// Created by libAntimony v2.8.0 model *Markevich2004_MAPK_orderedelementary() // Compartments and Species: compartment uVol; species M in uVol, Mp in uVol, Mpp in uVol, MAPKK in uVol, MKP3 in uVol; species M_MAPKK in uVol, Mp_MAPKK in uVol, Mpp_MKP3 in uVol, Mp_MKP3_dep in uVol; species Mp_MKP3 in uVol, M_MKP3 in uVol; // Reactions: v1a: M + MAPKK -> M_MAPKK; uVol*(k1*M*MAPKK - k_1*M_MAPKK); v1b: M_MAPKK => Mp + MAPKK; uVol*k2*M_MAPKK; v2a: Mp + MAPKK -> Mp_MAPKK; uVol*(k3*Mp*MAPKK - k_3*Mp_MAPKK); v2b: Mp_MAPKK => Mpp + MAPKK; uVol*k4*Mp_MAPKK; v3a: Mpp + MKP3 -> Mpp_MKP3; uVol*(h1*Mpp*MKP3 - h_1*Mpp_MKP3); v3b: Mpp_MKP3 => Mp_MKP3_dep; uVol*h2*Mpp_MKP3; v3c: Mp_MKP3_dep -> Mp + MKP3; h3*Mp_MKP3_dep - h_3*Mp*MKP3; v4a: Mp + MKP3 -> Mp_MKP3; uVol*(h4*Mp*MKP3 - h_4*Mp_MKP3); v4b: Mp_MKP3 => M_MKP3; uVol*h5*Mp_MKP3; v4c: M_MKP3 -> M + MKP3; uVol*(h6*M_MKP3 - h_6*M*MKP3); // Species initializations: M = 500/uVol; Mp = 0; Mpp = 0; MAPKK = 50/uVol; MKP3 = 100/uVol; M_MAPKK = 0; Mp_MAPKK = 0; Mpp_MKP3 = 0; Mp_MKP3_dep = 0; Mp_MKP3 = 0; M_MKP3 = 0; // Compartment initializations: uVol = 1; // Variable initializations: k1 = 0.02; k_1 = 1; k2 = 0.01; k3 = 0.032; k_3 = 1; k4 = 15; h1 = 0.045; h_1 = 1; h2 = 0.092; h3 = 1; h_3 = 0.01; h4 = 0.01; h_4 = 1; h5 = 0.5; h6 = 0.086; h_6 = 0.0011; // Other declarations: const uVol, k1, k_1, k2, k3, k_3, k4, h1, h_1, h2, h3, h_3, h4, h_4, h5; const h6, h_6; // Unit definitions: unit substance = 1e-9 mole; // Display Names: substance is "nanomole (default)"; MKP3 is "MKP"; Mpp_MKP3 is "Mpp_MKP"; Mp_MKP3_dep is "Mp_MKP"; Mp_MKP3 is "Mp_MKP*"; M_MKP3 is "M_MKP"; v1a is "binding MAPK and PP-MAPKK"; v1b is "phosphorylation of MAPK"; v2a is "binding PP-MAPKK and P-MAPK"; v2b is "phosphorylation of P-MAPK"; v3a is "binding MKP and PP-MAPK"; v3b is "dephosphorylation of PP-MAPK"; v3c is "dissociation of MKP from P-MAPK"; v4a is "binding MKP and P-MAPK"; v4b is "dephosphorylation of P-MAPK"; v4c is "dissociation of MKP from MAPK"; end