// Created by libAntimony v2.8.0
model *Yang2007_ArachidonicAcid()
// Compartments and Species:
compartment cell;
species x1 in cell, x10 in cell, x11 in cell, x12 in cell, x13 in cell;
species x14 in cell, x15 in cell, x16 in cell, x17 in cell, x18 in cell;
species x19 in cell, x2 in cell, x20 in cell, x21 in cell, x22 in cell;
species x23 in cell, x24 in cell, x25 in cell, x3 in cell, x4 in cell, x5 in cell;
species x6 in cell, x7 in cell, x8 in cell, x9 in cell;
// Reactions:
R1: => x1; (cell*K15*x15*lin*(1 + x4/KI19 + x2/KI20 + x13/KI21 + x11/KI22))/(lin + k15*(1 + x1/ks));
R2: x1 -> x2; (cell*K16*x16*x1)/(x1 + k16*(1 + x2/ks));
R3: x2 -> x3; (cell*K24*x24*x2)/(x2 + k24*(1 + x3/ks));
R4: x1 -> x4; (cell*K17*x17*x1)/(x1 + k17*(1 + x4/ki18 + x3/ki16 + x4/ks));
R5: x4 -> x5; (cell*K24*x24*x4)/(x4 + k24*(1 + x5/ks));
R6: x1 -> x6; (cell*K18*x18*x1)/(x1 + k18*(1 + x7/ki3 + x6/ks));
R7: x6 -> x7; (cell*K19*x19*x6)/(x6 + k19*(1 + x1/ki1 + x3/ki2 + x7/ks));
R8: x6 -> x8; (cell*K20*x20*x6)/(x6 + k20*(1 + x8/ks));
R9: => x9; kd8*x8*cell;
R10: x1 -> x10; (cell*K21*x21*x1)/(x1 + k21*(1 + x5/ki7 + x3/ki8 + x7/ki11 + x11/ki12 + x10/ks));
R11: x10 -> x11; (cell*K24*x24*x10)/(x10 + k24*(1 + x11/ks));
R12: x10 -> x12; (cell*K21*x21*x10)/(x10 + k21*(1 + x5/ki7 + x3/ki8 + x7/ki11 + x11/ki12 + x12/ks));
R13: x12 -> x13; (cell*K22*x22*x12)/(x12 + k22*(1 + x13/ks));
R14: x13 -> x14; (cell*K23*x23*x13)/(x13 + k23*(1 + x5/ki14 + x11/ki15 + x14/ks));
R16: => x16; (cell*a24*x7*x7)/(x7*x7 + KI24*KI24);
R17: x17 => ; cell*ki17*x2*x17;
R20: x20 => ; ki4*x2*x20*cell;
R21: => x21; cell*KI23*x13*x21;
R22: x22 => ; (cell*K22*x22*x12)/((x12 + k22)*129);
R18: x9 => ; kd9*x9*cell;
R19: x20 => ; cell*ki5*x6*x20;
R25: x8 => ; cell*kd8*x8;
R24: x13 => ; cell*kd13*x13;
R23: x12 => ; cell*x12*kd12;
R26: x3 => ; kd3*x3*cell;
R27: x2 => ; kd2*cell*x2;
R28: x16 => ; cell*kd16*x16;
R29: x11 => ; kd11*x11*cell;
R30: x21 => ; cell*ki9*x12*x21;
R31: x21 => ; cell*ki10*x10*x21;
R32: x21 => ; cell*ki6*x21*x2;
R34: x1 => ; 0.1*x1*cell;
// Species initializations:
x1 = 0.001;
x10 = 0.001;
x11 = 0.001;
x12 = 0.001;
x13 = 0.001;
x14 = 0.001;
x15 = 1.5;
x16 = 1.5;
x17 = 0.5;
x18 = 0.2;
x19 = 0.5;
x2 = 0.001;
x20 = 0.5;
x21 = 5;
x22 = 0.76;
x23 = 0.07;
x24 = 0.8;
x25 = 0;
x3 = 0.001;
x4 = 0.001;
x5 = 0.001;
x6 = 0.001;
x7 = 0.001;
x8 = 0.001;
x9 = 0.001;
// Compartment initializations:
cell = 1;
// Variable initializations:
lin = 12;
K15 = 3600;
k15 = 2600;
K16 = 1000;
k16 = 70;
K17 = 1000;
k17 = 50;
K18 = 1000;
k18 = 50;
K19 = 3000;
k19 = 160;
K20 = 1599;
k20 = 4;
K21 = 5000;
k21 = 5;
K22 = 125;
k22 = 20;
K23 = 150;
k23 = 3.9;
K24 = 500;
k24 = 70;
kd2 = 0.05;
kd3 = 0.01;
kd8 = 0.1;
kd9 = 0.001;
kd11 = 0.001;
kd12 = 0.07;
kd13 = 0.01;
kd16 = 0.01;
ki1 = 0.3;
ki2 = 30;
ki3 = 30;
ki4 = 0.6;
ki5 = 0.1;
ki6 = 0.01;
ki7 = 30;
ki8 = 4;
ki9 = 0.175;
ki10 = 0.01;
ki11 = 15;
ki12 = 6.3;
ki14 = 0.2;
ki15 = 0.86;
ki16 = 10;
ki17 = 10;
ki18 = 10;
KI19 = 500;
KI20 = 200;
KI21 = 500;
KI22 = 500;
KI23 = 0.053;
KI24 = 2.3e-005;
a24 = 0.15;
ks = 500;
// Other declarations:
const cell, lin, K15, k15, K16, k16, K17, k17, K18, k18, K19, k19, K20;
const k20, K21, k21, K22, k22, K23, k23, K24, k24, kd2, kd3, kd8, kd9, kd11;
const kd12, kd13, kd16, ki1, ki2, ki3, ki4, ki5, ki6, ki7, ki8, ki9, ki10;
const ki11, ki12, ki14, ki15, ki16, ki17, ki18, KI19, KI20, KI21, KI22;
const KI23, KI24, a24, ks;
// Unit definitions:
unit substance = 1e-6 mole;
unit time_unit = 60 second;
// Display Names:
substance is "micromole";
time_unit is "minute";
x1 is "AA";
x10 is "5-HPETE";
x11 is "5-HETE";
x12 is "LTA4";
x13 is "LTB4";
x14 is "w-LTB4";
x15 is "PLA2";
x16 is "15-LOX";
x17 is "12-LOX";
x18 is "COX-2";
x19 is "PGES";
x2 is "15-HPETE";
x20 is "TXAS";
x21 is "5-LOX";
x22 is "LTA4H";
x23 is "CYP4F3";
x24 is "PHGPx";
x25 is "exo-AA";
x3 is "15-HETE";
x4 is "12-HPETE";
x5 is "12-HETE";
x6 is "PGH2";
x7 is "PGE2";
x8 is "TXA2";
x9 is "TXB2";
K15 is "Kcat(PLA2)";
k15 is "Km(PLA2)";
K16 is "Kcat(15-LOX)";
k16 is "Km(15-LOX)";
K17 is "Kcat(12-LOX)";
k17 is "Km(12-LOX)";
K18 is "Kcat(COX-2)";
k18 is "Km(COX-2)";
K19 is "Kcat(PGES)";
k19 is "Km(PGES)";
K20 is "Kcat(TXAS)";
k20 is "Km(TXAS)";
K21 is "Kcat(5-LOX)";
k21 is "Km(5-LOX)";
K22 is "Kcat(LTA4H)";
k22 is "Km(LTA4H)";
K23 is "Kcat(CYP4F3)";
k23 is "Km(CYP4F3)";
K24 is "Kcat(PHGPx)";
k24 is "Km(PHGPx)";
R1 is "AA production";
R2 is "15-HPETE production";
R3 is "15-HETE production";
R4 is "12-HPETE production";
R5 is "12-HETE production";
R6 is "PGH2 production";
R7 is "PGE2 production";
R8 is "TXA2 production";
R9 is "TXB2 production";
R10 is "5-HPETE production";
R11 is "5-HETE production";
R12 is "LTA4 production";
R13 is "LTB4 production";
R14 is "20-OH-LTB4 production";
R16 is "15-LOX upregulation";
R17 is "12-LOX inhibition";
R20 is "TXAS inhibition";
R21 is "5-LOX upregulation";
R22 is "LTA4H inhibition";
R18 is "TXB2 decay";
R19 is "TXAS inhibition by PGH2";
R25 is "TAX2 decay";
R24 is "LTB4 decay";
R23 is "LTA4 decay";
R26 is "15-HETE decay";
R27 is "15-HPETE decay";
R28 is "15-LOX decay";
R29 is "5-HETE decay";
R30 is "5-LOX inhibition by x12";
R31 is "5-LOX inhibition by x10";
R32 is "5-LOX inhibition by x2";
R34 is "AA decay";
end