// Created by libAntimony v2.8.0 model *MODEL1305280000() // Compartments and Species: compartment compartment_; species L in compartment_, R in compartment_, LR in compartment_, Gabg in compartment_; species RGabg in compartment_, LRGabg in compartment_, RRGSm in compartment_; species LRRGSm in compartment_, RRGSmGabg in compartment_, LRRGSmGabg in compartment_; species GaGTP in compartment_, Gbg in compartment_, Effector in compartment_; species GaGTPEffector in compartment_, RGSc in compartment_, RGSm in compartment_; species RGSmGaGTP in compartment_, GaGTPEffectorOFF in compartment_, RGSmGaGTPEffectorOFF in compartment_; species GaGDPP in compartment_, LRRGSmGaGTP in compartment_, RRGSmGaGTP in compartment_; species LRRGSmGaGTPEffectorOFF in compartment_, GaGDP in compartment_, P in compartment_; species z1 in compartment_, z2 in compartment_, z3 in compartment_; // Reactions: R1: L + R => LR; compartment_*L*R*R1_k1; R2: R + Gabg => RGabg; compartment_*R*Gabg*R2_k2; R3: LR + Gabg => LRGabg; compartment_*LR*Gabg*R3_k3; R4: L + RGabg => LRGabg; compartment_*L*RGabg*R4_k4; R5: L + RRGSm => LRRGSm; compartment_*L*RRGSm*R5_k5; R6: RRGSm + Gabg => RRGSmGabg; compartment_*RRGSm*Gabg*R6_k6; R7: LRRGSm + Gabg => LRRGSmGabg; compartment_*LRRGSm*Gabg*R7_k7; R8: L + RRGSmGabg => LRRGSmGabg; compartment_*L*RRGSmGabg*R8_k8; R9: LRGabg => LR + GaGTP + Gbg; compartment_*LRGabg*R9_k9; R10: Gabg => GaGTP + Gbg; compartment_*Gabg*R10_k10; R11: LRRGSmGabg => GaGTP + Gbg + LRRGSm; compartment_*LRRGSmGabg*R11_k11; R12: Effector + GaGTP => GaGTPEffector; compartment_*Effector*GaGTP*R12_k12; R13: RGSc => RGSm; compartment_*RGSc*R13_k13; R14: RGSm => RGSc; compartment_*RGSm*R14_k14; R15: R + RGSc => RRGSm; compartment_*R*RGSc*R15_k15; R16: RRGSm => R + RGSm; compartment_*RRGSm*R16_k16; R17: LR + RGSc => LRRGSm; compartment_*LR*RGSc*R17_k17; R18: LRRGSm => LR + RGSm; compartment_*LRRGSm*R18_k18; R19: RGabg + RGSc => RRGSmGabg; compartment_*RGabg*RGSc*R19_k19; R20: RRGSmGabg => RGabg + RGSm; compartment_*RRGSmGabg*R20_k20; R21: LRGabg + RGSc => LRRGSmGabg; compartment_*LRGabg*RGSc*R21_k21; R22: GaGTP + RGSc => RGSmGaGTP; compartment_*GaGTP*RGSc*R22_k22; R23: RGSmGaGTP => GaGTP + RGSc; compartment_*RGSmGaGTP*R23_k23; R24: GaGTPEffectorOFF + RGSc => RGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*RGSc*R24_k24; R25: GaGTPEffector => GaGTPEffectorOFF; compartment_*GaGTPEffector*R25_k25; R26: GaGTP => GaGDPP; compartment_*GaGTP*R26_k26; R27: GaGTP + RGSm => RGSmGaGTP; compartment_*GaGTP*RGSm*R27_k27; R28: RGSmGaGTP => GaGDPP + RGSc; compartment_*RGSmGaGTP*R28_k28; R29: GaGTP + LRRGSm => LRRGSmGaGTP; compartment_*GaGTP*LRRGSm*R29_k29; R30: LRRGSmGaGTP => GaGDPP + LRRGSm; compartment_*LRRGSmGaGTP*R30_k30; R31: GaGTP + RRGSm => RRGSmGaGTP; compartment_*GaGTP*RRGSm*R31_k31; R32: RRGSmGaGTP => GaGDPP + RRGSm; compartment_*RRGSmGaGTP*R32_k32; R33: GaGTPEffectorOFF => GaGDPP + Effector; compartment_*GaGTPEffectorOFF*R33_k33; R34: GaGTPEffectorOFF + RGSm => RGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*RGSm*R34_k34; R35: RGSmGaGTPEffectorOFF => GaGDPP + RGSc + Effector; compartment_*RGSmGaGTPEffectorOFF*R35_k35; R36: GaGTPEffectorOFF + LRRGSm => LRRGSmGaGTPEffectorOFF; compartment_*GaGTPEffectorOFF*LRRGSm*R36_k36; R37: LRRGSmGaGTPEffectorOFF => GaGDPP + LRRGSm + Effector; compartment_*LRRGSmGaGTPEffectorOFF*R37_k37; R38: GaGDPP => GaGDP + P; compartment_*GaGDPP*R38_k38; R39: GaGDP + Gbg => Gabg; compartment_*GaGDP*Gbg*R39_k39; R40: P => ; compartment_*P*R40_k40; R41: => z1; compartment_*GaGTPEffector*ka; R42: z1 => z2; compartment_*z1*ka; R43: z2 => z3; compartment_*z2*ka; R44: z3 => ; compartment_*z3*ka; // Events: Ligand_addition: at time >= 14: L = L + Ligand_conc; // Species initializations: L = 0; L has nanoMolar; R = 205; R has nanoMolar; LR = 0; LR has nanoMolar; Gabg = 0; Gabg has nanoMolar; RGabg = 0; RGabg has nanoMolar; LRGabg = 0; LRGabg has nanoMolar; RRGSm = 0; RRGSm has nanoMolar; LRRGSm = 0; LRRGSm has nanoMolar; RRGSmGabg = 0; RRGSmGabg has nanoMolar; LRRGSmGabg = 0; LRRGSmGabg has nanoMolar; GaGTP = 0; GaGTP has nanoMolar; Gbg = 205; Gbg has nanoMolar; Effector = 305; Effector has nanoMolar; GaGTPEffector = 0; GaGTPEffector has nanoMolar; RGSc = 60; RGSc has nanoMolar; RGSm = 0; RGSm has nanoMolar; RGSmGaGTP = 0; RGSmGaGTP has nanoMolar; GaGTPEffectorOFF = 0; GaGTPEffectorOFF has nanoMolar; RGSmGaGTPEffectorOFF = 0; RGSmGaGTPEffectorOFF has nanoMolar; GaGDPP = 0; GaGDPP has nanoMolar; LRRGSmGaGTP = 0; LRRGSmGaGTP has nanoMolar; RRGSmGaGTP = 0; RRGSmGaGTP has nanoMolar; LRRGSmGaGTPEffectorOFF = 0; LRRGSmGaGTPEffectorOFF has nanoMolar; GaGDP = 205; GaGDP has nanoMolar; P = 0; P has nanoMolar; z1 = 0; z1 has nanoMolar; z2 = 0; z2 has nanoMolar; z3 = 0; z3 has nanoMolar; // Compartment initializations: compartment_ = 1; // Variable initializations: Ligand_conc = 0.1; Ligand_conc has nanoMolar; ka = 1.5; ka has FirstOrder; R1_k1 = 0.0025; R1_k1 has SecondOrder; R2_k2 = 0.005; R2_k2 has SecondOrder; R3_k3 = 0.02; R3_k3 has SecondOrder; R4_k4 = 0.005; R4_k4 has SecondOrder; R5_k5 = 0.005; R5_k5 has SecondOrder; R6_k6 = 0.005; R6_k6 has SecondOrder; R7_k7 = 0.02; R7_k7 has SecondOrder; R8_k8 = 0.005; R8_k8 has SecondOrder; R9_k9 = 50; R9_k9 has FirstOrder; R10_k10 = 0.2; R10_k10 has FirstOrder; R11_k11 = 40; R11_k11 has FirstOrder; R12_k12 = 10; R12_k12 has SecondOrder; R13_k13 = 0.0005; R13_k13 has FirstOrder; R14_k14 = 0.005; R14_k14 has FirstOrder; R15_k15 = 0.1; R15_k15 has SecondOrder; R16_k16 = 100; R16_k16 has FirstOrder; R17_k17 = 0.1; R17_k17 has SecondOrder; R18_k18 = 100; R18_k18 has FirstOrder; R19_k19 = 0.1; R19_k19 has SecondOrder; R20_k20 = 0.1; R20_k20 has FirstOrder; R21_k21 = 0.1; R21_k21 has SecondOrder; R22_k22 = 60; R22_k22 has SecondOrder; R23_k23 = 0.05; R23_k23 has FirstOrder; R24_k24 = 0.0001; R24_k24 has SecondOrder; R25_k25 = 1; R25_k25 has FirstOrder; R26_k26 = 0.005; R26_k26 has FirstOrder; R27_k27 = 500; R27_k27 has SecondOrder; R28_k28 = 2.5; R28_k28 has FirstOrder; R29_k29 = 100; R29_k29 has SecondOrder; R30_k30 = 2.5; R30_k30 has FirstOrder; R31_k31 = 0.5; R31_k31 has SecondOrder; R32_k32 = 0.5; R32_k32 has FirstOrder; R33_k33 = 0.005; R33_k33 has FirstOrder; R34_k34 = 50; R34_k34 has SecondOrder; R35_k35 = 0.3; R35_k35 has FirstOrder; R36_k36 = 50; R36_k36 has SecondOrder; R37_k37 = 0.3; R37_k37 has FirstOrder; R38_k38 = 1000; R38_k38 has FirstOrder; R39_k39 = 1000; R39_k39 has SecondOrder; R40_k40 = 10; R40_k40 has FirstOrder; // Other declarations: const compartment_, Ligand_conc, ka; // Unit definitions: unit nanoMolar = 1e-9 mole / litre; unit hour = 3600 second; unit FirstOrder = 1 / 3600 second; unit SecondOrder = litre / (1e-9 mole * 3600 second); unit nanoMolar_volume = 1e-9 mole; // Display Names: nanoMolar is "nM"; hour is "hr"; FirstOrder is "1/hr"; SecondOrder is "1/(nM*hr)"; compartment_ is "cell"; R1 is "Receptor-Ligand association"; R2 is "Receptor-Gprotein association"; R3 is "LR-Gprotein association"; R4 is "Ligand-RGabg association"; R5 is "Ligand-RRGSm association"; R6 is "RRGSm-Gprotein association"; R7 is "LRRGSm-Gprotein association"; R8 is "Ligand-RRGSmGabg association"; R9 is "Gprotein activation by LR"; R10 is "Gprotein spontaneous activation"; R11 is "Gprotein activation by LRRGSm"; R12 is "Effector-GaGTP association"; R13 is "RGS in cytosol moves to membrane"; R14 is "RGS in membrane moves to cytosol"; R15 is "Receptor recruits RGSc to membrane"; R16 is "R-RGSm dissociation"; R17 is "LR recruits RGSc to membrane"; R18 is "LR-RGSm dissociation"; R19 is "RGabg recruits RGSc to membrane"; R20 is "RRGSmGabg dissociation"; R21 is "LRGabg recruits RGSc to membrane"; R22 is "GaGTP recruits RGSc to membrane"; R23 is "RGSmGaGTP dissociation"; R24 is "GaGTPEffectorOFF recruits RGS from cytosol"; R25 is "Effector turns off"; R26 is "GaGTP hydrolyzes GTP"; R27 is "GaGTP-RGSm association"; R28 is "RGSmGaGTP hydrolyzes GTP"; R29 is "GaGTP-LRRGSm association"; R30 is "LRRGSmGaGTP hydrolyzes GTP"; R31 is "GaGTP-RRGSm association"; R32 is "RRGSmGaGTP hydrolyzes GTP"; R33 is "GaGTPEffectorOFF hydrolyzes GTP"; R34 is "GaGTPEffectorOFF-RGSm association"; R35 is "RGSmGaGTPEffectorOFF hydrolyzes GTP"; R36 is "GaGTPEffectorOFF-LRRGSm association"; R37 is "LRRGSmGaGTPEffectorOFF hydrolyzes GTP"; R38 is "Phosphate release"; R39 is "Gprotein subunits association"; R40 is "Phosphate degradation"; R41 is "Delay 1"; R42 is "Delay 2"; R43 is "Delay 3"; R44 is "Final output"; end