// Created by libAntimony v2.8.0 model *InsEGFdiam_2008_10_03_debugged() // Compartments and Species: compartment cell, extra; species EGF in extra, I in extra, RE in cell, Rd in cell, Rp in cell, GS in cell; species Rp_GS in cell, Shc in cell, Rp_Shc in cell, Rp_pShc in cell, pShc in cell; species Rp_pShc_GS in cell, PI3K in cell, Rp_PI3K in cell, RasGAP in cell; species Rp_RasGAP in cell, IRL in cell, IRp in cell, IRp_PI3K in cell, IRp_RasGAP in cell; species IRS in cell, IRp_IRS in cell, IRp_IRSp in cell, IRSp in cell, iSrc in cell; species mIRS in cell, mIRSp in cell, mIRSp_GS in cell, mIRSp_PI3K in cell; species SHP2 in cell, mIRSp_SHP2 in cell, GAB in cell, mGAB in cell, mGABp in cell; species mGABp_GS in cell, mGABp_PI3K in cell, mGABp_SHP2 in cell, mGABp_pSHP2 in cell; species PIP3 in cell, dRas in cell, Raf in cell, aRaf in cell, Mek in cell; species Erk in cell, pErk in cell, PDK1 in cell, Akt in cell, pAkt in cell; species mTOR in cell, Null in cell, aaRaf in cell, PKA in cell, pShc_GS in cell; species ppMek in cell, mGABp_pSHP2_GS in cell, R in cell, ppErk in cell; species IR in cell, mPDK1 in cell, tRas in cell, tRas_PI3K in cell, ppAkt in cell; species mGABp_RasGAP in cell, amTOR in cell, iGS in cell, imGAB in cell; species imIRS in cell, aSrc in cell, Ri in cell, IRi in cell, iPX in cell; species aPX in cell, aPX_GS in cell, IRSp_PI3K in cell, IRSp_GS in cell; species IRSp_SHP2 in cell, GABp in cell, GABp_PI3K in cell, GABp_GS in cell; species GABp_RasGAP in cell, GABp_SHP2 in cell, GABp_pSHP2 in cell, GABp_pSHP2_GS in cell; species imGABp in cell, bRasGAP in cell, $phosphorylated_Akt in cell; // Assignment Rules: phosphorylated_Akt := pAkt + ppAkt; EGF_tot := EGF + (RE + 2*(Rd + Rp + Ri + Rp_GS + Rp_Shc + Rp_pShc + Rp_pShc_GS + Rp_PI3K + Rp_RasGAP))*(cell/extra); k11 := k9; k_1 := Kd1*k1; k_2 := Kd2*k2; k_4 := Kd4*k4; k_5 := Kd5*k5; k_7 := Kd7*k7; k_9 := Kd9*k9; k_10 := Kd10*k10; k_11 := k_9; k_12 := Kd12*k12; k_13 := Kd13*k13; k_24 := Kd24*k24; k_26 := Kd26*k26; k_27 := Kd27*k27; k_28 := Kd28*k28; k_30 := Kd30*k30; k_42 := Kd42*k42; k_45 := k45*Kd45; k_46 := Kd46*k46; k_47 := Kd47*k47; k_49 := Kd49*k49; k_52 := k52*Kd52; k_53 := Kd53*k53; k_54 := Kd54*k54; k_55 := Kd55*k55; k_59 := Kd59*k59; k_74 := k74*Kd74; // Reactions: reaction_1: R + EGF -> RE; (k1*R*EGF - k_1*RE)*cell; reaction_2: 2RE -> Rd; (k2*RE*RE - k_2*Rd)*cell; reaction_3: Rd => Rp; k3*Rd*cell; reaction_4: Rp + GS -> Rp_GS; (k4*Rp*GS - k_4*Rp_GS)*cell; reaction_5: Rp + Shc -> Rp_Shc; (k5*Rp*Shc - k_5*Rp_Shc)*cell; reaction_6: Rp_Shc => Rp_pShc; k6*Rp_Shc*cell; reaction_7: Rp_pShc -> Rp + pShc; (k_7*Rp_pShc - k7*Rp*pShc)*cell; reaction_8: pShc => Shc; (V8*pShc)/(Km8 + pShc)*cell; reaction_9: GS + Rp_pShc -> Rp_pShc_GS; (k9*Rp_pShc*GS - k_9*Rp_pShc_GS)*cell; reaction_10: Rp_pShc_GS -> Rp + pShc_GS; (k_10*Rp_pShc_GS - k10*Rp*pShc_GS)*cell; reaction_11: pShc_GS -> GS + pShc; (k_11*pShc_GS - k11*pShc*GS)*cell; reaction_12: Rp + PI3K -> Rp_PI3K; (k12*Rp*PI3K - k_12*Rp_PI3K)*cell; reaction_13: Rp + RasGAP -> Rp_RasGAP; (k13*Rp*RasGAP - k_13*Rp_RasGAP)*cell; reaction_17: Rp => Null; k17*Rp*cell; reaction_18: Rp_GS => GS; k17*Rp_GS*cell; reaction_19: Rp_Shc => Shc; k17*Rp_Shc*cell; reaction_20: Rp_pShc => pShc; k17*Rp_pShc*cell; reaction_21: Rp_pShc_GS => pShc_GS; k17*Rp_pShc_GS*cell; reaction_22: Rp_PI3K => PI3K; k17*Rp_PI3K*cell; reaction_23: Rp_RasGAP => RasGAP; k17*Rp_RasGAP*cell; reaction_24: I + IR -> IRL; (k24*IR*I - k_24*IRL)*cell; reaction_25: IRL => IRp; k25*IRL*cell; reaction_26: PI3K + IRp -> IRp_PI3K; (k26*IRp*PI3K - k_26*IRp_PI3K)*cell; reaction_27: RasGAP + IRp -> IRp_RasGAP; (k27*IRp*RasGAP - k_27*IRp_RasGAP)*cell; reaction_28: IRp + IRS -> IRp_IRS; (k28*IRp*IRS - k_28*IRp_IRS)*cell; reaction_29: IRp_IRS => IRp_IRSp; k29*IRp_IRS*cell; reaction_30: IRp_IRSp -> IRp + IRSp; (k_30*IRp_IRSp - k30*IRp*IRSp)*cell; reaction_31: IRSp => IRS; (V31*IRSp)/(Km31 + IRSp)*cell; reaction_34: IRp => Null; k17*IRp*cell; reaction_35: IRp_PI3K => PI3K; k17*IRp_PI3K*cell; reaction_36: IRp_RasGAP => RasGAP; k17*IRp_RasGAP*cell; reaction_37: IRp_IRS => IRS; k17*IRp_IRS*cell; reaction_38: IRp_IRSp => IRSp; k17*IRp_IRSp*cell; reaction_40: iSrc => aSrc; (kcat40*iSrc*(Rp + alpha40*IRp))/(Km40 + iSrc)*cell; reaction_41: aSrc => iSrc; (V41*aSrc)/(Km41 + aSrc)*cell; reaction_42: IRS + PIP3 -> mIRS; (k42*IRS*PIP3 - k_42*mIRS)*cell; reaction_43: mIRS => mIRSp; (kcat43*mIRS*(IRp + alpha43*Rp))/(Km43 + mIRS)*cell; reaction_44: mIRSp => mIRS; (V31*mIRSp)/(Km31 + mIRSp)*cell; reaction_45: GS + mIRSp -> mIRSp_GS; (k45*mIRSp*GS - k_45*mIRSp_GS)*cell; reaction_46: PI3K + mIRSp -> mIRSp_PI3K; (k46*mIRSp*PI3K - k_46*mIRSp_PI3K)*cell; reaction_47: mIRSp + SHP2 -> mIRSp_SHP2; (k47*mIRSp*SHP2 - k_47*mIRSp_SHP2)*cell; reaction_48: mIRSp_SHP2 => mIRS + SHP2; k48*mIRSp_SHP2*cell; reaction_49: GAB + PIP3 -> mGAB; (k49*GAB*PIP3 - k_49*mGAB)*cell; reaction_50: mGAB => mGABp; (kcat50*mGAB*(Rp + alpha50*aSrc))/(Km50 + mGAB)*cell; reaction_51: mGABp => mGAB; (V51*mGABp)/(Km51 + mGABp)*cell; reaction_52: GS + mGABp -> mGABp_GS; (k52*mGABp*GS - k_52*mGABp_GS)*cell; reaction_53: PI3K + mGABp -> mGABp_PI3K; (k53*mGABp*PI3K - k_53*mGABp_PI3K)*cell; reaction_54: RasGAP + mGABp -> mGABp_RasGAP; (k54*mGABp*RasGAP - k_54*mGABp_RasGAP)*cell; reaction_55: SHP2 + mGABp -> mGABp_SHP2; (k55*mGABp*SHP2 - k_55*mGABp_SHP2)*cell; reaction_56: mGABp_SHP2 => SHP2 + mGAB; k56*mGABp_SHP2*cell; reaction_57: mGABp_SHP2 => mGABp_pSHP2; (kcat57*mGABp_SHP2*(Rp + aSrc))/(Km57 + mGABp_SHP2)*cell; reaction_58: mGABp_pSHP2 => mGABp_SHP2; (V58*mGABp_pSHP2)/(Km58 + mGABp_pSHP2)*cell; reaction_59: GS + mGABp_pSHP2 -> mGABp_pSHP2_GS; (k59*mGABp_pSHP2*GS - k_59*mGABp_pSHP2_GS)*cell; reaction_60: => PIP3; k60*(Rp_PI3K + IRp_PI3K + mIRSp_PI3K + mGABp_PI3K + tRas_PI3K)*cell; reaction_61: PIP3 => Null; k61*PIP3*cell; reaction_62: dRas => tRas; (kcat62*dRas*(Rp_GS + Rp_pShc_GS + mIRSp_GS + mGABp_GS + mGABp_pSHP2_GS))/(Km62 + dRas)*cell; reaction_63: tRas => dRas; (kcat63*tRas*(bRasGAP + mGABp_RasGAP + Rp_RasGAP + IRp_RasGAP))/(Km63 + tRas)*cell; reaction_64: PI3K + tRas => tRas_PI3K; (k64*tRas*PI3K - k_64*tRas_PI3K)*cell; reaction_65: Raf => aRaf; (kcat65*tRas*Raf)/(Km65 + Raf)*cell; reaction_66: aRaf => aaRaf; (kcat66*aSrc*aRaf)/(Km66 + aRaf)*cell; reaction_67: aaRaf => Raf; (kcat67*aaRaf*(PKA/(Km67 + aaRaf)) + alpha67*aaRaf*(pAkt + beta67*ppAkt))*cell; reaction_68: Mek => ppMek; (kcat68*aaRaf*Mek)/(Km68 + Mek)*cell; reaction_69: ppMek => Mek; (V69*ppMek)/(Km69 + ppMek)*cell; reaction_70: Erk => pErk; (kcat70*Erk*ppMek)/(Km70 + Erk + pErk*(Km70/Km71))*cell; reaction_71: pErk => ppErk; (kcat71*pErk*ppMek)/(Km71 + pErk + Erk*(Km71/Km70))*cell; reaction_72: ppErk => pErk; (V72*ppErk)/(Km72 + ppErk + pErk*(Km72/Km73))*cell; reaction_73: pErk => Erk; (V73*pErk)/(Km73 + pErk + ppErk*(Km73/Km72))*cell; reaction_74: PIP3 + PDK1 -> mPDK1; (k74*PDK1*PIP3 - k_74*mPDK1)*cell; reaction_75: Akt => pAkt; (kcat75*mPDK1*Akt)/(Km75 + Akt)*cell; reaction_76: pAkt => Akt; (V76*pAkt)/(Km76 + pAkt)*cell; reaction_77: mTOR -> amTOR; (kcat77*mTOR*((alpha77*pAkt + ppAkt)/(Km77 + mTOR)) - k_77*amTOR)*cell; reaction_78: pAkt -> ppAkt; (kcat78*amTOR*(pAkt/(Km78 + pAkt)) - k_78*ppAkt)*cell; reaction_79: GS -> iGS; (kcat79*ppErk*(GS/(Km79 + GS)) - k_79*iGS)*cell; reaction_80: mGAB -> imGAB; (kcat80*mGAB*(ppErk/(Km80 + mGAB)) - k_80*imGAB)*cell; reaction_81: mIRS -> imIRS; (kcat81*mIRS*(amTOR/(Km81 + mIRS)) - k_81*imIRS)*cell; reaction_82: Rp => Ri; (V_82*Rp)/(Km82 + Rp)*cell; reaction_83: Ri => Rd; k83*Ri*cell; reaction_84: IRp => IRi; (V_84*IRp)/(Km84 + IRp)*cell; reaction_85: IRi => IRL; k85*IRi*cell; reaction_88: mIRSp -> IRSp + PIP3; (k_42*mIRSp - k42*PIP3*IRSp)*cell; reaction_89: mIRSp_PI3K -> PIP3 + IRSp_PI3K; (k_42*mIRSp_PI3K - k42*PIP3*IRSp_PI3K)*cell; reaction_90: mIRSp_GS -> PIP3 + IRSp_GS; (k_42*mIRSp_GS - k42*PIP3*IRSp_GS)*cell; reaction_91: mIRSp_SHP2 -> PIP3 + IRSp_SHP2; (k_42*mIRSp_SHP2 - k42*PIP3*IRSp_SHP2)*cell; reaction_92: mGABp -> PIP3 + GABp; (k_42*mGABp - k42*PIP3*GABp)*cell; reaction_93: mGABp_PI3K -> PIP3 + GABp_PI3K; (k_42*mGABp_PI3K - k42*PIP3*GABp_PI3K)*cell; reaction_94: mGABp_GS -> PIP3 + GABp_GS; (k_42*mGABp_GS - k42*PIP3*GABp_GS)*cell; reaction_95: mGABp_RasGAP -> PIP3 + GABp_RasGAP; (k_42*mGABp_RasGAP - k49*PIP3*GABp_RasGAP)*cell; reaction_96: mGABp_SHP2 -> PIP3 + GABp_SHP2; (k_42*mGABp_SHP2 - k42*PIP3*GABp_SHP2)*cell; reaction_97: mGABp_pSHP2 -> PIP3 + GABp_pSHP2; (k_42*mGABp_pSHP2 - k42*PIP3*GABp_pSHP2)*cell; reaction_98: mGABp_pSHP2_GS -> PIP3 + GABp_pSHP2_GS; (k_42*mGABp_pSHP2_GS - k42*PIP3*GABp_pSHP2_GS)*cell; reaction_99: IRSp_PI3K => PI3K + IRS; (V31*IRSp_PI3K)/(Km31 + IRSp_PI3K)*cell; reaction_100: IRSp_GS => GS + IRS; (V31*IRSp_GS)/(Km31 + IRSp_GS)*cell; reaction_101: IRSp_SHP2 => IRS + SHP2; k48*IRSp_SHP2*cell; reaction_102: mGABp_pSHP2 => SHP2 + mGAB; k56*mGABp_pSHP2*cell; reaction_103: mGABp_pSHP2_GS => GS + SHP2 + mGAB; k56*mGABp_pSHP2_GS*cell; reaction_104: GABp => GAB; (V51*GABp)/(Km51 + GABp)*cell; reaction_105: GABp_PI3K => PI3K + GAB; (V51*GABp_PI3K)/(Km51 + GABp_PI3K)*cell; reaction_106: GABp_GS => GS + GAB; (V51*GABp_GS)/(Km51 + GABp_GS)*cell; reaction_107: GABp_RasGAP => RasGAP + GAB; (V51*GABp_RasGAP)/(Km51 + GABp_RasGAP)*cell; reaction_108: GABp_SHP2 => SHP2 + GAB; k56*GABp_SHP2*cell; reaction_109: GABp_pSHP2 => SHP2 + GAB; k56*GABp_pSHP2*cell; reaction_110: GABp_pSHP2_GS => GS + SHP2 + GAB; k56*GABp_pSHP2_GS*cell; reaction_111: mGABp_RasGAP => RasGAP + mGAB; k111*(mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS + mIRSp_SHP2)*mGABp_RasGAP*cell; reaction_112: Rp_RasGAP => Rp + RasGAP; k111*(mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS)*Rp_RasGAP*cell; reaction_113: IRp_RasGAP => RasGAP + IRp; k111*(mGABp_SHP2 + mGABp_pSHP2 + mGABp_pSHP2_GS)*IRp_RasGAP*cell; reaction_114: Rp_RasGAP => Rp + RasGAP; k111*mIRSp_SHP2*Rp_RasGAP*cell; reaction_115: IRp_RasGAP => RasGAP + IRp; k111*mIRSp_SHP2*IRp_RasGAP*cell; reaction_117: mGABp -> imGABp; ((2*kcat80*mGABp*ppErk)/(Km80 + mGABp) - k_80*imGABp)*cell; reaction_118: imGABp => imGAB; k118*imGABp*cell; // Species initializations: EGF = 1; I = 0; RE = 0; Rd = 0; Rp = 0; GS = 200; Rp_GS = 0; Shc = 270; Rp_Shc = 0; Rp_pShc = 0; pShc = 0; Rp_pShc_GS = 0; PI3K = 200; Rp_PI3K = 0; RasGAP = 50; Rp_RasGAP = 0; IRL = 0; IRp = 0; IRp_PI3K = 0; IRp_RasGAP = 0; IRS = 300; IRp_IRS = 0; IRp_IRSp = 0; IRSp = 0; iSrc = 518; mIRS = 0; mIRSp = 0; mIRSp_GS = 0; mIRSp_PI3K = 0; SHP2 = 300; mIRSp_SHP2 = 0; GAB = 225; mGAB = 0; mGABp = 0; mGABp_GS = 0; mGABp_PI3K = 0; mGABp_SHP2 = 0; mGABp_pSHP2 = 0; PIP3 = 0; dRas = 150; Raf = 100; aRaf = 0; Mek = 200; Erk = 400; pErk = 0; PDK1 = 100; Akt = 100; pAkt = 0; mTOR = 100; Null = 0; aaRaf = 0; PKA = 100; pShc_GS = 0; ppMek = 0; mGABp_pSHP2_GS = 0; R = 100; ppErk = 0; IR = 150; mPDK1 = 0; tRas = 0; tRas_PI3K = 0; ppAkt = 0; mGABp_RasGAP = 0; amTOR = 0; iGS = 0; imGAB = 0; imIRS = 0; aSrc = 0; Ri = 0; IRi = 0; iPX = 200; aPX = 0; aPX_GS = 0; IRSp_PI3K = 0; IRSp_GS = 0; IRSp_SHP2 = 0; GABp = 0; GABp_PI3K = 0; GABp_GS = 0; GABp_RasGAP = 0; GABp_SHP2 = 0; GABp_pSHP2 = 0; GABp_pSHP2_GS = 0; imGABp = 0; bRasGAP = 1e-005; // Compartment initializations: cell = 1; extra = 34; EGF_tot has nM; // Variable initializations: k1 = 0.068; k1 has per_nMs; Kd1 = 0.58824; Kd1 has nM; k2 = 0.033; k2 has per_nMs; Kd2 = 15; Kd2 has nM; k3 = 0.4; k3 has per_sec; k4 = 0.000666; k4 has per_nMs; Kd4 = 10; Kd4 has nM; Kd5 = 10; Kd5 has nM; k5 = 0.0133; k5 has per_nMs; k6 = 0.333; k6 has per_sec; k7 = 0.000666; k7 has per_nMs; Kd7 = 400; Kd7 has nM; V8 = 200; V8 has nM_per_s; Km8 = 100; Km8 has nM; Kd9 = 10; Kd9 has nM; k9 = 0.00666; k9 has per_nMs; Kd10 = 400; Kd10 has nM; k10 = 0.0004; k10 has per_nMs; k11 has per_nMs; k12 = 0.00933; k12 has per_nMs; Kd12 = 12.45; Kd12 has nM; k13 = 6.66e-006; k13 has per_nMs; Kd13 = 200; Kd13 has nM; k17 = 0.000185; k17 has per_sec; k24 = 0.011322; k24 has per_nMs; Kd24 = 0.029412; Kd24 has nM; k25 = 1.66; k25 has per_sec; k26 = 0.00933; k26 has per_nMs; Kd26 = 124.5; Kd26 has nM; k27 = 6.66e-008; k27 has per_nMs; Kd27 = 2000000; Kd27 has nM; k28 = 0.1066; k28 has per_nMs; Kd28 = 3.75; Kd28 has nM; k29 = 0.66; k29 has per_sec; k30 = 0.0066; k30 has per_nMs; Kd30 = 10; Kd30 has nM; V31 = 333; V31 has nM_per_s; Km31 = 143.3; Km31 has nM; kcat40 = 6.6; kcat40 has per_sec; Km40 = 110; Km40 has nM; alpha40 = 0.00025; alpha40 has dimensionless; V41 = 6.66; V41 has nM_per_s; Km41 = 50; Km41 has nM; k42 = 0.00666; k42 has per_nMs; Kd42 = 10; Kd42 has nM; kcat43 = 33.3; kcat43 has per_sec; Km43 = 150; Km43 has nM; alpha43 = 0.05; alpha43 has dimensionless; Kd45 = 100000; Kd45 has nM; k45 = 0.000666; k45 has per_nMs; k46 = 0.00666; k46 has per_nMs; Kd46 = 1; Kd46 has nM; k47 = 0.000666; k47 has per_nMs; Kd47 = 1000; Kd47 has nM; k48 = 0.666; k48 has per_sec; k49 = 0.000666; k49 has per_nMs; Kd49 = 1; Kd49 has nM; kcat50 = 3333; kcat50 has per_sec; alpha50 = 0.0001; alpha50 has dimensionless; Km50 = 150; Km50 has nM; V51 = 333; V51 has nM_per_s; Km51 = 130; Km51 has nM; k52 = 0.002; k52 has per_nMs; Kd52 = 1; Kd52 has nM; k53 = 0.0133; k53 has per_nMs; Kd53 = 2.5; Kd53 has nM; k54 = 1e-005; k54 has per_nMs; Kd54 = 66666; Kd54 has nM; k55 = 0.000666; k55 has per_nMs; Kd55 = 100; Kd55 has nM; k56 = 0.666; k56 has per_sec; kcat57 = 0.133; kcat57 has per_sec; Km57 = 150; Km57 has nM; V58 = 2; V58 has nM_per_s; Km58 = 130; Km58 has nM; k59 = 0.01; k59 has per_nMs; Kd59 = 20; Kd59 has nM; k60 = 4.66; k60 has per_sec; k61 = 3.33; k61 has per_sec; kcat62 = 5.33; kcat62 has per_sec; Km62 = 50; Km62 has nM; kcat63 = 20000; kcat63 has per_sec; Km63 = 50; Km63 has nM; k64 = 0; k64 has per_nMs; k_64 = 2.5; k_64 has per_sec; kcat65 = 0.1; kcat65 has per_sec; Km65 = 400; Km65 has nM; kcat66 = 3.33; kcat66 has per_sec; Km66 = 10; Km66 has nM; kcat67 = 0.666; kcat67 has per_sec; Km67 = 10000; Km67 has nM; alpha67 = 1e-006; alpha67 has per_nMs; beta67 = 2; beta67 has dimensionless; kcat68 = 0.133; kcat68 has per_sec; Km68 = 50; Km68 has nM; V69 = 16.6; V69 has nM_per_s; Km69 = 675.299; Km69 has nM; kcat70 = 0.333; kcat70 has per_sec; Km70 = 500; Km70 has nM; kcat71 = 0.666; kcat71 has per_sec; Km71 = 500; Km71 has nM; V72 = 33.3; V72 has nM_per_s; Km72 = 500; Km72 has nM; V73 = 23.33; V73 has nM_per_s; Km73 = 500; Km73 has nM; k74 = 0.00666; k74 has per_nMs; Kd74 = 100; Kd74 has nM; kcat75 = 4.66; kcat75 has per_sec; Km75 = 500; Km75 has nM; V76 = 16.66; V76 has nM_per_s; Km76 = 1; Km76 has nM; kcat77 = 0.666; kcat77 has per_sec; alpha77 = 0.5; alpha77 has dimensionless; Km77 = 100; Km77 has nM; k_77 = 0.666; k_77 has per_sec; kcat78 = 0.666; kcat78 has per_sec; Km78 = 100; Km78 has nM; k_78 = 0.666; k_78 has per_sec; kcat79 = 0.0466; kcat79 has per_sec; Km79 = 5000; Km79 has nM; k_79 = 6.66e-005; k_79 has per_sec; kcat80 = 0.04; kcat80 has per_sec; Km80 = 700; Km80 has nM; k_80 = 6.66e-005; k_80 has per_sec; kcat81 = 0.166; kcat81 has per_sec; Km81 = 300; Km81 has nM; k_81 = 6.66e-005; k_81 has per_sec; V_82 = 133; V_82 has nM_per_s; Km82 = 50; Km82 has nM; k83 = 0.0166; k83 has per_sec; V_84 = 333; V_84 has nM_per_s; Km84 = 266; Km84 has nM; k85 = 0.0166; k85 has per_sec; k111 = 0.0133; k111 has per_nMs; k118 = 0.001; k118 has per_sec; k_1 has per_sec; k_2 has per_sec; k_4 has per_sec; k_5 has per_sec; k_7 has per_sec; k_9 has per_sec; k_10 has per_sec; k_11 has per_sec; k_12 has per_sec; k_13 has per_sec; k_24 has per_sec; k_26 has per_sec; k_27 has per_sec; k_28 has per_sec; k_30 has per_sec; k_42 has per_sec; k_45 has per_sec; k_46 has per_sec; k_47 has per_sec; k_49 has per_sec; k_52 has per_sec; k_53 has per_sec; k_54 has per_sec; k_55 has per_sec; k_59 has per_sec; k_74 has per_sec; // Other declarations: var EGF_tot, k11, k_1, k_2, k_4, k_5, k_7, k_9, k_10, k_11, k_12, k_13; var k_24, k_26, k_27, k_28, k_30, k_42, k_45, k_46, k_47, k_49, k_52, k_53; var k_54, k_55, k_59, k_74; const cell, extra, k1, Kd1, k2, Kd2, k3, k4, Kd4, Kd5, k5, k6, k7, Kd7; const V8, Km8, Kd9, k9, Kd10, k10, k12, Kd12, k13, Kd13, k17, k24, Kd24; const k25, k26, Kd26, k27, Kd27, k28, Kd28, k29, k30, Kd30, V31, Km31, kcat40; const Km40, alpha40, V41, Km41, k42, Kd42, kcat43, Km43, alpha43, Kd45; const k45, k46, Kd46, k47, Kd47, k48, k49, Kd49, kcat50, alpha50, Km50; const V51, Km51, k52, Kd52, k53, Kd53, k54, Kd54, k55, Kd55, k56, kcat57; const Km57, V58, Km58, k59, Kd59, k60, k61, kcat62, Km62, kcat63, Km63; const k64, k_64, kcat65, Km65, kcat66, Km66, kcat67, Km67, alpha67, beta67; const kcat68, Km68, V69, Km69, kcat70, Km70, kcat71, Km71, V72, Km72, V73; const Km73, k74, Kd74, kcat75, Km75, V76, Km76, kcat77, alpha77, Km77, k_77; const kcat78, Km78, k_78, kcat79, Km79, k_79, kcat80, Km80, k_80, kcat81; const Km81, k_81, V_82, Km82, k83, V_84, Km84, k85, k111, k118; // Unit definitions: unit substance = 1e-9 mole; unit time_unit = second; unit nM = 1e-9 mole / litre; unit per_nM = litre / 1e-9 mole; unit per_sec = 1 / second; unit nM_per_s = 1e-9 mole / (litre * second); unit per_nMs = litre / (1e-9 mole * second); // Display Names: substance is "nanomole"; time_unit is "seconds"; per_sec is "per second"; nM_per_s is "nM per sec"; per_nMs is "per nM per s"; extra is "extracellular space"; end