// Created by libAntimony v2.8.0 model *Markevich2004_MAPK_orderedMM2kinases() // Compartments and Species: compartment uVol; species M in uVol, Mp in uVol, Mpp in uVol, $MAPKK1 in uVol, $MAPKK2 in uVol; species $MKP3 in uVol; // Reactions: v1: M => Mp; uVol*((k1cat*MAPKK1*M)/Km1/(1 + M/Km1)); v2: Mp => Mpp; uVol*((k2cat*MAPKK2*Mp)/Km2/(1 + Mp/Km2)); v3: Mpp => Mp; uVol*((k3cat*MKP3*Mpp)/Km3/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); v4: Mp => M; uVol*((k4cat*MKP3*Mp)/Km4/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); // Species initializations: M = 500/uVol; Mp = 0; Mpp = 0; MAPKK1 = 100/uVol; MAPKK2 = 1/uVol; MKP3 = 100/uVol; // Compartment initializations: uVol = 1; // Variable initializations: k1cat = 0.01; Km1 = 50; k2cat = 15; Km2 = 500; k3cat = 0.084; Km3 = 5; k4cat = 0.06; Km4 = 18; Km5 = 78; // Other declarations: const uVol, k1cat, Km1, k2cat, Km2, k3cat, Km3, k4cat, Km4, Km5; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nanomole (default)"; v1 is "phosphorylation of MAPK"; v2 is "phosphorylation of P-MAPK"; v3 is "dephosphorylation of PP-MAPK"; v4 is "dephosphorylation of P-MAPK"; end