// Created by libAntimony v2.8.0 model *Bungay2003_Thrombin_Generation() // Compartments and Species: compartment compartment_; species II_f in compartment_, II_l in compartment_, mIIa_f in compartment_; species mIIa_l in compartment_, V_f in compartment_, V_l in compartment_; species Va_f in compartment_, Va_l in compartment_, VII_f in compartment_; species VII_l in compartment_, VIIa_f in compartment_, VIIa_l in compartment_; species VIII_f in compartment_, VIII_l in compartment_, VIIIa_f in compartment_; species VIIIa_l in compartment_, IX_f in compartment_, IX_l in compartment_; species IXa_f in compartment_, IXa_l in compartment_, X_f in compartment_; species X_l in compartment_, Xa_f in compartment_, Xa_l in compartment_; species APC_f in compartment_, APC_l in compartment_, PS_f in compartment_; species PS_l in compartment_, VIIIai_f in compartment_, VIIIai_l in compartment_; species Vai_f in compartment_, Vai_l in compartment_, PC_f in compartment_; species PC_l in compartment_, TF_l in compartment_, TF_VIIa_l in compartment_; species TF_VII_l in compartment_, TF_VIIa_IX_l in compartment_, TF_VIIa_IXa_l in compartment_; species TF_VIIa_X_l in compartment_, TF_VIIa_Xa_l in compartment_, TF_VII_Xa_l in compartment_; species IXa_VIIIa_l in compartment_, Xa_Va_l in compartment_, IXa_VIIIa_X_l in compartment_; species V_Xa_l in compartment_, VIII_Xa_l in compartment_, IIa_f in compartment_; species V_IIa_l in compartment_, VIII_IIa_l in compartment_, Xa_Va_II_l in compartment_; species Xa_Va_mIIa_l in compartment_, XI_f in compartment_, XI_IIa_l in compartment_; species XIa_l in compartment_, APC_PS_l in compartment_, APC_PS_VIIIa_l in compartment_; species TFPI_f in compartment_, AT_f in compartment_, IIa_AT_f in compartment_; species TFPI_Xa_l in compartment_, TFPI_Xa_TF_VIIa_l in compartment_, APC_PS_Va_l in compartment_; species IXa_AT_f in compartment_, Xa_AT_f in compartment_, VII_Xa_l in compartment_; species V_mIIa_l in compartment_, VIII_mIIa_l in compartment_, TM_l in compartment_; species IIa_TM_l in compartment_, IIa_TM_PC_l in compartment_, mIIa_AT_l in compartment_; species XIa_IX_l in compartment_, LIPID in compartment_; // Reactions: LB1: II_f + 100LIPID => II_l; compartment_*((konII*II_f*LIPID)/nva - koffII*II_l); LB2: mIIa_f + 100LIPID => mIIa_l; compartment_*((konmIIa*mIIa_f*LIPID)/nva - koffmIIa*mIIa_l); LB3: V_f + 100LIPID => V_l; compartment_*((konV*V_f*LIPID)/nva - koffV*V_l); LB4: Va_f + 100LIPID => Va_l; compartment_*((konVa*Va_f*LIPID)/nva - koffVa*Va_l); LB5: VII_f + 100LIPID => VII_l; compartment_*((konVII*VII_f*LIPID)/nva - koffVII*VII_l); LB6: VIIa_f + 100LIPID => VIIa_l; compartment_*((konVIIa*VIIa_f*LIPID)/nva - koffVIIa*VIIa_l); LB7: VIII_f + 100LIPID => VIII_l; compartment_*((konVIII*VIII_f*LIPID)/nva - koffVIII*VIII_l); LB8: VIIIa_f + 100LIPID => VIIIa_l; compartment_*((konVIIIa*VIIIa_f*LIPID)/nva - koffVIIIa*VIIIa_l); LB9: IX_f + 100LIPID => IX_l; compartment_*((konIX*IX_f*LIPID)/nva - koffIX*IX_l); LB10: IXa_f + 100LIPID => IXa_l; compartment_*((konIXa*IXa_f*LIPID)/nva - koffIXa*IXa_l); LB11: X_f + 100LIPID => X_l; compartment_*((konX*X_f*LIPID)/nva - koffX*X_l); LB12: Xa_f + 100LIPID => Xa_l; (konXa*Xa_f*LIPID)/nva - koffXa*Xa_l; LB13: APC_f + 100LIPID => APC_l; compartment_*((konAPC*APC_f*LIPID)/nva - koffAPC*APC_l); LB14: PS_f + 100LIPID => PS_l; compartment_*((konPS*PS_f*LIPID)/nva - koffPS*PS_l); LB15: VIIIai_f + 100LIPID => VIIIai_l; compartment_*((konVIIIai*VIIIai_f*LIPID)/nva - koffVIIIai*VIIIai_l); LB16: Vai_f + 100LIPID => Vai_l; compartment_*((konVai*Vai_f*LIPID)/nva - koffVai*Vai_l); LB17: PC_f + 100LIPID => PC_l; compartment_*((konPC*PC_f*LIPID)/nva - koffPC*PC_l); R1: VIIa_l + TF_l => TF_VIIa_l; compartment_*(k1*TF_l*VIIa_l - k2*TF_VIIa_l); R2: VII_l + TF_l => TF_VII_l; compartment_*(k3*TF_l*VII_l - k4*TF_VII_l); R3: IX_l + TF_VIIa_l => TF_VIIa_IX_l; compartment_*(k5*TF_VIIa_l*IX_l - k6*TF_VIIa_IX_l); R3b: TF_VIIa_IX_l => TF_VIIa_l + IXa_l; compartment_*k7*TF_VIIa_IX_l; R4: X_l + TF_VIIa_l => TF_VIIa_X_l; compartment_*(k8*TF_VIIa_l*X_l - k9*TF_VIIa_X_l); R4b: TF_VIIa_X_l => TF_VIIa_Xa_l; compartment_*k10*TF_VIIa_X_l; R4c: TF_VIIa_Xa_l => Xa_l + TF_VIIa_l; compartment_*k75*TF_VIIa_Xa_l; R5: Xa_l + TF_VII_l => TF_VII_Xa_l; compartment_*(k11*TF_VII_l*Xa_l - k12*TF_VII_Xa_l); R5b: TF_VII_Xa_l => Xa_l + TF_VIIa_l; compartment_*k13*TF_VII_Xa_l; R6: VIIIa_l + IXa_l => IXa_VIIIa_l; compartment_*(k14*IXa_l*VIIIa_l - k15*IXa_VIIIa_l); R7: Va_l + Xa_l => Xa_Va_l; compartment_*(k16*Xa_l*Va_l - k17*Xa_Va_l); R8: X_l + IXa_VIIIa_l => IXa_VIIIa_X_l; compartment_*(k18*IXa_VIIIa_l*X_l - k19*IXa_VIIIa_X_l); R8b: IXa_VIIIa_X_l => Xa_l + IXa_VIIIa_l; compartment_*k20*IXa_VIIIa_X_l; R9: Xa_l + V_l => V_Xa_l; compartment_*(k21*V_l*Xa_l - k22*V_Xa_l); R9b: V_Xa_l => Xa_l + Va_l; compartment_*k23*V_Xa_l; R10: Xa_l + VIII_l => VIII_Xa_l; k24*VIII_l*Xa_l - k25*VIII_Xa_l; R10b: VIII_Xa_l => Xa_l + VIIIa_l; compartment_*k26*VIII_Xa_l; R11: IIa_f + V_l => V_IIa_l; compartment_*(k27*V_l*IIa_f - k28*V_IIa_l); R11b: V_IIa_l => IIa_f + Va_l; compartment_*k29*V_IIa_l; R12: IIa_f + VIII_l => VIII_IIa_l; compartment_*(k30*VIII_l*IIa_f - k31*VIII_IIa_l); R12b: VIII_IIa_l => IIa_f + VIIIa_l; compartment_*k32*VIII_IIa_l; R13: II_l + Xa_Va_l => Xa_Va_II_l; compartment_*(k33*Xa_Va_l*II_l - k34*Xa_Va_II_l); R14: mIIa_l + Xa_Va_l => Xa_Va_mIIa_l; compartment_*(k35*Xa_Va_l*mIIa_l - k36*Xa_Va_mIIa_l); R15: Xa_Va_II_l => Xa_Va_mIIa_l; compartment_*k37*Xa_Va_II_l; R15b: Xa_Va_mIIa_l => IIa_f + Xa_Va_l; compartment_*k38*Xa_Va_mIIa_l; R16: Xa_l + VII_l => VII_Xa_l; compartment_*(k39*VII_l*Xa_l - k40*VII_Xa_l); R16b: VII_Xa_l => Xa_l + VIIa_l; compartment_*k41*VII_Xa_l; R17: IIa_f + XI_f => XI_IIa_l; compartment_*(k42*XI_f*IIa_f - k43*XI_IIa_l); R17b: XI_IIa_l => IIa_f + XIa_l; compartment_*k44*XI_IIa_l; R18: VIIIa_l + APC_PS_l => APC_PS_VIIIa_l; compartment_*(k45*APC_PS_l*VIIIa_l - k46*APC_PS_VIIIa_l); R18b: APC_PS_VIIIa_l => VIIIai_l + APC_PS_l; compartment_*k47*APC_PS_VIIIa_l; R19: Va_l + APC_PS_l => APC_PS_Va_l; compartment_*(k48*APC_PS_l*Va_l - k49*APC_PS_Va_l); R19b: APC_PS_Va_l => Vai_l + APC_PS_l; compartment_*k50*APC_PS_Va_l; R20: Xa_f + TFPI_f => TFPI_Xa_l; compartment_*(k51*TFPI_f*Xa_f - k52*TFPI_Xa_l); R21: TF_VIIa_l + TFPI_Xa_l => TFPI_Xa_TF_VIIa_l; compartment_*(k53*TFPI_Xa_l*TF_VIIa_l - k54*TFPI_Xa_TF_VIIa_l); R22: AT_f + IXa_f => IXa_AT_f; compartment_*k55*IXa_f*AT_f; R23: AT_f + Xa_f => Xa_AT_f; compartment_*k56*Xa_f*AT_f; R24: AT_f + IIa_f => IIa_AT_f; compartment_*k57*IIa_f*AT_f; R25: mIIa_l + V_l => V_mIIa_l; compartment_*(k58*V_l*mIIa_l - k59*V_mIIa_l); R25b: V_mIIa_l => mIIa_l + Va_l; compartment_*k60*V_mIIa_l; R26: mIIa_l + VIII_l => VIII_mIIa_l; compartment_*(k61*VIII_l*mIIa_l - k62*VIII_mIIa_l); R26b: VIII_mIIa_l => mIIa_l + VIIIa_l; compartment_*k63*VIII_mIIa_l; R27: TM_l + IIa_f => IIa_TM_l; compartment_*(k64*IIa_f*TM_l - k65*IIa_TM_l); R28: PC_l + IIa_TM_l => IIa_TM_PC_l; compartment_*(k66*IIa_TM_l*PC_l - k67*IIa_TM_PC_l); R28b: IIa_TM_PC_l => APC_l + IIa_TM_l; compartment_*k68*IIa_TM_PC_l; R29: AT_f + mIIa_f => mIIa_AT_l; compartment_*k69*mIIa_f*AT_f; R30: PS_l + APC_l => APC_PS_l; compartment_*(k70*APC_l*PS_l - k71*APC_PS_l); R31: IX_l + XIa_l => XIa_IX_l; compartment_*(k72*XIa_l*IX_l - k73*XIa_IX_l); R31b: XIa_IX_l => IXa_l + XIa_l; compartment_*k74*XIa_IX_l; // Species initializations: II_f = 1400; II_l = 0; mIIa_f = 0; mIIa_l = 0; V_f = 20; V_l = 0; Va_f = 0; Va_l = 0; VII_f = 10; VII_l = 0; VIIa_f = 0.1; VIIa_l = 0; VIII_f = 0.7; VIII_l = 0; VIIIa_f = 0; VIIIa_l = 0; IX_f = 90; IX_l = 0; IXa_f = 0; IXa_l = 0; X_f = 170; X_l = 0; Xa_f = 0; Xa_l = 0; APC_f = 0; APC_l = 0; PS_f = 300; PS_l = 0; VIIIai_f = 0; VIIIai_l = 0; Vai_f = 0; Vai_l = 0; PC_f = 60; PC_l = 0; TF_l = 0.005; TF_VIIa_l = 0; TF_VII_l = 0; TF_VIIa_IX_l = 0; TF_VIIa_IXa_l = 0; TF_VIIa_X_l = 0; TF_VIIa_Xa_l = 0; TF_VII_Xa_l = 0; IXa_VIIIa_l = 0; Xa_Va_l = 0; IXa_VIIIa_X_l = 0; V_Xa_l = 0; VIII_Xa_l = 0; IIa_f = 0; V_IIa_l = 0; VIII_IIa_l = 0; Xa_Va_II_l = 0; Xa_Va_mIIa_l = 0; XI_f = 30; XI_IIa_l = 0; XIa_l = 0; APC_PS_l = 0; APC_PS_VIIIa_l = 0; TFPI_f = 2.5; AT_f = 3400; IIa_AT_f = 0; TFPI_Xa_l = 0; TFPI_Xa_TF_VIIa_l = 0; APC_PS_Va_l = 0; IXa_AT_f = 0; Xa_AT_f = 0; VII_Xa_l = 0; V_mIIa_l = 0; VIII_mIIa_l = 0; TM_l = 1; IIa_TM_l = 0; IIa_TM_PC_l = 0; mIIa_AT_l = 0; XIa_IX_l = 0; LIPID = 849079; // Compartment initializations: compartment_ = 1; // Variable initializations: konII = 0.0043; nva = 100; koffII = 1; konmIIa = 0.05; koffmIIa = 0.475; konV = 0.05; koffV = 0.145; konVa = 0.057; koffVa = 0.17; konVII = 0.05; koffVII = 0.66; konVIIa = 0.05; koffVIIa = 0.227; konVIII = 0.05; koffVIII = 0.1; konVIIIa = 0.05; koffVIIIa = 0.335; konIX = 0.05; koffIX = 0.115; konIXa = 0.05; koffIXa = 0.115; konX = 0.01; koffX = 1.9; konXa = 0.029; koffXa = 3.3; konAPC = 0.05; koffAPC = 3.5; konPS = 0.05; koffPS = 0.2; konVIIIai = 0.05; koffVIIIai = 0.335; konVai = 0.057; koffVai = 0.17; konPC = 0.05; koffPC = 11.5; k1 = 0.5; k2 = 0.005; k3 = 0.005; k4 = 0.005; k5 = 0.01; k6 = 2.09; k7 = 0.34; k8 = 0.1; k9 = 32.5; k10 = 1.5; k75 = 1; k11 = 0.05; k12 = 44.8; k13 = 15.2; k14 = 0.1; k15 = 0.2; k16 = 1; k17 = 1; k18 = 0.1; k19 = 10.7; k20 = 8.3; k21 = 0.1; k22 = 1; k23 = 0.043; k24 = 0.1; k25 = 2.1; k26 = 0.023; k27 = 0.1; k28 = 6.94; k29 = 0.23; k30 = 0.1; k31 = 13.8; k32 = 0.9; k33 = 0.1; k34 = 100; k35 = 0.1; k36 = 66; k37 = 13; k38 = 15; k39 = 0.05; k40 = 44.8; k41 = 15.2; k42 = 0.1; k43 = 10; k44 = 1.43; k45 = 0.1; k46 = 1.6; k47 = 0.4; k48 = 0.1; k49 = 1.6; k50 = 0.4; k51 = 0.016; k52 = 0.00033; k53 = 0.01; k54 = 0.0011; k55 = 4.9e-007; k56 = 2.3e-006; k57 = 6.83e-005; k58 = 0.1; k59 = 6.94; k60 = 1.035; k61 = 0.1; k62 = 13.8; k63 = 0.9; k64 = 1; k65 = 0.5; k66 = 0.1; k67 = 6.4; k68 = 3.6; k69 = 6.83e-006; k70 = 0.1; k71 = 0.5; k72 = 0.01; k73 = 1.417; k74 = 0.183; // Other declarations: const compartment_, konII, nva, koffII, konmIIa, koffmIIa, konV, koffV; const konVa, koffVa, konVII, koffVII, konVIIa, koffVIIa, konVIII, koffVIII; const konVIIIa, koffVIIIa, konIX, koffIX, konIXa, koffIXa, konX, koffX; const konXa, koffXa, konAPC, koffAPC, konPS, koffPS, konVIIIai, koffVIIIai; const konVai, koffVai, konPC, koffPC, k1, k2, k3, k4, k5, k6, k7, k8, k9; const k10, k75, k11, k12, k13, k14, k15, k16, k17, k18, k19, k20, k21, k22; const k23, k24, k25, k26, k27, k28, k29, k30, k31, k32, k33, k34, k35, k36; const k37, k38, k39, k40, k41, k42, k43, k44, k45, k46, k47, k48, k49, k50; const k51, k52, k53, k54, k55, k56, k57, k58, k59, k60, k61, k62, k63, k64; const k65, k66, k67, k68, k69, k70, k71, k72, k73, k74; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nano mole"; compartment_ is "Cell"; LB1 is "Factor II lipid binding"; LB2 is "Factor mIIa lipid binding"; LB3 is "Factor V lipid binding"; LB4 is "Factor Va lipid binding"; LB5 is "Factor VII lipid binding"; LB6 is "Factor VIIa lipid binding"; LB7 is "Factor VIII lipid binding"; LB8 is "Factor VIIIa lipid binding"; LB9 is "Factor IX lipid binding"; LB10 is "Factor IXa lipid binding"; LB11 is "Factor X lipid binding"; LB12 is "Factor Xa lipid binding"; LB13 is "APC lipid binding"; LB14 is "PS lipid binding"; LB15 is "Factor VIIIai lipid binding"; LB16 is "Factor Vai lipid binding"; LB17 is "PC lipid binding"; R1 is "TF_VIIa binding"; R2 is "TF_VII binding"; R3 is "IX_TF_VIIa binding"; R3b is "Factor IX activation"; R4 is "X_TF_VIIa complex formation"; R4b is "Factor X activation"; R4c is "Factor Xa release"; R5 is "Xa_TF_VII binding"; R5b is "TF_VII activation"; R6 is "VIIIa_IXa binding"; R7 is "Va_Xa binding"; R8 is "X_IXa_VIIIa complex formation"; R8b is "Factor X activation"; R9 is "V_Xa binding"; R9b is "Factor V activation"; R10 is "Xa_VIII binding"; R10b is "Factor VIII activation"; end