// Created by libAntimony v2.8.0 model *Fisher2006_NFAT_Activation() // Compartments and Species: compartment cytosol, nucleus; species Ca_Nuc in nucleus, Ca_Cyt in cytosol, NFAT_Nuc in nucleus, Act_C_Nuc in nucleus; species NFAT_Pi_Nuc in nucleus, NFAT_Act_C_Nuc in nucleus, NFAT_Pi_Act_C_Nuc in nucleus; species Inact_C_Nuc in nucleus, NFAT_Cyt in cytosol, Act_C_Cyt in cytosol; species NFAT_Pi_Cyt in cytosol, NFAT_Act_C_Cyt in cytosol, NFAT_Pi_Act_C_Cyt in cytosol; species Inact_C_Cyt in cytosol; // Reactions: R1: NFAT_Pi_Nuc + Act_C_Nuc -> Act_C_Nuc + NFAT_Nuc; nucleus*(k1*NFAT_Pi_Nuc - k2*NFAT_Nuc); R2: Act_C_Nuc + NFAT_Nuc -> NFAT_Act_C_Nuc; nucleus*(k16*NFAT_Nuc*Act_C_Nuc - k15*NFAT_Act_C_Nuc); R3: NFAT_Nuc -> NFAT_Cyt; nucleus*k18*NFAT_Nuc - cytosol*k17*NFAT_Cyt; R4: Act_C_Nuc -> Act_C_Cyt; nucleus*k6*Act_C_Nuc - cytosol*k5*Act_C_Cyt; R5: NFAT_Act_C_Nuc -> NFAT_Pi_Act_C_Nuc; nucleus*(k14*NFAT_Act_C_Nuc - k13*NFAT_Pi_Act_C_Nuc); R6: NFAT_Pi_Act_C_Nuc -> Act_C_Nuc + NFAT_Pi_Nuc; nucleus*(k12*NFAT_Pi_Act_C_Nuc - k11*NFAT_Pi_Nuc*Act_C_Nuc); R7: NFAT_Act_C_Nuc -> NFAT_Act_C_Cyt; nucleus*k10*NFAT_Act_C_Nuc - cytosol*k9*NFAT_Act_C_Cyt; R8: NFAT_Act_C_Cyt -> NFAT_Pi_Act_C_Cyt; cytosol*(k14*NFAT_Act_C_Cyt - k13*NFAT_Pi_Act_C_Cyt); R9: NFAT_Pi_Act_C_Cyt -> Act_C_Cyt + NFAT_Pi_Cyt; cytosol*(k12*NFAT_Pi_Act_C_Cyt - k11*NFAT_Pi_Cyt*Act_C_Cyt); R10: NFAT_Pi_Cyt -> NFAT_Pi_Nuc; cytosol*k3*NFAT_Pi_Cyt - nucleus*k4*NFAT_Pi_Nuc; R11: NFAT_Act_C_Cyt -> Act_C_Cyt + NFAT_Cyt; cytosol*(k15*NFAT_Act_C_Cyt - k16*NFAT_Cyt*Act_C_Cyt); R17: NFAT_Pi_Act_C_Cyt -> NFAT_Pi_Act_C_Nuc; cytosol*k7*NFAT_Pi_Act_C_Cyt - nucleus*k8*NFAT_Pi_Act_C_Nuc; R12: NFAT_Pi_Cyt + Act_C_Cyt -> Act_C_Cyt + NFAT_Cyt; cytosol*(k1*NFAT_Pi_Cyt - k2*NFAT_Cyt); R13: 3Ca_Cyt + Inact_C_Cyt -> Act_C_Cyt; cytosol*(k19*Inact_C_Cyt*Ca_Cyt^3 - k20*Act_C_Cyt); R14: 3Ca_Nuc + Inact_C_Nuc -> Act_C_Nuc; nucleus*(k19*Inact_C_Nuc*Ca_Nuc^3 - k20*Act_C_Nuc); R15: Inact_C_Cyt -> Inact_C_Nuc; cytosol*k5*Inact_C_Cyt - nucleus*k6*Inact_C_Nuc; R16: Ca_Cyt -> Ca_Nuc; cytosol*k21*Ca_Cyt - nucleus*k22*Ca_Nuc; // Species initializations: Ca_Nuc = 1; Ca_Cyt = 1; NFAT_Nuc = 0.0005219; Act_C_Nuc = 5.05e-005; NFAT_Pi_Nuc = 0.0002272; NFAT_Act_C_Nuc = 0.0009477; NFAT_Pi_Act_C_Nuc = 2.5e-006; Inact_C_Nuc = 0.049198; NFAT_Cyt = 0.0001101; Act_C_Cyt = 9.1e-006; NFAT_Pi_Cyt = 0.0094397; NFAT_Act_C_Cyt = 6.1e-006; NFAT_Pi_Act_C_Cyt = 2.2e-006; Inact_C_Cyt = 0.0097108; // Compartment initializations: cytosol = 2.69e-013; nucleus = 1.13e-013; // Variable initializations: k1 = 2.56e-005; k2 = 0.00256; k16 = 6.63; k15 = 0.00168; k18 = 0.00096; k17 = 0.0015; k6 = 0.00092; k5 = 0.0019; k14 = 0.00256; k13 = 0.5; k12 = 0.00168; k11 = 6.63; k10 = 0.005; k9 = 0.5; k3 = 0.005; k4 = 0.5; k7 = 0.005; k8 = 0.5; k19 = 1; k20 = 1; k21 = 0.21; k22 = 0.5; // Other declarations: const cytosol, nucleus, k1, k2, k16, k15, k18, k17, k6, k5, k14, k13, k12; const k11, k10, k9, k3, k4, k7, k8, k19, k20, k21, k22; // Unit definitions: unit substance = 1e-6 mole; // Display Names: substance is "micro mole"; Ca_Nuc is "Calcium in Nucleus"; Ca_Cyt is "Calcium in Cytosol"; Act_C_Nuc is "Active Calcineurin in nucleus"; NFAT_Pi_Nuc is "Phosphorylated NFAT in nucleus"; NFAT_Act_C_Nuc is "NFAT Calcineurin complex in nucleus"; NFAT_Pi_Act_C_Nuc is "Phosphorylated NFAT Calcineurin complex in nucleus"; Inact_C_Nuc is "Inactive Calcineurin in nucleus"; Act_C_Cyt is "Active Calcineurin in cytosol"; NFAT_Pi_Cyt is "Phosphorylated NFAT in cytosol"; NFAT_Act_C_Cyt is "NFAT Calcineurin complex in cytosol"; NFAT_Pi_Act_C_Cyt is "Phosphorylated NFAT Calcineurin complex in cytosol"; Inact_C_Cyt is "Inactive Calcineurin in cytosol"; R1 is "Calcineurin dpdnt NFAT dephosphorylation"; R2 is "NFAT Calcineurin complex formation"; R3 is "NFAT transport"; R4 is "Active Calcineurin transport"; R5 is "NFAT Calcineurin complex phosphorylation"; R6 is "Phosphorylated NFAT Calcineurin complex disassembly"; R7 is "NFAT Calcineurin complex transport"; R8 is "NFAT Calcineurin complex phosphorylation"; R9 is "Phosphorylated NFAT Calcineurin complex disassembly"; R10 is "Phosphorylated NFAT transport"; R11 is "NFAT Calcineurin complex disassembly"; R17 is "Phosphorylated NFAT Calcineurin complex transport"; R12 is "Calcineurin dpdnt NFAT dephosphorylation"; R13 is "Calcineurin activation"; R14 is "Calcineurin activation"; R15 is "Inactive Calcineurin transport"; R16 is "Calcium transport"; end