// Created by libAntimony v2.8.0 model *Alexander2010_Tcell_Regulation_Sys2() // Compartments and Species: compartment body; substanceOnly species A in body, R in body, E in body, G in body, $A_im in body; // Assignment Rules: mA := b1 + muA; mG := muG + v_max/k; R0 := (f*(v_max/k)*lambdaE*gamma)/(mG*mA*muE); // Reactions: r1a: G => ; v_max/(k + G)*G; r1b: $A_im => A; f*(v_max/(k + G))*G; r2: => G; gamma*E; r3: => R; beta*A; r4: => R; pi1*E*A; r5: => E; lambdaE*A; r6: A => ; muA*A; r7: R => ; muR*R; r8: E => ; muE*E; r9: G => ; muG*G; r10: A => ; b1*A; r11: A => ; sigma1*A*R; // Species initializations: A = 1/body; R = 0; E = 0; G = 100000000/body; A_im = 0; // Compartment initializations: body = 1; // Variable initializations: v_max = 125000; v_max has items_per_day; k = 50000000; k has substance; f = 0.0001; f has dimensionless; gamma = 2000; gamma has per_day; beta = 200; beta has per_day; pi1 = 0.016; pi1 has per_day_per_item; lambdaE = 1000; lambdaE has per_day; muA = 0.25; muA has per_day; muR = 0.25; muR has per_day; muE = 0.25; muE has per_day; muG = 5; muG has per_day; b1 = 0.25; b1 has per_day; sigma1 = 3e-006; sigma1 has per_day_per_item; mA has per_day; mG has per_day; R0 has dimensionless; // Other declarations: var mA, mG, R0; const body, v_max, k, f, gamma, beta, pi1, lambdaE, muA, muR, muE, muG; const b1, sigma1; // Unit definitions: unit substance = item; unit time_unit = 86400 second; unit per_day = 1 / 86400 second; unit per_day_per_item = 1 / (86400 second * item); unit items_per_day = item / 86400 second; // Display Names: substance is "number"; time_unit is "days"; r1a is "r1a: self-antigen uptake"; r1b is "r1b: pAPC maturation"; r2 is "r2: self-antigen release triggered by E"; r3 is "r3: R activation by A"; r4 is "r4: R activation by A and E"; r5 is "r5: E generation by A"; r6 is "r6: A death"; r7 is "r7: R death"; r8 is "r8: E death"; r9 is "r9: G clearance"; r10 is "r10: A suppression by Tregs of other specificity"; r11 is "r11: A suppression by R"; end