// Created by libAntimony v2.8.0 model *Singh2006_IL6_Signal_Transduction() // Compartments and Species: compartment cytosol, nucleus; species $x1 in cytosol, x2 in cytosol, x6 in cytosol, x5 in cytosol, x7 in cytosol; species x8 in cytosol, x16 in cytosol, x15 in cytosol, x9 in cytosol, x11 in cytosol; species x10 in cytosol, x12 in cytosol, x29 in cytosol, x30 in cytosol; species x39 in cytosol, x46 in cytosol, x40 in cytosol, x45 in cytosol; species x41 in cytosol, x44 in cytosol, x18 in cytosol, x17 in cytosol; species x14 in cytosol, x22 in nucleus, x32 in cytosol, x13 in cytosol; species x20 in nucleus, x21 in nucleus, x23 in nucleus, x27 in nucleus; species x24 in nucleus, x25 in nucleus, x34 in cytosol, x36 in cytosol; species x42 in cytosol, x37 in cytosol, x47 in cytosol, x48 in cytosol; species x52 in cytosol, x51 in cytosol, x50 in cytosol, x53 in cytosol; species x54 in cytosol, x55 in cytosol, x60 in cytosol, x59 in cytosol; species x57 in cytosol, x61 in cytosol, x62 in cytosol, x63 in cytosol; species x65 in cytosol, x68 in cytosol, x35 in cytosol, x28 in nucleus; species x31 in cytosol, x56 in cytosol, x43 in cytosol, $x3 in cytosol; species x58 in cytosol, x4 in cytosol, x26 in nucleus, x49 in cytosol, x33 in cytosol; species x64 in cytosol, x19 in cytosol, x38 in cytosol, x66 in cytosol; species x67 in cytosol; // Reactions: R1: => x2; cytosol*kf0*x1*IL6; R2: x2 => ; cytosol*kr0*x2; R3: x6 => x5 + x2; cytosol*(kr2*x6 - kf2*x2*x5); R5: x4 => x5; cytosol*(kf1*x3*x4 - kr1*x5); R7: 2x6 => x7; cytosol*kf3*x6^2; R8: x7 => 2x6; cytosol*kr3*x7; R9: x7 => x8; cytosol*k4*x7; R10: x16 => x15 + x7; cytosol*k10*x16; R11: x9 + x8 => x11; cytosol*(kf5*x8*x9 - kr5*x11); R12: x11 => x10 + x8; cytosol*k6*x11; R13: x10 + x8 -> x12; cytosol*(kf7*x8*x10 - kr7*x12); R14: x15 + x8 -> x16; cytosol*(kf9*x8*x15 - kr9*x16); R15: x29 + x8 -> x30; cytosol*(kf21*x29*x8 - kr21*x30); R16: x39 -> x46 + x8; cytosol*(kf37*x39 - kr37*x8*x46); R16a: x40 -> x45 + x8; cytosol*(kf39*x40 - kr39*x45*x8); R17: x41 -> x44 + x8; cytosol*(kf32*x41 - kr32*x44*x8); R18: x18 => x17 + x9; cytosol*k12*x18; R19: x10 + x9 -> x14; cytosol*(kf13*x9*x10 - kr13*x14); R20: x22 => x9; nucleus*k17*x22; R21: x30 + x9 -> x31; cytosol*(kf5*x9*x30 - kr5*x31); R22: x32 => x29 + x15 + x9 + x7; cytosol*k10*x32; R23: x10 -> 0.5x13; cytosol*(2*kf8*x10^2 - 2*kr8*x13); R24: x17 + x10 -> x18; cytosol*(kf11*x10*x17 - kr11*x18); R25: x17 + x13 -> x19; cytosol*(kf11*x13*x17 - kr11*x19); R26: x13 => x20; cytosol*k14*x13; R27: x19 => x17 + x14; cytosol*k12*x19; R28: x31 + x15 => x32; cytosol*(kf9*x15*x31 - kr9*x32); R29: x46 => x15; (cytosol*Vm*x46)/(Km + x46); R30: x16 -> x39; cytosol*(kf34*x16 - kr34*x39); R31: x20 -> 2x21; nucleus*(kr8*x20 - kf8*x21^2); R32: x23 + x20 -> x27; nucleus*(kf15*x23*x20 - kr15*x27); R33: x23 + x21 -> x28; nucleus*(kf15*x23*x21 - kr15*x28); R34: x24 -> x22 + x21; nucleus*(kr13*x24 - kf13*x21*x22); R35: x28 => x23 + x22; nucleus*k16*x28; R36: x27 => x24 + x23; nucleus*k16*x27; R37: => x25; nucleus*((k18a*x20)/(k18b + x20)); R38: x25 => x26; nucleus*k19*x25; R39: x26 => ; nucleus*k22*x26; R40: => x29; nucleus*k20*x26; R41: x29 => ; cytosol*k23*x29; R42: x32 => x33 + x29; cytosol*k23*x32; R43: x46 + x34 -> x45; cytosol*(kf38*x34*x46 - kr38*x45); R44: x38 -> x35 + x34; cytosol*(kf35*x38 - kr35*x34*x35); R45: x39 + x34 -> x40; cytosol*(kf24*x39*x34 - kr24*x40); R46: x40 + x35 -> x41; cytosol*(kf25*x35*x40 - kr25*x41); R47: x45 + x35 -> x44; cytosol*(kf40*x35*x45 - kr40*x44); R48: x41 + x36 -> x42; cytosol*(kf26*x36*x41 - kr26*x42); R49: x43 -> x41 + x36; cytosol*(kf31*x43 - kr31*x36*x41); R50: x42 -> x41 + x37; cytosol*(kf27*x42 - kr27*x37*x41); R51: x47 + x37 -> x48; cytosol*(kf28*x37*x47 - kr28*x48); R52: x39 + x38 -> x41; cytosol*(kf41*x38*x39 - kr41*x41); R53: x44 -> x46 + x38; cytosol*(kf33*x44 - kr33*x38*x46); R54: x49 + x41 -> x43; cytosol*(kf30*x49*x41 - kr30*x43); R55: x52 => x47 + x50; cytosol*k43*x52; R56: x48 -> x51 + x49; cytosol*(kf29*x48 - kr29*x49*x51); R57: x51 + x50 -> x52; cytosol*(kf42*x50*x51 - kr42*x52); R58: x53 + x51 -> x54; cytosol*(kf44*x51*x53 - kr44*x54); R59: x54 => x55 + x51; cytosol*k45*x54; R60: x55 + x51 -> x56; cytosol*(kf46*x55*x51 - kr46*x56); R61: x60 => x59 + x53; cytosol*k51*x60; R62: x58 => x59 + x55; cytosol*k49*x58; R63: x59 + x55 -> x60; cytosol*(kf50*x55*x59 - kr50*x60); R64: x56 => x51 + x57; cytosol*k47*x56; R65: x59 + x57 -> x58; cytosol*(kf48*x57*x59 - kr48*x58); R66: x61 + x57 -> x62; cytosol*(kf52*x57*x61 - kr52*x62); R67: x62 => x63 + x57; cytosol*k53*x62; R68: x64 -> x63 + x57; cytosol*(kr54*x64 - kf54*x57*x63); R69: x64 => x65 + x57; cytosol*k55*x64; R70: x68 => x66 + x61; cytosol*k59*x68; R71: x67 => x66 + x63; cytosol*k57*x67; R72: x66 + x63 -> x68; cytosol*(kf58*x63*x66 - kr58*x68); R73: x66 + x65 -> x67; cytosol*(kf56*x65*x66 - kr56*x67); // Species initializations: x1 = 8; x2 = 0; x6 = 0; x5 = 0; x7 = 0; x8 = 0; x16 = 0; x15 = 100; x9 = 1000; x11 = 0; x10 = 0; x12 = 0; x29 = 0; x30 = 0; x39 = 0; x46 = 0; x40 = 0; x45 = 0; x41 = 0; x44 = 0; x18 = 0; x17 = 50; x14 = 0; x22 = 0; x32 = 0; x13 = 0; x20 = 0; x21 = 0; x23 = 60; x27 = 0; x24 = 0; x25 = 0; x34 = 85; x36 = 19000; x42 = 0; x37 = 0; x47 = 67; x48 = 0; x52 = 0; x51 = 0; x50 = 67; x53 = 41667; x54 = 0; x55 = 0; x60 = 0; x59 = 67; x57 = 0; x61 = 35000; x62 = 0; x63 = 0; x65 = 0; x68 = 0; x35 = 34; x28 = 0; x31 = 0; x56 = 0; x43 = 0; x3 = 0.8; x58 = 0; x4 = 12; x26 = 0; x49 = 0; x33 = 0; x64 = 0; x19 = 0; x38 = 0; x66 = 16667; x67 = 0; // Compartment initializations: cytosol = 1; nucleus = 1; // Variable initializations: IL6 = 0.38; kf0 = 0.1; kr0 = 0.05; kf1 = 0.1; kr1 = 0.05; kf2 = 0.02; kr2 = 0.02; kf3 = 0.04; kr3 = 0.2; k4 = 0.005; k10 = 0.003; kf5 = 0.008; kr5 = 0.8; k6 = 0.4; kf7 = 0.005; kr7 = 0.5; kf9 = 0.001; kr9 = 0.2; kf21 = 0.02; kr21 = 0.1; kf37 = 0.3; kr37 = 0.0009; kf39 = 0.3; kr39 = 0.0009; kf32 = 0.1; kr32 = 0.000245; k12 = 0.003; kf13 = 2e-007; kr13 = 0.2; k17 = 0.05; kf8 = 0.02; kr8 = 0.1; kf11 = 0.001; kr11 = 0.2; k14 = 0.005; Vm = 1.7; Km = 340; kf34 = 6; kr34 = 0.06; kf60 = 0.5; kr60 = 0.005; kf15 = 0.001; kr15 = 0.2; kf61 = 0.2; kr61 = 2e-007; k16 = 0.005; k18a = 0.01; k18b = 400; k19 = 0.001; k22 = 0.0005; k20 = 0.01; k23 = 0.0005; kf38 = 0.01; kr38 = 0.55; kf35 = 0.0015; kr35 = 0.0045; kf24 = 0.01; kr24 = 0.55; kf25 = 0.01; kr25 = 0.0214; kf40 = 0.03; kr40 = 0.064; kf26 = 0.015; kr26 = 1.3; kf31 = 0.023; kr31 = 0.00022; kf27 = 0.5; kr27 = 0.0001; kf28 = 0.001; kr28 = 0.0053; kf41 = 0.03; kr41 = 0.0429; kf33 = 0.3; kr33 = 0.021; kf30 = 0.0079; kr30 = 0.4; k43 = 1; kf29 = 1; kr29 = 0.0007; kf42 = 0.0717; kr42 = 0.2; kf44 = 0.011; kr44 = 0.001833; k45 = 3.5; kf46 = 0.011; kr46 = 0.001833; k51 = 0.058; k49 = 0.058; kf50 = 0.00025; kr50 = 0.5; k47 = 2.9; kf48 = 0.0143; kr48 = 0.8; kf52 = 0.00011; kr52 = 0.033; k53 = 16; kr54 = 0.033; kf54 = 0.00011; k55 = 6.7; k59 = 0.3; k57 = 0.27; kf58 = 0.005; kr58 = 0.5; kf56 = 0.014; kr56 = 0.6; // Other declarations: const cytosol, nucleus, IL6, kf0, kr0, kf1, kr1, kf2, kr2, kf3, kr3, k4; const k10, kf5, kr5, k6, kf7, kr7, kf9, kr9, kf21, kr21, kf37, kr37, kf39; const kr39, kf32, kr32, k12, kf13, kr13, k17, kf8, kr8, kf11, kr11, k14; const Vm, Km, kf34, kr34, kf60, kr60, kf15, kr15, kf61, kr61, k16, k18a; const k18b, k19, k22, k20, k23, kf38, kr38, kf35, kr35, kf24, kr24, kf25; const kr25, kf40, kr40, kf26, kr26, kf31, kr31, kf27, kr27, kf28, kr28; const kf41, kr41, kf33, kr33, kf30, kr30, k43, kf29, kr29, kf42, kr42, kf44; const kr44, k45, kf46, kr46, k51, k49, kf50, kr50, k47, kf48, kr48, kf52; const kr52, k53, kr54, kf54, k55, k59, k57, kf58, kr58, kf56, kr56; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nano mole"; x1 is "gp80"; x2 is "IL6-gp80"; x6 is "IL6-gp80-gp130-JAK"; x5 is "gp130-JAK"; x7 is "(IL6-gp80-gp130-JAK)2"; x8 is "(IL6-gp80-gp130-JAK)_ast2"; x16 is "(IL6-gp80-gp130-JAK)ast2-JAK"; x15 is "SHP2"; x9 is "STAT3C"; x11 is "(IL6-gp80-gp130-JAK)ast2-STAT3C"; x10 is "STAT3Cast"; x12 is "(IL6-gp80-gp130-JAK)ast2-STAT3Cast"; x29 is "SOCS3"; x30 is "(IL6-gp80-gp130-JAK)ast2-SOCS3"; x39 is "(IL6-gp80-gp130-JAK)ast2-SHP2ast"; x46 is "SHP2ast"; x40 is "(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2"; x45 is "SHP2ast-Grb2"; x41 is "(IL6-gp80-gp130-JAK)ast2-SHP2-Grb2"; x44 is "SHP2ast-Grb2-SOS"; x18 is "PP1-STAT3Cast"; x17 is "PP1"; x14 is "STAT3C-STAT3Cast"; x22 is "STAT3N"; x32 is "(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3-SHP2"; x13 is "STAT3Cast-STAT3Cast"; x20 is "STAT3Nast-STAT3Nast"; x21 is "STAT3Nast"; x23 is "PP2"; x27 is "PP2-STAT3Nast-STAT3Nast"; x24 is "STAT3N-STAT3Nast"; x25 is "Mrna-SOCS3N"; x34 is "Grb2"; x36 is "Ras-GDP"; x42 is "(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GDP"; x37 is "Ras-GTP"; x47 is "Raf"; x48 is "Raf-Ras-GTP"; x52 is "Rafast-Phosp1"; x51 is "Rafast"; x50 is "Phosp1"; x53 is "MEK"; x54 is "MEK-Rafast"; x55 is "MEK-P"; x60 is "MEK-P-Phosp2"; x59 is "Phosp2"; x57 is "MEK-PP"; x61 is "ERK"; x62 is "ERK-MEK-PP"; x63 is "ERK-P"; x65 is "ERK-PP"; x68 is "ERK-P-Phosp3"; x35 is "SOS"; x28 is "PP2-STAT3Nast"; x31 is "(IL6-gp80-gp130-JAK)ast2-STAT3C-SOCS3"; x56 is "MEK-P-Rafast"; x43 is "(IL6-gp80-gp130-JAK)ast2-SHP2ast-Grb2-SOS-Ras-GTP"; x3 is "gp130"; x58 is "MEK-PP-Phosp2"; x4 is "JAK"; x26 is "Mrna-SOCS3C"; x49 is "Ras-GTPast"; x33 is "(IL6-gp80-gp130-JAK)ast2-STAT3C-SHP2"; x64 is "ERK-P-MEK-PP"; x19 is "PP1-STAT3Cast-STAT3Cast"; x38 is "Grb2-SOS"; x66 is "Phosp3"; x67 is "ERK-PP-Phosp3"; R1 is "IL6-gp80 complex formation"; R2 is "IL6-gp80 complex dissociation"; R3 is "IL6-gp80-gp130-JAK dissociation"; R5 is "gp130-JAK complex formation"; R7 is "IL6-gp80-gp130-JAK dimerization"; R8 is "IL6-gp80-gp130-JAK dimer dissociation"; R9 is "IL6-gp80-gp130-JAK dimer phosphorylation"; R10 is "IL6-gp80-gp130-JAK dimer-SHP2 dissociation"; R11 is "IL6-gp80-gp130-JAK -STAT3C complex formation"; R12 is "IL6-gp80-gp130-JAK -STAT3C dissociation"; R13 is "IL6-gp80-gp130-JAK-STAT3Cast complex formation"; R14 is "IL6-gp80-gp130-JAK -SHP2 complex formation"; R15 is "IL6-gp80-gp130-JAK -SOCS3 complex formation"; R16 is "IL6-gp80-gp130-JAK -SHP2 dimer dissociation"; R16a is "IL6-gp80-gp130-JAK SHP2 Grb2 dissociation"; R17 is "IL6-gp80-gp130-JAK-SHP2-Grb2-SOS dissociation"; R18 is "PP1-STAT3Cast dissociation"; R19 is "STAT3C dimerization"; R20 is "STAT3N transport"; R21 is "IL6-gp80-gp130-JAK-SOCS2-STAT3C complex formation"; R22 is "IL6-gp80-gp130-JAK-STAT3C-SOCS3-SHP2 dissociation"; R23 is "STAT3C dimerization"; R24 is "IL6-gp80-gp130-JAK STAT3Cast complex formation"; R25 is "PP1-STAT3C dimer complex formation"; R26 is "STAT3C dimer phosphorylation"; R27 is "PP1-STAT3C dimer dissociation"; R28 is "Complex formation"; R29 is "SHP2 dephosphorylation"; R30 is "IL6-gp80-gp130-JAK-SHP2 phosphorylation"; R31 is "STAT3N dimer dissociation"; R32 is "PP2-STAT3N dimer complex formation"; R33 is "PP2-STAT3N complex formation"; R34 is "STAT3N dimer dissociation"; R35 is "PP2-STAT3N dissociation"; R36 is "PP2-STAT3N dimer dissociation"; R37 is "SOCS3N transcription"; R38 is "SOCS3 mRNA translocation"; R39 is "SOCS3 mRNA degradation"; R40 is "SOCS3 translation"; R41 is "SOCS3 degradation"; R42 is "Complex dissociation"; R43 is "SHP2-Grb2 complex formation"; R44 is "Grb2-SOS dissociation"; R45 is "Complex formation"; R46 is "Complex formation"; R47 is "SHP2Grb2-SOS complex formation"; R48 is "Complex formation"; R49 is "Complex dissociation"; R50 is "Complex dissociation"; R51 is "Ras-GTP-Raf complex formation"; R52 is "Complex formation"; R53 is "SHP2-Grb2-SOS dissociation"; R54 is "Complex formation"; R55 is "Raf-Phosp1 dissociation"; R56 is "Raf-Ras-GTP dissociation"; R57 is "Raf-Phosp1 complex formation"; R58 is "MEK-Raf complex formation"; R59 is "MEK-Raf complex dissociation"; R60 is "MEK-P-Raf complex formation"; R61 is "MEK-P-Phosp2 dissociation"; R62 is "MEK-PP-Phosp2 dissociation"; R63 is "MEK-P-Phosp2 complex formation"; R64 is "MEK-P-Raf complex dissociation"; R65 is "MEK-PP-Phosp2 complex formation"; R66 is "ERK-MEK-PP complex formation"; R67 is "ERK-MEK-PP complex dissociation"; R68 is "ERK-P-MEK-PP complex dissociation"; R69 is "ERK-PP formation"; R70 is "ERK-P-Phosp3 complex dissociation"; R71 is "ERK-PP-Phosp3 dissociation"; R72 is "ERK-P-Phosp3 formation"; R73 is "ERK-PP-Phosp3 formation"; end