// Created by libAntimony v2.8.0
model *Sivakumar2011_EGFReceptorSignalingPathway()
// Compartments and Species:
compartment default, c2;
species s21 in c2, s22 in c2, s25 in c2, s26 in c2, s27 in c2, s28 in c2;
species s29 in c2, s30 in c2, s31 in c2, s33 in c2, s34 in c2, s23 in c2;
species s24 in c2, s3 in default, s123 in c2, s124 in c2, s125 in c2, s126 in c2;
species s127 in c2, s129 in c2, s142 in default, s144 in c2, s147 in c2;
// Reactions:
r8: s23 -> s24; kI_r8_s22/(kI_r8_s22 + s22)*(kI_r8_s29/(kI_r8_s29 + s29))*(kI_r8_s33/(kI_r8_s33 + s33))*(s124*((kcatp_r8_s124/kM_r8_s124_s23*s23 - kcatn_r8_s124/kM_r8_s124_s24*s24)/(1 + s23/kM_r8_s124_s23 + s24/kM_r8_s124_s24)) + s31*((kcatp_r8_s31/kM_r8_s31_s23*s23 - kcatn_r8_s31/kM_r8_s31_s24*s24)/(1 + s23/kM_r8_s31_s23 + s24/kM_r8_s31_s24)));
r9: s25 -> s26; s24*((kcatp_r9/kM_r9_s25*s25 - kcatn_r9/kM_r9_s26*s26)/(1 + s25/kM_r9_s25 + s26/kM_r9_s26));
r11: s29 -> s30; s127*((kcatp_r11/kM_r11_s29*s29 - kcatn_r11/kM_r11_s30*s30)/(1 + s29/kM_r11_s29 + s30/kM_r11_s30));
r14: s27 -> s28; s26*((kcatp_r14/kM_r14_s27*s27 - kcatn_r14/kM_r14_s28*s28)/(1 + s27/kM_r14_s27 + s28/kM_r14_s28));
r15: s28 -> s34; kass_r15*s28 - kdiss_r15*s34;
r17: 2s123 -> s129; s3*(kass_r17_s3*s123^2 - kdiss_r17_s3*s129);
r6: s127 -> s127; s144*(kass_r6_s144*s127 - kdiss_r6_s144*s127);
r7: s21 -> s22; s144*(kass_r7_s144*s21 - kdiss_r7_s144*s22);
r4: s124 + s125 -> s124 + s126; s144*(kass_r4_s144*s124*s125 - kdiss_r4_s144*s124*s126);
re11: s129 + s147 => s144; kI_re11_s142/(kI_re11_s142 + s142)*((Vp_re11*s129*s147)/(ki_re11_s129*kM_re11_s147 + kM_re11_s147*s129 + kM_re11_s129*s147 + s129*s147));
// Species initializations:
s21 = 5/c2;
s22 = 0;
s25 = 5/c2;
s26 = 0;
s27 = 5/c2;
s28 = 0;
s29 = 5/c2;
s30 = 0;
s31 = 5/c2;
s33 = 5/c2;
s34 = 1/c2;
s23 = 5/c2;
s24 = 0;
s3 = 5/default;
s123 = 5/c2;
s124 = 5/c2;
s125 = 0.5/c2;
s126 = 0;
s127 = 2/c2;
s129 = 0;
s142 = 0.5/default;
s144 = 0;
s147 = 5/c2;
// Compartment initializations:
default = 1;
c2 = 1;
// Variable initializations:
kcatp_r8_s124 = 0.511;
kM_r8_s124_s23 = 0.47;
kcatn_r8_s124 = 1.083;
kM_r8_s124_s24 = 0.786;
kcatp_r8_s31 = 0.727;
kM_r8_s31_s23 = 0.614;
kcatn_r8_s31 = 0.636;
kM_r8_s31_s24 = 1.367;
kI_r8_s22 = 0.583;
kI_r8_s29 = 1.219;
kI_r8_s33 = 0.293;
kcatp_r9 = 2;
kM_r9_s25 = 0.626;
kcatn_r9 = 0.693;
kM_r9_s26 = 0.463;
kcatp_r11 = 0.787;
kM_r11_s29 = 1.459;
kcatn_r11 = 0.566;
kM_r11_s30 = 1.021;
kcatp_r14 = 0.558;
kM_r14_s27 = 0.038;
kcatn_r14 = 0.725;
kM_r14_s28 = 1.65;
kass_r15 = 2;
kdiss_r15 = 0.074;
kass_r17_s3 = 0.73;
kdiss_r17_s3 = 1.13;
kI_re11_s142 = 1;
kass_r6_s144 = 1;
kdiss_r6_s144 = 1;
kass_r7_s144 = 1;
kdiss_r7_s144 = 1;
kass_r4_s144 = 1;
kdiss_r4_s144 = 1;
Vp_re11 = 1;
kM_re11_s129 = 1;
kM_re11_s147 = 1;
ki_re11_s129 = 1;
// Other declarations:
const default, c2, kcatp_r8_s124, kM_r8_s124_s23, kcatn_r8_s124, kM_r8_s124_s24;
const kcatp_r8_s31, kM_r8_s31_s23, kcatn_r8_s31, kM_r8_s31_s24, kI_r8_s22;
const kI_r8_s29, kI_r8_s33, kcatp_r9, kM_r9_s25, kcatn_r9, kM_r9_s26, kcatp_r11;
const kM_r11_s29, kcatn_r11, kM_r11_s30, kcatp_r14, kM_r14_s27, kcatn_r14;
const kM_r14_s28, kass_r15, kdiss_r15, kass_r17_s3, kdiss_r17_s3, kI_re11_s142;
const kass_r6_s144, kdiss_r6_s144, kass_r7_s144, kdiss_r7_s144, kass_r4_s144;
const kdiss_r4_s144, Vp_re11, kM_re11_s129, kM_re11_s147, ki_re11_s129;
// Display Names:
c2 is "Cytosol";
s21 is "Akt";
s22 is "Akt";
s25 is "MEK1_minus_2";
s26 is "MEK1_minus_2";
s27 is "ERK1_minus_2";
s28 is "ERK1_minus_2";
s29 is "RKIP";
s30 is "RKIP";
s31 is "PP2A";
s33 is "14_minus_3_minus_3";
s34 is "Mitogenesis_br_Differentiation";
s23 is "Raf_minus_1";
s24 is "Raf_minus_1";
s3 is "EGF";
s123 is "EGFR";
s124 is "Ras";
s125 is "GDP";
s126 is "GTP";
s127 is "PKC";
s129 is "EGFR";
s142 is "erlotinib";
s144 is "Complex_br_(EGFR/../_br_GAP)";
s147 is "Complex(Grb2/../PLC)";
end