// Created by libAntimony v2.8.0 model *MODEL1212030000() // Compartments and Species: compartment cell; substanceOnly species Mdm2 in cell, p53 in cell, Mdm2_p53 in cell, Mdm2_mRNA in cell; substanceOnly species p53_mRNA in cell, ATMA in cell, ATMI in cell, p53_P in cell; substanceOnly species Mdm2_P in cell, IR in cell, ROS in cell, damDNA in cell; substanceOnly species E1 in cell, E2 in cell, E1_Ub in cell, E2_Ub in cell; substanceOnly species Proteasome in cell, Ub in cell, p53DUB in cell, Mdm2DUB in cell; substanceOnly species DUB in cell, Mdm2_p53_Ub in cell, Mdm2_p53_Ub2 in cell; substanceOnly species Mdm2_p53_Ub3 in cell, Mdm2_p53_Ub4 in cell, Mdm2_P1_p53_Ub4 in cell; substanceOnly species Mdm2_Ub in cell, Mdm2_Ub2 in cell, Mdm2_Ub3 in cell; substanceOnly species Mdm2_Ub4 in cell, Mdm2_P_Ub in cell, Mdm2_P_Ub2 in cell; substanceOnly species Mdm2_P_Ub3 in cell, Mdm2_P_Ub4 in cell, p53_Ub4_Proteasome in cell; substanceOnly species Mdm2_Ub4_Proteasome in cell, Mdm2_P_Ub4_Proteasome in cell; substanceOnly species GSK3b in cell, GSK3b_p53 in cell, GSK3b_p53_P in cell; substanceOnly species Abeta in cell, AggAbeta_Proteasome in cell, AbetaPlaque in cell; substanceOnly species Tau in cell, Tau_P1 in cell, Tau_P2 in cell, MT_Tau in cell; substanceOnly species AggTau in cell, AggTau_Proteasome in cell, Proteasome_Tau in cell; substanceOnly species PP1 in cell, NFT in cell, $ATP in cell, $ADP in cell; substanceOnly species $AMP in cell, AbetaDimer in cell, AbetaPlaque_GliaA in cell; substanceOnly species GliaI in cell, GliaM1 in cell, GliaM2 in cell, GliaA in cell; substanceOnly species antiAb in cell, Abeta_antiAb in cell, AbetaDimer_antiAb in cell; substanceOnly species degAbetaGlia in cell, disaggPlaque1 in cell, disaggPlaque2 in cell; substanceOnly species $Source in cell, $Sink in cell; // Reactions: p53mRNASynthesis: $Source => p53_mRNA; ksynp53mRNA*Source; p53mRNADegradation: p53_mRNA => $Sink; kdegp53mRNA*p53_mRNA; Mdm2Synthesis: Mdm2_mRNA => Mdm2_mRNA + Mdm2; ksynMdm2*Mdm2_mRNA; Mdm2mRNASynthesis1: p53 => p53 + Mdm2_mRNA; ksynMdm2mRNA*p53; Mdm2mRNASynthesis2: p53_P => p53_P + Mdm2_mRNA; ksynMdm2mRNA*p53_P; Mdm2mRNASynthesis3: GSK3b_p53 => GSK3b_p53 + Mdm2_mRNA; ksynMdm2mRNAGSK3bp53*GSK3b_p53; Mdm2mRNASynthesis4: GSK3b_p53_P => GSK3b_p53_P + Mdm2_mRNA; ksynMdm2mRNAGSK3bp53*GSK3b_p53_P; Mdm2mRNADegradation: Mdm2_mRNA => $Sink; kdegMdm2mRNA*Mdm2_mRNA; P53Mdm2Binding: p53 + Mdm2 => Mdm2_p53; kbinMdm2p53*p53*Mdm2; P53Mdm2Release: Mdm2_p53 => p53 + Mdm2; krelMdm2p53*Mdm2_p53; GSK3p53Binding: GSK3b + p53 => GSK3b_p53; kbinGSK3bp53*GSK3b*p53; GSK3p53Release: GSK3b_p53 => GSK3b + p53; krelGSK3bp53*GSK3b_p53; GSK3p53PBinding: GSK3b + p53_P => GSK3b_p53_P; kbinGSK3bp53*GSK3b*p53_P; GSK3_p53PRelease: GSK3b_p53_P => GSK3b + p53_P; krelGSK3bp53*GSK3b_p53_P; E1UbBinding: E1 + Ub + $ATP => E1_Ub + $AMP; (kbinE1Ub*E1*Ub*ATP)/(5000 + ATP); E2UbBinding: E2 + E1_Ub => E2_Ub + E1; kbinE2Ub*E2*E1_Ub; Mdm2Ubiquitination: Mdm2 + E2_Ub => Mdm2_Ub + E2; kMdm2Ub*Mdm2*E2_Ub; Mdm2polyUbiquitination1: Mdm2_Ub + E2_Ub => Mdm2_Ub2 + E2; kMdm2PolyUb*Mdm2_Ub*E2_Ub; Mdm2polyUbiquitination2: Mdm2_Ub2 + E2_Ub => Mdm2_Ub3 + E2; kMdm2PolyUb*Mdm2_Ub2*E2_Ub; Mdm2polyUbiquitination3: Mdm2_Ub3 + E2_Ub => Mdm2_Ub4 + E2; kMdm2PolyUb*Mdm2_Ub3*E2_Ub; Mdm2Deubiquitination4: Mdm2_Ub4 + Mdm2DUB => Mdm2_Ub3 + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_Ub4*Mdm2DUB; Mdm2Deubiquitination3: Mdm2_Ub3 + Mdm2DUB => Mdm2_Ub2 + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_Ub3*Mdm2DUB; Mdm2Deubiquitination2: Mdm2_Ub2 + Mdm2DUB => Mdm2_Ub + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_Ub2*Mdm2DUB; Mdm2Deubiquitination1: Mdm2_Ub + Mdm2DUB => Mdm2 + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_Ub*Mdm2DUB; Mdm2ProteasomeBinding1: Mdm2_Ub4 + Proteasome => Mdm2_Ub4_Proteasome; kbinProt*Mdm2_Ub4*Proteasome; Mdm2Degradation: Mdm2_Ub4_Proteasome => Proteasome + 4Ub; kdegMdm2*Mdm2_Ub4_Proteasome*kproteff; p53Synthesis: p53_mRNA => p53 + p53_mRNA; ksynp53*p53_mRNA; p53Monoubiquitination: E2_Ub + Mdm2_p53 => Mdm2_p53_Ub + E2; kp53Ub*E2_Ub*Mdm2_p53; p53Polyubiquitination1: Mdm2_p53_Ub + E2_Ub => Mdm2_p53_Ub2 + E2; kp53PolyUb*Mdm2_p53_Ub*E2_Ub; p53Polyubiquitination2: Mdm2_p53_Ub2 + E2_Ub => Mdm2_p53_Ub3 + E2; kp53PolyUb*Mdm2_p53_Ub2*E2_Ub; p53Polyubiquitination3: Mdm2_p53_Ub3 + E2_Ub => Mdm2_p53_Ub4 + E2; kp53PolyUb*Mdm2_p53_Ub3*E2_Ub; p53Deubiqutination4: Mdm2_p53_Ub4 + p53DUB => Mdm2_p53_Ub3 + p53DUB + Ub; kactDUBp53*Mdm2_p53_Ub4*p53DUB; p53Deubiquitination3: Mdm2_p53_Ub3 + p53DUB => Mdm2_p53_Ub2 + p53DUB + Ub; kactDUBp53*Mdm2_p53_Ub3*p53DUB; p53Deubiquitination2: Mdm2_p53_Ub2 + p53DUB => Mdm2_p53_Ub + p53DUB + Ub; kactDUBp53*Mdm2_p53_Ub2*p53DUB; p53Deubiquitination1: Mdm2_p53_Ub + p53DUB => Mdm2_p53 + p53DUB + Ub; kactDUBp53*Mdm2_p53_Ub*p53DUB; Mdm2GSK3phosphorylation1: Mdm2_p53_Ub4 + GSK3b => Mdm2_P1_p53_Ub4 + GSK3b; kphosMdm2GSK3b*Mdm2_p53_Ub4*GSK3b; Mdm2GSK3phosphorylation2: Mdm2_p53_Ub4 + GSK3b_p53 => Mdm2_P1_p53_Ub4 + GSK3b_p53; kphosMdm2GSK3bp53*Mdm2_p53_Ub4*GSK3b_p53; Mdm2GSK3phosphorylation3: Mdm2_p53_Ub4 + GSK3b_p53_P => Mdm2_P1_p53_Ub4 + GSK3b_p53_P; kphosMdm2GSK3bp53*Mdm2_p53_Ub4*GSK3b_p53_P; p53ProteasomeBinding1: Mdm2_P1_p53_Ub4 + Proteasome => p53_Ub4_Proteasome + Mdm2; kbinProt*Mdm2_P1_p53_Ub4*Proteasome; Degradationp53_Ub4: p53_Ub4_Proteasome + $ATP => 4Ub + Proteasome + $ADP; (kdegp53*kproteff*p53_Ub4_Proteasome*ATP)/(5000 + ATP); TauMTbinding: Tau => MT_Tau; kbinMTTau*Tau; TauMTrelease: MT_Tau => Tau; krelMTTau*MT_Tau; Tauphosphorylation1: GSK3b_p53 + Tau => GSK3b_p53 + Tau_P1; kphospTauGSK3bp53*GSK3b_p53*Tau; Tauphosphorylation2: GSK3b_p53 + Tau_P1 => GSK3b_p53 + Tau_P2; kphospTauGSK3bp53*GSK3b_p53*Tau_P1; Tauphosphorylation3: GSK3b_p53_P + Tau => GSK3b_p53_P + Tau_P1; kphospTauGSK3bp53*GSK3b_p53_P*Tau; Tauphosphorylation4: GSK3b_p53_P + Tau_P1 => GSK3b_p53_P + Tau_P2; kphospTauGSK3bp53*GSK3b_p53_P*Tau_P1; Tauphosphorylation5: GSK3b + Tau => GSK3b + Tau_P1; kphospTauGSK3b*GSK3b*Tau; Tauphosphorylation6: GSK3b + Tau_P1 => GSK3b + Tau_P2; kphospTauGSK3b*GSK3b*Tau_P1; Taudephosphorylation1: Tau_P2 + PP1 => Tau_P1 + PP1; kdephospTau*Tau_P2*PP1; Taudephosphorylation2: Tau_P1 + PP1 => Tau + PP1; kdephospTau*Tau_P1*PP1; TauP1Aggregation1: 2Tau_P1 => 2AggTau; kaggTauP1*Tau_P1^2*0.5; TauP1Aggregation2: Tau_P1 + AggTau => 2AggTau; kaggTauP1*Tau_P1*AggTau; TauP2Aggregation1: 2Tau_P2 => 2AggTau; kaggTauP2*Tau_P2^2*0.5; TauP2Aggregation2: Tau_P2 + AggTau => 2AggTau; kaggTauP2*Tau_P2*AggTau; TauAggregation1: 2Tau => 2AggTau; kaggTau*Tau^2*0.5; TauAggregation2: Tau + AggTau => 2AggTau; kaggTau*Tau*AggTau; TangleFormation1: 2AggTau => 2NFT; ktangfor*AggTau^2*0.5; TangleFormation2: AggTau + NFT => 2NFT; ktangfor*AggTau*NFT; ProteasomeInhibitionAggTau: AggTau + Proteasome => AggTau_Proteasome; kinhibprot*AggTau*Proteasome; Abetaproduction1: $Source => Abeta; kprodAbeta*Source; Abetaproduction2: GSK3b_p53 => Abeta + GSK3b_p53; kprodAbeta2*GSK3b_p53; Abetaproduction3: GSK3b_p53_P => Abeta + GSK3b_p53_P; kprodAbeta2*GSK3b_p53_P; ProteasomeInhibitionAbeta: AbetaDimer + Proteasome => AggAbeta_Proteasome; kinhibprot*AbetaDimer*Proteasome; AbetaDegradation: Abeta => $Sink; kdegAbeta*Abeta; p53transcriptionViaAbeta: Abeta => p53_mRNA + Abeta; ksynp53mRNAAbeta*Abeta; DNAdamage: IR => IR + damDNA; kdam*IR; DNArepair: damDNA => $Sink; krepair*damDNA; ATMactivation: damDNA + ATMI => damDNA + ATMA; kactATM*damDNA*ATMI; p53phosphorylation: p53 + ATMA => p53_P + ATMA; kphosp53*p53*ATMA; p53dephosphorylation: p53_P => p53; kdephosp53*p53_P; Mdm2phosphorylation: Mdm2 + ATMA => Mdm2_P + ATMA; kphosMdm2*Mdm2*ATMA; Mdm2dephosphorylation: Mdm2_P => Mdm2; kdephosMdm2*Mdm2_P; Mdm2PUbiquitination: Mdm2_P + E2_Ub => Mdm2_P_Ub + E2; kMdm2PUb*Mdm2_P*E2_Ub; Mdm2PpolyUbiquitination1: Mdm2_P_Ub + E2_Ub => Mdm2_P_Ub2 + E2; kMdm2PolyUb*Mdm2_P_Ub*E2_Ub; Mdm2PpolyUbiquitination2: Mdm2_P_Ub2 + E2_Ub => Mdm2_P_Ub3 + E2; kMdm2PolyUb*Mdm2_P_Ub2*E2_Ub; Mdm2PpolyUbiquitination3: Mdm2_P_Ub3 + E2_Ub => Mdm2_P_Ub4 + E2; kMdm2PolyUb*Mdm2_P_Ub3*E2_Ub; Mdm2PDeubiquitination4: Mdm2_P_Ub4 + Mdm2DUB => Mdm2_P_Ub3 + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_P_Ub4*Mdm2DUB; Mdm2PDeubiquitination3: Mdm2_P_Ub3 + Mdm2DUB => Mdm2_P_Ub2 + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_P_Ub3*Mdm2DUB; Mdm2PDeubiquitination2: Mdm2_P_Ub2 + Mdm2DUB => Mdm2_P_Ub + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_P_Ub2*Mdm2DUB; Mdm2PDeubiquitination1: Mdm2_P_Ub + Mdm2DUB => Mdm2_P + Mdm2DUB + Ub; kactDUBMdm2*Mdm2_P_Ub*Mdm2DUB; Mdm2PProteasomeBinding1: Mdm2_P_Ub4 + Proteasome => Mdm2_P_Ub4_Proteasome; kbinProt*Mdm2_P_Ub4*Proteasome; Mdm2PDegradation: Mdm2_P_Ub4_Proteasome => Proteasome + 4Ub; kdegMdm2*Mdm2_P_Ub4_Proteasome*kproteff; ATMInactivation: ATMA => ATMI; kinactATM*ATMA; AbetaROSproduction1: Abeta => Abeta + ROS; kgenROSAbeta*Abeta; PlaqueROSproduction: AbetaPlaque => AbetaPlaque + ROS; kgenROSPlaque*AbetaPlaque; AggAbetaROSproduction2: AggAbeta_Proteasome => AggAbeta_Proteasome + ROS; kgenROSAbeta*AggAbeta_Proteasome; ROSDNAdamage: ROS => ROS + damDNA; kdamROS*ROS; TauSynthesis: $Source => Tau; ksynTau*Source; TauProteasomeBinding: Tau + Proteasome => Proteasome_Tau; kbinTauProt*Tau*Proteasome; Tau20SProteasomeDegradation: Proteasome_Tau => Proteasome; kdegTau20SProt*Proteasome_Tau; AbetaAggregation1: 2Abeta => AbetaDimer; kaggAbeta*Abeta^2*0.5; AbetaPlaqueFormation1: 2AbetaDimer => AbetaPlaque; kpf*AbetaDimer^2*0.5; AbetaPlaqueGrowth: AbetaDimer + AbetaPlaque => 2AbetaPlaque; (kpg*AbetaDimer*AbetaPlaque^2)/(kpghalf^2 + AbetaPlaque^2); AbetaDisaggregation1: AbetaDimer => 2Abeta; kdisaggAbeta*AbetaDimer; AbetaDisaggregation3: AbetaPlaque => AbetaDimer + disaggPlaque1; kdisaggAbeta1*AbetaPlaque; AbetaDisaggregation4: AbetaPlaque + antiAb => AbetaDimer + antiAb + disaggPlaque2; kdisaggAbeta2*antiAb*AbetaPlaque; Abeta_antiAbBinding: Abeta + antiAb => Abeta_antiAb; kbinAbantiAb*Abeta*antiAb; AbetaDimer_antiAbBinding: AbetaDimer + antiAb => AbetaDimer_antiAb; kbinAbantiAb*AbetaDimer*antiAb; Abeta_antiAbDegredation: Abeta_antiAb => antiAb; 10*kdegAbeta*Abeta_antiAb; AbetaDimer_antiAbDegredation: AbetaDimer_antiAb => antiAb; 10*kdegAbeta*AbetaDimer_antiAb; GliaActivationStep1: GliaI + AbetaPlaque => GliaM1 + AbetaPlaque; kactglia1*GliaI*AbetaPlaque; GliaActivationStep2: GliaM1 + AbetaPlaque => GliaM2 + AbetaPlaque; kactglia1*GliaM1*AbetaPlaque; GliaActivationStep3: GliaM2 + antiAb => GliaA + antiAb; kactglia2*GliaM2*antiAb; GliaInactivationStep1: GliaA => GliaM2; kinactglia1*GliaA; GliaInactivationStep2: GliaM2 => GliaM1; kinactglia2*GliaM2; GliaInactivationStep3: GliaM1 => GliaI; kinactglia2*GliaM1; AbetaBindingToGlia: AbetaPlaque + GliaA => AbetaPlaque_GliaA; kbinAbetaGlia*AbetaPlaque*GliaA; AbetaReleaseFromGlia: AbetaPlaque_GliaA => AbetaPlaque + GliaA; krelAbetaGlia*AbetaPlaque_GliaA; AbetaPlaqueClearanceByGlia: AbetaPlaque_GliaA => GliaA + degAbetaGlia; kdegAbetaGlia*AbetaPlaque_GliaA; ROSgenerationByGlia: AbetaPlaque_GliaA => AbetaPlaque_GliaA + ROS; kgenROSGlia*AbetaPlaque_GliaA; antiAbRemoval: antiAb => $Sink; kdegAntiAb*antiAb; ROSremoval: ROS => $Sink; kremROS*ROS; // Events: ImmunizeCell: at time >= 345600: antiAb = 50; // Species initializations: Mdm2 = 5/cell; p53 = 5/cell; Mdm2_p53 = 95/cell; Mdm2_mRNA = 10/cell; p53_mRNA = 10/cell; ATMA = 0; ATMI = 200/cell; p53_P = 0; Mdm2_P = 0; IR = 0; ROS = 0; damDNA = 0; E1 = 100/cell; E2 = 100/cell; E1_Ub = 0; E2_Ub = 0; Proteasome = 500/cell; Ub = 4000/cell; p53DUB = 200/cell; Mdm2DUB = 200/cell; DUB = 200/cell; Mdm2_p53_Ub = 0; Mdm2_p53_Ub2 = 0; Mdm2_p53_Ub3 = 0; Mdm2_p53_Ub4 = 0; Mdm2_P1_p53_Ub4 = 0; Mdm2_Ub = 0; Mdm2_Ub2 = 0; Mdm2_Ub3 = 0; Mdm2_Ub4 = 0; Mdm2_P_Ub = 0; Mdm2_P_Ub2 = 0; Mdm2_P_Ub3 = 0; Mdm2_P_Ub4 = 0; p53_Ub4_Proteasome = 0; Mdm2_Ub4_Proteasome = 0; Mdm2_P_Ub4_Proteasome = 0; GSK3b = 500/cell; GSK3b_p53 = 0; GSK3b_p53_P = 0; Abeta = 0; AggAbeta_Proteasome = 0; AbetaPlaque = 0; Tau = 0; Tau_P1 = 0; Tau_P2 = 0; MT_Tau = 100/cell; AggTau = 0; AggTau_Proteasome = 0; Proteasome_Tau = 0; PP1 = 50/cell; NFT = 0; ATP = 10000/cell; ADP = 1000/cell; AMP = 1000/cell; AbetaDimer = 0; AbetaPlaque_GliaA = 0; GliaI = 100/cell; GliaM1 = 0; GliaM2 = 0; GliaA = 0; antiAb = 0; Abeta_antiAb = 0; AbetaDimer_antiAb = 0; degAbetaGlia = 0; disaggPlaque1 = 0; disaggPlaque2 = 0; Source = 1/cell; Sink = 1/cell; // Compartment initializations: cell = 1; // Variable initializations: ksynp53mRNA = 0.001; kdegp53mRNA = 0.0001; ksynMdm2mRNA = 0.0005; kdegMdm2mRNA = 0.0005; ksynMdm2mRNAGSK3bp53 = 0.0007; ksynp53 = 0.007; kdegp53 = 0.005; kbinMdm2p53 = 0.001155; krelMdm2p53 = 1.155e-005; kbinGSK3bp53 = 2e-006; krelGSK3bp53 = 0.002; ksynMdm2 = 0.000495; kdegMdm2 = 0.01; kbinE1Ub = 0.0002; kbinE2Ub = 0.001; kp53Ub = 5e-005; kp53PolyUb = 0.01; kbinProt = 2e-006; kactDUBp53 = 1e-007; kactDUBProtp53 = 0.0001; kactDUBMdm2 = 1e-007; kMdm2Ub = 4.56e-006; kMdm2PUb = 6.84e-006; kMdm2PolyUb = 0.00456; kdam = 0.08; krepair = 2e-005; kactATM = 0.0001; kinactATM = 0.0005; kphosp53 = 0.0002; kdephosp53 = 0.5; kphosMdm2 = 2; kdephosMdm2 = 0.5; kphosMdm2GSK3b = 0.005; kphosMdm2GSK3bp53 = 0.5; kphospTauGSK3bp53 = 0.1; kphospTauGSK3b = 0.0002; kdephospTau = 0.01; kbinMTTau = 0.1; krelMTTau = 0.0001; ksynTau = 8e-005; kbinTauProt = 1.925e-007; kdegTau20SProt = 0.01; kaggTau = 1e-008; kaggTauP1 = 1e-008; kaggTauP2 = 1e-007; ktangfor = 0.001; kinhibprot = 1e-007; ksynp53mRNAAbeta = 1e-005; kdamROS = 1e-005; kgenROSAbeta = 2e-005; kgenROSPlaque = 1e-005; kgenROSGlia = 1e-005; kproteff = 1; kremROS = 7e-005; kprodAbeta = 1.86e-005; kprodAbeta2 = 1.86e-005; kdegAbeta = 1.5e-005; kaggAbeta = 3e-006; kdisaggAbeta = 1e-006; kdisaggAbeta1 = 0.0002; kdisaggAbeta2 = 1e-006; kdegAbetaGlia = 0.005; kpf = 0.2; kpg = 0.15; kpghalf = 10; kactglia1 = 6e-007; kactglia2 = 6e-007; kinactglia1 = 5e-006; kinactglia2 = 5e-006; kbinAbetaGlia = 1e-005; krelAbetaGlia = 5e-005; kdegAntiAb = 2.75e-006; kbinAbantiAb = 1e-006; // Other declarations: var kproteff; const cell, ksynp53mRNA, kdegp53mRNA, ksynMdm2mRNA, kdegMdm2mRNA, ksynMdm2mRNAGSK3bp53; const ksynp53, kdegp53, kbinMdm2p53, krelMdm2p53, kbinGSK3bp53, krelGSK3bp53; const ksynMdm2, kdegMdm2, kbinE1Ub, kbinE2Ub, kp53Ub, kp53PolyUb, kbinProt; const kactDUBp53, kactDUBProtp53, kactDUBMdm2, kMdm2Ub, kMdm2PUb, kMdm2PolyUb; const kdam, krepair, kactATM, kinactATM, kphosp53, kdephosp53, kphosMdm2; const kdephosMdm2, kphosMdm2GSK3b, kphosMdm2GSK3bp53, kphospTauGSK3bp53; const kphospTauGSK3b, kdephospTau, kbinMTTau, krelMTTau, ksynTau, kbinTauProt; const kdegTau20SProt, kaggTau, kaggTauP1, kaggTauP2, ktangfor, kinhibprot; const ksynp53mRNAAbeta, kdamROS, kgenROSAbeta, kgenROSPlaque, kgenROSGlia; const kremROS, kprodAbeta, kprodAbeta2, kdegAbeta, kaggAbeta, kdisaggAbeta; const kdisaggAbeta1, kdisaggAbeta2, kdegAbetaGlia, kpf, kpg, kpghalf, kactglia1; const kactglia2, kinactglia1, kinactglia2, kbinAbetaGlia, krelAbetaGlia; const kdegAntiAb, kbinAbantiAb; // Unit definitions: unit substance = item; end