// Created by libAntimony v2.8.0 model *model_0000001() // Compartments and Species: compartment compartment_0000001; species Akt in compartment_0000001, AktPIP3 in compartment_0000001, AktPIP in compartment_0000001; species AktPIPP in compartment_0000001, ERK in compartment_0000001, ERKP in compartment_0000001; species ERKPP in compartment_0000001, GS in compartment_0000001, HRG in compartment_0000001; species MEK in compartment_0000001, MEKP in compartment_0000001, MEKPP in compartment_0000001; species PI3K in compartment_0000001, PI3Kstar in compartment_0000001, PIP3 in compartment_0000001; species R in compartment_0000001, RP in compartment_0000001, RHRG in compartment_0000001; species RHRG2 in compartment_0000001, RPI3K in compartment_0000001, RPI3Kstar in compartment_0000001; species RShGS in compartment_0000001, RShP in compartment_0000001, RShc in compartment_0000001; species Raf in compartment_0000001, Rafstar in compartment_0000001, RasGDP in compartment_0000001; species RasGTP in compartment_0000001, ShGS in compartment_0000001, ShP in compartment_0000001; species Shc in compartment_0000001, P_I in compartment_0000001, internalization in compartment_0000001; species $E in compartment_0000001, $MKP3 in compartment_0000001, $PP2A in compartment_0000001; // Assignment Rules: RP_percent := ((RP + RPI3K + RPI3Kstar + RShGS + RShP + RShc)*200)/80; AktPP_percent := (AktPIPP*100)/10; MEKPP_percent := (MEKPP*100)/120; ERKPP_percent := (ERKPP*100)/1000; Rafstar_percent := (Rafstar*100)/100; ShP_percent := (ShP*100)/1000; PI3Kstar_percent := (PI3Kstar*100)/10; // Reactions: reaction_0000001: R + HRG -> RHRG; compartment_0000001*(k1*R*HRG - k_1*RHRG); reaction_0000002: 2RHRG -> RHRG2; compartment_0000001*(k2*RHRG^2 - k_2*RHRG2); reaction_0000003: RHRG2 -> RP; compartment_0000001*(k3*RHRG2 - k_3*RP); reaction_0000004: RP => RHRG2; (compartment_0000001*V4*RP)/(K4 + RP); reaction_0000005: RP + Shc -> RShc; compartment_0000001*(k5*RP*Shc - k_5*RShc); reaction_0000006: RShc -> RShP; compartment_0000001*(k6*RShc - k_6*RShP); reaction_0000007: RShP + GS -> RShGS; compartment_0000001*(k7*RShP*GS - k_7*RShGS); reaction_0000008: RShGS -> ShGS + RP; compartment_0000001*(k8*RShGS - k_8*ShGS*RP); reaction_0000009: ShGS -> GS + ShP; compartment_0000001*(k9*ShGS - k_9*GS*ShP); reaction_0000010: ShP => Shc; (compartment_0000001*V10*ShP)/(K10 + ShP); reaction_0000011: RasGDP => RasGTP; compartment_0000001*((k11*ShGS*RasGDP)/(K11 + RasGDP)); reaction_0000012: RasGTP => RasGDP; compartment_0000001*((V12*RasGTP)/(K12 + RasGTP)); reaction_0000013: Raf => Rafstar; compartment_0000001*((k13*RasGTP*Raf)/(K13 + Raf)); reaction_0000014: Rafstar => Raf; (compartment_0000001*k14*(AktPIPP + E)*Rafstar)/(K14 + Rafstar); reaction_0000015: MEK => MEKP; (compartment_0000001*k15*Rafstar*MEK)/(K15*(1 + MEKP/K17) + MEK); reaction_0000016: MEKP => MEK; (compartment_0000001*k16*PP2A*MEKP)/(K16*(1 + MEKPP/K18 + AktPIP/K31 + AktPIPP/K33) + MEKP); reaction_0000017: MEKP => MEKPP; (compartment_0000001*k17*Rafstar*MEKP)/(K17*(1 + MEK/K15) + MEKP); reaction_0000018: MEKPP => MEKP; (compartment_0000001*k18*PP2A*MEKPP)/(K18*(1 + MEKP/K16 + AktPIPP/K31 + AktPIPP/K33) + MEKPP); reaction_0000019: ERK => ERKP; (compartment_0000001*k19*MEKPP*ERK)/(K19*(1 + ERKP/K21) + ERK); reaction_0000020: ERKP => ERK; (compartment_0000001*k20*MKP3*ERKP)/(K20*(1 + ERKPP/K22) + ERKP); reaction_0000021: ERKP => ERKPP; (compartment_0000001*k21*MEKPP*ERKP)/(K21*(1 + ERK/K19) + ERKP); reaction_0000022: ERKPP => ERKP; (compartment_0000001*k22*MKP3*ERKPP)/(K22*(1 + ERKP/K20) + ERKPP); reaction_0000023: RP + PI3K -> RPI3K; compartment_0000001*(k23*RP*PI3K - k_23*RPI3K); reaction_0000024: RPI3K -> RPI3Kstar; compartment_0000001*(k24*RPI3K - k_24*RPI3Kstar); reaction_0000025: RPI3Kstar -> RP + PI3Kstar; compartment_0000001*(k25*RPI3Kstar - k_25*RP*PI3Kstar); reaction_0000026: PI3Kstar => PI3K; (compartment_0000001*V26*PI3Kstar)/(K26 + PI3Kstar); reaction_0000029: PIP3 + Akt -> AktPIP3; compartment_0000001*(k29*PIP3*Akt - k_29*AktPIP3); reaction_0000028: PIP3 => P_I; compartment_0000001*((V28*PIP3)/(K28 + PIP3)); reaction_0000027: P_I => PIP3; (compartment_0000001*k27*PI3Kstar*P_I)/(K27 + P_I); reaction_0000030: AktPIP3 => AktPIP; (compartment_0000001*V30*AktPIP3)/(K30*(1 + AktPIP/K32) + AktPIP3); reaction_0000031: AktPIP => AktPIP3; (compartment_0000001*k31*PP2A*AktPIP)/(K31*(1 + MEKP/K16 + MEKPP/K18 + AktPIPP/K33) + AktPIP); reaction_0000032: AktPIP => AktPIPP; (compartment_0000001*V32*AktPIP)/(K32*(1 + AktPIP3/K30) + AktPIP); reaction_0000033: AktPIPP => AktPIP; (compartment_0000001*k33*PP2A*AktPIPP)/(K33*(1 + MEKP/K16 + MEKPP/K18 + AktPIP/K31) + AktPIPP); reaction_0000034: RP -> internalization; compartment_0000001*(k34*RP - k_34*internalization); // Species initializations: Akt = 10; AktPIP3 = 0; AktPIP = 0; AktPIPP = 0; ERK = 1000; ERKP = 0; ERKPP = 0; GS = 10; HRG = 330; MEK = 120; MEKP = 0; MEKPP = 0; PI3K = 10; PI3Kstar = 0; PIP3 = 0; R = 80; RP = 0; RHRG = 0; RHRG2 = 0; RPI3K = 0; RPI3Kstar = 0; RShGS = 0; RShP = 0; RShc = 0; Raf = 100; Rafstar = 0; RasGDP = 120; RasGTP = 0; ShGS = 0; ShP = 0; Shc = 1000; P_I = 800; internalization = 0; E = 7; MKP3 = 2.4; PP2A = 11.4; // Compartment initializations: compartment_0000001 = 1; // Variable initializations: k1 = 0.0012; k2 = 0.01; k3 = 1; k5 = 0.1; k6 = 20; k7 = 60; k8 = 2040; k9 = 40.8; V10 = 0.0154; k11 = 0.222; V12 = 0.289; k13 = 1.53; k14 = 0.00673; k15 = 3.5; k16 = 0.058; k17 = 2.9; k20 = 0.3; k18 = 0.058; k19 = 9.5; k21 = 16; k22 = 0.27; k23 = 0.1; k24 = 9.85; k25 = 45.8; k27 = 16.9; V26 = 2620; V28 = 17000; k29 = 507; V30 = 20000; k31 = 0.107; V32 = 20000; k33 = 0.211; k34 = 0.001; k_1 = 0.00076; k_2 = 0.1; k_3 = 0.01; K4 = 50; k_5 = 1; k_6 = 5; k_7 = 546; k_8 = 15700; k_9 = 0; K10 = 340; K11 = 0.181; K12 = 0.0571; K13 = 11.7; K14 = 8.07; K15 = 317; K18 = 60; K19 = 146000; K20 = 160; K21 = 146000; K22 = 60; k_23 = 2; k_24 = 0.0985; k_25 = 0.047; K26 = 3680; K27 = 39.1; K28 = 9.02; K30 = 80000; K31 = 4.35; K32 = 80000; K33 = 12; k_34 = 0; V4 = 62.5; K17 = 317; K16 = 2200; k_29 = 234; // Other declarations: var RP_percent, AktPP_percent, MEKPP_percent, ERKPP_percent, Rafstar_percent; var ShP_percent, PI3Kstar_percent; const compartment_0000001, k1, k2, k3, k5, k6, k7, k8, k9, V10, k11, V12; const k13, k14, k15, k16, k17, k20, k18, k19, k21, k22, k23, k24, k25, k27; const V26, V28, k29, V30, k31, V32, k33, k34, k_1, k_2, k_3, K4, k_5, k_6; const k_7, k_8, k_9, K10, K11, K12, K13, K14, K15, K18, K19, K20, K21, K22; const k_23, k_24, k_25, K26, K27, K28, K30, K31, K32, K33, k_34, V4, K17; const K16, k_29; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nM"; compartment_0000001 is "cell"; end