// Created by libAntimony v2.8.0 model *Goldbeter1990_CalciumSpike_CICR() // Compartments and Species: compartment cytosol, store; species Z in cytosol, Y in store; // Reactions: R0: => Z; cytosol*v0; R1: => Z; cytosol*v1*beta; R2: Z => Y; cytosol*((Vm2*Z^n)/(K2^n + Z^n)); R3: Y => Z; store*((Vm3*Y^m*Z^p)/((Kr^m + Y^m)*(Ka^p + Z^p))); Rf: Y => Z; store*kf*Y; R_eff: Z => ; cytosol*k*Z; // Species initializations: Z = 0.15; Y = 1.6; // Compartment initializations: cytosol = 1; store = 1; // Variable initializations: v0 = 1; v0 has uM_per_sec; v1 = 7.3; v1 has uM_per_sec; beta = 0.301; beta has dimensionless; Vm2 = 65; Vm2 has uM_per_sec; n = 2; n has dimensionless; K2 = 1; K2 has uM; Vm3 = 500; Vm3 has uM_per_sec; m = 2; m has dimensionless; Kr = 2; Kr has uM; Ka = 0.9; Ka has uM; kf = 1; kf has sec_inv; k = 10; k has sec_inv; p = 4; p has dimensionless; // Other declarations: const cytosol, store, v0, v1, beta, Vm2, n, K2, Vm3, m, Kr, Ka, kf, k, p; // Unit definitions: unit substance = 1e-6 mole; unit uM_per_sec = 1e-6 mole / (litre * second); unit sec_inv = 1 / second; unit uM = 1e-6 mole / litre; // Display Names: substance is "micromole"; R0 is "Ca influx"; R1 is "InsP3 dependent Ca influx"; R2 is "ATP driven Ca pumping into store"; R3 is "ATP driven pumping into cytosol"; Rf is "Ca leak"; R_eff is "Ca efflux"; end