// Created by libAntimony v2.8.0 model *Folate2004() // Compartments and Species: compartment compartment_; species _5mTHF in compartment_, THF in compartment_, DHF in compartment_; species _5_10_CH2THF in compartment_, _5_10_CHTHF in compartment_, _10fTHF in compartment_; species $Ser in compartment_, $Gly in compartment_, $dUMP in compartment_; species $GAR in compartment_, $AICAR in compartment_, $HCOOH in compartment_; species $NADPH in compartment_, $Hcy in compartment_; // Reactions: V_NE: THF => _5_10_CH2THF; HCOOH*NE_k1*THF - NE_k2*_5_10_CH2THF; V_MS: _5mTHF => THF; (MS_Vmax*(_5mTHF/MS_Km_5mTHF)*(Hcy/MS_Km_Hcy))/(MS_Kd/MS_Km_5mTHF + _5mTHF/MS_Km_5mTHF + Hcy/MS_Km_Hcy + (_5mTHF*Hcy)/(MS_Km_5mTHF*MS_Km_Hcy)); V_MTHFR: _5_10_CH2THF => _5mTHF; MTHFR_Vmax*(NADPH/(MTHFR_Km_NADPH + NADPH))*(_5_10_CH2THF/(MTHFR_Km_5_10_CH2THF + _5_10_CH2THF)); V_FTD: _10fTHF => THF; FTD_Vmax*(_10fTHF/(FTD_Km_10fTHF + _10fTHF)); V_FTS: THF => _10fTHF; FTS_Vmax*(HCOOH/(FTS_Km_HCOOH + HCOOH))*(THF/(FTS_Km_THF + THF)); V_AICART: _10fTHF => THF; AICART_Vmax*(AICAR/(AICART_Km_AICAR + AICAR))*(_10fTHF/(AICART_Km_10fTHF + _10fTHF)); V_PGT: _10fTHF => THF; PGT_Vmax*(GAR/(PGT_Km_GAR + GAR))*(_10fTHF/(PGT_Km_10fTHF + _10fTHF)); V_TS: _5_10_CH2THF => DHF; TS_Vmax*(dUMP/(TS_Km_dUMP + dUMP))*(_5_10_CH2THF/(TS_Km_5_10_CH2THF + _5_10_CH2THF)); V_DHFR: DHF => THF; DHFR_Vmax*(NADPH/(DHFR_Km_NADPH + NADPH))*(DHF/(DHFR_Km_DHF + DHF)); V_MTCH: _5_10_CHTHF => _10fTHF; MTCH_VmaxF*(_5_10_CHTHF/(MTCH_Km_5_10_CHTHF + _5_10_CHTHF)) - MTCH_VmaxR*(_10fTHF/(MTCH_Km_10fTHF + _10fTHF)); V_SHMT: THF => _5_10_CH2THF; SHMT_VmaxF*(Ser/(SHMT_Km_Ser + Ser))*(THF/(SHMT_Km_THF + THF)) - SHMT_VmaxR*(Gly/(SHMT_Km_Ser + Gly))*(_5_10_CH2THF/(SHMT_Km_THF + _5_10_CH2THF)); V_MTD: _5_10_CH2THF => _5_10_CHTHF; MTD_VmaxF*(_5_10_CH2THF/(MTD_Km_5_10_CH2THF + _5_10_CH2THF)) - MTD_VmaxR*(_5_10_CHTHF/(MTD_Km_5_10_CHTHF + _5_10_CHTHF)); // Species initializations: _5mTHF = 5.16; THF = 6.73; DHF = 0.027; _5_10_CH2THF = 0.94; _5_10_CHTHF = 1.153; _10fTHF = 5.99; Ser = 468; Gly = 1850; dUMP = 20; GAR = 10; AICAR = 2.1; HCOOH = 900; NADPH = 50; Hcy = 1; // Compartment initializations: compartment_ = 1; // Variable initializations: NE_k1 = 0.15; NE_k2 = 12; MS_Vmax = 500; MS_Km_5mTHF = 25; MS_Km_Hcy = 0.1; MS_Kd = 1; MTHFR_Vmax = 6000; MTHFR_Km_NADPH = 16; MTHFR_Km_5_10_CH2THF = 50; FTD_Vmax = 14000; FTD_Km_10fTHF = 20; FTS_Vmax = 2000; FTS_Km_HCOOH = 43; FTS_Km_THF = 3; AICART_Vmax = 45000; AICART_Km_AICAR = 100; AICART_Km_10fTHF = 5.9; PGT_Vmax = 16200; PGT_Km_GAR = 520; PGT_Km_10fTHF = 4.9; TS_Vmax = 50; TS_Km_dUMP = 6.3; TS_Km_5_10_CH2THF = 14; DHFR_Vmax = 50; DHFR_Km_NADPH = 4; DHFR_Km_DHF = 0.5; MTCH_VmaxF = 800000; MTCH_Km_5_10_CHTHF = 250; MTCH_VmaxR = 20000; MTCH_Km_10fTHF = 100; SHMT_VmaxF = 40000; SHMT_Km_Ser = 600; SHMT_Km_THF = 50; SHMT_VmaxR = 25000; MTD_VmaxF = 200000; MTD_Km_5_10_CH2THF = 2; MTD_VmaxR = 594000; MTD_Km_5_10_CHTHF = 10; // Other declarations: const compartment_, NE_k1, NE_k2, MS_Vmax, MS_Km_5mTHF, MS_Km_Hcy, MS_Kd; const MTHFR_Vmax, MTHFR_Km_NADPH, MTHFR_Km_5_10_CH2THF, FTD_Vmax, FTD_Km_10fTHF; const FTS_Vmax, FTS_Km_HCOOH, FTS_Km_THF, AICART_Vmax, AICART_Km_AICAR; const AICART_Km_10fTHF, PGT_Vmax, PGT_Km_GAR, PGT_Km_10fTHF, TS_Vmax, TS_Km_dUMP; const TS_Km_5_10_CH2THF, DHFR_Vmax, DHFR_Km_NADPH, DHFR_Km_DHF, MTCH_VmaxF; const MTCH_Km_5_10_CHTHF, MTCH_VmaxR, MTCH_Km_10fTHF, SHMT_VmaxF, SHMT_Km_Ser; const SHMT_Km_THF, SHMT_VmaxR, MTD_VmaxF, MTD_Km_5_10_CH2THF, MTD_VmaxR; const MTD_Km_5_10_CHTHF; end