// Created by libAntimony v2.8.0 model *Sivakumar2011_NotchSignalingPathway() // Compartments and Species: compartment default, c1, c5; species s2 in default, s4 in default, s7 in default, s15 in c1, s19 in c1; species s21 in c1, s22 in default, s23 in default, s25 in c1, s27 in c5; species s26 in c5, s28 in c5, s32 in c5, s29 in c5, s24 in c5, s35 in c5; species s37 in c5, s38 in c5, s39 in c5, s40 in c5, s1 in c1, s18 in default; species s41 in c1, s42 in default, s48 in default, s53 in c1, s60 in default; species s63 in c1, s64 in c1, s65 in c1, s67 in c1, s75 in c5, s76 in default; species s77 in default, s81 in default, s82 in default; // Reactions: r30: s32 => s75; kass_r30*s32; r31: s35 => s75; kass_r31*s35 - kdiss_r31*s75; r8: s15 -> s19 + s63; s82*((kcatp_r8*(s15/kM_r8_s15) - kcatn_r8*(s19/kM_r8_s19)*(s63/kM_r8_s63))/(s15/kM_r8_s15 + (1 + s19/kM_r8_s19)*(1 + s63/kM_r8_s63))); r9: s7 -> s22; s23*((kcatp_r9/kM_r9_s7*s7 - kcatn_r9/kM_r9_s22*s22)/(1 + s7/kM_r9_s7 + s22/kM_r9_s22)); r10: s63 -> s24; kI_r10_s25/(kI_r10_s25 + s25)*(kass_r10*s63 - kdiss_r10*s24); r11: s32 -> s26 + s28; s24*((kcatp_r11*(s32/kM_r11_s32) - kcatn_r11*(s26/kM_r11_s26)*(s28/kM_r11_s28))/(s32/kM_r11_s32 + (1 + s26/kM_r11_s26)*(1 + s28/kM_r11_s28))); r13: s24 + s26 + s27 + s29 -> s35; kass_r13*s24*s26*s27*s29 - kdiss_r13*s35; r16: s24 + s39 -> s37; (kcatp_r16/(ki_r16_s39*kM_r16_s39)*s38*s24*s39 - kcatn_r16/kM_r16_s39*s38*s37)/(1 + s24/ki_r16_s39 + s39/ki_r16_s39 + (s24*s39)/(ki_r16_s39*kM_r16_s39) + s37/kM_r16_s39); r17: s37 -> s40; kass_r17*s37 - kdiss_r17*s40; r18: s1 + s4 -> s41; (kcatp_r18/(ki_r18_s4*kM_r18_s4)*s42*s1*s4 - kcatn_r18/kM_r18_s4*s42*s41)/(1 + s1/ki_r18_s4 + s4/ki_r18_s4 + (s1*s4)/(ki_r18_s4*kM_r18_s4) + s41/kM_r18_s4); r21: s41 + s48 -> s53; kI_r21_s2/(kI_r21_s2 + s2)*(kass_r21*s41*s48 - kdiss_r21*s53); r25: s53 -> s60 + s15; s21*((kcatp_r25*(s53/kM_r25_s53) - kcatn_r25*(s60/kM_r25_s60)*(s15/kM_r25_s15))/(s53/kM_r25_s53 + (1 + s60/kM_r25_s60)*(1 + s15/kM_r25_s15))); r26: s25 -> s64; s65*((kcatp_r26/kM_r26_s25*s25 - kcatn_r26/kM_r26_s64*s64)/(1 + s25/kM_r26_s25 + s64/kM_r26_s64)); r28: s7 + s41 -> s67; (kcatp_r28/(ki_r28_s41*kM_r28_s41)*s2*s7*s41 - kcatn_r28/kM_r28_s41*s2*s67)/(1 + s7/ki_r28_s41 + s41/ki_r28_s41 + (s7*s41)/(ki_r28_s41*kM_r28_s41) + s67/kM_r28_s41); r29: s67 -> s18 + s15; s21*((kcatp_r29*(s67/kM_r29_s67) - kcatn_r29*(s18/kM_r29_s18)*(s15/kM_r29_s15))/(s67/kM_r29_s67 + (1 + s18/kM_r29_s18)*(1 + s15/kM_r29_s15))); re16: s76 + s77 -> s82; kI_re16_s81/(kI_re16_s81 + s81)*(kass_re16*s76*s77 - kdiss_re16*s82); // Species initializations: s2 = 5/default; s4 = 5/default; s7 = 5/default; s15 = 5/c1; s19 = 0; s21 = 0.5/c1; s22 = 0; s23 = 0.5/default; s25 = 0.64/c1; s27 = 0.5/c5; s26 = 5/c5; s28 = 5/c5; s32 = 0; s29 = 0.5/c5; s24 = 0; s35 = 0; s37 = 0; s38 = 0.6/c5; s39 = 0.5/c5; s40 = 0; s1 = 5/c1; s18 = 0; s41 = 0; s42 = 5/default; s48 = 5/default; s53 = 0; s60 = 0; s63 = 0; s64 = 0; s65 = 0.33/c1; s67 = 0; s75 = 0; s76 = 5/default; s77 = 5/default; s81 = 0; s82 = 0; // Compartment initializations: default = 1; c1 = 1; c5 = 1; // Variable initializations: kcatp_r8 = 0.5; kM_r8_s15 = 1; kcatn_r8 = 1.5; kM_r8_s19 = 2; kM_r8_s63 = 1.5; kcatp_r9 = 1.5; kM_r9_s7 = 1; kcatn_r9 = 0.04; kM_r9_s22 = 0.05; kass_r10 = 2; kdiss_r10 = 0.01; kI_r10_s25 = 1; kcatp_r11 = 0.5; kM_r11_s32 = 1; kcatn_r11 = 0.5; kM_r11_s26 = 1.5; kM_r11_s28 = 1; kass_r13 = 0.5; kdiss_r13 = 2; kcatp_r16 = 1; kcatn_r16 = 1; kM_r16_s39 = 1; ki_r16_s39 = 1; kass_r17 = 1.5; kdiss_r17 = 1.5; kcatp_r18 = 1; kcatn_r18 = 1.5; kM_r18_s4 = 1; ki_r18_s4 = 1.5; kass_r21 = 1.5; kdiss_r21 = 1.5; kI_r21_s2 = 1.5; kcatp_r25 = 1; kM_r25_s53 = 1.5; kcatn_r25 = 1.5; kM_r25_s60 = 1.25; kM_r25_s15 = 1.5; kcatp_r26 = 0.5; kM_r26_s25 = 1.7; kcatn_r26 = 1; kM_r26_s64 = 1.61; kcatp_r28 = 1.71; kcatn_r28 = 1.48; kM_r28_s41 = 1.64; ki_r28_s41 = 1.28; kcatp_r29 = 1.86; kM_r29_s67 = 1.61; kcatn_r29 = 1.78; kM_r29_s18 = 0.15; kM_r29_s15 = 1.87; kass_r30 = 1.95; kass_r31 = 0.055; kdiss_r31 = 2; kass_re16 = 0.004; kdiss_re16 = 2; kI_re16_s81 = 0.00594; // Other declarations: const default, c1, c5, kcatp_r8, kM_r8_s15, kcatn_r8, kM_r8_s19, kM_r8_s63; const kcatp_r9, kM_r9_s7, kcatn_r9, kM_r9_s22, kass_r10, kdiss_r10, kI_r10_s25; const kcatp_r11, kM_r11_s32, kcatn_r11, kM_r11_s26, kM_r11_s28, kass_r13; const kdiss_r13, kcatp_r16, kcatn_r16, kM_r16_s39, ki_r16_s39, kass_r17; const kdiss_r17, kcatp_r18, kcatn_r18, kM_r18_s4, ki_r18_s4, kass_r21, kdiss_r21; const kI_r21_s2, kcatp_r25, kM_r25_s53, kcatn_r25, kM_r25_s60, kM_r25_s15; const kcatp_r26, kM_r26_s25, kcatn_r26, kM_r26_s64, kcatp_r28, kcatn_r28; const kM_r28_s41, ki_r28_s41, kcatp_r29, kM_r29_s67, kcatn_r29, kM_r29_s18; const kM_r29_s15, kass_r30, kass_r31, kdiss_r31, kass_re16, kdiss_re16; const kI_re16_s81; // Display Names: c1 is "cytosol"; c5 is "nucleus"; s2 is "Fringe"; s4 is "fucose"; s7 is "Delta"; s15 is "NI_sub_c_sub_t"; s19 is "N_sub_tm"; s21 is "TACE"; s22 is "a7_degraded"; s23 is "Neuralized"; s25 is "Numb"; s27 is "Mastermind"; s26 is "Su(H)"; s28 is "CoR"; s32 is "Complex_br_(Su(H)/CoR)"; s29 is "CoA"; s24 is "NI_sub_c_sub_s"; s35 is "Complex_br_(Mastermind/Su(H)/_br_CoA/NI_sub_c_sub_s)"; s37 is "NI_sub_c_sub_s"; s38 is "Sel 10"; s39 is "Ub"; s40 is "a46_degraded"; s1 is "Notch"; s18 is "Complex_br_(Delta/N_sub_ext)"; s41 is "Notch"; s42 is "Neurotic"; s48 is "Serrate"; s53 is "Complex_br_(Serrate/Notch)"; s60 is "Complex_br_(Serrate/N_sub_ext)"; s63 is "NI_sub_c_sub_s"; s64 is "a25_degraded"; s65 is "LNXp80"; s67 is "Complex_br_(Notch/Delta)"; s75 is "E(spl)-C genes"; s81 is "dapt"; s82 is "gama secretase"; end