// Created by libAntimony v2.8.0 model *Galazzo1990_FermentationPathwayKinetics() // Compartments and Species: compartment extracellular, cytoplasm; species Glci in cytoplasm, ATP in cytoplasm, G6P in cytoplasm, FDP in cytoplasm; species PEP in cytoplasm, $Gly in cytoplasm, $EtOH in cytoplasm, $Carbo in cytoplasm; species $Glco in extracellular; // Assignment Rules: VappGly := (parameter_4*G6P^parameter_5)/(parameter_6^parameter_5 + G6P^parameter_5); VratioVmax := Vhk/(cytoplasm*parameter_7); // Reactions: Vhk: ATP + Glci -> G6P; (cytoplasm*Vhk_Vm2)/(1 + Vhk_Km2Glc/Glci + Vhk_Km2ATP/ATP + (Vhk_Ks2Glc*Vhk_Km2ATP)/(Glci*ATP)); Vin: $Glco -> Glci; cytoplasm*(Vin_Vm1 - Vin_Ki1G6P*G6P); Vpol: ATP + G6P -> $Carbo; (cytoplasm*1.1*Vpol_Vm3*G6P^Vpol_n3)/(Vpol_K3Gly^Vpol_n3 + G6P^Vpol_n3)/(1 + Vpol_Km30/0.7*(1 + Vpol_Km3G6P/G6P)); Vpfk: ATP + G6P -> FDP; (((cytoplasm*Vpfk_Vm4*Vpfk_g4R*0.3*G6P)/Vpfk_K4F6P*ATP)/Vpfk_K4ATP*(1 + (0.3*G6P)/Vpfk_K4F6P + ATP/Vpfk_K4ATP + ((Vpfk_g4R*0.3*G6P)/Vpfk_K4F6P*ATP)/Vpfk_K4ATP))/((1 + (0.3*G6P)/Vpfk_K4F6P + ATP/Vpfk_K4ATP + ((Vpfk_g4R*0.3*G6P)/Vpfk_K4F6P*ATP)/Vpfk_K4ATP)^2 + Vpfk_L40*((1 + (Vpfk_c4AMP*(3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)))/Vpfk_K4AMP)/(1 + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpfk_K4AMP))^2*(1 + (Vpfk_c4F6P*0.3*G6P)/Vpfk_K4F6P + (Vpfk_c4ATP*ATP)/Vpfk_K4ATP + ((Vpfk_gT*Vpfk_c4F6P*0.3*G6P)/Vpfk_K4F6P*Vpfk_c4ATP*ATP)/Vpfk_K4ATP)^2); Vgapd: FDP -> 2ATP + 2PEP; (cytoplasm*Vgapd_Vm5)/(1 + Vgapd_K5G3P/(0.01*FDP) + (Vgapd_K5NAD/Vgapd_NAD + (Vgapd_K5G3P*Vgapd_K5NAD)/(Vgapd_NAD*0.01*FDP) + (Vgapd_K5G3P*Vgapd_K5NAD*Vgapd_NADH)/(Vgapd_NAD*0.01*FDP*Vgapd_K5NADH))*(1 + (0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgapd_K5ADP + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgapd_K5AMP + ATP/Vgapd_K5ATP)); Vpk: PEP -> ATP + $EtOH; (cytoplasm*Vpk_Vm6*((PEP/Vpk_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP)*(Vpk_g6R*(1 + PEP/Vpk_K6PEP + (0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP + ((Vpk_g6R*PEP)/Vpk_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP) + ((Vpk_q6*Vpk_L60*((1 + (Vpk_c6FDP*FDP)/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*Vpk_g6T*Vpk_c6PEP*PEP)/Vpk_K6PEP*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP*(1 + (Vpk_c6PEP*PEP)/Vpk_K6PEP + (Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP + ((Vpk_g6T*Vpk_c6PEP*PEP)/Vpk_K6PEP*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP)))/((1 + (9.55*10^-9)/Vpk_h6)*((1 + PEP/Vpk_K6PEP + (0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP + ((Vpk_g6R*PEP)/Vpk_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP)^2 + Vpk_L60*((1 + (Vpk_c6FDP*FDP)/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*(1 + (Vpk_c6PEP*PEP)/Vpk_K6PEP + (Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP + ((Vpk_g6T*Vpk_c6PEP*PEP)/Vpk_K6PEP*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpk_K6ADP)^2)); Vgol: 0.5FDP -> $Gly; (Vgol_Vm7*cytoplasm*((PEP/Vgol_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP)*(Vgol_g6R*(1 + PEP/Vgol_K6PEP + (0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP + ((Vgol_g6R*PEP)/Vgol_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP) + ((Vgol_q6*Vgol_L60*((1 + (Vgol_c6FDP*FDP)/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*Vgol_g6T*Vgol_c6PEP*PEP)/Vgol_K6PEP*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP*(1 + (Vgol_c6PEP*PEP)/Vgol_K6PEP + (Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP + ((Vgol_g6T*Vgol_c6PEP*PEP)/Vgol_K6PEP*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP)))/((1 + (9.55*10^-9)/Vgol_h6)*((1 + PEP/Vgol_K6PEP + (0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP + ((Vgol_g6R*PEP)/Vgol_K6PEP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP)^2 + Vgol_L60*((1 + (Vgol_c6FDP*FDP)/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*(1 + (Vgol_c6PEP*PEP)/Vgol_K6PEP + (Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP + ((Vgol_g6T*Vgol_c6PEP*PEP)/Vgol_K6PEP*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgol_K6ADP)^2)); Vatpase: ATP -> ; cytoplasm*Vatpase_Vm8*ATP; // Species initializations: Glci = 0.0345; ATP = 1.19; G6P = 1.011; FDP = 9.144; PEP = 0.0095; Gly = 0; EtOH = 0; Carbo = 0; Glco = 1; // Compartment initializations: extracellular = 1; cytoplasm = 1; VappGly has mM_per_minute; // Variable initializations: parameter_4 = 14.31; parameter_4 has mM_per_minute; parameter_5 = 8.25; parameter_5 has dimensionless; parameter_6 = 2; parameter_6 has mM; VratioVmax has dimensionless; parameter_7 = 68.5; parameter_7 has mM_per_minute; Vin_Vm1 = 19.7; Vin_Vm1 has mM_per_minute; Vin_Ki1G6P = 3.7; Vin_Ki1G6P has min_inv; Vhk_Vm2 = 68.5; Vhk_Vm2 has mM_per_minute; Vhk_Km2Glc = 0.11; Vhk_Km2Glc has mM; Vhk_Km2ATP = 0.1; Vhk_Km2ATP has mM; Vhk_Ks2Glc = 0.0062; Vhk_Ks2Glc has mM; Vpol_Vm3 = 14.31; Vpol_Vm3 has mM_per_minute; Vpol_n3 = 8.25; Vpol_n3 has dimensionless; Vpol_K3Gly = 2; Vpol_K3Gly has mM; Vpol_Km30 = 1; Vpol_Km30 has mM; Vpol_Km3G6P = 1.1; Vpol_Km3G6P has mM; Vpfk_Vm4 = 31.7; Vpfk_Vm4 has mM_per_minute; Vpfk_g4R = 10; Vpfk_g4R has dimensionless; Vpfk_K4F6P = 1; Vpfk_K4F6P has mM; Vpfk_K4ATP = 0.06; Vpfk_K4ATP has mM; Vpfk_L40 = 3342; Vpfk_L40 has dimensionless; Vpfk_c4AMP = 0.019; Vpfk_c4AMP has dimensionless; Vpfk_K4AMP = 0.025; Vpfk_K4AMP has mM; Vpfk_c4F6P = 0.0005; Vpfk_c4F6P has dimensionless; Vpfk_c4ATP = 1; Vpfk_c4ATP has dimensionless; Vpfk_gT = 1; Vpfk_gT has dimensionless; Vgapd_Vm5 = 49.9; Vgapd_Vm5 has mM_per_minute; Vgapd_K5G3P = 0.0025; Vgapd_K5G3P has mM; Vgapd_K5NAD = 0.18; Vgapd_K5NAD has dimensionless; Vgapd_NAD = 1.91939; Vgapd_NAD has mM; Vgapd_NADH = 0.0806142; Vgapd_NADH has mM; Vgapd_K5NADH = 0.0003; Vgapd_K5NADH has mM; Vgapd_K5ADP = 1.5; Vgapd_K5ADP has mM; Vgapd_K5AMP = 1.1; Vgapd_K5AMP has mM; Vgapd_K5ATP = 2.5; Vgapd_K5ATP has mM; Vpk_Vm6 = 3440; Vpk_Vm6 has mM_per_minute; Vpk_K6PEP = 0.00793966; Vpk_K6PEP has mM; Vpk_K6ADP = 5; Vpk_K6ADP has mM; Vpk_g6R = 0.1; Vpk_g6R has dimensionless; Vpk_q6 = 1; Vpk_q6 has dimensionless; Vpk_L60 = 164.084; Vpk_L60 has dimensionless; Vpk_c6FDP = 0.01; Vpk_c6FDP has dimensionless; Vpk_K6FDP = 0.2; Vpk_K6FDP has mM; Vpk_g6T = 1; Vpk_g6T has dimensionless; Vpk_c6PEP = 0.000158793; Vpk_c6PEP has dimensionless; Vpk_c6ADP = 1; Vpk_c6ADP has dimensionless; Vpk_h6 = 1.14815e-007; Vpk_h6 has dimensionless; Vgol_Vm7 = 203; Vgol_Vm7 has mM_per_minute; Vgol_K6PEP = 0.00793966; Vgol_K6PEP has mM; Vgol_K6ADP = 5; Vgol_K6ADP has mM; Vgol_g6R = 0.1; Vgol_g6R has dimensionless; Vgol_q6 = 1; Vgol_q6 has dimensionless; Vgol_L60 = 164.084; Vgol_L60 has dimensionless; Vgol_c6FDP = 0.01; Vgol_c6FDP has dimensionless; Vgol_K6FDP = 0.2; Vgol_K6FDP has mM; Vgol_g6T = 1; Vgol_g6T has dimensionless; Vgol_c6PEP = 0.000158793; Vgol_c6PEP has dimensionless; Vgol_c6ADP = 1; Vgol_c6ADP has dimensionless; Vgol_h6 = 1.14815e-007; Vgol_h6 has dimensionless; Vatpase_Vm8 = 25.1; Vatpase_Vm8 has min_inv; // Other declarations: var VappGly, VratioVmax; const extracellular, cytoplasm, parameter_4, parameter_5, parameter_6, parameter_7; // Unit definitions: unit substance = 1e-3 mole; unit time_unit = 60 second; unit mM = 1e-3 mole / litre; unit mM_per_minute = 1e-3 mole / (litre * 60 second); unit min_inv = 1 / 60 second; // Display Names: substance is "millimole"; time_unit is "minute"; mM is "milliMolar"; mM_per_minute is "mM per minute"; min_inv is "minute_inverse"; extracellular is "Extracellular"; cytoplasm is "Cytoplasm"; Glci is "Glucose inside the cell"; G6P is "Glucose 6-phosphate"; FDP is "Fructose 1,6-phosphate"; PEP is "Phosphoenol pyruvate"; Gly is "Glycerol"; EtOH is "Ethanol"; Carbo is "Glycogen and Trehalose"; Glco is "Glucose outside the cell"; parameter_4 is "Trehalose and Glycogen formation_Vm3"; parameter_5 is "Trehalose and Glycogen formation_n3"; parameter_6 is "Trehalose and Glycogen formation_K3Gly"; VratioVmax is "VratioVmax_ATP"; Vhk is "Hexokinase"; parameter_7 is "Hexokinase_Vm2"; Vin is "Glucose in"; Vpol is "Trehalose and Glycogen formation"; Vpfk is "Phosphofructokinase"; Vgapd is "GAPD"; Vpk is "Pyruvate kinase"; Vgol is "Glycerol synthesis"; Vatpase is "ATPase"; end