// Created by libAntimony v2.8.0 model *MODEL8390025091() // Compartments and Species: compartment cell; species $OCT4_Gene in cell, $NANOG_Gene in cell, $SOX2_Gene in cell, $GATA6_Gene in cell; species $CDX2_Gene in cell, $GCNF_Gene in cell, $targetGene in cell, $degradation in cell; species $p53 in cell, $A in cell, $SG in cell, $SN in cell, OCT4 in cell; species SOX2 in cell, NANOG in cell, GATA6 in cell, CDX2 in cell, GCNF in cell; species OCT4_SOX2 in cell, Protein in cell; // Reactions: R1: $OCT4_Gene => OCT4; (a0 + a1*A + a2*OCT4*SOX2 + a3*OCT4*SOX2*NANOG)/(1 + b0*A + b1*OCT4 + b2*OCT4*SOX2 + b3*OCT4*SOX2*NANOG + b4*CDX2*OCT4 + b5*GCNF); R2: OCT4 => $degradation; gamma1*OCT4; R3: $SOX2_Gene => SOX2; (c0 + c1*OCT4*SOX2 + c2*OCT4*SOX2*NANOG)/(1 + d0*OCT4 + d1*OCT4*SOX2 + d2*OCT4*SOX2*NANOG); R4: SOX2 => $degradation; gamma2*SOX2; R5: $NANOG_Gene => NANOG; (e0 + e1*OCT4*SOX2 + e2*OCT4*SOX2*NANOG + e3*SN)/(1 + f0*OCT4 + f1*OCT4*SOX2 + f2*OCT4*SOX2*NANOG + f3*OCT4*GATA6 + f4*SN); R6: NANOG => $degradation; gamma3*NANOG; R7: $CDX2_Gene => CDX2; (g0 + g1*CDX2)/(1 + h0*CDX2 + h1*CDX2*OCT4); R8: CDX2 => $degradation; gamma4*CDX2; R9: $GCNF_Gene => GCNF; (i0 + i1*CDX2 + i2*GATA6)/(1 + j0*CDX2 + j1*GATA6); R10: GCNF => $degradation; gamma5*GCNF; R11: $GATA6_Gene => GATA6; (p0 + p1*OCT4 + p2*GATA6)/(1 + q0*OCT4 + q1*GATA6 + q2*NANOG + q3*SG); R12: GATA6 => $degradation; gammag*GATA6; // Species initializations: OCT4_Gene = 0; NANOG_Gene = 0; SOX2_Gene = 0; GATA6_Gene = 0; CDX2_Gene = 0; GCNF_Gene = 0; targetGene = 0.01; degradation = 0; p53 = 0; A = 25; SG = 0; SN = 0; OCT4 = 0.01; SOX2 = 0.01; NANOG = 0.01; GATA6 = 0.01; CDX2 = 0.01; GCNF = 0.01; OCT4_SOX2 = 0.1; Protein = 0; // Compartment initializations: cell = 1; // Variable initializations: a0 = 0.001; a1 = 1; a2 = 0.005; a3 = 0.025; b0 = 1; b1 = 0.001; b2 = 0.005; b3 = 0.025; b4 = 10; b5 = 10; gamma1 = 0.1; c0 = 0.001; c1 = 0.005; c2 = 0.025; d0 = 0.001; d1 = 0.005; d2 = 0.025; d3 = 0.05; gamma2 = 0.1; e0 = 0.001; e1 = 0.1; e2 = 0.1; e3 = 1; f0 = 0.001; f1 = 0.1; f2 = 0.1; f3 = 10; f4 = 1; gamma3 = 0.1; g0 = 0.001; g1 = 2; h0 = 2; h1 = 5; gamma4 = 0.1; i0 = 0.001; i1 = 0.1; i2 = 0.1; j0 = 0.1; j1 = 0.1; gamma5 = 0.1; p0 = 0.1; p1 = 1; p2 = 0.00025; q0 = 1; q1 = 0.00025; q2 = 15; q3 = 10; gammag = 0.1; gamman = 0.01; // Other declarations: const cell, a0, a1, a2, a3, b0, b1, b2, b3, b4, b5, gamma1, c0, c1, c2; const d0, d1, d2, d3, gamma2, e0, e1, e2, e3, f0, f1, f2, f3, f4, gamma3; const g0, g1, h0, h1, gamma4, i0, i1, i2, j0, j1, gamma5, p0, p1, p2, q0; const q1, q2, q3, gammag, gamman; // Unit definitions: unit substance = dimensionless; unit volume = litre; unit time_unit = dimensionless; // Display Names: substance is "arb_substance"; volume is "arb_volume"; time_unit is "arb_time"; end