// Created by libAntimony v2.8.0 model *model_0000001() // Compartments and Species: compartment extracellular, Cytosol, intracellular_Ca_storepool; species z in Cytosol, y in intracellular_Ca_storepool; // Assignment Rules: beta := flag*0.96*exp(-0.2*(time - tstim)); // Reactions: reaction_0000001: => z; v1*beta*Cytosol; reaction_0000002: => z; v0*Cytosol; reaction_0000003: y => z; kf*y*Cytosol; reaction_0000004: z => y; (intracellular_Ca_storepool*VM2*z^n)/(K2^n + z^n); reaction_0000005: y => z; Cytosol*VM3*(y^m/(KR^m + y^m))*(z^p/(KA^p + z^p)); reaction_0000006: z => ; k*z*extracellular; // Events: event_0000001: at time > tstim: flag = 1; // Species initializations: z = 0.1; y = 1.4; // Compartment initializations: extracellular = 1; Cytosol = 1; intracellular_Ca_storepool = 1; // Variable initializations: tstim = 4; flag = 0; v0 = 1; v1 = 7.3; VM2 = 65; VM3 = 500; KR = 2; KA = 0.9; K2 = 1; kf = 1; k = 10; n = 2; m = 2; p = 4; // Other declarations: var flag, beta; const extracellular, Cytosol, intracellular_Ca_storepool, tstim, v0, v1; const VM2, VM3, KR, KA, K2, kf, k, n, m, p; // Unit definitions: unit substance = 1e-6 mole; // Display Names: substance is "microM"; z is "Ca in the cytosol"; y is "Ca in the InsP3-insensitive pool"; tstim is "stimulation time"; reaction_0000001 is "InsP3 modulated release of Ca from the InsP3 sensitive store"; reaction_0000002 is "Constant input of Ca from the extracellular medium"; reaction_0000003 is "Leak Ca from pool to cytosol"; reaction_0000004 is "Pumping Ca into the InsP3-insensitive store"; reaction_0000005 is "Release of Ca from the pool into the cytosol"; reaction_0000006 is "Transport of cytosolic ca into the extracellular medium"; end