// Created by libAntimony v2.8.0 model *Tyson1999() // Compartments and Species: compartment default, CYTOPLASM; species $EmptySet in default, M in CYTOPLASM, P in CYTOPLASM; // Reactions: TC: $EmptySet => M; CYTOPLASM*(TC_Vm/(1 + ((P*(1 - 2/(1 + (1 + 8*TC_Keq*P)^0.5)))/(2*TC_Pcrit))^2)); TL: $EmptySet => P; TL_V*M*CYTOPLASM; mRNAD: M => $EmptySet; mRNAD_D*M*CYTOPLASM; ProteinD: P => $EmptySet; ProteinD_D*P*CYTOPLASM; DBT: P => $EmptySet; CYTOPLASM*((DBT_k1*P*(2/(1 + (1 + 8*DBT_Keq*P)^0.5)) + DBT_k2*P)/(DBT_J + P)); // Species initializations: EmptySet = 0; M = 1/CYTOPLASM; P = 1/CYTOPLASM; // Compartment initializations: default = 1; CYTOPLASM = 1; // Variable initializations: N_A = 6.0221367e+023; TC_Vm = 1; TC_Pcrit = 0.1; TC_Keq = 200; TL_V = 0.5; mRNAD_D = 0.1; ProteinD_D = 0.1; DBT_k1 = 10; DBT_k2 = 0.03; DBT_J = 0.05; DBT_Keq = 200; // Other declarations: const default, CYTOPLASM, N_A; // Unit definitions: unit time_unit = 3600 second; // Display Names: time_unit is "hour"; P is "Pt"; TC is "transcription"; TL is "translation"; mRNAD is "mRNA degradation"; ProteinD is "protein degradation"; DBT is "Per phosphorylation and degradation"; end