// Created by libAntimony v2.8.0 model *Leloup1999_CircadianRhythms_Drosophila() // Compartments and Species: compartment Compartment_; species $MP in Compartment_, $CN in Compartment_, $C in Compartment_, $P2 in Compartment_; species $T2 in Compartment_, $T1 in Compartment_, $T0 in Compartment_, $MT in Compartment_; species $P0 in Compartment_, $P1 in Compartment_; // Assignment Rules: Pt := P0 + P1 + P2 + C + CN; // Rate Rules: MP' = vsP*(KIP^n/(KIP^n + CN^n)) - (vmP*(MP/(KmP + MP)) + kd*MP); CN' = k1*C - (k2*CN + kdN*CN); C' = (k3*P2*T2 + k2*CN) - (k4*C + k1*C + kdC*C); P2' = (V3P*(P1/(K3P + P1)) + k4*C) - (V4P*(P2/(K4P + P2)) + k3*P2*T2 + vdP*(P2/(KdP + P2)) + kd*P2); T2' = (V3T*(T1/(K3T + T1)) + k4*C) - (V4T*(T2/(K4T + T2)) + k3*P2*T2 + vdT*(T2/(KdT + T2)) + kd*T2); T1' = (V1T*(T0/(K1T + T0)) + V4T*(T2/(K4T + T2))) - (V2T*(T1/(K2T + T1)) + V3T*(T1/(K3T + T1)) + kd*T1); T0' = (ksT*MT + V2T*(T1/(K2T + T1))) - (V1T*(T0/(K1T + T0)) + kd*T0); MT' = vsT*(KIT^n/(KIT^n + CN^n)) - (vmT*(MT/(KmT + MT)) + kd*MT); P0' = (ksP*MP + V2P*(P1/(K2P + P1))) - (V1P*(P0/(K1P + P0)) + kd*P0); P1' = (V1P*(P0/(K1P + P0)) + V4P*(P2/(K4P + P2))) - (V2P*(P1/(K2P + P1)) + V3P*(P1/(K3P + P1)) + kd*P1); // Species initializations: MP = 0.0614368; CN = 1.34728; C = 0.207614; P2 = 0.0614368; T2 = 0.0145428; T1 = 0.0213384; T0 = 0.0217261; MT = 0.0860342; P0 = 0.0169928; P1 = 0.0141356; // Compartment initializations: Compartment_ = 1; // Variable initializations: vsP = 1.1; KIP = 1; n = 4; vmP = 1; KmP = 0.2; kd = 0.01; k1 = 0.8; k2 = 0.2; kdN = 0.01; k3 = 1.2; k4 = 0.6; kdC = 0.01; V3T = 8; K3T = 2; V4T = 1; K4T = 2; vdT = 3; KdT = 0.2; V1T = 8; K1T = 2; V2T = 1; K2T = 2; ksT = 0.9; vsT = 1; KIT = 1; vmT = 0.7; KmT = 0.2; ksP = 0.9; V2P = 1; K2P = 2; V1P = 8; K1P = 2; V4P = 1; K4P = 2; V3P = 8; K3P = 2; vdP = 2.2; KdP = 0.2; // Other declarations: var Pt; const Compartment_, vsP, KIP, n, vmP, KmP, kd, k1, k2, kdN, k3, k4, kdC; const V3T, K3T, V4T, K4T, vdT, KdT, V1T, K1T, V2T, K2T, ksT, vsT, KIT, vmT; const KmT, ksP, V2P, K2P, V1P, K1P, V4P, K4P, V3P, K3P, vdP, KdP; end