// Created by libAntimony v2.8.0
model *Abell2011_CalciumSignaling_WithoutAdaptation()

  // Compartments and Species:
  compartment cytosol, outside, ER_store, mitochondria;
  species CaI in cytosol, IP3 in cytosol, g in cytosol, CaO in outside, CaS in ER_store;
  species CaM in mitochondria;

  // Reactions:
  kPLC:  => IP3; R*CaI;
  JPump: CaI => CaS; (B*CaI^2)/(CaI^2 + k2^2);
  JChannel: CaS => CaI; (1 - mwc714c217_c8fd_4024_912c_681cd6931f59)*(L + (((1 - g)*A*IP3^2)/(IP3^2 + kIP3R^2)*CaI^2)/(CaI^2 + mw78dd80b8_e003_4c62_81d1_547d001767af^2))*CaS;
  kPhosphatase: IP3 => ; D*IP3;
  inhibition_parameter1:  => g; (E*CaI^4)/(CaI^4 + mwf998b218_be11_4aa4_81ae_41141861fb42^4)*(1 - g);
  inhibition_parameter2: g => ; F*g;
  mwbdcd6a40_1ae7_4c86_a99f_1fba0b8beaf7:  => CaI; mw004dcb62_da5f_41c7_a7bd_033574894f48*(PMleak + kSTIM^8/(CaS^8 + kSTIM^8));
  mw530793e3_76b2_4483_be11_e94364306712: CaI => ; (mwd21d3f76_d133_4053_8e44_02a538657e0a*CaI^2)/(CaI^2 + mw3a93c3a6_623a_44fe_84e9_a47823defd1f^2);
  mwfaf5e05a_b642_4ee2_a069_3c2fc783fba4: CaI => CaM; (mw886be93a_22c7_4966_a1fa_113afd832ae3*CaI^4)/(CaI^4 + mwc8d6bdb5_59d4_43fa_b96d_7426f4857e0d^4);
  mw69f19152_7258_45b0_bf9e_b196f19d7e03: CaM => CaI; (mwd90ce3ea_f8d5_4f0a_8093_e39a2d3dbf33*CaM)/(CaM + 0.01);
  ERtoMito: CaS => CaM; mwc714c217_c8fd_4024_912c_681cd6931f59*(L + (((1 - g)*A*IP3^2)/(IP3^2 + kIP3R^2)*CaI^2)/(CaI^2 + mw78dd80b8_e003_4c62_81d1_547d001767af^2))*CaS;

  // Species initializations:
  CaI = 0.05/cytosol;
  IP3 = 0;
  g = 0.002/cytosol;
  CaO = 1000/outside;
  CaS = 2/ER_store;
  CaM = 0;

  // Compartment initializations:
  cytosol = 1;
  outside = 1;
  ER_store = 1;
  mitochondria = 1;

  // Variable initializations:
  A = 3;
  B = 0.266;
  D = 2;
  E = 5;
  F = 0.018;
  k2 = 0.175;
  L = 0.01;
  R = 1;
  kIP3R = 0.175;
  PMleak = 0.0346;
  kSTIM = 1;
  mw004dcb62_da5f_41c7_a7bd_033574894f48 = 0.02;
  mw78dd80b8_e003_4c62_81d1_547d001767af = 0.13;
  mw3a93c3a6_623a_44fe_84e9_a47823defd1f = 0.2;
  mwd21d3f76_d133_4053_8e44_02a538657e0a = 0.013;
  mwf998b218_be11_4aa4_81ae_41141861fb42 = 1;
  mwc714c217_c8fd_4024_912c_681cd6931f59 = 0.03;
  mwd90ce3ea_f8d5_4f0a_8093_e39a2d3dbf33 = 0.005;
  mw886be93a_22c7_4966_a1fa_113afd832ae3 = 0.03;
  mwc8d6bdb5_59d4_43fa_b96d_7426f4857e0d = 0.6;

  // Other declarations:
  var cytosol, ER_store;
  const outside, mitochondria, A, B, D, E, F, k2, L, R, kIP3R, PMleak, kSTIM;
  const mw004dcb62_da5f_41c7_a7bd_033574894f48, mw78dd80b8_e003_4c62_81d1_547d001767af;
  const mw3a93c3a6_623a_44fe_84e9_a47823defd1f, mwd21d3f76_d133_4053_8e44_02a538657e0a;
  const mwf998b218_be11_4aa4_81ae_41141861fb42, mwc714c217_c8fd_4024_912c_681cd6931f59;
  const mwd90ce3ea_f8d5_4f0a_8093_e39a2d3dbf33, mw886be93a_22c7_4966_a1fa_113afd832ae3;
  const mwc8d6bdb5_59d4_43fa_b96d_7426f4857e0d;

  // Display Names:
  outside is "Outside";
  mitochondria is "mito";
  A is "IP3R";
  B is "SERCA";
  D is "IP3degradation";
  E is "IP3Rinhibition";
  F is "IP3Rrecovery";
  k2 is "kSERCA";
  L is "ERleak";
  mw004dcb62_da5f_41c7_a7bd_033574894f48 is "STIM";
  mw78dd80b8_e003_4c62_81d1_547d001767af is "kIP3Rca";
  mw3a93c3a6_623a_44fe_84e9_a47823defd1f is "kPMCA";
  mwd21d3f76_d133_4053_8e44_02a538657e0a is "PMCA";
  mwf998b218_be11_4aa4_81ae_41141861fb42 is "kG";
  mwc714c217_c8fd_4024_912c_681cd6931f59 is "DirTransf";
  mwd90ce3ea_f8d5_4f0a_8093_e39a2d3dbf33 is "MitNaCaEx";
  mw886be93a_22c7_4966_a1fa_113afd832ae3 is "UniPort";
  mwc8d6bdb5_59d4_43fa_b96d_7426f4857e0d is "kUniP";
  kPLC is "PLC: Receptor and Ca2+ regulated IP3 production";
  JPump is "SERCA: Pumps Ca2+ into ER Ca2+ stores";
  JChannel is "IP3R: IP3 and Ca2+ regulated Ca2+ channel,  plus leak";
  kPhosphatase is "IP3 phosphatase:  Degradation of IP3";
  inhibition_parameter1 is "Inhibition of IP3R (mechanism not well understood)";
  inhibition_parameter2 is "Recovery of IP3R from Ca2+ iinhibition when Ca2+ drops";
  mwbdcd6a40_1ae7_4c86_a99f_1fba0b8beaf7 is "Regulation of Orai by STIM, plus leak";
  mw530793e3_76b2_4483_be11_e94364306712 is "PMCA:  Pumps Ca2+ across PM out of cell";
  mwfaf5e05a_b642_4ee2_a069_3c2fc783fba4 is "UniporterFromCytosol";
  mw69f19152_7258_45b0_bf9e_b196f19d7e03 is "MitoToCytosol";
end