// Created by libAntimony v2.8.0 model *KDM() // Compartments and Species: compartment Cytoplasm; species Mad1_CMad2 in Cytoplasm, OMad2 in Cytoplasm, Mad1_CMad2_OMad2 in Cytoplasm; species Cdc20 in Cytoplasm, Cdc20_CMad2 in Cytoplasm, Bub3_BubR1 in Cytoplasm; species MCC in Cytoplasm, Bub3_BubR1_Cdc20 in Cytoplasm; // Reactions: R1: Mad1_CMad2 + OMad2 -> Mad1_CMad2_OMad2; Cytoplasm*(u*k1f*Mad1_CMad2*OMad2 - k1r*Mad1_CMad2_OMad2); R2: Mad1_CMad2_OMad2 + Cdc20 => Mad1_CMad2 + Cdc20_CMad2; Cytoplasm*u*k2f*Mad1_CMad2_OMad2*Cdc20; R3: Cdc20_CMad2 => Cdc20 + OMad2; Cytoplasm*k3f*Cdc20_CMad2; R4: Cdc20_CMad2 + Bub3_BubR1 -> MCC; Cytoplasm*(u*k4f*Cdc20_CMad2*Bub3_BubR1 - k4r*MCC); R5: Bub3_BubR1 + Cdc20 -> Bub3_BubR1_Cdc20; Cytoplasm*(u*k5f*Bub3_BubR1*Cdc20 - k5r*Bub3_BubR1_Cdc20); R6: OMad2 + Cdc20 => Cdc20_CMad2; Cytoplasm*kf6*OMad2*Cdc20; // Events: mt_attachment: at time > 2000: u = const_val_0; // Species initializations: Mad1_CMad2 = 5e-008; Mad1_CMad2 has mole_per_volume; OMad2 = 1.3e-007; OMad2 has mole_per_volume; Mad1_CMad2_OMad2 = 0; Mad1_CMad2_OMad2 has mole_per_volume; Cdc20 = 2.2e-007; Cdc20 has mole_per_volume; Cdc20_CMad2 = 0; Cdc20_CMad2 has mole_per_volume; Bub3_BubR1 = 1.3e-007; Bub3_BubR1 has mole_per_volume; MCC = 0; MCC has mole_per_volume; Bub3_BubR1_Cdc20 = 0; Bub3_BubR1_Cdc20 has mole_per_volume; // Compartment initializations: Cytoplasm = 1; // Variable initializations: u = 1; u has dimensionless; const_val_0 = 0; const_val_0 has dimensionless; k3f = 0.01; k3f has ps; kf6 = 1000; kf6 has pMp; k5f = 10000; k5f has pMp; k5r = 0.2; k5r has ps; k2f = 10000000; k2f has pMp; k1f = 200000; k1f has pMp; k1r = 0.2; k1r has ps; k4f = 10000000; k4f has pMp; k4r = 0.02; k4r has ps; const_val_1 = 1; const_val_1 has dimensionless; // Other declarations: var u; const Cytoplasm, const_val_0, k3f, kf6, k5f, k5r, k2f, k1f, k1r, k4f, k4r; const const_val_1; // Unit definitions: unit ps = 1 / second; unit pMp = litre / (mole * second); unit mole_per_volume = mole / litre; // Display Names: ps is "per second"; pMp is "liter per mole per second"; Mad1_CMad2 is "Mad1:C-Mad2"; OMad2 is "O-Mad2"; Mad1_CMad2_OMad2 is "Mad1:C-Mad2:O-Mad2*"; Cdc20_CMad2 is "Cdc20:C-Mad2"; Bub3_BubR1 is "Bub3:BubR1"; Bub3_BubR1_Cdc20 is "Bub3:BubR1:Cdc20"; mt_attachment is "Microtubule attachment"; end