// Created by libAntimony v2.8.0 model *Chan2004_TCell_receptor_activation() // Compartments and Species: compartment compartment_; substanceOnly species lck_inactive in compartment_, lck_active in compartment_; substanceOnly species phosphatase_inactive in compartment_, phosphatase_active in compartment_; substanceOnly species $lck_total in compartment_; // Assignment Rules: lck_total := lck_inactive + lck_active; // Reactions: v1: => lck_inactive; r_l; v2: lck_active => lck_inactive; n1*lck_active*phosphatase_active; v3: lck_inactive => lck_active; k1*lck_inactive; v4: lck_inactive => lck_active; m1*lck_active^n*lck_inactive; v5: lck_inactive => ; d0*lck_inactive; v6: lck_active => ; d1*lck_active; v7: phosphatase_inactive => phosphatase_active; k2*phosphatase_inactive; v8: phosphatase_inactive => phosphatase_active; m2*lck_active*phosphatase_inactive; v9: phosphatase_active => phosphatase_inactive; n2*phosphatase_active; v10: phosphatase_active => ; d2*phosphatase_active; // Events: event_0000001: at time >= 10: r_l = 1; event_0000002: at time >= 24: r_l = 0; // Species initializations: lck_inactive = 0; lck_active = 0; phosphatase_inactive = 0.6/compartment_; phosphatase_active = 0.6/compartment_; // Compartment initializations: compartment_ = 1; // Variable initializations: r_l = 0; r_l has items_per_time; n1 = 1; n1 has sec_inv_item_inv; k1 = 0.01; k1 has sec_inv; m1 = 1; d0 = 0.15; d0 has sec_inv; d1 = 0.15; d1 has sec_inv; k2 = 0.01; k2 has sec_inv; m2 = 1; m2 has sec_inv_item_inv; n2 = 0.02; n2 has sec_inv; d2 = 0; d2 has sec_inv; n = 1.95; n has dimensionless; // Other declarations: var r_l; const compartment_, n1, k1, m1, d0, d1, k2, m2, n2, d2, n; // Unit definitions: unit substance = item; unit items_per_time = item / second; unit sec_inv = 1 / second; unit sec_inv_item_inv = 1 / (item * second); // Display Names: sec_inv_item_inv is "per_sec_per_item"; compartment_ is "cell"; lck_inactive is "Inactive lck"; lck_active is "Active lck"; phosphatase_inactive is "Inactive phosphatase"; phosphatase_active is "Active phosphatase"; lck_total is "Total kinase"; event_0000001 is "Setting r(l) to 1 "; event_0000002 is "Resetting r(l) to 0"; v1 is "Kinase recruitment to T-cell receptor"; v2 is "Kinase inactivation"; v3 is "Basal kinase activation"; v4 is "Catalytic kinase activation"; v5 is "Inactive kinase diffusion"; v6 is "Active kinase diffusion"; v7 is "Basal phosphatase activation"; v8 is "Catalyzed phosphatase activation"; v9 is "Phosphatase inactivation"; v10 is "Active phosphatase diffusion"; end