// Created by libAntimony v2.8.0 model *Vinod2011_MitoticExit() // Compartments and Species: compartment cell_1; species $Clb2T_1 in cell_1, $Mcm_1 in cell_1, $Clb5T_1 in cell_1, $MBF_1 in cell_1; species $Cln_1 in cell_1, $Cdc20_1 in cell_1, $Cdh1_1 in cell_1, $Sic1T_1 in cell_1; species $Swi5_1 in cell_1, $Trim2_1 in cell_1, $Clb2_2 in cell_1, $Sic1_1 in cell_1; species $Trim5_1 in cell_1, $Clb5_1 in cell_1, $Pds1T_1 in cell_1, $Esp1T_1 in cell_1; species $PoloT_1 in cell_1, $Polo_1 in cell_1, $Net1dep_1 in cell_1, $Net1pp_1 in cell_1; species $RENT_1 in cell_1, $Cdc14n_1 in cell_1, $RENTp_1 in cell_1, $Cdc14c_1 in cell_1; species $Tem1_1 in cell_1, $Esp1_1 in cell_1, $Cdc15_1 in cell_1, $MEN_1 in cell_1; species $Pds1_1 in cell_1, $Esp1b_1 in cell_1, Net1p_1 in cell_1, $Net1_2 in cell_1; // Assignment Rules: V2_1 := kdclb2_1 + kdclb2_2*Cdc20_1 + kdclb2_3*Cdh1_1; V6_1 := kdclb5_1 + kdclb5_2*Cdc20_1; Vacdh_1 := kdcdh_1*Cdc14n_1 + kdcdh_2*Cdc14c_1; Vicdh_1 := kpcdh_1 + kpcdh_2*Clb2_2 + kpcdh_3*Clb5_1; Vdsic_1 := kdsic_3 + kdsic_1*Clb5_1 + kdsic_2*Clb2_2 + kdsic_4*Cln_1; Clb2_2 := (Clb2T_1 + Clb2nd_1) - Trim2_1; Sic1_1 := Sic1T_1 - Trim2_1 - Trim5_1; Clb5_1 := Clb5T_1 - Trim5_1; Vaswi_1 := kaswi_1*Cdc14n_1 + kaswi_2*Cdc14c_1; Viswi_1 := kiswi_1 + kiswi_2*Clb2_2 + kiswi_3*Clb5_1; Vd_1 := (kd_2*PP_1 + kd_1*Cdc14n_1)/((Jnet_1 + Net1T_1) - Net1dep_1); Vp_1 := (kp_3*Clb2_2 + kp_4*MEN_1)/(Jnet_1 + Net1dep_1); Vexp_1 := kexp_1 + kexp_2*MEN_1; Cdc14c_1 := Cdc14T_1 - Cdc14n_1 - RENT_1; Esp1_1 := Esp1T_1 - Esp1b_1; Pds1_1 := Pds1T_1 - Esp1b_1; Net1_2 := Net1T_1 - Net1p_1 - RENT_1 - Net1pp_1; PP_1 := PPT_1*((1 + kpp_1*ki_1*Esp1_1)/(1 + ki_1 + Esp1_1)); // Rate Rules: Clb2T_1' = (ksclb2_1 + ksclb2_2*Mcm_1) - V2_1*Clb2T_1; Mcm_1' = ((ksmcm_3 + ksmcm_1*Clb2_2)*(1 - Mcm_1))/((Jmcm_1 + 1) - Mcm_1) - (kdmcm_1*Mcm_1)/(Jmcm_1 + Mcm_1); Clb5T_1' = (ksclb5_2 + ksclb5_1*MBF_1) - V6_1*Clb5T_1; MBF_1' = (kambf_1*(1 - MBF_1))/((Jmbf_1 + 1) - MBF_1) - ((kimbf_1*Clb2_2 + kimbf_3*Clb5_1)*MBF_1)/(Jmbf_1 + MBF_1); Cln_1' = (kscln_2 + kscln_1*MBF_1) - kdcln_1*Cln_1; Cdc20_1' = (ks20_2 + ks20_1*Mcm_1) - (kd20_1 + kd20_2*Cdh1_1)*Cdc20_1; Cdh1_1' = (Vacdh_1*(1 - Cdh1_1))/((Jcdh_1 + 1) - Cdh1_1) - (Vicdh_1*Cdh1_1)/(Jcdh_1 + Cdh1_1); Sic1T_1' = (kssic_2 + kssic_1*Swi5_1) - Vdsic_1*Sic1T_1; Swi5_1' = (Vaswi_1*(Swi5T_1 - Swi5_1))/((Jswi_1 + Swi5T_1) - Swi5_1) - (Viswi_1*Swi5_1)/(Jswi_1 + Swi5_1); Trim2_1' = kasic2_1*Clb2_2*Sic1_1 - (kdsic2_1 + V2_1 + Vdsic_1)*Trim2_1; Trim5_1' = kasic5_1*Clb5_1*Sic1_1 - (kdsic5_1 + V6_1 + Vdsic_1)*Trim5_1; Pds1T_1' = (kspds_2 + kspds_1*MBF_1) - (kdpds_1 + kdpds_2*Cdc20_1)*Pds1T_1; Esp1T_1' = ksesp_1 - kdesp_1*Esp1T_1; PoloT_1' = (kspolo_2 + kspolo_1*Mcm_1) - (kdpolo_1 + kdpolo_2*Cdh1_1)*PoloT_1; Polo_1' = ((kapolo_1 + kapolo_2*Clb2_2)*(PoloT_1 - Polo_1))/((Jpolo_1 + PoloT_1) - Polo_1) - (kipolo_1*Polo_1)/(Jpolo_1 + Polo_1) - (kdpolo_1 + kdpolo_2*Cdh1_1)*Polo_1; Net1dep_1' = Vd_1*(Net1T_1 - Net1dep_1) - Vp_1*Net1dep_1; Net1pp_1' = kp_1*Polo_1*(Net1T_1 - Net1dep_1 - Net1pp_1) - Vd_1*Net1pp_1; RENT_1' = lanet_1*(Net1T_1 - Net1pp_1 - RENT_1)*Cdc14n_1 - ldnet_1*RENT_1 - kp_1*Polo_1*RENTp_1; Cdc14n_1' = (kp_1*Polo_1*RENTp_1 - lanet_1*(Net1T_1 - Net1pp_1 - RENT_1)*Cdc14n_1 + ldnet_1*RENT_1) - Vexp_1*Cdc14n_1 + kimp_1*Cdc14c_1; RENTp_1' = (Vp_1*(RENT_1 - RENTp_1) - Vd_1*RENTp_1 + lanet_1*(Net1T_1 - Net1dep_1 - Net1pp_1 - RENTp_1)*Cdc14n_1) - ldnet_1*RENTp_1 - kp_1*Polo_1*RENTp_1; Tem1_1' = ((katem_1 + katem_2*Polo_1)*(1 - Tem1_1))/((Jtem1_1 + 1) - Tem1_1) - (kitem_3 + kitem_2/(1 + kitem_1*Esp1_1))/(Jtem1_1 + Tem1_1)*Tem1_1; Cdc15_1' = ((kac15_1 + kac15_2*Cdc14c_1)*(1 - Cdc15_1))/((Jcdc15_1 + 1) - Cdc15_1) - ((kic15_1 + kic15_2*Clb2_2)*Cdc15_1)/(Jcdc15_1 + Cdc15_1); MEN_1' = lamen_1*(Tem1_1 - MEN_1)*(Cdc15_1 - MEN_1) - ldmen_1*MEN_1 - (kitem_3 + kitem_2/(1 + kitem_3*Esp1_1))/(Jtem1_1 + Tem1_1)*MEN_1 - (kic15_1 + kic15_2*Clb2_2)/(Jcdc15_1 + Cdc15_1)*MEN_1; Esp1b_1' = lapds_1*Pds1_1*Esp1_1 - (ldpds_1 + kdesp_1 + kdpds_1 + kdpds_2*Cdc20_1)*Esp1b_1; // Species initializations: Clb2T_1 = 0.999107; Mcm_1 = 0.996743; Clb5T_1 = 0.201977; MBF_1 = 0.001977; Cln_1 = 0.04079; Cdc20_1 = 0; Cdh1_1 = 0; Sic1T_1 = 0.001683; Swi5_1 = 0; Trim2_1 = 0.00145; Trim5_1 = 0; Pds1T_1 = 0.601977; Esp1T_1 = 0.25; PoloT_1 = 1; Polo_1 = 1; Net1dep_1 = 0.0119; Net1pp_1 = 0.0119; RENT_1 = 0.483; Cdc14n_1 = 0.00214; RENTp_1 = 0.014; Tem1_1 = 1; Cdc15_1 = 0.933; MEN_1 = 0; Esp1b_1 = 0.24857; Net1p_1 = 0.013; // Compartment initializations: cell_1 = 1; // Variable initializations: ksclb2_1 = 0.015; ksclb2_2 = 0.005; ksclb5_2 = 0.002; ksclb5_1 = 0.01; kscln_2 = 0.01; kscln_1 = 0.1; kdcln_1 = 0.25; ks20_2 = 0.001; ks20_1 = 0.05; kd20_1 = 0.1; kd20_2 = 1; Jcdh_1 = 0.01; kssic_2 = 0.004; kssic_1 = 0.2; kasic2_1 = 40; kdsic2_1 = 0.1; kasic5_1 = 10; kdsic5_1 = 0.1; Swi5T_1 = 1; Jswi_1 = 0.1; ksmcm_3 = 0.01; ksmcm_1 = 1; Jmcm_1 = 0.01; kdmcm_1 = 0.25; kambf_1 = 0.1; Jmbf_1 = 0.01; kimbf_1 = 0.5; kimbf_3 = 0.5; kspds_2 = 0.006; kspds_1 = 0.01; kdpds_1 = 0.01; kdpds_2 = 2; ksesp_1 = 0.001; kdesp_1 = 0.004; kspolo_2 = 0.001; kspolo_1 = 0.05; kdpolo_1 = 0.05; kdpolo_2 = 0.5; kapolo_1 = 0; kapolo_2 = 1; Jpolo_1 = 0.1; kipolo_1 = 0.1; Net1T_1 = 1; kp_1 = 2; lanet_1 = 500; ldnet_1 = 1; kimp_1 = 1; katem_1 = 0; katem_2 = 0.6; Jtem1_1 = 0.005; kitem_3 = 0.1; kitem_2 = 1; kitem_1 = 20; kac15_1 = 0.03; kac15_2 = 0.5; Jcdc15_1 = 1; kic15_1 = 0.03; kic15_2 = 0.2; lamen_1 = 100; ldmen_1 = 0.1; Clb2nd_1 = 0; lapds_1 = 500; ldpds_1 = 1; Cdc14T_1 = 0.5; PPT_1 = 1; kpp_1 = 0.1; ki_1 = 40; kdclb2_1 = 0.02; kdclb2_2 = 0.1; kdclb2_3 = 0.4; kdclb5_1 = 0.01; kdclb5_2 = 1; kdsic_3 = 0.04; kdsic_1 = 2; kdsic_2 = 2; kdsic_4 = 1.5; kdcdh_1 = 0.03; kdcdh_2 = 0.3; kpcdh_1 = 0.001; kpcdh_2 = 0.04; kpcdh_3 = 0.75; kaswi_1 = 0.2; kaswi_2 = 1; kiswi_1 = 0.01; kiswi_2 = 0.5; kiswi_3 = 0.75; kd_2 = 0.45; kd_1 = 0.1; Jnet_1 = 0.05; kp_3 = 0.2; kp_4 = 3; kexp_1 = 0.01; kexp_2 = 20; kimbf_2 = 0; // Other declarations: var V2_1, V6_1, Vacdh_1, Vicdh_1, Vdsic_1, Vaswi_1, Viswi_1, Vd_1, Vp_1; var Vexp_1, lamen_1, PP_1; const cell_1, ksclb2_1, ksclb2_2, ksclb5_2, ksclb5_1, kscln_2, kscln_1; const kdcln_1, ks20_2, ks20_1, kd20_1, kd20_2, Jcdh_1, kssic_2, kssic_1; const kasic2_1, kdsic2_1, kasic5_1, kdsic5_1, Swi5T_1, Jswi_1, ksmcm_3; const ksmcm_1, Jmcm_1, kdmcm_1, kambf_1, Jmbf_1, kimbf_1, kimbf_3, kspds_2; const kspds_1, kdpds_1, kdpds_2, ksesp_1, kdesp_1, kspolo_2, kspolo_1, kdpolo_1; const kdpolo_2, kapolo_1, kapolo_2, Jpolo_1, kipolo_1, Net1T_1, kp_1, lanet_1; const ldnet_1, kimp_1, katem_1, katem_2, Jtem1_1, kitem_3, kitem_2, kitem_1; const kac15_1, kac15_2, Jcdc15_1, kic15_1, kic15_2, ldmen_1, Clb2nd_1, lapds_1; const ldpds_1, Cdc14T_1, PPT_1, kpp_1, ki_1, kdclb2_1, kdclb2_2, kdclb2_3; const kdclb5_1, kdclb5_2, kdsic_3, kdsic_1, kdsic_2, kdsic_4, kdcdh_1, kdcdh_2; const kpcdh_1, kpcdh_2, kpcdh_3, kaswi_1, kaswi_2, kiswi_1, kiswi_2, kiswi_3; const kd_2, kd_1, Jnet_1, kp_3, kp_4, kexp_1, kexp_2, kimbf_2; // Unit definitions: unit area_1 = metre^2; unit length_1 = metre; unit substance_1 = mole; unit time_1 = second; unit volume_1 = litre; // Display Names: area_1 is "area"; length_1 is "length"; substance_1 is "substance"; time_1 is "time"; volume_1 is "volume"; cell_1 is "cell"; Clb2T_1 is "Clb2T"; ksclb2_1 is "ksclb2"; ksclb2_2 is "ksclb2'"; Mcm_1 is "Mcm"; V2_1 is "V2"; Clb5T_1 is "Clb5T"; ksclb5_2 is "ksclb5"; ksclb5_1 is "ksclb5'"; MBF_1 is "MBF"; V6_1 is "V6"; Cln_1 is "Cln"; kscln_2 is "kscln"; kscln_1 is "kscln'"; kdcln_1 is "kdcln"; Cdc20_1 is "Cdc20"; ks20_2 is "ks20"; ks20_1 is "ks20'"; kd20_1 is "kd20"; kd20_2 is "kd20'"; Cdh1_1 is "Cdh1"; Vacdh_1 is "Vacdh"; Jcdh_1 is "Jcdh"; Vicdh_1 is "Vicdh"; Sic1T_1 is "Sic1T"; kssic_2 is "kssic"; kssic_1 is "kssic'"; Swi5_1 is "Swi5"; Vdsic_1 is "Vdsic"; Trim2_1 is "Trim2"; kasic2_1 is "kasic2"; Clb2_2 is "Clb2"; Sic1_1 is "Sic1"; kdsic2_1 is "kdsic2"; Trim5_1 is "Trim5"; kasic5_1 is "kasic5"; Clb5_1 is "Clb5"; kdsic5_1 is "kdsic5"; Vaswi_1 is "Vaswi"; Swi5T_1 is "Swi5T"; Jswi_1 is "Jswi"; Viswi_1 is "Viswi"; ksmcm_3 is "ksmcm"; ksmcm_1 is "ksmcm'"; Jmcm_1 is "Jmcm"; kdmcm_1 is "kdmcm"; kambf_1 is "kambf"; Jmbf_1 is "Jmbf"; kimbf_1 is "kimbf'"; kimbf_3 is "kimbf''"; Pds1T_1 is "Pds1T"; kspds_2 is "kspds"; kspds_1 is "kspds'"; kdpds_1 is "kdpds"; kdpds_2 is "kdpds'"; Esp1T_1 is "Esp1T"; ksesp_1 is "ksesp"; kdesp_1 is "kdesp"; PoloT_1 is "PoloT"; kspolo_2 is "kspolo"; kspolo_1 is "kspolo'"; kdpolo_1 is "kdpolo"; kdpolo_2 is "kdpolo'"; Polo_1 is "Polo"; kapolo_1 is "kapolo"; kapolo_2 is "kapolo'"; Jpolo_1 is "Jpolo"; kipolo_1 is "kipolo"; Net1dep_1 is "Net1dep"; Vd_1 is "Vd"; Net1T_1 is "Net1T"; Vp_1 is "Vp"; Net1pp_1 is "Net1pp"; kp_1 is "kp'"; RENT_1 is "RENT"; lanet_1 is "lanet"; Cdc14n_1 is "Cdc14n"; ldnet_1 is "ldnet"; RENTp_1 is "RENTp"; Vexp_1 is "Vexp"; kimp_1 is "kimp"; Cdc14c_1 is "Cdc14c"; Tem1_1 is "Tem1"; katem_1 is "katem"; katem_2 is "katem'"; Jtem1_1 is "Jtem1"; kitem_3 is "kitem"; kitem_2 is "kitem'"; kitem_1 is "kitem''"; Esp1_1 is "Esp1"; Cdc15_1 is "Cdc15"; kac15_1 is "kac15"; kac15_2 is "kac15'"; Jcdc15_1 is "Jcdc15"; kic15_1 is "kic15"; kic15_2 is "kic15'"; MEN_1 is "MEN"; lamen_1 is "lamen"; ldmen_1 is "ldmen"; Clb2nd_1 is "Clb2nd"; Pds1_1 is "Pds1"; Esp1b_1 is "Esp1b"; lapds_1 is "lapds"; ldpds_1 is "ldpds"; Net1p_1 is "Net1p"; Net1_2 is "Net1"; Cdc14T_1 is "Cdc14T"; PP_1 is "PP"; PPT_1 is "PPT"; kpp_1 is "kpp"; ki_1 is "ki"; kdclb2_1 is "kdclb2"; kdclb2_2 is "kdclb2'"; kdclb2_3 is "kdclb2''"; kdclb5_1 is "kdclb5"; kdclb5_2 is "kdclb5'"; kdsic_3 is "kdsic"; kdsic_1 is "kdsic'"; kdsic_2 is "kdsic""; kdsic_4 is "kdsic'''"; kdcdh_1 is "kdcdh"; kdcdh_2 is "kdcdh'"; kpcdh_1 is "kpcdh"; kpcdh_2 is "kpcdh'"; kpcdh_3 is "kpcdh''"; kaswi_1 is "kaswi"; kaswi_2 is "kaswi'"; kiswi_1 is "kiswi"; kiswi_2 is "kiswi'"; kiswi_3 is "kiswi''"; kd_2 is "kd"; kd_1 is "kd'"; Jnet_1 is "Jnet"; kp_3 is "kp''"; kp_4 is "kp'''"; kexp_1 is "kexp"; kexp_2 is "kexp'"; kimbf_2 is "kimbf"; end