)); species_19' = parameter_19*species_21 - parameter_3*(species_18 + parameter_11*species_17); species_24' = parameter_1*(parameter_18*species_4*species_9 - (parameter_22 + parameter_12*(1 - parameter_28))*species_24); // Species initializations: species_1 = 0; species_13 = 0; species_2 = 0; species_17 = 0; species_3 = 0; species_26 = 0; species_22 = 0; species_6 = (parameter_14*parameter_2*(1 + parameter_13))/(parameter_3 + parameter_13*parameter_2); species_4 = parameter_23*parameter_24; species_5 = (1 - parameter_16)/(parameter_4 + 1); species_7 = (parameter_16 + parameter_4)/(1 + parameter_4); species_8 = 0; species_19 = parameter_15; species_24 = 0; // Compartment initializations: compartment_1 = 1; // Variable initializations: parameter_13 = 2.27; parameter_8 = 60; parameter_6 = 21.3715; parameter_17 = 0.196565; parameter_7 = 24; parameter_23 = 2; parameter_24 = 2; parameter_1 = 0.32; parameter_27 = 0; parameter_26 = 0; parameter_18 = 100; parameter_25 = 0.35; parameter_16 = 0.05; parameter_4 = 0.08; parameter_5 = 0; parameter_28 = 0; parameter_14 = 1; parameter_2 = 20; parameter_3 = 9.36; parameter_11 = 5.7; parameter_15 = 1; parameter_22 = 24.5383; parameter_12 = 4; Metabolite_9 = species_10; // Other declarations: var parameter_9, parameter_21, parameter_19, parameter_10, parameter_20; const compartment_1, parameter_13, parameter_8, parameter_6, parameter_17; const parameter_7, parameter_23, parameter_24, parameter_1, parameter_27; const parameter_26, parameter_18, parameter_25, parameter_16, parameter_4; const parameter_5, parameter_28, parameter_14, parameter_2, parameter_3; const parameter_11, parameter_15, parameter_22, parameter_12, Metabolite_9; // Unit definitions: unit volume = dimensionless; unit time_unit = 3600 second; unit substance = dimensionless; // Display Names: time_unit is "time"; compartment_1 is "Cell"; species_1 is "S22"; parameter_13 is "a"; parameter_9 is "kon"; species_20 is "pS2fc"; species_15 is "pS2fn"; parameter_8 is "koff"; species_13 is "S22c"; species_11 is "S22n"; species_2 is "S24"; species_18 is "S4fc"; species_21 is "S4fn"; species_17 is "S24c"; species_16 is "S24n"; species_3 is "pS2tot"; parameter_6 is "kp"; species_26 is "Ract"; parameter_17 is "KSBI"; species_22 is "SBI"; species_6 is "S2c"; parameter_7 is "kdp"; species_4 is "TGF"; parameter_23 is "Tmax in ng/ml"; parameter_24 is "TSca"; parameter_1 is "kd"; parameter_27 is "k'synTbas"; parameter_26 is "k'synT"; parameter_18 is "k'T"; species_9 is "Rcom_S"; parameter_25 is "k'cc"; species_5 is "R"; parameter_16 is "rc0"; parameter_4 is "alpha"; parameter_5 is "CHX"; parameter_28 is "MG132"; parameter_14 is "S2tot"; parameter_2 is "kex"; parameter_3 is "kin"; species_10 is "S2n"; species_7 is "Rcom"; species_25 is "Rcom_I"; species_8 is "pS2c"; parameter_11 is "CIF"; parameter_21 is "Ktr"; species_12 is "S4n"; parameter_15 is "S4tot"; species_19 is "S4c"; species_14 is "pS2n"; parameter_19 is "kex4"; species_23 is "Rtot"; species_24 is "RT"; parameter_22 is "k'act"; parameter_12 is "D"; parameter_10 is "KDiss"; parameter_20 is "Total Nuc S2 for fit"; Metabolite_9 is "Initial for S2n"; end