// Created by libAntimony v2.8.0
model *MODEL1209230000()

  // Compartments and Species:
  compartment cell_nsclc;
  species EGFR_active in cell_nsclc, D_SOS in cell_nsclc, A_SOS in cell_nsclc;
  species Raf in cell_nsclc, Ras_active in cell_nsclc, Mek_active in cell_nsclc;
  species ERK in cell_nsclc, ERK_active in cell_nsclc, IGFR_active in cell_nsclc;
  species PI3KCA in cell_nsclc, PI3KCA_active in cell_nsclc, AKT_active in cell_nsclc;
  species AKT in cell_nsclc, PP2A in cell_nsclc, Ras in cell_nsclc, Raf_active in cell_nsclc;
  species Mek in cell_nsclc, RasGapActive in cell_nsclc, RafPP in cell_nsclc;
  species P90RskInactive in cell_nsclc, P90Rsk_Active in cell_nsclc;

  // Reactions:
  SOS_conformational_activation: D_SOS + EGFR_active => A_SOS + EGFR_active; (SOS_conformational_activation_k_SOS_E*EGFR_active*D_SOS^SOS_conformational_activation_n_SOS)/(SOS_conformational_activation_KM_SOS_E^SOS_conformational_activation_n_SOS + D_SOS^SOS_conformational_activation_n_SOS);
  kRas_Activation: A_SOS + Ras => Ras_active + A_SOS; (A_SOS*kRas_Activation_k_Ras_SOS*Ras^kRas_Activation_n_Ras_SOS)/(kRas_Activation_KM_Ras_SOS^kRas_Activation_n_Ras_SOS + Ras^kRas_Activation_n_Ras_SOS);
  EGFR_degradation: EGFR_active => ; gamma_EGFR*EGFR_active;
  ERK_activationBy_Mek: ERK + Mek_active => ERK_active + Mek_active; (Mek_active*ERK_activationBy_Mek_k_ERK_MekActive*ERK)/(ERK_activationBy_Mek_KM_ERK_MekActive + ERK);
  SOS_deactivationBy_P90: P90Rsk_Active + A_SOS => D_SOS + P90Rsk_Active; (P90Rsk_Active*SOS_deactivationBy_P90_k_D_SOS_P90Rsk*A_SOS^SOS_deactivationBy_P90_n_D_SOS)/(SOS_deactivationBy_P90_KM_D_SOS_P90Rsk^SOS_deactivationBy_P90_n_D_SOS + A_SOS^SOS_deactivationBy_P90_n_D_SOS);
  SOS_activationBy_IGF: IGFR_active + D_SOS => A_SOS + IGFR_active; (IGFR_active*SOS_activationBy_IGF_k_A_SOS_I*D_SOS^SOS_activationBy_IGF_n_A_SOS_I)/(SOS_activationBy_IGF_KM_A_SOS_I^SOS_activationBy_IGF_n_A_SOS_I + D_SOS^SOS_activationBy_IGF_n_A_SOS_I);
  PI3KCA_activationBy_IGF1R: PI3KCA + IGFR_active => PI3KCA_active + IGFR_active; (IGFR_active*PI3KCA_activationBy_IGF1R_k_PI3K_IGF1R*PI3KCA^PI3KCA_activationBy_IGF1R_n_PI3K_I)/(PI3KCA_activationBy_IGF1R_KM_PI3K_IGF1R^PI3KCA_activationBy_IGF1R_n_PI3K_I + PI3KCA^PI3KCA_activationBy_IGF1R_n_PI3K_I);
  PI3KCA_activationBy_EGF: PI3KCA + EGFR_active => PI3KCA_active + EGFR_active; (EGFR_active*PI3KCA_activationBy_EGF_k_PI3K_EGF1R*EGFR_active*PI3KCA^PI3KCA_activationBy_EGF_n_PI3K_E)/(PI3KCA_activationBy_EGF_KM_PI3K_EGF1R^PI3KCA_activationBy_EGF_n_PI3K_E + PI3KCA^PI3KCA_activationBy_EGF_n_PI3K_E);
  Akt_activationBy_PI3KCA: AKT + PI3KCA_active => AKT_active + PI3KCA_active; (PI3KCA_active*Akt_activationBy_PI3KCA_k_AKT_PI3K*AKT^Akt_activationBy_PI3KCA_n_AKT_PI3K)/(Akt_activationBy_PI3KCA_KM_AKT_PI3K^Akt_activationBy_PI3KCA_n_AKT_PI3K + AKT^Akt_activationBy_PI3KCA_n_AKT_PI3K);
  Akt_deactivation: AKT_active => AKT; Akt_deactivation_kd_AKT*AKT_active;
  ERK_deactivationBy_PP2A: ERK_active + PP2A => ERK + PP2A; (PP2A*ERK_deactivationBy_PP2A_k_ERKactive_PP2A*ERK_active^ERK_deactivationBy_PP2A_n_ERKactive_PP2A)/(ERK_deactivationBy_PP2A_KM_ERKactive_PP2A^ERK_deactivationBy_PP2A_n_ERKactive_PP2A + ERK_active^ERK_deactivationBy_PP2A_n_ERKactive_PP2A);
  PI3KCA_activationBy_kRas: PI3KCA + Ras_active => PI3KCA_active + Ras_active; (Ras_active*PI3KCA_activationBy_kRas_k_PI3K_Ras*PI3KCA^PI3KCA_activationBy_kRas_n_PI3K_Ras)/(PI3KCA_activationBy_kRas_KM_PI3K_Ras^PI3KCA_activationBy_kRas_n_PI3K_Ras + PI3KCA^PI3KCA_activationBy_kRas_n_PI3K_Ras);
  Raf_activationBy_kRas: Ras_active + Raf => Raf_active + Ras_active; (Ras_active*Raf_activationBy_kRas_k_Raf_RasActive*Raf^Raf_activationBy_kRas_n_Raf_RasActive)/(Raf_activationBy_kRas_KM_Raf_RasActive + Raf^Raf_activationBy_kRas_n_Raf_RasActive);
  Mek_activationBy_Raf: Raf_active + Mek => Mek_active + Raf_active; (Raf_active*Mek_activationBy_Raf_k_Mek_PP2A*Mek^Mek_activationBy_Raf_n_Mek_PP2A)/(Mek_activationBy_Raf_KM_MekPP2A^Mek_activationBy_Raf_n_Mek_PP2A + Mek^Mek_activationBy_Raf_n_Mek_PP2A);
  Raf_deactivationBy_Akt: AKT_active + Raf_active => Raf + AKT_active; (AKT_active*Raf_deactivationBy_Akt_k_Raf_AKT*Raf_active^Raf_deactivationBy_Akt_n_Raf_AKT)/(Raf_deactivationBy_Akt_KM_Raf_AKT^Raf_deactivationBy_Akt_n_Raf_AKT + Raf_active^Raf_deactivationBy_Akt_n_Raf_AKT);
  Ras_deactivation: RasGapActive + Ras_active => Ras + RasGapActive; (RasGapActive*Ras_deactivation_k_RasActiveRasGap*Ras_active^Ras_deactivation_n_RasActiveRasGap)/(Ras_deactivation_KM_RasActiveRasGap^Ras_deactivation_n_RasActiveRasGap + Ras_active^Ras_deactivation_n_RasActiveRasGap);
  Mek_deactivation: PP2A + Mek_active => Mek + PP2A; (PP2A*Mek_deactivation_k_MekActivePP2A*Mek_active^Mek_deactivation_n_MekActivePP2A)/(Mek_deactivation_KM_MekActivePP2A^Mek_deactivation_n_MekActivePP2A + Mek_active^Mek_deactivation_n_MekActivePP2A);
  IGFR_active_degradation: IGFR_active => ; gamma_IGFR*IGFR_active;
  PI3KCA_deactivation: PI3KCA_active => PI3KCA; kd_PI3K_a*PI3KCA_active;
  Raf_deactivation: RafPP + Raf_active => Raf + RafPP; (RafPP*Raf_deactivation_k_RasActive_RafPP*Raf_active^Raf_deactivation_n_RasActive_RafPP)/(Raf_deactivation_KM_RasActive_RafPP^Raf_deactivation_n_RasActive_RafPP + Raf_active^Raf_deactivation_n_RasActive_RafPP);
  P90_activationBy_ERK: P90RskInactive + ERK_active => P90Rsk_Active + ERK_active; (ERK_active*k_P90Rsk_ERKActive*P90RskInactive)/(KM_P90Rsk_ERKActive + P90RskInactive);
  P90_deactivation: P90Rsk_Active => P90RskInactive; P90_deactivation_kd_P90Rsk*P90Rsk_Active;

  // Species initializations:
  EGFR_active = 8000/cell_nsclc;
  D_SOS = 120000/cell_nsclc;
  A_SOS = 0;
  Raf = 120000/cell_nsclc;
  Ras_active = 0;
  Mek_active = 0;
  ERK = 600000/cell_nsclc;
  ERK_active = 0;
  IGFR_active = 800/cell_nsclc;
  PI3KCA = 120000/cell_nsclc;
  PI3KCA_active = 0;
  AKT_active = 0;
  AKT = 600000/cell_nsclc;
  PP2A = 120000/cell_nsclc;
  Ras = 120000/cell_nsclc;
  Raf_active = 0;
  Mek = 600000/cell_nsclc;
  RasGapActive = 120000/cell_nsclc;
  RafPP = 120000/cell_nsclc;
  P90RskInactive = 120000/cell_nsclc;
  P90Rsk_Active = 0;

  // Compartment initializations:
  cell_nsclc = 1;

  // Variable initializations:
  gamma_IGFR = 0.02;
  kd_PI3K_a = 0.005;
  k_P90Rsk_ERKActive = 0.0213697;
  KM_P90Rsk_ERKActive = 763523;
  gamma_EGFR = 0.02;
  SOS_conformational_activation_k_SOS_E = 694.731;
  SOS_conformational_activation_n_SOS = 1;
  SOS_conformational_activation_KM_SOS_E = 6086070;
  kRas_Activation_k_Ras_SOS = 32.344;
  kRas_Activation_n_Ras_SOS = 1;
  kRas_Activation_KM_Ras_SOS = 35954.3;
  ERK_activationBy_Mek_k_ERK_MekActive = 9.85367;
  ERK_activationBy_Mek_KM_ERK_MekActive = 1007340;
  SOS_deactivationBy_P90_k_D_SOS_P90Rsk = 161197;
  SOS_deactivationBy_P90_n_D_SOS = 1;
  SOS_deactivationBy_P90_KM_D_SOS_P90Rsk = 896896;
  SOS_activationBy_IGF_k_A_SOS_I = 500;
  SOS_activationBy_IGF_n_A_SOS_I = 1;
  SOS_activationBy_IGF_KM_A_SOS_I = 100000;
  PI3KCA_activationBy_IGF1R_k_PI3K_IGF1R = 10.6737;
  PI3KCA_activationBy_IGF1R_n_PI3K_I = 1;
  PI3KCA_activationBy_IGF1R_KM_PI3K_IGF1R = 184912;
  PI3KCA_activationBy_EGF_k_PI3K_EGF1R = 10.6737;
  PI3KCA_activationBy_EGF_n_PI3K_E = 1;
  PI3KCA_activationBy_EGF_KM_PI3K_EGF1R = 184912;
  Akt_activationBy_PI3KCA_k_AKT_PI3K = 0.0566279;
  Akt_activationBy_PI3KCA_n_AKT_PI3K = 1;
  Akt_activationBy_PI3KCA_KM_AKT_PI3K = 653951;
  Akt_deactivation_kd_AKT = 0.005;
  ERK_deactivationBy_PP2A_k_ERKactive_PP2A = 8.8912;
  ERK_deactivationBy_PP2A_n_ERKactive_PP2A = 1;
  ERK_deactivationBy_PP2A_KM_ERKactive_PP2A = 3496490;
  PI3KCA_activationBy_kRas_k_PI3K_Ras = 0.0771067;
  PI3KCA_activationBy_kRas_n_PI3K_Ras = 1;
  PI3KCA_activationBy_kRas_KM_PI3K_Ras = 272056;
  Raf_activationBy_kRas_k_Raf_RasActive = 0.884096;
  Raf_activationBy_kRas_n_Raf_RasActive = 1;
  Raf_activationBy_kRas_KM_Raf_RasActive = 62464.6;
  Mek_activationBy_Raf_k_Mek_PP2A = 185.759;
  Mek_activationBy_Raf_n_Mek_PP2A = 1;
  Mek_activationBy_Raf_KM_MekPP2A = 4768350;
  Raf_deactivationBy_Akt_k_Raf_AKT = 15.1212;
  Raf_deactivationBy_Akt_n_Raf_AKT = 1;
  Raf_deactivationBy_Akt_KM_Raf_AKT = 119355;
  Ras_deactivation_k_RasActiveRasGap = 1509.36;
  Ras_deactivation_n_RasActiveRasGap = 1;
  Ras_deactivation_KM_RasActiveRasGap = 1432410;
  Mek_deactivation_k_MekActivePP2A = 2.83243;
  Mek_deactivation_n_MekActivePP2A = 1;
  Mek_deactivation_KM_MekActivePP2A = 518753;
  Raf_deactivation_k_RasActive_RafPP = 0.126329;
  Raf_deactivation_n_RasActive_RafPP = 1;
  Raf_deactivation_KM_RasActive_RafPP = 1061.71;
  P90_deactivation_kd_P90Rsk = 0.005;

  // Other declarations:
  const cell_nsclc, gamma_IGFR, kd_PI3K_a, k_P90Rsk_ERKActive, KM_P90Rsk_ERKActive;
  const gamma_EGFR;

  // Display Names:
  SOS_conformational_activation is "SOS conformational activation";
  kRas_Activation is "kRas Activation";
  EGFR_degradation is "EGFR degradation";
  ERK_activationBy_Mek is "ERK activation by Mek";
  SOS_deactivationBy_P90 is "SOS deactivation by P90";
  SOS_activationBy_IGF is "SOS activation by IGF";
  PI3KCA_activationBy_IGF1R is "PI3KCA activation by IGF1R";
  PI3KCA_activationBy_EGF is "PI3KCA activation by EGF";
  Akt_activationBy_PI3KCA is "Akt activation by PI3KCA";
  Akt_deactivation is "Akt deactivation";
  ERK_deactivationBy_PP2A is "ERK deactivation by PP2A";
  PI3KCA_activationBy_kRas is "PI3KCA activation by kRas";
  Raf_activationBy_kRas is "Raf activation by kRas";
  Mek_activationBy_Raf is "Mek activation by Raf";
  Raf_deactivationBy_Akt is "Raf deactivation by Akt";
  Ras_deactivation is "Ras deactivation by RasGab";
  Mek_deactivation is "Mek deactivation by PP2A";
  IGFR_active_degradation is "IGFR active degradation";
  PI3KCA_deactivation is "PI3KCA deactivation";
  Raf_deactivation is "Raf deactivation by RafPP";
  P90_activationBy_ERK is "P90 activation by ERK";
  P90_deactivation is "P90 deactivation";
end