// Created by libAntimony v2.8.0 model *Kongas___Van_Beek() // Compartments and Species: compartment IMS, CYT; species ADPi in IMS, ATPi in IMS, Cri in IMS, PCri in IMS, PCr in CYT, ADP in CYT; species ATP in CYT, Cr in CYT, Pi_ in IMS, P in CYT; // Reactions: OxPhos: ADPi + Pi_ -> ATPi; IMS*((OxPhos_V_1*ADPi*Pi_)/(OxPhos_Ka_1*OxPhos_Kb_1*(1 + ADPi/OxPhos_Ka_1 + Pi_/OxPhos_Kb_1 + (ADPi*Pi_)/(OxPhos_Ka_1*OxPhos_Kb_1)))); MiCK: ATPi + Cri -> ADPi + PCri; IMS*(((MiCK_Vf_2*ATPi*Cri)/(MiCK_Kia_2*MiCK_Kb_2) - (MiCK_Vb_2*ADPi*PCri)/(MiCK_Kic_2*MiCK_Kd_2))/(1 + Cri/MiCK_Kib_2 + PCri/MiCK_Kid_2 + ATPi*(1/MiCK_Kia_2 + Cri/(MiCK_Kia_2*MiCK_Kb_2)) + ADPi*(1/MiCK_Kic_2 + Cri/(MiCK_Kic_2*MiCK_Kib_2) + PCri/(MiCK_Kid_2*((MiCK_Kic_2*MiCK_Kd_2)/MiCK_Kid_2))))); MMCK: ATP + Cr -> PCr + ADP; CYT*(((MMCK_Vf_3*ATP*Cr)/(MMCK_Kia_3*MMCK_Kb_3) - (MMCK_Vb_3*ADP*PCr)/(MMCK_Kic_3*MMCK_Kd_3))/(1 + Cr/MMCK_Kib_3 + PCr/MMCK_Kid_3 + ATP*(1/MMCK_Kia_3 + Cr/(MMCK_Kia_3*MMCK_Kb_3)) + ADP*(1/MMCK_Kic_3 + Cr/(MMCK_Kic_3*MMCK_Kib_3) + PCr/(MMCK_Kid_3*((MMCK_Kic_3*MMCK_Kd_3)/MMCK_Kid_3))))); ATPase: ATP => ADP + P; CYT*ATPase_v_4*ATP; Pi_diffusion: Pi_ -> P; IMS*Pi_diffusion_k2_5*Pi_ - CYT*Pi_diffusion_k2_5*P; Cr_diffusion: Cri -> Cr; IMS*Cr_diffusion_k1_6*Cri - CYT*Cr_diffusion_k1_6*Cr; ADP_diffusion: ADPi -> ADP; IMS*ADP_diffusion_k1_7*ADPi - CYT*ADP_diffusion_k1_7*ADP; PCr_diffusion: PCri -> PCr; IMS*PCr_diffusion_k1_8*PCri - CYT*PCr_diffusion_k1_8*PCr; ATP_diffusion: ATPi -> ATP; IMS*ATP_diffusion_k1_9*ATPi - CYT*ATP_diffusion_k1_9*ATP; // Species initializations: ADPi = 0; ATPi = 0; Cri = 0; PCri = 0; PCr = 0; ADP = 0; ATP = 9700; Cr = 26000; Pi_ = 32000; P = 0; // Compartment initializations: IMS = 0.0625; CYT = 0.75; // Variable initializations: OxPhos_V_1 = 4600; OxPhos_Ka_1 = 800; OxPhos_Kb_1 = 20; MiCK_Vf_2 = 2658; MiCK_Kia_2 = 750; MiCK_Kb_2 = 5200; MiCK_Vb_2 = 11160; MiCK_Kic_2 = 204.8; MiCK_Kd_2 = 500; MiCK_Kib_2 = 28800; MiCK_Kid_2 = 1600; MMCK_Vf_3 = 6966; MMCK_Kia_3 = 900; MMCK_Kb_3 = 15500; MMCK_Vb_3 = 29250; MMCK_Kic_3 = 222.4; MMCK_Kd_3 = 1670; MMCK_Kib_3 = 34900; MMCK_Kid_3 = 4730; ATPase_v_4 = 4600; Pi_diffusion_k2_5 = 18.4; Cr_diffusion_k1_6 = 14.6; ADP_diffusion_k1_7 = 8.16; PCr_diffusion_k1_8 = 14.6; ATP_diffusion_k1_9 = 8.16; // Other declarations: const IMS, CYT; // Unit definitions: unit substance = 1e-6 mole; // Display Names: substance is "micromole"; Pi_ is "Pii"; P is "Pi"; OxPhos is "Vsyn"; MiCK is "Vmick"; MMCK is "Vmmck"; ATPase is "Vhyd"; Pi_diffusion is "Jpi"; Cr_diffusion is "Jcr"; ADP_diffusion is "Jadp"; PCr_diffusion is "Jpcr"; ATP_diffusion is "Jatp"; end