// Created by libAntimony v2.8.0 model *BIOMD0000000149() // Compartments and Species: compartment cytoplasm, nucleus; species X1 in cytoplasm, X2 in cytoplasm, X3 in cytoplasm, X4 in cytoplasm; species X5 in cytoplasm, X6 in cytoplasm, X7 in cytoplasm, X8 in cytoplasm; species X9 in cytoplasm, X10 in cytoplasm, X11 in nucleus, X12 in cytoplasm; species X13 in nucleus, X14 in nucleus, X15 in cytoplasm, X16 in cytoplasm; species X17 in cytoplasm, X18 in cytoplasm, X19 in cytoplasm, X20 in cytoplasm; species X21 in cytoplasm, X22 in cytoplasm, X23 in cytoplasm, X24 in cytoplasm; species X25 in cytoplasm, X26 in cytoplasm, X27 in cytoplasm, X28 in cytoplasm; // Assignment Rules: X13X14 := X13 + X14; // Reactions: R1: X1 => X2; cytoplasm*k1*X1*W; R2: X2 => X1; cytoplasm*k2*X2; R3: X4 => X6 + X5; cytoplasm*k3*X2*X4; R4: X4 => X3; cytoplasm*k4*X4; R5: X3 => X4; cytoplasm*k5*X3; R6: X6 + X5 -> X4; cytoplasm*(k_plus6*X5*X6 - k_minus6*X4); R7: X12 + X7 -> X6; cytoplasm*(k_plus7*X7*X12 - k_minus7*X6); R8: X11 + X3 -> X8; cytoplasm*(k_plus8*X3*X11 - k_minus8*X8); R9: X8 => X9; cytoplasm*k9*X8; R10: X9 => X3 + X10; cytoplasm*k10*X9; R11: X10 => ; cytoplasm*k11*X10; R12: => X11; cytoplasm*V12; R13: X11 => ; nucleus*k13*X11; R14: => X12; nucleus*(k14 + k21*(X11 + X14)); R15: X12 => ; cytoplasm*k15*X12; R16: X13 + X11 -> X14; nucleus*(k_plus16*X11*X13 - k_minus16*X14); R17: X11 + X7 -> X15; cytoplasm*(k_plus17*X7*X11 - k_minus17*X15); R18: X16 => X17; cytoplasm*((Vmax1*X16*W)/(Km1 + X16))*(Ki/(Ki + X23)); R19: X17 => X16; cytoplasm*((Vmax2*X17)/(Km2 + X17)); R20: X18 => X19; cytoplasm*((kcat1*X17*X18)/(Km3 + X18)); R21: X19 => X18; (cytoplasm*Vmax3*X19)/(Km4 + X19); R22: X20 => X21; (cytoplasm*kcat2*X19*X20)/(Km5 + X20); R23: X21 => X20; (cytoplasm*Vmax4*X21)/(Km6 + X21); R24: X22 => X23; (cytoplasm*kcat3*X21*X22)/(Km7 + X22); R25: X23 => X22; (cytoplasm*Vmax5*X23)/(Km8 + X23); R26: X24 => X18 + X26; (cytoplasm*kcat4*X23*X24)/(Km9 + X24); R27: X18 + X25 -> X24; cytoplasm*(k18*X18*X25 - k19*X24); R28: X26 => X25; (cytoplasm*Vmax6*X26)/(Km10 + X26); R29: => X27; cytoplasm*((kcat5*X14^n1)/(Km11^n1 + X14^n1)); R30: X27 => ; cytoplasm*k20*X27; R31: X18 => X19; cytoplasm*((kcat6*X27*X18)/(Km12 + X18)); R32: X5 => X28; (cytoplasm*kcat7*X23*X5)/(Km13 + X5); R33: X28 => X5; (cytoplasm*Vmax7*X28)/(Km14 + X28); // Events: event_0000001: at time >= 500 && time <= 1000: W = 1; event_0000002: at time > 1000: W = 0; // Species initializations: X1 = 100; X2 = 0; X3 = 0.0153; X4 = 0.0076; X5 = 49.1372; X6 = 0.0015; X7 = 96.6019; X8 = 0.002; X9 = 0.002; X10 = 0.9881; X11 = 42.7224; X12 = 0.0008; X13 = 6.1879; X14 = 8.8121; X15 = 3.4392; X16 = 200; X17 = 0; X18 = 112.5585; X19 = 6.486; X20 = 296.1137; X21 = 3.8863; X22 = 297.8897; X23 = 2.1103; X24 = 180.9595; X25 = 418.1788; X26 = 0.8619; X27 = 10.263; X28 = 0.85544; // Compartment initializations: cytoplasm = 1; nucleus = 1; // Variable initializations: W = 0; k1 = 0.182; k2 = 0.0182; k3 = 0.05; k4 = 0.267; k5 = 0.133; k_plus6 = 0.0909; k_minus6 = 0.909; k_plus7 = 1; k_minus7 = 50; k_plus8 = 1; k_minus8 = 120; k9 = 206; k10 = 206; k11 = 0.417; V12 = 0.423; k13 = 0.000257; k14 = 8.22e-005; k21 = 1e-006; k15 = 0.167; k_plus16 = 1; k_minus16 = 30; k_plus17 = 1; k_minus17 = 1200; Vmax1 = 150; Km1 = 10; Ki = 9; Vmax2 = 15; Km2 = 8; kcat1 = 1.5; Km3 = 15; Vmax3 = 45; Km4 = 15; kcat2 = 1.5; Km5 = 15; Vmax4 = 45; Km6 = 15; kcat3 = 1.5; Km7 = 15; Vmax5 = 45; Km8 = 15; kcat4 = 1.5; Km9 = 9; k18 = 0.15; k19 = 39; Vmax6 = 45; Km10 = 12; kcat5 = 0.6; n1 = 2; Km11 = 15; k20 = 0.015; kcat6 = 1.5; Km12 = 15; kcat7 = 1.5; Km13 = 15; Vmax7 = 45; Km14 = 15; flag_for_wnt_signal = 0; // Other declarations: var W, flag_for_wnt_signal, X13X14; const cytoplasm, nucleus, k1, k2, k3, k4, k5, k_plus6, k_minus6, k_plus7; const k_minus7, k_plus8, k_minus8, k9, k10, k11, V12, k13, k14, k21, k15; const k_plus16, k_minus16, k_plus17, k_minus17, Vmax1, Km1, Ki, Vmax2, Km2; const kcat1, Km3, Vmax3, Km4, kcat2, Km5, Vmax4, Km6, kcat3, Km7, Vmax5; const Km8, kcat4, Km9, k18, k19, Vmax6, Km10, kcat5, n1, Km11, k20, kcat6; const Km12, kcat7, Km13, Vmax7, Km14; // Unit definitions: unit substance = 1e-9 mole; unit time_unit = 60 second; // Display Names: substance is "nanomole"; time_unit is "minute"; X1 is "Dshi"; X2 is "Dsha"; X3 is "APC_ast/Axin_ast/GSK3beta"; X4 is "APC/Axin/GSK3beta"; X5 is "GSK3beta"; X6 is "APC/Axin"; X7 is "APC"; X8 is "bCatenin/APC_Ast/Axin_ast/GSK3beta"; X9 is "bCatenin_ast/APC_ast/Axin_ast/GSK3beta"; X10 is "bCatenin_ast"; X11 is "bCatenin"; X12 is "Axin"; X13 is "TCF"; X14 is "bCatenin/TCF"; X15 is "bCatenin/APC"; X16 is "Rasi"; X17 is "Rasa"; X18 is "Raf-1"; X19 is "Raf-1_ast"; X20 is "MEK"; X21 is "MEK_ast"; X22 is "ERK"; X23 is "ERK_ast"; X24 is "Raf1/RKIP"; X25 is "RKIP"; X26 is "RKIP_ast"; X27 is "unknown molecule X"; X28 is "GSK3beta"; R1 is "Dishevelled activation"; R2 is "Dishevelled inactivation"; R3 is "Dishevelled mediated GSK/Axin/APC complex disassembly"; R4 is "Activation of GSK/Axin/APC complex"; R5 is "Inactivation of GSK/Axin/APC complex"; R6 is "GSK/Axin/APC complex reassembly"; R7 is "Axin/APC complex formation"; R8 is "bCatenin binding to GSK/Axin/APC complex"; R9 is "bCatenin phosphorylation"; R10 is "GSK.Axin/APC/bCatenin complex disassembly"; R11 is "Phosphorylated bCatenin degradation"; R12 is "bCatenin synthesis"; R13 is "Unphosphorylated bCatenin degradation"; R14 is "Axin synthesis"; R15 is "Axin degradation"; R16 is "bCatenin/TCF complex formation"; R17 is "APC/bCatenin complex formation"; R18 is "Ras activation"; R19 is "Ras inactivation"; R20 is "Raf activation"; R21 is "Raf inactivation"; R22 is "MEK activation"; R23 is "MEK inactivation"; R24 is "ERK activation"; R25 is "ERK inactivation"; R26 is "Raf/RKIP complex disassembly"; R27 is "Raf-RKIP complex formation"; R28 is "RKIP dephosphorylation"; R29 is "Unknown factor-X formation"; R30 is "Factor-X degradation"; R31 is "Factor-X mediated Raf activation"; R32 is "ERK mediated GSK3beta phosphorylation"; R33 is "GSK3beta dephosphorylation"; end