// Created by libAntimony v2.8.0 function RUPE(Vmax, RU5P, X5P, Keq_RUPE, KRu5P, KX5P) (Vmax*(RU5P - X5P/Keq_RUPE))/(RU5P + KRu5P*(1 + X5P/KX5P)); end function PGDH(Vmax, K6PG1, KNADP, PGN, NADP, RU5P, NADPH, Kapp, BPG, KPGA23, ATP, KATP, K6PG2, KNADPH) (Vmax/K6PG1/KNADP*(PGN*NADP - (RU5P*NADPH)/Kapp))/((1 + NADP/KNADP)*(1 + PGN/K6PG1 + BPG/KPGA23) + ATP/KATP + (NADPH*(1 + PGN/K6PG2))/KNADPH); end function G6PDH(Vmax, KG6P, KNADP, G6P, NADP, PGN, NADPH, Kapp, ATP, KATP, KNADPH, BPG, KPGA23) (Vmax/KG6P/KNADP*(G6P*NADP - (PGN*NADPH)/Kapp))/(1 + (NADP*(1 + G6P/KG6P))/KNADP + ATP/KATP + NADPH/KNADPH + BPG/KPGA23); end function TKL(Vmax, R5P, X5P, GAP, S7P, Keq_TKL, K1, K2, K6, K3, K5, K4, K7) (Vmax*(R5P*X5P - (GAP*S7P)/Keq_TKL))/((K1 + R5P)*X5P + (K2 + K6*S7P)*R5P + (K3 + K5*S7P)*GAP + K4*S7P + K7*X5P*GAP); end function PGI(Vmf, A, Kg6p, Vmr, P, Kf6p, E4P, Kery4p, F16P, Kfbp, PGN, Kpg) ((Vmf*A)/Kg6p - (Vmr*P)/Kf6p)/(1 + A/Kg6p + P/Kf6p + E4P/Kery4p + F16P/Kfbp + PGN/Kpg); end function TKL2(Vmax, E4P, X5P, GAP, F6P, Keq_TKL2, K1, K2, K6, K3, K5, K4, K7) (Vmax*(E4P*X5P - (GAP*F6P)/Keq_TKL2))/((K1 + E4P)*X5P + (K2 + K6*F6P)*E4P + (K3 + K5*F6P)*GAP + K4*F6P + K7*X5P*GAP); end function HK(Vmf, Ka, Kb, A, B, P, Q, Kapp, Kp, Kq) (Vmf/(Ka*Kb)*(A*B - (P*Q)/Kapp))/(1 + A/Ka + B/Kb + (A*B)/(Ka*Kb) + P/Kp + Q/Kq + (P*Q)/(Kp*Kq) + (A*Q)/(Ka*Kq) + (P*B)/(Kp*Kb)); end function R5PI(Vmax, RU5P, R5P, Keq_R5PI, KRu5P, KR5P) (Vmax*(RU5P - R5P/Keq_R5PI))/(RU5P + KRu5P*(1 + R5P/KR5P)); end function GLUT(Vmaxf, GLC_e, GLC, keq, KGlc_e, KGlc) (Vmaxf*(GLC_e - GLC/keq))/(KGlc_e*(1 + GLC/KGlc) + GLC_e); end function TAL(Vmax, S7P, GAP, E4P, F6P, Keq_TAL, K1, K2, K6, K3, K5, K4, K7) (Vmax*(S7P*GAP - (E4P*F6P)/Keq_TAL))/((K1 + GAP)*S7P + (K2 + K6*F6P)*GAP + (K3 + K5*F6P)*E4P + K4*F6P + K7*S7P*E4P); end function PGLM(Vmaxf, G1P, KG1P, Vmaxr, G6P, KG6P) ((Vmaxf*G1P)/KG1P - (Vmaxr*G6P)/KG6P)/(1 + G1P/KG1P + G6P/KG6P); end function PRPPS(Vmax, R5P, ATP, PRPP, AMP, Kapp, KATP, KR5P) (Vmax*(R5P*ATP - (PRPP*AMP)/Kapp))/((KATP + ATP)*(KR5P + R5P)); end function GPa(Vmaxf, GLY, Pi_, KiGLYf, KPi, Vmaxr, G1P, KGLYb, KiG1P, KiPi, KiGLYb) (Vmaxf*((GLY*Pi_)/(KiGLYf*KPi)) - Vmaxr*((GLY*G1P)/(KGLYb*KiG1P)))/(1 + GLY/KiGLYf + Pi_/KiPi + GLY/KiGLYb + G1P/KiG1P + (GLY*Pi_)/(KiGLYf*KiPi) + (GLY*G1P)/(KiGLYb*KiG1P)); end function GPb(Vmaxf, GLY, Pi_, KiGLYf, KPi, Vmaxr, G1P, KiGLYb, KG1P, KiPi, KiG1P, AMP, nH, Kamp) ((Vmaxf*((GLY*Pi_)/(KiGLYf*KPi)) - Vmaxr*((GLY*G1P)/(KiGLYb*KG1P)))/(1 + GLY/KiGLYf + Pi_/KiPi + GLY/KiGLYb + G1P/KiG1P + (GLY*Pi_)/(KiGLYf*KPi) + (GLY*G1P)/(KiGLYb*KG1P))*(AMP^nH/Kamp))/(1 + AMP^nH/Kamp); end function FBA(Vmf, A, Kfbp, Vmr, P, Q, Kdhap, Kg3p) ((Vmf*A)/Kfbp - (Vmr*P*Q)/(Kdhap*Kg3p))/(1 + A/Kfbp + P/Kdhap + Q/Kg3p + (P*Q)/(Kdhap*Kg3p)); end function TPI(Vf, GAP, Kms, Vr, DHAP, Kmp) ((Vf*GAP)/Kms - (Vr*DHAP)/Kmp)/(1 + GAP/Kms + DHAP/Kmp); end function GAPDH(Vmf, A, B, C, Knad, Kg3p, Kp, Vmr, P, Q, Kdpg, Knadh) ((Vmf*A*B*C)/(Knad*Kg3p*Kp) - (Vmr*P*Q)/(Kdpg*Knadh))/(1 + A/Knad + (A*B)/(Knad*Kg3p) + (A*B*C)/(Knad*Kg3p*Kp) + (P*Q)/(Kdpg*Knadh) + Q/Knadh); end function PGK(Vmf, A, B, alfa, Ka, Kb, Vmr, P, Q, beta, Kp, Kq) ((Vmf*A*B)/(alfa*Ka*Kb) - (Vmr*P*Q)/(beta*Kp*Kq))/(1 + A/Ka + B/Kb + (A*B)/(alfa*Ka*Kb) + (P*Q)/(beta*Kp*Kq) + P/Kp + Q/Kq); end function PFK(Vm, a, B, Katp, beta, F26P, alfa, Kf26bp, A, Kf6p, L, CIT, Kcit, Kiatp, Q, P, Kadp, Kfbp, Kapp) Vm*((a*B)/Katp/(1 + (a*B)/Katp))*((1 + (beta*a*F26P)/(alfa*Kf26bp))/(1 + (a*F26P)/(alfa*Kf26bp)))*(((a*A*(1 + (a*F26P)/(alfa*Kf26bp)))/(Kf6p*(1 + (a*F26P)/Kf26bp))*(1 + (a*A*(1 + (a*F26P)/(alfa*Kf26bp)))/(Kf6p*(1 + (a*F26P)/Kf26bp)))^3)/((L*(1 + (a*CIT)/Kcit)^4*(1 + (a*B)/Kiatp)^4)/(1 + (a*F26P)/Kf26bp)^4 + (1 + (a*A*(1 + (a*F26P)/(alfa*Kf26bp)))/(Kf6p*(1 + (a*F26P)/Kf26bp)))^4) - (a*Q*a*P)/(Kadp*Kfbp*Kapp)/((a*Q)/Kadp + (a*P)/Kfbp + (a*Q*a*P)/(Kadp*Kfbp) + 1)); end function function_1(Vmf, PG3, Kms, Vmr, PG2, Kmp) ((Vmf*PG3)/Kms - (Vmr*PG2)/Kmp)/(1 + PG3/Kms + PG2/Kmp); end function GS(Vmaxf, Kf, a, G1P, ATP, GLY, Pi_, ADP, Keq, Kr) (Vmaxf/Kf*a*G1P*a*ATP*a*GLY*(1 - ((a*Pi_)^2*a*ADP)/(a*G1P*a*ATP*Keq)))/(1 + (a*G1P*a*ATP*a*GLY)/Kf + (a*GLY*(a*Pi_)^2*a*ADP)/Kr); end function function_2(Vmf, PG2, Kms, Vmr, PEP, Kmp) ((Vmf*PG2)/Kms - (Vmr*PEP)/Kmp)/(1 + PG2/Kms + PEP/Kmp); end function function_3(Vm, B, Kadp, A, Kpep, L, Q, Kiatp, F16P, Kfbp, P, Katp, Kpyr, Kapp, a) Vm*((a*B)/Kadp/(1 + (a*B)/Kadp)*(((a*A)/Kpep*(1 + (a*A)/Kpep)^3)/((L*(1 + (a*Q)/Kiatp)^4)/(1 + (a*F16P)/Kfbp)^4 + (1 + (a*A)/Kpep)^4)) - (a*Q*a*P)/(Katp*Kpyr*Kapp)/((a*Q)/Katp + (a*P)/Kpyr + (a*Q*a*P)/(Katp*Kpyr) + 1)); end function function_4(Vmf, A, B, alfa, Ka, Kb, Vmr, P, Q, beta, Kp, Kq) ((Vmf*A*B)/(alfa*Ka*Kb) - (Vmr*P*Q)/(beta*Kp*Kq))/(1 + A/Ka + B/Kb + (A*B)/(alfa*Ka*Kb) + (P*Q)/(beta*Kp*Kq) + P/Kp + Q/Kq); end function function_5(Vf, ADP, ATP, AMP, Keq) (Vf*ADP^2*(1 - (ATP*AMP)/Keq))/(((1 + ADP)^2 + (1 + ATP)*(1 + AMP)) - 1); end function function_6(Vf, NADH, NAD, Keq) (Vf*NADH*(1 - NAD/(NADH*Keq)))/((1 + NADH + 1 + NAD) - 1); end function function_7(Vf, NADPH, NADP, Keq) (Vf*NADPH*(1 - NADP/(NADPH*Keq)))/((1 + NADPH + 1 + NADP) - 1); end function function_8(Vmf, PYR, y, Pi_, ADP, O2, ATP, CO2, Keq) (Vmf*PYR^(1/y)*Pi_*ADP*O2^(5/(2*y))*(1 - (ATP*CO2^(3/y))/(PYR^(1/y)*O2^(5/(2*y))*Pi_*ADP*Keq)))/(((1 + PYR)^(1/y)*(1 + O2)^(5/(2*y))*(1 + Pi_)*(1 + ADP) + (1 + ATP)*(1 + CO2)^(3/y)) - 1); end model *MODEL1210150000() // Compartments and Species: compartment compartment_1; species species_1 in compartment_1, species_2 in compartment_1, $species_3 in compartment_1; species species_4 in compartment_1, species_5 in compartment_1, species_6 in compartment_1; species species_7 in compartment_1, species_8 in compartment_1, $species_9 in compartment_1; species $species_10 in compartment_1, species_11 in compartment_1, species_12 in compartment_1; species species_13 in compartment_1, species_14 in compartment_1, species_15 in compartment_1; species species_16 in compartment_1, species_17 in compartment_1, $species_18 in compartment_1; species species_19 in compartment_1, $species_20 in compartment_1, $species_21 in compartment_1; species species_22 in compartment_1, $species_23 in compartment_1, $species_24 in compartment_1; species $species_25 in compartment_1, $species_26 in compartment_1, species_27 in compartment_1; species species_28 in compartment_1, species_29 in compartment_1, species_30 in compartment_1; species species_31 in compartment_1, $species_32 in compartment_1, $species_33 in compartment_1; species $species_34 in compartment_1; // Assignment Rules: species_3 := parameter_1 - species_4; species_10 := parameter_2 - species_11; species_18 := parameter_3 - species_19; parameter_4 := (parameter_58*parameter_59*parameter_60)/(parameter_61*parameter_62*parameter_5); parameter_7 := (parameter_63*parameter_64*parameter_65)/(parameter_66*parameter_67*parameter_6); parameter_8 := (parameter_37*parameter_68*parameter_69)/(parameter_12*parameter_70); parameter_37 := 14.63*parameter_28; parameter_9 := (parameter_38*parameter_71)/(parameter_72*parameter_18); parameter_38 := 5.976*parameter_28; parameter_10 := (parameter_39*parameter_73*parameter_74)/(parameter_75*parameter_76*parameter_77*parameter_19); parameter_39 := 109.1*parameter_28; parameter_11 := (parameter_40*parameter_49*parameter_50)/(parameter_51*parameter_52*parameter_20); parameter_40 := 73.41*parameter_28; parameter_13 := parameter_32*(parameter_81/(parameter_82*parameter_14)); parameter_32 := 7778*parameter_28; parameter_15 := (parameter_55*parameter_56)/(parameter_57*parameter_16); parameter_22 := (parameter_78*parameter_79)/(parameter_80*parameter_21); parameter_24 := (parameter_43*parameter_53)/(parameter_54*parameter_23); parameter_43 := 160.9*parameter_28; parameter_26 := (parameter_45*parameter_83*parameter_84)/(parameter_85*parameter_86*parameter_25); parameter_45 := 340.3*parameter_28; parameter_27 := species_20; parameter_30 := 23.03*parameter_28; parameter_31 := 86.85*parameter_28; parameter_33 := 1.008*parameter_28; parameter_34 := 31.02*parameter_28; parameter_35 := 1056*parameter_28; parameter_36 := 0.1761*parameter_28; parameter_41 := 32040*parameter_28; parameter_42 := 107.6*parameter_28; parameter_44 := 27.81*parameter_28; parameter_46 := 4982000*parameter_28; parameter_47 := 127800*parameter_28; parameter_48 := 9801000*parameter_29; // Reactions: reaction_1: $species_9 -> species_1; compartment_1*GLUT(parameter_30, species_9, species_1, reaction_1_keq, reaction_1_KGlc_e, reaction_1_KGlc); reaction_2: species_1 + species_4 -> species_2 + $species_3; compartment_1*HK(parameter_31, reaction_2_Ka, reaction_2_Kb, species_1, species_4, species_2, species_3, reaction_2_Kapp, reaction_2_Kp, reaction_2_Kq); reaction_3: species_2 -> species_5; compartment_1*PGI(parameter_32, species_2, parameter_82, parameter_13, species_5, parameter_81, species_7, reaction_3_Kery4p, species_6, reaction_3_Kfbp, species_8, reaction_3_Kpg); reaction_4: species_2 + $species_10 -> species_8 + species_11; compartment_1*G6PDH(parameter_33, reaction_4_KG6P, reaction_4_KNADP, species_2, species_10, species_8, species_11, reaction_4_Kapp, species_4, reaction_4_KATP, reaction_4_KNADPH, species_12, reaction_4_KPGA23); reaction_5: species_8 + $species_10 -> species_13 + species_11; compartment_1*PGDH(parameter_34, reaction_5_K6PG1, reaction_5_KNADP, species_8, species_10, species_13, species_11, reaction_5_Kapp, species_12, reaction_5_KPGA23, species_4, reaction_5_KATP, reaction_5_K6PG2, reaction_5_KNADPH); reaction_6: species_13 -> species_14; compartment_1*RUPE(reaction_6_Vmax, species_13, species_14, reaction_6_Keq_RUPE, reaction_6_KRu5P, reaction_6_KX5P); reaction_7: species_13 -> species_15; compartment_1*R5PI(reaction_7_Vmax, species_13, species_15, reaction_7_Keq_R5PI, reaction_7_KRu5P, reaction_7_KR5P); reaction_8: species_15 + species_14 -> species_16 + species_17; compartment_1*TKL(parameter_35, species_15, species_14, species_16, species_17, reaction_8_Keq_TKL, reaction_8_K1, reaction_8_K2, reaction_8_K6, reaction_8_K3, reaction_8_K5, reaction_8_K4, reaction_8_K7); reaction_9: species_14 + species_7 -> species_16 + species_5; compartment_1*TKL2(parameter_36, species_7, species_14, species_16, species_5, reaction_9_Keq_TKL2, reaction_9_K1, reaction_9_K2, reaction_9_K6, reaction_9_K3, reaction_9_K5, reaction_9_K4, reaction_9_K7); reaction_10: species_17 + species_16 -> species_5 + species_7; compartment_1*TAL(reaction_10_Vmax, species_17, species_16, species_7, species_5, reaction_10_Keq_TAL, reaction_10_K1, reaction_10_K2, reaction_10_K6, reaction_10_K3, reaction_10_K5, reaction_10_K4, reaction_10_K7); reaction_11: species_15 + species_4 -> $species_20 + $species_21; compartment_1*PRPPS(reaction_11_Vmax, species_15, species_4, species_21, species_20, reaction_11_Kapp, reaction_11_KATP, reaction_11_KR5P); reaction_12: species_22 -> species_2; compartment_1*PGLM(parameter_55, species_22, parameter_57, parameter_15, species_2, parameter_56); reaction_13: $species_24 + $species_23 -> $species_24 + species_22; compartment_1*GPa(parameter_58, species_24, species_23, parameter_61, parameter_62, parameter_4, species_22, reaction_13_KGLYb, parameter_60, reaction_13_KiPi, parameter_59); reaction_14: species_6 -> species_16 + species_27; compartment_1*FBA(parameter_37, species_6, parameter_70, parameter_8, species_27, species_16, parameter_68, parameter_69); reaction_15: species_16 -> species_27; compartment_1*TPI(parameter_38, species_16, parameter_72, parameter_9, species_27, parameter_71); reaction_16: species_16 + species_19 + $species_23 -> species_12 + $species_18; compartment_1*GAPDH(parameter_39, species_19, species_16, species_23, parameter_76, parameter_75, parameter_77, parameter_10, species_12, species_18, parameter_73, parameter_74); reaction_17: species_12 + $species_3 -> species_28 + species_4; compartment_1*PGK(parameter_40, species_12, species_3, reaction_17_alfa, parameter_51, parameter_52, parameter_11, species_28, species_4, reaction_17_beta, parameter_49, parameter_50); reaction_18: $species_24 + $species_23 -> $species_24 + species_22; compartment_1*GPb(parameter_63, species_24, species_23, parameter_66, reaction_18_KPi, parameter_7, species_22, parameter_64, parameter_65, parameter_67, reaction_18_KiG1P, parameter_27, reaction_18_nH, reaction_18_Kamp); reaction_19: species_22 + species_4 -> $species_24 + $species_3 + 2$species_23; compartment_1*GS(parameter_41, reaction_19_Kf, parameter_17, species_22, species_4, species_24, species_23, species_3, reaction_19_Keq, reaction_19_Kr); reaction_20: species_5 + species_4 -> species_6 + $species_3; compartment_1*PFK(parameter_42, parameter_17, species_4, reaction_20_Katp, reaction_20_beta, species_26, reaction_20_alfa, reaction_20_Kf26bp, species_5, reaction_20_Kf6p, reaction_20_L, species_25, reaction_20_Kcit, reaction_20_Kiatp, species_3, species_6, reaction_20_Kadp, reaction_20_Kfbp, reaction_20_Kapp); reaction_21: species_28 -> species_29; compartment_1*function_1(parameter_78, species_28, parameter_80, parameter_22, species_29, parameter_79); reaction_22: species_29 -> species_30; compartment_1*function_2(parameter_43, species_29, parameter_54, parameter_24, species_30, parameter_53); reaction_23: species_30 + $species_3 -> species_31 + species_4; compartment_1*function_3(parameter_44, species_3, reaction_23_Kadp, species_30, reaction_23_Kpep, reaction_23_L, species_4, reaction_23_Kiatp, species_6, reaction_23_Kfbp, species_31, reaction_23_Katp, reaction_23_Kpyr, reaction_23_Kapp, parameter_17); reaction_24: species_31 + $species_18 -> $species_32 + species_19; compartment_1*function_4(parameter_45, species_18, species_31, reaction_24_alfa, parameter_85, parameter_86, parameter_26, species_32, species_19, reaction_24_beta, parameter_83, parameter_84); reaction_25: 2$species_3 -> species_4 + $species_20; compartment_1*function_5(reaction_25_Vf, species_3, species_4, species_20, reaction_25_Keq); reaction_26: $species_18 -> species_19; compartment_1*function_6(parameter_46, species_18, species_19, reaction_26_Keq); reaction_27: species_11 -> $species_10; compartment_1*function_7(parameter_47, species_11, species_10, reaction_27_Keq); reaction_28: 0.08species_31 + 0.2$species_34 + $species_23 + $species_3 -> 0.24$species_33 + species_4; compartment_1*function_8(parameter_48, species_31, reaction_28_y, species_23, species_3, species_34, species_4, species_33, reaction_28_Keq); reaction_29: species_4 => $species_3 + $species_23; compartment_1*reaction_29_k1*species_4; // Species initializations: species_1 = 0.000897; species_2 = 0.00109; species_4 = 0.0087; species_5 = 3.62e-005; species_6 = 0.000367; species_7 = 0.00093; species_8 = 0.0001; species_9 = 0.01; species_11 = 1.87082e-005; species_12 = 6.29e-005; species_13 = 0.000143; species_14 = 0.000242; species_15 = 2.74e-005; species_16 = 0.000153; species_17 = 8.58e-005; species_19 = 0.00134; species_20 = 0.00311; species_21 = 0.001; species_22 = 3.41e-005; species_23 = 0.02; species_24 = 0.208403745497308; species_25 = 0.00108; species_26 = 3.67e-006; species_27 = 0.000553; species_28 = 3.07e-005; species_29 = 4.98e-006; species_30 = 5.79e-005; species_31 = 0.00183; species_32 = 0.0155; species_33 = 0.0214; species_34 = 6.5e-005; // Compartment initializations: compartment_1 = 1; // Variable initializations: parameter_1 = 0.0114; parameter_2 = 1.932e-005; parameter_3 = 0.001345; parameter_58 = 0.03347; parameter_59 = 0.00015; parameter_60 = 0.0101; parameter_61 = 0.0017; parameter_62 = 0.004; parameter_5 = 0.42; parameter_6 = 16.62; parameter_63 = 0.01049; parameter_64 = 0.0044; parameter_65 = 0.0015; parameter_66 = 0.015; parameter_67 = 0.0046; parameter_68 = 8e-005; parameter_69 = 0.00016; parameter_12 = 0.0018; parameter_70 = 9e-006; parameter_71 = 0.0016; parameter_72 = 0.00051; parameter_18 = 0.381; parameter_73 = 2.2e-005; parameter_74 = 1e-005; parameter_75 = 0.00019; parameter_76 = 9e-005; parameter_77 = 0.029; parameter_19 = 0.3574; parameter_49 = 0.00013; parameter_50 = 0.00027; parameter_51 = 7.9e-005; parameter_52 = 4e-005; parameter_20 = 11.369; parameter_81 = 5e-005; parameter_82 = 0.0004; parameter_14 = 0.0556; parameter_55 = 7.364; parameter_56 = 3e-005; parameter_57 = 6.3e-005; parameter_16 = 17.2; parameter_17 = 1000; parameter_21 = 1.6491; parameter_78 = 154; parameter_79 = 0.00012; parameter_80 = 0.00019; parameter_23 = 1.4127; parameter_53 = 6e-005; parameter_54 = 3.8e-005; parameter_25 = 3452.5; parameter_83 = 0.0047; parameter_84 = 7e-005; parameter_85 = 2e-006; parameter_86 = 0.0003; parameter_28 = 1; parameter_29 = 1; reaction_1_keq = 1; reaction_1_KGlc_e = 0.01; reaction_1_KGlc = 0.0093; reaction_2_Ka = 0.0001; reaction_2_Kb = 0.0011; reaction_2_Kapp = 651; reaction_2_Kp = 2e-005; reaction_2_Kq = 0.0035; reaction_3_Kery4p = 1e-006; reaction_3_Kfbp = 6e-005; reaction_3_Kpg = 1.5e-005; reaction_4_KG6P = 6.67e-008; reaction_4_KNADP = 3.67e-009; reaction_4_Kapp = 2000; reaction_4_KATP = 7.49e-007; reaction_4_KNADPH = 3.12e-009; reaction_4_KPGA23 = 2.289e-006; reaction_5_K6PG1 = 1e-008; reaction_5_KNADP = 1.8e-008; reaction_5_Kapp = 141.7; reaction_5_KPGA23 = 1.2e-007; reaction_5_KATP = 1.54e-007; reaction_5_K6PG2 = 5.8e-008; reaction_5_KNADPH = 4.5e-009; reaction_6_Vmax = 1.471; reaction_6_Keq_RUPE = 2.7; reaction_6_KRu5P = 1.9e-007; reaction_6_KX5P = 5e-007; reaction_7_Vmax = 0.7646; reaction_7_Keq_R5PI = 3; reaction_7_KRu5P = 7.8e-007; reaction_7_KR5P = 2.2e-006; reaction_8_Keq_TKL = 2.08; reaction_8_K1 = 4.177e-007; reaction_8_K2 = 3.055e-007; reaction_8_K6 = 0.00774; reaction_8_K3 = 1.2432e-005; reaction_8_K5 = 0.41139; reaction_8_K4 = 4.96e-009; reaction_8_K7 = 48.8; reaction_9_Keq_TKL2 = 29.7; reaction_9_K1 = 1.84e-009; reaction_9_K2 = 3.055e-007; reaction_9_K6 = 0.122; reaction_9_K3 = 5.48e-008; reaction_9_K5 = 0.0287; reaction_9_K4 = 3e-010; reaction_9_K7 = 0.215; reaction_10_Vmax = 58.27; reaction_10_Keq_TAL = 2.703; reaction_10_K1 = 8.23e-009; reaction_10_K2 = 4.765e-008; reaction_10_K6 = 0.4653; reaction_10_K3 = 1.733e-007; reaction_10_K5 = 0.8683; reaction_10_K4 = 6.095e-009; reaction_10_K7 = 2.524; reaction_11_Vmax = 0.5104; reaction_11_Kapp = 100000; reaction_11_KATP = 3e-008; reaction_11_KR5P = 5.7e-007; reaction_13_KGLYb = 0.00015; reaction_13_KiPi = 0.0047; reaction_17_alfa = 1; reaction_17_beta = 1; reaction_18_KPi = 0.0002; reaction_18_KiG1P = 0.0074; reaction_18_nH = 1.75; reaction_18_Kamp = 1.9e-012; reaction_19_Kf = 17400; reaction_19_Keq = 267100; reaction_19_Kr = 158; reaction_20_Katp = 2.1e-005; reaction_20_beta = 0.98; reaction_20_alfa = 0.32; reaction_20_Kf26bp = 8.4e-007; reaction_20_Kf6p = 1; reaction_20_L = 4.1; reaction_20_Kcit = 6.8; reaction_20_Kiatp = 20; reaction_20_Kadp = 5; reaction_20_Kfbp = 5; reaction_20_Kapp = 247; reaction_23_Kadp = 0.4; reaction_23_Kpep = 0.014; reaction_23_L = 1; reaction_23_Kiatp = 2.5; reaction_23_Kfbp = 0.0004; reaction_23_Katp = 0.86; reaction_23_Kpyr = 10; reaction_23_Kapp = 195172; reaction_24_alfa = 1; reaction_24_beta = 1; reaction_25_Vf = 141.2; reaction_25_Keq = 2.26; reaction_26_Keq = 300; reaction_27_Keq = 0.2; reaction_28_y = 12.5; reaction_28_Keq = 1000000; reaction_29_k1 = 6210; // Other declarations: var parameter_4, parameter_7, parameter_8, parameter_37, parameter_9, parameter_38; var parameter_10, parameter_39, parameter_11, parameter_40, parameter_13; var parameter_32, parameter_15, parameter_22, parameter_24, parameter_43; var parameter_26, parameter_45, parameter_27, parameter_30, parameter_31; var parameter_33, parameter_34, parameter_35, parameter_36, parameter_41; var parameter_42, parameter_44, parameter_46, parameter_47, parameter_48; const compartment_1, parameter_1, parameter_2, parameter_3, parameter_58; const parameter_59, parameter_60, parameter_61, parameter_62, parameter_5; const parameter_6, parameter_63, parameter_64, parameter_65, parameter_66; const parameter_67, parameter_68, parameter_69, parameter_12, parameter_70; const parameter_71, parameter_72, parameter_18, parameter_73, parameter_74; const parameter_75, parameter_76, parameter_77, parameter_19, parameter_49; const parameter_50, parameter_51, parameter_52, parameter_20, parameter_81; const parameter_82, parameter_14, parameter_55, parameter_56, parameter_57; const parameter_16, parameter_17, parameter_21, parameter_78, parameter_79; const parameter_80, parameter_23, parameter_53, parameter_54, parameter_25; const parameter_83, parameter_84, parameter_85, parameter_86, parameter_28; const parameter_29; // Unit definitions: unit volume = 1e-9 litre; unit time_unit = 60 second; unit substance = 1e-9 mole; // Display Names: time_unit is "time"; compartment_1 is "compartment"; species_1 is "GLC"; species_2 is "G6P"; species_3 is "ADP"; parameter_1 is "Atot"; species_4 is "ATP"; species_5 is "F6P"; species_6 is "F16P"; species_7 is "E4P"; species_8 is "PGN"; species_9 is "GLC_e"; species_10 is "NADP"; parameter_2 is "NPtot"; species_11 is "NADPH"; species_12 is "BPG"; species_13 is "RU5P"; species_14 is "X5P"; species_15 is "R5P"; species_16 is "GAP"; species_17 is "S7P"; species_18 is "NADH"; parameter_3 is "Ntot"; species_19 is "NAD"; species_20 is "AMP"; species_21 is "PRPP"; species_22 is "G1P"; species_23 is "Pi"; species_24 is "GLY"; species_25 is "CIT"; species_26 is "F26P"; species_27 is "DHAP"; species_28 is "PG3"; species_29 is "PG2"; species_30 is "PEP"; species_31 is "PYR"; species_32 is "LAC"; species_33 is "CO2"; species_34 is "O2"; parameter_4 is "GPa_Vr"; parameter_58 is "GPa_Vmaxf"; parameter_59 is "GPa_KiGLYb"; parameter_60 is "GPa_KiG1P"; parameter_61 is "GPa_KiGLYf"; parameter_62 is "GPa_KPi"; parameter_5 is "GPa_Keq"; parameter_6 is "GPb_Keq"; parameter_7 is "GPb_Vr"; parameter_63 is "GPb_Vmaxf"; parameter_64 is "GPb_KiGLYb"; parameter_65 is "GPb_KG1P"; parameter_66 is "GPb_KiGLYf"; parameter_67 is "GPb_KiPi"; parameter_8 is "FBA_Vr"; parameter_37 is "FBA_Vf"; parameter_68 is "FBA_Kdhap"; parameter_69 is "FBA_Kg3p"; parameter_12 is "FBA_Keq"; parameter_70 is "FBA_Kfbp"; parameter_9 is "TPI_Vr"; parameter_38 is "TPI_Vf"; parameter_71 is "TPI_Kmp"; parameter_72 is "TPI_Kms"; parameter_18 is "TPI_Keq"; parameter_10 is "GAPDH_Vr"; parameter_39 is "GAPDH_Vf"; parameter_73 is "GAPDH_Kdpg"; parameter_74 is "GAPDH_Knadh"; parameter_75 is "GAPDH_Kg3p"; parameter_76 is "GAPDH_Knad"; parameter_77 is "GAPDH_Kp"; parameter_19 is "GAPDH_Keq"; parameter_11 is "PGK_Vr"; parameter_40 is "PGK_Vf"; parameter_49 is "PGK_Kp"; parameter_50 is "PGK_Kq"; parameter_51 is "PGK_Ka"; parameter_52 is "PGK_Kb"; parameter_20 is "PGK_Keq"; parameter_13 is "PGI_Vmr"; parameter_32 is "PGI_Vmf"; parameter_81 is "PGI_Kf6p"; parameter_82 is "PGI_Kg6p"; parameter_14 is "PGI_Keq"; parameter_15 is "PGLM_Vmr"; parameter_55 is "PGLM_Vmaxf"; parameter_56 is "PGLM_KG6P"; parameter_57 is "PGLM_KG1P"; parameter_16 is "PGLM_Keq"; parameter_17 is "scale1e3"; parameter_21 is "PGYM_Keq"; parameter_22 is "PGYM_Vr"; parameter_78 is "PGYM_Vmf"; parameter_79 is "PGYM_Kmp"; parameter_80 is "PGYM_Kms"; parameter_23 is "ENO_Keq"; parameter_24 is "ENO_Vr"; parameter_43 is "ENO_Vf"; parameter_53 is "ENO_Kmp"; parameter_54 is "ENO_Kms"; parameter_25 is "LDH_Keq"; parameter_26 is "LDH_Vr"; parameter_45 is "LDH_Vf"; parameter_83 is "LDH_Kp"; parameter_84 is "LDH_Kq"; parameter_85 is "LDH_Ka"; parameter_86 is "LDH_Kb"; parameter_27 is "AMP"; parameter_28 is "AKT"; parameter_29 is "AKT_MPM"; parameter_30 is "GLUT_Vf"; parameter_31 is "HK_Vf"; parameter_33 is "G6PDH_Vf"; parameter_34 is "PGDH_Vf"; parameter_35 is "TKL_Vf"; parameter_36 is "TKL2_Vf"; parameter_41 is "GS_Vf"; parameter_42 is "PFK_Vf"; parameter_44 is "PK_Vf"; parameter_46 is "DHase_Vf"; parameter_47 is "DPHase_Vf"; parameter_48 is "MPM_Vf"; reaction_1 is "GLUT"; reaction_2 is "HK"; reaction_3 is "PGI"; reaction_4 is "G6PDH"; reaction_5 is "PGDH"; reaction_6 is "RUPE"; reaction_7 is "R5PI"; reaction_8 is "TKL"; reaction_9 is "TKL2"; reaction_10 is "TAL"; reaction_11 is "PRPPS"; reaction_12 is "PGLM"; reaction_13 is "GPa"; reaction_14 is "FBA"; reaction_15 is "TPI"; reaction_16 is "GAPDH"; reaction_17 is "PGK"; reaction_18 is "GPb"; reaction_19 is "GS"; reaction_20 is "PFK"; reaction_21 is "PGYM"; reaction_22 is "ENO"; reaction_23 is "PK"; reaction_24 is "LDH"; reaction_25 is "AK"; reaction_26 is "DHase"; reaction_27 is "DPHase"; reaction_28 is "MPM"; reaction_29 is "ATPase"; end