// Created by libAntimony v2.8.0 model *Qu2003_CellCycle() // Compartments and Species: compartment cell; species x1 in cell, x in cell, c0 in cell, $c in cell, ix in cell, ixp in cell; species z0 in cell, z1 in cell, z2 in cell, w0 in cell, w1 in cell, u in cell; species i in cell, y in cell, $totalCyclin in cell; // Assignment Rules: c := (c0 - (x + x1 + ix + ixp))/(c0*cell); totalCyclin := x + x1 + y; // Reactions: reaction_0000001: => y; k1*cell; reaction_0000002: y -> x1; cell*(k3*c*y - x1*k4); reaction_0000003: y => ; cell*(k2 + k2u*u)*y; reaction_0000004: z0 -> z1; cell*((bz + cz*x)*z0 - z1*az); reaction_0000005: x -> x1; cell*((k6 + w0)*x - (k5 + z2)*x1); reaction_0000006: z1 -> z2; cell*((bz + cz*x)*z1 - az*z2); reaction_0000007: => w0; k10*cell; reaction_000008: w0 -> w1; cell*((bw + cw*x)*w0 - aw*w1); reaction_000009: => u; (cell*x^2)/(a^2 + x^2)/Tau; reaction_0000010: => i; k12*cell; reaction_0000011: i + x -> ix; (k14*x*i - k15*ix)*cell; reaction_0000014: ix -> ixp; cell*((bi + ci*x)*ix - ai*ixp); reaction_0000013: u => ; (cell*u)/Tau; reaction_0000015: i => ; cell*k13*i; reaction_0000016: ixp => x; cell*k16*k16u*ixp; reaction_0000017: w0 => ; cell*w0*k11; reaction_0000018: w1 => ; cell*k11*w1; reaction_0000019: z0 => ; cell*k9*z0; reaction_0000020: z1 => ; cell*k9*z1; reaction_0000021: z2 -> ; cell*k9*z2; reaction_0000022: => z0; cell*k8; reaction_0000023: x => ; cell*(k7 + k7u*u)*x; // Species initializations: x1 = 0.1; x = 0.1; c0 = 200; ix = 0; ixp = 0; z0 = 0; z1 = 0; z2 = 0; w0 = 0; w1 = 0; u = 0; i = 0; y = 0; // Compartment initializations: cell = 1; // Variable initializations: k1 = 300; k2 = 5; k3 = 30; k4 = 30; k5 = 0.1; k6 = 1; k7 = 10; k8 = 100; k9 = 1; k10 = 10; k11 = 1; k12 = 0; k13 = 1; k14 = 1; k15 = 1; k16 = 2; k2u = 50; k7u = 0; k16u = 25; a = 4; az = 10; aw = 10; ai = 10; bz = 0.1; bw = 0.1; bi = 0.1; cz = 1; cw = 1; ci = 1; Tau = 25; // Other declarations: const cell, k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, k13, k14; const k15, k16, k2u, k7u, k16u, a, az, aw, ai, bz, bw, bi, cz, cw, ci, Tau; // Unit definitions: unit substance = dimensionless; unit volume = dimensionless; // Display Names: substance is "arbitrary subst."; volume is "arbitrary vol"; x1 is " Inactive Cyclin:CDK complex"; x is "Active Cyclin:CDK complex"; c0 is "Total CDK"; c is "Free CDK"; ix is "Cyclin:CDK:CKI complex with CKI unphosphorylated"; ixp is "Cyclin:CDK:CKI complex with CKI phosphorylated"; z0 is "Unphosphorylated CDC25"; z1 is "One-site phosphorylated CDC25"; z2 is "Two-site phosphorylated CDC25"; w0 is "Unphosphorylated wee1"; w1 is "phosphorylated wee1"; u is "Active SKP2 or APC"; i is "Free CKI"; y is "Free cyclin"; reaction_0000001 is "Free cyclin synthesis"; reaction_0000002 is "Cyclin binding with CDK"; reaction_0000003 is "Cyclin degradation"; reaction_0000004 is "z0 phosphorylation"; reaction_0000005 is "x phosphorylation"; reaction_0000006 is "z1 phosphorylation"; reaction_0000007 is "unphosphorylated wee1 synthesis"; reaction_000008 is "wee1 phosphorylation"; reaction_000009 is "SKP2 synthesis"; reaction_0000010 is "CKI synthesis"; reaction_0000011 is "CKI binding to Active Cyclin:CDK complex"; reaction_0000014 is "ix phosphorylation"; reaction_0000013 is "SKP2 degradation"; reaction_0000015 is "CKI degradation"; reaction_0000016 is "Cyclin:CDK:CKIp degradation"; reaction_0000017 is "unphosphorylated wee1 degradation"; reaction_0000018 is "phosphorylated wee1 degradation"; reaction_0000019 is "Unphosphorylated CDC25 degradation"; reaction_0000020 is "One site phosphorylated CDC25 degradaton"; reaction_0000021 is "Two site phosphorylated CDC25 degradation"; reaction_0000022 is "Unphosphorylation CDC25 synthesis"; reaction_0000023 is "Active cyclin:CDK complex degradation"; end