// Created by libAntimony v2.8.0 model *BIOMD0000000239() // Compartments and Species: compartment CYTOPLASM, MT_IMS, MT_IM, MATRIX; species GLC in CYTOPLASM, F6P in CYTOPLASM, FBP in CYTOPLASM, GAP in CYTOPLASM; species DPG in CYTOPLASM, PEP in CYTOPLASM, PYR_cyt in CYTOPLASM, AMP in CYTOPLASM; species LAC in CYTOPLASM, G3P in CYTOPLASM, DHAP in CYTOPLASM, OXA_cyt in CYTOPLASM; species Asp_cyt in CYTOPLASM, Glu_cyt in CYTOPLASM, OG_cyt in CYTOPLASM; species Mal_cyt in CYTOPLASM, Acetyl_CoA_cyt in CYTOPLASM, CoA_cyt in CYTOPLASM; species IsoCitcyt in CYTOPLASM, Cit_cyt in CYTOPLASM, ATP_cyt in CYTOPLASM; species ADP_cyt in CYTOPLASM, NAD in CYTOPLASM, NADH_cyt in CYTOPLASM, NADP_cyt in CYTOPLASM; species NADPH_cyt in CYTOPLASM, Pyr in MATRIX, CO2 in MATRIX, CoA in MATRIX; species Acetyl_CoA in MATRIX, Pi_ in MATRIX, Fum in MATRIX, SCoA in MATRIX; species Suc in MATRIX, GTP in MATRIX, GDP in MATRIX, Ala in MATRIX, Asp in MATRIX; species Glu in MATRIX, H2O in MATRIX, ETFred in MATRIX, ETFox in MATRIX; species FADH2 in MATRIX, FAD in MATRIX, OG in MATRIX, Mal in MATRIX, OXA in MATRIX; species Cit in MATRIX, IsoCit in MATRIX, ATP in MATRIX, ADP in MATRIX, NADP_p in MATRIX; species NADPH in MATRIX, NAD_p in MATRIX, NADH in MATRIX, Q in MT_IMS, QH2 in MT_IMS; species Cytc3p in MT_IMS, Cytc2p in MT_IMS; // Reactions: GLCflow: -> GLC; CYTOPLASM*(GLCflow_Glc_F*10^-3 - GLC)*flow; LACflow: LAC => ; CYTOPLASM*LAC*flow; GAPflow: GAP => ; CYTOPLASM*GAP*flow; v1: GLC + ATP_cyt => F6P + ADP_cyt; CYTOPLASM*((v1_V1*ATP_cyt*GLC)/((v1_K1GLC + GLC)*(v1_K1ATP + ATP_cyt))); v2: F6P + ATP_cyt => FBP + ADP_cyt; CYTOPLASM*((v2_V2*ATP_cyt*F6P^2)/((v2_K2*(1 + v2_k2*(ATP_cyt/AMP)^2) + F6P^2)*(v2_K2ATP + ATP_cyt))); v3: FBP -> 2GAP; CYTOPLASM*(v3_k3f*FBP - v3_k3b*GAP^2); v4: GAP + NAD => DPG + NADH_cyt; CYTOPLASM*((v4_V4*NAD*GAP)/((v4_K4GAP + GAP)*(v4_K4NAD + NAD))); v5: DPG + ADP_cyt -> PEP + ATP_cyt; CYTOPLASM*(v5_k5f*DPG*ADP_cyt - v5_k5b*PEP*ATP_cyt); v6: PEP + ADP_cyt => PYR_cyt + ATP_cyt; CYTOPLASM*((v6_V6*ADP_cyt*PEP)/((v6_K6PEP + PEP)*(v6_K6ADP + ADP_cyt))); v7: PYR_cyt + NADH_cyt -> LAC + NAD; CYTOPLASM*(v7_k8f*NADH_cyt*PYR_cyt - v7_k8b*NAD*LAC); hidden_1: AMP + ATP_cyt -> 2ADP_cyt; CYTOPLASM*(hidden_1_k9f*AMP*ATP_cyt - hidden_1_k9b*ADP_cyt^2); v8: PYR_cyt -> Pyr; MATRIX*((v8_V*PYR_cyt*v8_v8_PYC)/(v8_K + PYR_cyt)); v9: Pyr + CoA + NAD_p => CO2 + Acetyl_CoA + NADH; MATRIX*((v9_KcF*v9_v9_PDC*Pyr*CoA*NAD_p)/(v9_KmC*Pyr*CoA + v9_KmB*Pyr*NAD_p + v9_KmA*CoA*NAD_p + Pyr*CoA*NAD_p + (v9_KmA*v9_KmP*v9_Kib*v9_Kic)/v9_KmR/v9_Kip/v9_Kiq*Acetyl_CoA*NADH + v9_KmC/v9_Kir*Pyr*CoA*NADH + v9_KmB/v9_Kiq*Pyr*NAD_p*Acetyl_CoA + (v9_KmA*v9_KmP*v9_Kib*v9_Kic)/v9_KmR/v9_Kip/v9_Kia/v9_Kiq*Pyr*Acetyl_CoA*NADH)); v10: OXA + Acetyl_CoA -> Cit + CoA; MATRIX*((v10_V*Acetyl_CoA*OXA*v10_v10_CS)/(Acetyl_CoA*OXA + v10_Ka*OXA + v10_Kb*Acetyl_CoA + v10_Kia*v10_Kib)); v11: Cit -> IsoCit; MATRIX*(((v11_KcF*v11_Kp*Cit - v11_KcR*v11_Ks*IsoCit)*v11_v11_ACO)/(v11_Ks*IsoCit + v11_Kp*Cit + v11_Ks*v11_Kp)); v12: IsoCit + NAD_p => OG + NADH; MATRIX*((v12_KcF*v12_v12_IDHa*(IsoCit*IsoCit + v12_b*ADP*IsoCit))/(IsoCit*IsoCit + v12_c*IsoCit + v12_d*ADP + v12_e*ADP*IsoCit + v12_f)); v14: OG + CoA + NAD_p => CO2 + SCoA + NADH; MATRIX*((v14_KcF*v14_v14_OGDC*OG*CoA*NAD_p)/(v14_KmC*OG*CoA + v14_KmB*OG*NAD_p + v14_KmA*CoA*NAD_p + OG*CoA*NAD_p + (v14_KmA*v14_KmP*v14_Kib*v14_Kic)/v14_KmR/v14_Kip/v14_Kiq*SCoA*NADH + v14_KmC/v14_Kir*OG*CoA*NADH + v14_KmB/v14_Kiq*OG*NAD_p*SCoA + (v14_KmA*v14_KmP*v14_Kib*v14_Kic)/v14_KmR/v14_Kip/v14_Kia/v14_Kiq*OG*SCoA*NADH)); v15: GDP + SCoA + Pi_ -> Suc + GTP + CoA; MATRIX*(((GDP*SCoA*pi - (Suc*GTP*CoA)/v15_Keq)*(v15_Kc1*v15_v15_SCS + v15_Kc2*v15_v15_SCS*((v15_KmC*Suc)/v15_KmC2*v15_Kip + pi/v15_KmC2)))/(v15_Kia*v15_KmB*pi + v15_KmB*GDP*pi + v15_KmA*SCoA*pi + v15_KmC*GDP*SCoA + GDP*SCoA*pi + (GDP*SCoA*pi*pi)/v15_KmC2 + (v15_Kia*v15_KmB*v15_KmC*Suc)/v15_Kip + (v15_Kia*v15_KmB*v15_KmC*Suc*GTP)/v15_Kip/v15_Kiq + (v15_Kia*v15_KmB*v15_KmC*Suc*CoA)/v15_Kip/v15_Kir + (v15_Kia*v15_KmB*v15_Kic*GTP*CoA)/v15_KmQ/v15_Kir + (v15_Kia*v15_KmB*v15_KmC*Suc*GTP*CoA)/v15_Kip/v15_KmQ/v15_Kir + (v15_Kia*v15_KmB*v15_KmC*Suc*Suc*GTP*CoA)/v15_Kip/v15_KmP2/v15_KmQ/v15_Kir + (v15_Kia*v15_KmB*pi*GTP)/v15_Kiq + (v15_Kia*v15_KmB*pi*CoA)/v15_Kir + (v15_Kia*v15_KmB*pi*GTP*CoA)/v15_KmQ/v15_Kir + (v15_Kia*v15_KmB*pi*Suc*GTP*CoA)/v15_KmP2/v15_KmQ/v15_Kir + (v15_KmB*v15_KmC*GDP*Suc)/v15_Kip + (v15_KmA*v15_KmC*SCoA*Suc)/v15_Kip + (v15_KmC*GDP*SCoA*Suc)/v15_Kip + (v15_KmC*GDP*SCoA*pi*Suc)/v15_KmC2/v15_Kip + (v15_KmA*SCoA*pi*GTP)/v15_Kiq + (v15_KmB*GDP*pi*CoA)/v15_Kir + (v15_KmA*v15_KmC*SCoA*Suc*GTP)/v15_Kip/v15_Kiq + (v15_KmB*v15_KmC*GDP*Suc*CoA)/v15_Kip/v15_Kir)); v16: Suc + Q -> Fum + QH2; MATRIX*((v16_KcF*v16_KcR*v16_v16_SDH*(Suc*Q - (Fum*QH2)/v16_Keq))/(v16_KcR*v16_KmS2*Suc + v16_KcR*v16_KmS1*Q + (v16_KcF*v16_KmP2*Fum)/v16_Keq + (v16_KcF*v16_KmP1*QH2)/v16_Keq + v16_KcR*Suc*Q + (v16_KcF*v16_KmP2*Suc*Fum)/(v16_Keq*v16_KiS1) + (v16_KcF*Fum*QH2)/v16_Keq + (v16_KcR*v16_KmS1*Q*QH2)/v16_KiP2)); v17: Fum -> Mal; MATRIX*(((v17_KcF*v17_Kp*Fum - v17_KcR*v17_Ks*Mal)*v17_v17_FM)/(v17_Ks*Mal + v17_Kp*Fum + v17_Ks*v17_Kp)); v18: Mal + NAD_p -> NADH + OXA; MATRIX*((((v18_KcF*Mal*NAD_p)/v18_KiS1/v18_KmS2 - (v18_KcR*OXA*NADH)/v18_KmP1/v18_KiP2)*v18_v18_MDH)/(1 + Mal/v18_KiS1 + (v18_KmS1*NAD_p)/v18_KiS1/v18_KmS2 + (v18_KmP2*OXA)/v18_KmP1/v18_KiP2 + NADH/v18_KiP2 + (Mal*NAD_p)/v18_KiS1/v18_KmS2 + (v18_KmP2*Mal*OXA)/v18_KiS1/v18_KmP1/v18_KiP2 + (v18_KmS1*NAD_p*NADH)/v18_KiS1/v18_KmS2/v18_KiP2 + (OXA*NADH)/v18_KmP1*v18_KiP2 + (Mal*NAD_p*OXA)/v18_KiS1/v18_KmS2/v18_KiP1 + (NAD_p*OXA*NADH)/v18_KiS2/v18_KmP1/v18_KiP2)); v20: Ala + OG -> Glu + Pyr; MATRIX*((v20_KcF*v20_KcR*v20_v20_AlaTA*(Ala*OG - (Glu*Pyr)/v20_Keq))/(v20_KcR*v20_KmS2*Ala + v20_KcR*v20_KmS1*OG + (v20_KcF*v20_KmP2*Glu)/v20_Keq + (v20_KcF*v20_KmP1*Pyr)/v20_Keq + v20_KcR*Ala*OG + (v20_KcF*v20_KmP2*Ala*Glu)/(v20_Keq*v20_KiS1) + (v20_KcF*Glu*Pyr)/v20_Keq + (v20_KcR*v20_KmS1*OG*Pyr)/v20_KiP2)); v21: OXA + Glu -> Asp + OG; MATRIX*((v21_KcF*v21_KcR*v21_v21_AspTA*(OXA*Glu - (Asp*OG)/v21_Keq))/(v21_KcR*v21_KmS2*OXA + v21_KcR*v21_KmS1*Glu + (v21_KcF*v21_KmP2*Asp)/v21_Keq + (v21_KcF*v21_KmP1*OG)/v21_Keq + v21_KcR*OXA*Glu + (v21_KcF*v21_KmP2*OXA*Asp)/(v21_Keq*v21_KiS1) + (v21_KcF*Asp*OG)/v21_Keq + (v21_KcR*v21_KmS1*Glu*OG)/v21_KiP2)); v22: Glu_cyt + Asp -> Asp_cyt + Glu; MATRIX*((((Asp*Glu_cyt)/v22_alpha/v22_KiS1/v22_KiS2*v22_KcF - (Glu*Asp_cyt)/v22_beta/v22_KiP1/v22_KiP2*v22_KcR)*v22_v22_AGC)/(1 + Asp/v22_KiS1 + Glu_cyt/v22_KiS2 + Glu/v22_KiP1 + Asp_cyt/v22_KiP2 + (Asp*Glu_cyt)/v22_alpha/v22_KiS1/v22_KiS2 + (Glu*Asp_cyt)/v22_beta/v22_KiP1/v22_KiP2 + (Glu_cyt*Asp_cyt)/v22_gamma/v22_KiS2/v22_KiP2 + (Asp*Glu)/v22_delta/v22_KiS1/v22_KiP1)); v24: NADH + Q -> NAD_p + QH2; MATRIX*((v24_KcF*v24_KcR*v24_v24_Complex_I*(NADH*Q - (NAD_p*QH2)/v24_Keq))/(v24_KcR*v24_KmS2*NADH + v24_KcR*v24_KmS1*Q + (v24_KcF*v24_KmP2*NAD_p)/v24_Keq + (v24_KcF*v24_KmP1*QH2)/v24_Keq + v24_KcR*NADH*Q + (v24_KcF*v24_KmP2*NADH*NAD_p)/(v24_Keq*v24_KiS1) + (v24_KcF*NAD_p*QH2)/v24_Keq + (v24_KcR*v24_KmS1*Q*QH2)/v24_KiP2)); v25: QH2 + 2Cytc3p => Q + 2Cytc2p; MT_IMS*((v25_KcF*v25_v25_Complex_III*QH2*Cytc3p)/((v25_KmA*v25_Kq2*v25_Kb2 + v25_KmA*v25_Kq2*Cytc3p + v25_KcF/v25_k8*v25_Kq1*QH2*v25_Kb1 + v25_KcF/v25_k8*v25_Kq1*QH2*Cytc3p)*Cytc2p + v25_KmA*Cytc3p + v25_KmB*QH2 + QH2*Cytc3p)); v26: Cytc2p => Cytc3p; MT_IMS*((v26_KcF*v26_v26_Complex_IV*Cytc2p)/(v26_Ks + Cytc2p)); v27: Cit_cyt + CoA_cyt -> OXA_cyt + Acetyl_CoA_cyt; (CYTOPLASM*v27_Kid*v27_Kc*((v27_V*Acetyl_CoA_cyt*OXA_cyt*v27_v10_CS)/(Acetyl_CoA_cyt*OXA_cyt + v27_Ka*OXA_cyt + v27_Kb*Acetyl_CoA_cyt + v27_Kia*v27_Kib)))/(v27_Keq*v27_Kia*v27_Kb); v28: ADP + Pi_ -> ATP + H2O; (MATRIX*v28_v28_Complex_V*v28_V*ADP)/(v28_Km + ADP + (ADP*ADP)/v28_Ki); v29: Cit_cyt -> IsoCitcyt; CYTOPLASM*(((v29_KcF*v29_Kp*Cit_cyt - v29_KcR*v29_Ks*IsoCitcyt)*v29_v29_ACO)/(v29_Ks*IsoCitcyt + v29_Kp*Cit_cyt + v29_Ks*v29_Kp)); v30: Mal_cyt + OG -> OG_cyt + Mal; MATRIX*((((OG*Mal_cyt)/v30_alpha/v30_KiS1/v30_KiS2*v30_KcF - (Mal*OG_cyt)/v30_beta/v30_KiP1/v30_KiP2*v30_KcR)*v30_v30_OGC)/(1 + OG/v30_KiS1 + Mal_cyt/v30_KiS2 + Mal/v30_KiP1 + OG_cyt/v30_KiP2 + (OG*Mal_cyt)/v30_alpha/v30_KiS1/v30_KiS2 + (Mal*OG_cyt)/v30_beta/v30_KiP1/v30_KiP2 + (Mal_cyt*OG_cyt)/v30_gamma/v30_KiS2/v30_KiP2 + (OG*Mal)/v30_delta/v30_KiS1/v30_KiP1)); v31: NADH_cyt + OXA_cyt => Mal_cyt + NAD; CYTOPLASM*((v31_v31_MDH*(v31_k1*v31_k2*v31_k3*v31_k4*NADH_cyt*OXA_cyt - v31_kminus1*v31_kminus2*v31_kminus3*v31_kminus4*Mal_cyt*NAD))/(v31_kminus1*(v31_kminus2 + v31_k3)*v31_k4 + v31_k1*(v31_kminus2 + v31_k3)*v31_k4*NADH_cyt + v31_kminus1*(v31_kminus2 + v31_k3)*v31_kminus4*NAD + v31_k2*v31_k3*v31_k4*OXA_cyt + v31_kminus1*v31_kminus2*v31_kminus3*Mal_cyt + v31_k1*v31_k2*(v31_k3 + v31_k4)*NADH_cyt*OXA_cyt + (v31_kminus1 + v31_kminus2)*v31_kminus3*v31_kminus4*Mal_cyt*NAD + v31_k1 + v31_kminus2 + v31_kminus3*NADH_cyt*Mal_cyt + v31_k1*v31_k2*v31_kminus3*NADH_cyt*OXA_cyt*Mal_cyt + v31_k2*v31_k3*v31_kminus4*OXA_cyt*NAD + v31_k2*v31_kminus3*v31_kminus4*OXA_cyt*Mal_cyt*NAD)); v32: Asp_cyt + OG_cyt -> OXA_cyt + Glu_cyt; CYTOPLASM*((v32_KcF*v32_KcR*v32_v32_AspTA*(Asp_cyt*OG_cyt - (OXA_cyt*Glu_cyt)/v32_Keq))/(v32_KcR*v32_KmS2*Asp_cyt + v32_KcR*v32_KmS1*OG_cyt + (v32_KcF*v32_KmP2*OXA_cyt)/v32_Keq + (v32_KcF*v32_KmP1*Glu_cyt)/v32_Keq + v32_KcR*Asp_cyt*OG_cyt + (v32_KcF*v32_KmP2*Asp_cyt*OXA_cyt)/(v32_Keq*v32_KiS1) + (v32_KcF*OXA_cyt*Glu_cyt)/v32_Keq + (v32_KcR*v32_KmS1*OG_cyt*Glu_cyt)/v32_KiP2)); v33: Cit_cyt + Mal -> Mal_cyt + Cit; MATRIX*((((Cit_cyt*Mal)/v33_alpha/v33_KiS1/v33_KiS2*v33_KcF - (Mal_cyt*Cit)/v33_beta/v33_KiP1/v33_KiP2*v33_KcR)*v33_v33_CIC)/(1 + Cit_cyt/v33_KiS1 + Mal/v33_KiS2 + Mal_cyt/v33_KiP1 + Cit/v33_KiP2 + (Cit_cyt*Mal)/v33_alpha/v33_KiS1/v33_KiS2 + (Mal_cyt*Cit)/v33_beta/v33_KiP1/v33_KiP2 + (Mal*Cit)/v33_gamma/v33_KiS2/v33_KiP2 + (Cit_cyt*Mal_cyt)/v33_delta/v33_KiS1/v33_KiP1)); v34: ETFred + Q -> ETFox + QH2; MATRIX*((v34_KcF*v34_KcR*v34_v34_ETF_QO*(ETFred*Q - (ETFox*QH2)/v34_Keq))/(v34_KcR*v34_KmS2*ETFred + v34_KcR*v34_KmS1*Q + (v34_KcF*v34_KmP2*ETFox)/v34_Keq + (v34_KcF*v34_KmP1*QH2)/v34_Keq + v34_KcR*ETFred*Q + (v34_KcF*v34_KmP2*ETFred*ETFox)/(v34_Keq*v34_KiS1) + (v34_KcF*ETFox*QH2)/v34_Keq + (v34_KcR*v34_KmS1*Q*QH2)/v34_KiP2)); v35: FADH2 + ETFox -> ETFred + FAD; MATRIX*((v35_KcF*v35_KcR*v35_v35_ACD*(FADH2*ETFox - (ETFred*FAD)/v35_Keq))/(v35_KcR*v35_KiS1*v35_KmS2 + v35_KcR*v35_KmS2*FADH2 + v35_KcR*v35_KmS1*ETFox + (v35_KcF*v35_KmP2*ETFred)/v35_Keq + (v35_KcF*v35_KmP1*FAD)/v35_Keq + v35_KcR*FADH2*ETFox + (v35_KcF*v35_KmP2*FADH2*ETFred)/(v35_Keq*v35_KiS1) + (v35_KcF*ETFred*FAD)/v35_Keq + (v35_KcR*v35_KmS1*ETFox*FAD)/v35_KiP2 + (v35_KcR*FADH2*ETFox*ETFred)/v35_KiP1 + (v35_KcF*ETFox*ETFred*FAD)/(v35_KiS2*v35_Keq))); v36: ATP + CO2 + Pyr -> Pi_ + ADP + OXA; MATRIX*((v36_KcF*v36_KcR*v36_v36_PC*(ATP*CO2*Pyr - (pi*ADP*OXA)/v36_Keq))/(v36_Kia*v36_KmB*v36_KcR*Pyr + v36_KmC*v36_KcR*ATP*CO2 + v36_KmA*v36_KcR*CO2*Pyr + v36_KmB*v36_KcR*ATP*Pyr + v36_KcR*ATP*CO2*Pyr + (v36_Kip*v36_KmQ*v36_KcF*OXA)/v36_Keq + (v36_KmQ*v36_KcF*pi*OXA)/v36_Keq + (v36_KmP*v36_KcF*ADP*OXA)/v36_Keq + (v36_KmR*v36_KcF*pi*ADP)/v36_Keq + (v36_KcF*pi*ADP*OXA)/v36_Keq + (v36_Kia*v36_KmB*v36_KcR*Pyr*pi)/v36_Kip + (v36_Kia*v36_KmB*v36_KcR*Pyr*ADP)/v36_Kia + (v36_Kiq*v36_KmP*v36_KcF*CO2*OXA)/v36_Kib/v36_Keq + (v36_Kia*v36_KmP*v36_KcF*ATP*OXA)/v36_Kia/v36_Keq + (v36_KmA*v36_KcR*ATP*CO2*OXA)/v36_Kir + (v36_KmR*v36_KcF*Pyr*pi*ADP)/v36_Kic/v36_Keq + (v36_KmA*v36_KcR*CO2*Pyr*ADP)/v36_Kiq + (v36_KmA*v36_KcR*CO2*Pyr*pi)/v36_Kip + (v36_KmP*v36_KcF*CO2*ADP*OXA)/v36_Kib/v36_Keq + (v36_KmQ*v36_KcF*CO2*pi*OXA)/v36_Kib/v36_Keq)); v37: G3P + FAD => FADH2 + DHAP; CYTOPLASM*((v37_V*v37_v37_GUT2P*G3P)/(v37_K + G3P)); v38: NADH_cyt + DHAP => G3P + NAD; CYTOPLASM*((v38_V*v38_v38_GUT2P*NADH_cyt)/(v38_K + NADH_cyt)); v40: ADP_cyt => ADP; MATRIX*((v40_V*v40_v40_AAC*ADP_cyt)/(v40_K + ADP_cyt)); v41: IsoCitcyt + NADP_cyt -> OG_cyt + NADPH_cyt; CYTOPLASM*v41_v41_IDHc*((IsoCitcyt*NADP_cyt)/(v41_phi0*IsoCitcyt*NADP_cyt + v41_phi1*NADP_cyt + v41_phi2*IsoCitcyt + v41_phi12) - (OG_cyt*NADPH_cyt*CO2)/(v41_phir0*OG_cyt*NADPH_cyt*CO2 + v41_phir1*NADPH_cyt*CO2 + v41_phir2*OG_cyt*CO2 + v41_phir3*OG_cyt*NADPH_cyt + v41_phir12*CO2 + v41_phir13*NADPH_cyt + v41_phir23*OG_cyt + v41_phir123)); v42: IsoCitcyt + Mal -> Mal_cyt + IsoCit; MATRIX*((((IsoCitcyt*Mal)/v42_alpha/v42_KiS1/v42_KiS2*v42_KcF - (Mal_cyt*IsoCit)/v42_beta/v42_KiP1/v42_KiP2*v42_KcR)*v42_v42_CIC)/(1 + IsoCitcyt/v42_KiS1 + Mal/v42_KiS2 + Mal_cyt/v42_KiP1 + IsoCit/v42_KiP2 + (IsoCitcyt*Mal)/v42_alpha/v42_KiS1/v42_KiS2 + (Mal_cyt*IsoCit)/v42_beta/v42_KiP1/v42_KiP2 + (Mal*IsoCit)/v42_gamma/v42_KiS2/v42_KiP2 + (IsoCitcyt*Mal_cyt)/v42_delta/v42_KiS1/v42_KiP1)); v43: ATP => ATP_cyt; MATRIX*((v43_V*v43_v43_AAC*ATP)/(v43_K + ATP)); v39: Mal_cyt + NADP_cyt -> NADPH_cyt + PYR_cyt; CYTOPLASM*((v39_v39_MDH*v39_Kcat*Mal_cyt*NADP_cyt)/((v39_Kmal + Mal_cyt)*(v39_Knadp + NADP_cyt))); v44: Mal + NADP_p -> NADPH + Pyr; MATRIX*((v44_v44_MDH*v44_Kcat*Mal)/(v44_Km + Mal)); // Species initializations: GLC = 1.12817e-005; F6P = 0.00065939; FBP = 7.70135e-006; GAP = 1.90919e-006; DPG = 0.000299109; PEP = 2.1125e-006; PYR_cyt = 4.22702e-006; AMP = 2.61149e-006; LAC = 0.00033981; G3P = 0.0076925; DHAP = 0.0076925; OXA_cyt = 4e-006; Asp_cyt = 0.00114; Glu_cyt = 0.00303; OG_cyt = 2.1e-005; Mal_cyt = 0.0005; Acetyl_CoA_cyt = 3e-005; CoA_cyt = 0.000272; IsoCitcyt = 0.00042; Cit_cyt = 0.00042; ATP_cyt = 0.00449064; ADP_cyt = 0.000108367; NAD = 0.00362057; NADH_cyt = 0.000616118; NADP_cyt = 0.00362057; NADPH_cyt = 0.000616118; Pyr = 0.001025; CO2 = 0.00163; CoA = 0.000272; Acetyl_CoA = 3e-005; Pi_ = 0.004; Fum = 6.5e-005; SCoA = 0.0002941; Suc = 0.00295; GTP = 0.0045; GDP = 0.00045; Ala = 0.00344; Asp = 0.00114; Glu = 0.00303; H2O = 0.001; ETFred = 0.00031; ETFox = 0.00032; FADH2 = 7.2e-005; FAD = 0.00101; OG = 2.1e-005; Mal = 0.0005; OXA = 4e-006; Cit = 0.00042; IsoCit = 0.00042; ATP = 0.0045; ADP = 0.00045; NADP_p = 0.0101; NADPH = 7.2e-005; NAD_p = 0.0101; NADH = 0.00072; Q = 0.026; QH2 = 0.028; Cytc3p = 0.003; Cytc2p = 0.00011; // Compartment initializations: CYTOPLASM = 1; MT_IMS = 1; MT_IM = 1; MATRIX = 1; // Variable initializations: flow = 0.011; GLCflow_Glc_F = 64.941; v1_V1 = 0.0005; v1_K1GLC = 0.0001; v1_K1ATP = 6.3e-005; v2_V2 = 0.0015; v2_K2 = 1.6e-009; v2_k2 = 0.017; v2_K2ATP = 1e-005; v3_k3f = 1; v3_k3b = 0.05; v4_V4 = 0.01; v4_K4GAP = 0.001; v4_K4NAD = 0.001; v5_k5f = 1000; v5_k5b = 500; v6_V6 = 0.01; v6_K6PEP = 0.0002; v6_K6ADP = 0.0003; v7_k8f = 1000; v7_k8b = 0.143; hidden_1_k9f = 10000; hidden_1_k9b = 10000; v8_V = 1e-008; v8_K = 1.5e-007; v8_v8_PYC = 0.00033211; v9_KmA = 2.5e-005; v9_KmB = 1.3e-005; v9_KmC = 5e-005; v9_KmP = 5.9e-007; v9_KmR = 6.9e-007; v9_Kia = 0.00055; v9_Kib = 0.0003; v9_Kic = 0.00018; v9_Kip = 6e-005; v9_Kiq = 3.5e-005; v9_Kir = 3.6e-005; v9_KcF = 856; v9_v9_PDC = 3.8617e-007; v10_V = 0.005267; v10_Ka = 1.18e-005; v10_Kb = 4.8e-006; v10_Kia = 1e-005; v10_Kib = 4e-006; v10_v10_CS = 3.8617e-007; v11_Ks = 0.0005; v11_Kp = 0.00011; v11_KcF = 20.47; v11_KcR = 31.44; v11_v11_ACO = 3.8617e-007; v12_KcF = 105; v12_b = 29.6; v12_c = 0.00023; v12_d = 7.8e-005; v12_e = 0.00064; v12_f = 0.00036; v12_v12_IDHa = 3.8617e-007; v14_KmA = 0.00022; v14_KmB = 2.5e-005; v14_KmC = 5e-005; v14_KmP = 0.0003; v14_KmR = 0.0006; v14_Kia = 0.00072; v14_Kib = 0.00074; v14_Kic = 0.0001; v14_Kip = 1.1e-006; v14_Kiq = 8.1e-005; v14_Kir = 2.5e-005; v14_KcF = 177; v14_v14_OGDC = 3.8617e-007; v15_KmA = 5e-006; v15_KmB = 3.5e-005; v15_KmC = 0.00045; v15_KmP = 0.0006; v15_KmQ = 7.5e-006; v15_KmC2 = 0.00045; v15_KmP2 = 0.0006; v15_Keq = 8.375; v15_Kia = 0.0004; v15_Kib = 2e-005; v15_Kic = 3e-005; v15_Kip = 0.07; v15_Kiq = 5e-006; v15_Kir = 6.7e-006; v15_Kc1 = 100; v15_Kc2 = 100; v15_v15_SCS = 3.8617e-007; v16_KmS1 = 3e-005; v16_KmS2 = 6.9e-005; v16_KmP1 = 3e-007; v16_KmP2 = 1.5e-006; v16_KiS1 = 4.1e-006; v16_KiP2 = 5.6e-006; v16_Keq = 0.037; v16_KcF = 69.3; v16_KcR = 1.73; v16_v16_SDH = 9.9211e-005; v17_Kp = 2.5e-005; v17_Ks = 5e-006; v17_KcF = 800; v17_KcR = 900; v17_v17_FM = 3.8617e-007; v18_KmS1 = 7.2e-005; v18_KmS2 = 0.00011; v18_KmP1 = 0.0016; v18_KmP2 = 0.00017; v18_KiS1 = 1.1e-005; v18_KiS2 = 0.0001; v18_KiP1 = 0.0071; v18_KiP2 = 0.0019; v18_KcF = 0.39; v18_KcR = 0.04; v18_v18_MDH = 3.8617e-007; v20_KmS1 = 0.002; v20_KmS2 = 0.0004; v20_KmP1 = 0.032; v20_KmP2 = 0.0004; v20_KiS1 = 0.0087; v20_KiP2 = 0.012; v20_Keq = 0.69; v20_KcF = 337; v20_KcR = 0.15; v20_v20_AlaTA = 3.8617e-007; v21_KmS1 = 0.0009; v21_KmS2 = 0.0001; v21_KmP1 = 4e-005; v21_KmP2 = 0.004; v21_KiS1 = 0.002; v21_KiP2 = 0.0083; v21_Keq = 6.2; v21_KcF = 300; v21_KcR = 1000; v21_v21_AspTA = 3.8617e-007; v22_KiS1 = 8e-005; v22_KiS2 = 0.0032; v22_KiP1 = 0.00018; v22_KiP2 = 0.0028; v22_KcF = 10; v22_KcR = 10; v22_alpha = 1; v22_beta = 1; v22_gamma = 1; v22_delta = 1; v22_v22_AGC = 0.00033211; v24_KmS1 = 9.2e-006; v24_KmS2 = 0.00026; v24_KmP1 = 9.9e-006; v24_KmP2 = 5.9e-005; v24_KiS1 = 2.1e-008; v24_KiP2 = 9.8e-008; v24_Keq = 407.9; v24_KcF = 498; v24_KcR = 229; v24_v24_Complex_I = 0.00033211; v25_KmA = 2.8e-005; v25_KmB = 3e-006; v25_Kb1 = 5.4e-006; v25_Kb2 = 5.7e-006; v25_Kq1 = 2.8e-006; v25_Kq2 = 1.9e-006; v25_k8 = 622.1; v25_KcF = 426.8; v25_v25_Complex_III = 9.963e-009; v26_Ks = 0.00011; v26_KcF = 0.000935; v26_v26_Complex_IV = 0.002325; v27_V = 0.004833; v27_Ka = 5e-006; v27_Kb = 4.5e-006; v27_Kc = 3.9e-005; v27_Kia = 5e-006; v27_Kib = 4.5e-006; v27_Kid = 0.0043; v27_Keq = 18000000; v27_v10_CS = 3.8617e-007; v28_V = 0.075; v28_Km = 0.0045; v28_Ki = 0.047; v28_v28_Complex_V = 0.0033211; v29_Ks = 0.0005; v29_Kp = 0.00011; v29_KcF = 20.47; v29_KcR = 31.44; v29_v29_ACO = 3.8617e-007; v30_KiS1 = 0.0003; v30_KiS2 = 0.0007; v30_KiP1 = 0.0014; v30_KiP2 = 0.00017; v30_KcF = 3.675; v30_KcR = 4.83; v30_alpha = 1; v30_beta = 1; v30_gamma = 1; v30_delta = 1; v30_v30_OGC = 0.00033211; v31_k1 = 34000000; v31_k2 = 35000000; v31_k3 = 4650; v31_k4 = 214; v31_kminus1 = 26; v31_kminus2 = 1400; v31_kminus3 = 570000; v31_kminus4 = 260000; v31_v31_MDH = 3.8617e-007; v32_KmS1 = 0.0009; v32_KmS2 = 0.0001; v32_KmP1 = 4e-005; v32_KmP2 = 0.004; v32_KiS1 = 0.002; v32_KiP2 = 0.0083; v32_Keq = 6.2; v32_KcF = 300; v32_KcR = 1000; v32_v32_AspTA = 3.8617e-007; v33_KiS1 = 0.00013; v33_KiS2 = 0.00044; v33_KiP1 = 0.00033; v33_KiP2 = 4.18e-005; v33_KcF = 5.6; v33_KcR = 3.5; v33_alpha = 1; v33_beta = 1; v33_gamma = 1; v33_delta = 1; v33_v33_CIC = 0.00033211; v34_KmS1 = 3.1e-007; v34_KmS2 = 3.9e-007; v34_KmP1 = 3.2e-007; v34_KmP2 = 4.2e-009; v34_KiS1 = 3.1e-007; v34_KiP2 = 3e-007; v34_Keq = 0.66; v34_KcF = 78; v34_KcR = 101; v34_v34_ETF_QO = 3.3211e-005; v35_KmS1 = 3.9e-005; v35_KmS2 = 1.2e-007; v35_KmP1 = 1.08e-006; v35_KmP2 = 2.42e-005; v35_KiS1 = 7.6e-005; v35_KiS2 = 2.4e-007; v35_KiP1 = 7.53e-005; v35_KiP2 = 1.19e-005; v35_Keq = 8.99; v35_KcF = 2.18; v35_KcR = 0.3; v35_v35_ACD = 3.3211e-005; v36_KmA = 0.00011; v36_KmB = 0.00163; v36_KmC = 0.00037; v36_KmP = 0.016; v36_KmQ = 0.00024; v36_KmR = 5.1e-005; v36_Keq = 9; v36_Kia = 0.00015; v36_Kib = 0.0016; v36_Kic = 0.00013; v36_Kip = 0.0079; v36_Kiq = 0.00019; v36_Kir = 0.00024; v36_KcF = 200; v36_KcR = 20; v36_v36_PC = 3.8617e-007; v37_K = 3.4e-005; v37_V = 3.99e-008; v37_v37_GUT2P = 0.001; v38_K = 34; v38_V = 0.0399; v38_v38_GUT2P = 0.001; v40_V = 0.1667; v40_K = 0.012; v40_v40_AAC = 0.00033211; v41_phi0 = 0.051; v41_phi1 = 9.5e-008; v41_phi2 = 9.6e-007; v41_phi12 = 9e-008; v41_phir0 = 0.066; v41_phir1 = 3.7e-007; v41_phir2 = 2.9e-005; v41_phir3 = 0.00025; v41_phir12 = 6e-012; v41_phir13 = 1.3e-010; v41_phir23 = 9.4e-008; v41_phir123 = 4.6e-014; v41_v41_IDHc = 3.8617e-007; v42_KiS1 = 0.00013; v42_KiS2 = 0.00044; v42_KiP1 = 0.00033; v42_KiP2 = 4.18e-005; v42_KcF = 5.6; v42_KcR = 3.5; v42_alpha = 1; v42_beta = 1; v42_gamma = 1; v42_delta = 1; v42_v42_CIC = 0.00033211; v43_V = 1.11667; v43_K = 0.005; v43_v43_AAC = 0.00033211; v39_Kcat = 0.333; v39_Kmal = 0.000125; v39_Knadp = 0.011; v39_v39_MDH = 3.8617e-007; v44_Kcat = 130.5; v44_Km = 0.01295; v44_v44_MDH = 3.8617e-007; // Other declarations: const CYTOPLASM, MT_IMS, MT_IM, MATRIX, flow; // Display Names: CYTOPLASM is "cytoplasm"; MT_IMS is "mitochondrial intermembrane space"; MT_IM is "mitochondrial inner membrane"; MATRIX is "mitochondrial matrix"; GLC is "glucose"; F6P is "fructose-6-phosphate"; FBP is "fructose-1,6-bisphosphate"; GAP is "glyceraldehyde 3-phosphate"; DPG is "1,2-bisphospho-D-glycerate"; PEP is "phosphoenolpyruvate"; PYR_cyt is "pyruvate"; AMP is "adenine monophosphate"; LAC is "lactate"; G3P is "glycerol-3-phosphate"; DHAP is "dihydrohxyacetone-phosphate"; OXA_cyt is "oxaloacetate"; Asp_cyt is "aspartate"; Glu_cyt is "glutamate"; OG_cyt is "oxoglutarate"; Mal_cyt is "malate"; Acetyl_CoA_cyt is "acetyl CoA"; CoA_cyt is "coenzyme A"; IsoCitcyt is "isocitrate"; Cit_cyt is "citrate"; ATP_cyt is "adenine triphosphate"; ADP_cyt is "adenine diphosphate"; NADH_cyt is "NADH"; NADP_cyt is "NADP"; NADPH_cyt is "NADPH"; Pyr is "pyruvate"; CO2 is "carbon dioxide"; CoA is "coenzyme A"; Acetyl_CoA is "acetyl CoA"; Pi_ is "phosphate"; Fum is "fumarate"; SCoA is "succinyl-CoA"; Suc is "succinate"; GTP is "guanosine triphosphate"; GDP is "guanosine diphosphate"; Ala is "slanine"; Asp is "aspartate"; Glu is "glutamate"; H2O is "water"; ETFred is "electron transfer flavoprotein (reduced form)"; ETFox is "electron transfer flavoprotein (oxidised form)"; OG is "oxoglutarate"; Mal is "malate"; OXA is "oxaloacetate"; Cit is "citrate"; IsoCit is "isocitrate"; ATP is "adenine triphosphate"; ADP is "adenine diphosphate"; NADP_p is "NADP+"; NAD_p is "NAD+"; Q is "ubiquinone"; QH2 is "ubiquinol"; Cytc3p is "ferrocytochrome c"; Cytc2p is "ferricytochrome c"; v1 is "glucokinase"; v2 is "6-phosphofructokinase"; v3 is "fructose-bisphosphate aldolase"; v4 is "glyceraldehyde 3-phosphate dehydrogenase"; v5 is "bisphosphoglycerate phosphotase (1/2)"; v6 is "pyruvate kinase"; v7 is "lactate dehydrogenase"; v8 is "pyruvate carrier"; v9 is "pyruvate dehydrogenase complex"; v10 is "citrate synthase"; v11 is "aconitase"; v12 is "isocitrate dehydrogenase (NAD+) (alpha/beta/gamma)"; v14 is "oxoglutarate dehydrogenase complex"; v15 is "succinyl-CoA synthetase"; v16 is "succinate dehydrogenase"; v17 is "fumarase"; v18 is "malate dehydrogenase (mitochondrion)"; v20 is "alanine transaminase"; v21 is "aspartate transaminase"; v22 is "aspartate/glutamate carrier"; v24 is "NADH:ubiquinone oxidoreductase"; v25 is "ubiquinol:cytochrome c oxidoreductase"; v26 is "cytochrome c oxidase"; v27 is "citrate synthase"; v28 is "ATPase complex"; v29 is "aconitase"; v30 is "oxoglutarate carrier"; v31 is "malate dehydrogenase (cytosol)"; v32 is "aspartate transaminase"; v33 is "citrate carrier"; v34 is "ETF:Q oxidoreductase"; v35 is "glutathione reductase"; v36 is "pyruvate decarboxylase"; v37 is "glycerol-3-phosphate dehydrogenase (FAD dependent)"; v38 is "glycerol-3-phosphate dehydrogenase (NAD+ dependent)"; v40 is "ATP/ADP carrier"; v41 is "cytosolic isocitrate dehydrogenase"; v42 is "citrate carrier"; v43 is "ATP/ADP carrier"; v39 is "malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)"; v44 is "malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)"; end