// Created by libAntimony v2.8.0
model *Model_1()

  // Compartments and Species:
  compartment cell;
  species H in cell, HR in cell, R in cell, HRRH in cell, E in cell, GQ in cell;
  species IP3 in cell, $CHO in cell;

  // Assignment Rules:
  CHO := (0.001*alpha*IP3*(0.3 + 0.3*beta*time*exp(1 - beta*time)))/(1 + 0.001*alpha*IP3);

  // Reactions:
  reaction_0: H + R -> HR; cell*(reaction_0_k1*H*R - reaction_0_k2*HR);
  reaction_1: 2HR -> HRRH; cell*(reaction_1_k1*HR^2 - reaction_1_k2*HRRH);
  reaction_2: HRRH + GQ -> E; cell*(reaction_2_k1*HRRH*GQ - reaction_2_k2*E);
  reaction_3: IP3 => ; cell*reaction_3_k1*IP3;
  reaction_4:  => IP3; cell*reaction_4_k*E;

  // Events:
  RemovalH: at time > 5: H = 0;

  // Species initializations:
  H = 1;
  HR = 0;
  R = 0.01;
  HRRH = 0;
  E = 0;
  GQ = 0.1;
  IP3 = 0;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  alpha = 2;
  alpha has substance;
  beta = 4;
  beta has unitDefinition_3;
  reaction_0_k1 = 2.5;
  reaction_0_k2 = 5;
  reaction_1_k1 = 2500;
  reaction_1_k2 = 5;
  reaction_2_k1 = 4000;
  reaction_2_k2 = 200;
  reaction_3_k1 = 10;
  reaction_4_k = 20000000;

  // Other declarations:
  const cell, alpha, beta;

  // Unit definitions:
  unit time_unit = 60 second;
  unit substance = 1e-9 mole;
  unit unitDefinition_3 = 1 / 60 second;

  // Display Names:
  unitDefinition_3 is "unit for beta";
  RemovalH is "removal of hormone";
  reaction_0 is "H binding to  R";
  reaction_1 is "HR forming HRRH";
  reaction_2 is "G protein react with dimer producing E";
  reaction_3 is "IP3 converted into inactive metabolites";
  reaction_4 is "Production of IP3";
end