// Created by libAntimony v2.8.0 model *model_0000001() // Compartments and Species: compartment cell; species M in cell, MpY in cell, MpT in cell, Mpp in cell, $MEK in cell; species $MKP3 in cell; // Reactions: v1: M => MpY; cell*((kcat1*MEK*M)/Km1/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); v2: MpY => Mpp; cell*((kcat2*MEK*MpY)/Km2/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); v3: M => MpT; cell*((kcat3*MEK*M)/Km3/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); v4: MpT => Mpp; cell*((kcat4*MEK*MpT)/Km4/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); v5: Mpp => MpT; cell*((kcat5*MKP3*Mpp)/Km5/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); v6: MpT => M; cell*((kcat6*MKP3*MpT)/Km6/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); v7: MpY => M; cell*((kcat7*MKP3*MpY)/Km7/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); // Species initializations: M = 800; MpY = 0; MpT = 0; Mpp = 0; MEK = 180; MKP3 = 100; // Compartment initializations: cell = 1; // Variable initializations: Km1 = 410; kcat1 = 1.08; Km2 = 40; kcat2 = 0.007; Km3 = 20; kcat3 = 0.008; Km4 = 300; kcat4 = 0.45; Km5 = 22; kcat5 = 0.084; Km6 = 18; kcat6 = 0.06; Km7 = 34; kcat7 = 0.108; Km8 = 40; // Other declarations: const cell, Km1, kcat1, Km2, kcat2, Km3, kcat3, Km4, kcat4, Km5, kcat5; const Km6, kcat6, Km7, kcat7, Km8; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nanomole (default)"; M is "ERK"; MpY is "ERK-PY"; MpT is "ERK-PT"; Mpp is "ERK-PP"; v1 is "phosphorylation of ERK on Tyr"; v2 is "phosphorylation of ERK-PY on Thr"; v3 is "phosphorylation of ERK on Thr"; v4 is "phosphorylation of ERK-PT on Tyr"; v5 is "dephosphorylation of ERK-PP on Tyr"; v6 is "dephosphorylation of ERK-PT"; v7 is "dephosphorylation of ERK-PY"; end