// Created by libAntimony v2.8.0
model *goldbeter2007()

  // Compartments and Species:
  compartment PSM;
  species RA in PSM, M_C in PSM, C in PSM, F in PSM, $M_F in PSM;

  // Assignment Rules:
  M_F := M_0*(x/L);
  vs1 := ks1*RALDH2_0*(1 - x/L);
  rho := alpha2/alpha1;
  alpha2 := F/(F + Kr2);
  alpha1 := RA/(RA + Kr1);

  // Reactions:
  RA_synthesis:  => RA; PSM*vs1;
  RA_decay: RA => ; PSM*kd5*RA;
  RA_deg_by_Cyp26: RA => ; PSM*kd1*RA*C;
  M_C_transcription:  => M_C; PSM*(V0 + (Vsc*F^n)/(Ka^n + F^n));
  M_C_decay: M_C => ; PSM*kd3*M_C;
  C_translation:  => C; PSM*ks2*M_C;
  C_decay: C => ; PSM*kd2*C;
  FGF_synthesis:  => F; PSM*ks3*M_F*(Ki^m/(Ki^m + RA^m));
  FGF_decay: F => ; PSM*kd4*F;

  // Species initializations:
  RA = 0.1;
  M_C = 0.1;
  C = 0.1;
  F = 1;

  // Compartment initializations:
  PSM = 1;

  // Variable initializations:
  M_0 = 5;
  M_0 has nM;
  x = 15;
  x has length;
  L = 50;
  L has length;
  vs1 has nM_per_min;
  ks1 = 1;
  ks1 has per_min;
  RALDH2_0 = 7.1;
  RALDH2_0 has nM;
  kd5 = 0;
  kd5 has per_min;
  kd1 = 1;
  kd1 has per_nM_per_min;
  V0 = 0.365;
  V0 has nM_per_min;
  Vsc = 7.1;
  Vsc has nM_per_min;
  n = 2;
  n has dimensionless;
  Ka = 0.2;
  Ka has nM;
  kd3 = 1;
  kd3 has per_min;
  ks2 = 1;
  ks2 has per_min;
  kd2 = 0.28;
  kd2 has per_min;
  ks3 = 1;
  ks3 has per_min;
  Ki = 0.2;
  Ki has nM;
  m = 2;
  m has dimensionless;
  kd4 = 1;
  kd4 has per_min;
  rho has dimensionless;
  alpha2 has dimensionless;
  alpha1 has dimensionless;
  Kr2 = 1;
  Kr2 has nM;
  Kr1 = 1;
  Kr1 has nM;

  // Other declarations:
  var vs1, rho, alpha2, alpha1;
  const PSM, M_0, x, L, ks1, RALDH2_0, kd5, kd1, V0, Vsc, n, Ka, kd3, ks2;
  const kd2, ks3, Ki, m, kd4, Kr2, Kr1;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit time_unit = 60 second;
  unit nM = 1e-9 mole / litre;
  unit nM_per_min = 1e-9 mole / (litre * 60 second);
  unit per_nM_per_min = litre / (1e-9 mole * 60 second);
  unit per_min = 1 / 60 second;
  unit length = dimensionless;

  // Display Names:
  substance is "nmole";
  time_unit is "min";
  nM_per_min is "nM per min";
  per_nM_per_min is "per nM per min";
  per_min is "per min";
  length is "arbit. length";
  M_C is "cyp26_mRNA";
  C is "CYP26";
  F is "FGF";
  M_F is "FGF_mRNA";
end